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High content cellular immune profiling reveals differences between rhesus monkeys and men.

Magalhaes I, Vudattu NK, Ahmed RK, Kühlmann-Berenzon S, Ngo Y, Sizemore DR, Wehlin L, Weichold F, Andersson J, Skeiky YA, Sadoff J, Gaines H, Thorstensson R, Spångberg M, Maeurer MJ.

Immunology. 2010 Sep;131(1):128-40. doi: 10.1111/j.1365-2567.2010.03284.x. Epub 2010 May 10.


Extensive major histocompatibility complex class I binding promiscuity for Mycobacterium tuberculosis TB10.4 peptides and immune dominance of human leucocyte antigen (HLA)-B*0702 and HLA-B*0801 alleles in TB10.4 CD8 T-cell responses.

Axelsson-Robertson R, Weichold F, Sizemore D, Wulf M, Skeiky YA, Sadoff J, Maeurer MJ.

Immunology. 2010 Apr;129(4):496-505. doi: 10.1111/j.1365-2567.2009.03201.x. Epub 2009 Nov 25.


Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimen.

Skeiky YA, Dietrich J, Lasco TM, Stagliano K, Dheenadhayalan V, Goetz MA, Cantarero L, Basaraba RJ, Bang P, Kromann I, McMclain JB, Sadoff JC, Andersen P.

Vaccine. 2010 Jan 22;28(4):1084-93. doi: 10.1016/j.vaccine.2009.10.114. Epub 2009 Nov 5.


Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis.

Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, Scanga C, Grover A, Derrick SC, Morris S, Hone DM, Horwitz MA, Kaufmann SH, Sadoff JC.

Vaccine. 2009 Jul 16;27(33):4412-23. doi: 10.1016/j.vaccine.2009.05.048. Epub 2009 Jun 2.


Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys.

Reed SG, Coler RN, Dalemans W, Tan EV, DeLa Cruz EC, Basaraba RJ, Orme IM, Skeiky YA, Alderson MR, Cowgill KD, Prieels JP, Abalos RM, Dubois MC, Cohen J, Mettens P, Lobet Y.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2301-6. doi: 10.1073/pnas.0712077106. Epub 2009 Feb 2. Erratum in: Proc Natl Acad Sci U S A.2009 May 5;106(18):7678. Dalemans, Wilifred [corrected to Dalemans, Wilfried].


rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector.

Magalhaes I, Sizemore DR, Ahmed RK, Mueller S, Wehlin L, Scanga C, Weichold F, Schirru G, Pau MG, Goudsmit J, Kühlmann-Berenzon S, Spångberg M, Andersson J, Gaines H, Thorstensson R, Skeiky YA, Sadoff J, Maeurer M.

PLoS One. 2008;3(11):e3790. doi: 10.1371/journal.pone.0003790. Epub 2008 Nov 21.


Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning.

Coler RN, Dillon DC, Skeiky YA, Kahn M, Orme IM, Lobet Y, Reed SG, Alderson MR.

Vaccine. 2009 Jan 7;27(2):223-33. doi: 10.1016/j.vaccine.2008.10.056. Epub 2008 Nov 8.


Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon.

Radosevic K, Wieland CW, Rodriguez A, Weverling GJ, Mintardjo R, Gillissen G, Vogels R, Skeiky YA, Hone DM, Sadoff JC, van der Poll T, Havenga M, Goudsmit J.

Infect Immun. 2007 Aug;75(8):4105-15. Epub 2007 May 25.


Variable expression of immunoreactive surface proteins of Propionibacterium acnes.

Lodes MJ, Secrist H, Benson DR, Jen S, Shanebeck KD, Guderian J, Maisonneuve JF, Bhatia A, Persing D, Patrick S, Skeiky YAW.

Microbiology. 2006 Dec;152(Pt 12):3667-3681. doi: 10.1099/mic.0.29219-0.


Immunogenicity of Mycobacterium tuberculosis antigens in Mycobacterium bovis BCG-vaccinated and M. bovis-infected cattle.

Mustafa AS, Skeiky YA, Al-Attiyah R, Alderson MR, Hewinson RG, Vordermeier HM.

Infect Immun. 2006 Aug;74(8):4566-72.


Novel replication-incompetent adenoviral B-group vectors: high vector stability and yield in PER.C6 cells.

Havenga M, Vogels R, Zuijdgeest D, Radosevic K, Mueller S, Sieuwerts M, Weichold F, Damen I, Kaspers J, Lemckert A, van Meerendonk M, van der Vlugt R, Holterman L, Hone D, Skeiky Y, Mintardjo R, Gillissen G, Barouch D, Sadoff J, Goudsmit J.

J Gen Virol. 2006 Aug;87(Pt 8):2135-43.


Advances in tuberculosis vaccine strategies.

Skeiky YA, Sadoff JC.

Nat Rev Microbiol. 2006 Jun;4(6):469-76. Review.


Evaluation of the Mtb72F polyprotein vaccine in a rabbit model of tuberculous meningitis.

Tsenova L, Harbacheuski R, Moreira AL, Ellison E, Dalemans W, Alderson MR, Mathema B, Reed SG, Skeiky YA, Kaplan G.

Infect Immun. 2006 Apr;74(4):2392-401.


Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein.

Irwin SM, Izzo AA, Dow SW, Skeiky YA, Reed SG, Alderson MR, Orme IM.

Infect Immun. 2005 Sep;73(9):5809-16.


Protection of mice and guinea pigs against tuberculosis induced by immunization with a single Mycobacterium tuberculosis recombinant antigen, MTB41.

Skeiky YA, Alderson MR, Ovendale PJ, Lobet Y, Dalemans W, Orme IM, Reed SG, Campos-Neto A.

Vaccine. 2005 Jun 10;23(30):3937-45. Epub 2005 Mar 30.


Novel recombinant BCG and DNA-vaccination against tuberculosis in a cynomolgus monkey model.

Kita Y, Tanaka T, Yoshida S, Ohara N, Kaneda Y, Kuwayama S, Muraki Y, Kanamaru N, Hashimoto S, Takai H, Okada C, Fukunaga Y, Sakaguchi Y, Furukawa I, Yamada K, Inoue Y, Takemoto Y, Naito M, Yamada T, Matsumoto M, McMurray DN, Cruz EC, Tan EV, Abalos RM, Burgos JA, Gelber R, Skeiky Y, Reed S, Sakatani M, Okada M.

Vaccine. 2005 Mar 18;23(17-18):2132-5.


The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs.

Brandt L, Skeiky YA, Alderson MR, Lobet Y, Dalemans W, Turner OC, Basaraba RJ, Izzo AA, Lasco TM, Chapman PL, Reed SG, Orme IM.

Infect Immun. 2004 Nov;72(11):6622-32.


In vitro cellular immune responses to complex and newly defined recombinant antigens of Mycobacterium tuberculosis.

Al-Attiyah R, Mustafa AS, Abal AT, El-Shamy AS, Dalemans W, Skeiky YA.

Clin Exp Immunol. 2004 Oct;138(1):139-44.


Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein.

Skeiky YA, Alderson MR, Ovendale PJ, Guderian JA, Brandt L, Dillon DC, Campos-Neto A, Lobet Y, Dalemans W, Orme IM, Reed SG.

J Immunol. 2004 Jun 15;172(12):7618-28.


Expression cloning.

Lodes MJ, Dillon DC, Houghton RL, Skeiky YA.

Methods Mol Med. 2004;94:91-106.


Immune responses to mycobacterial antigens in the Gambian population: implications for vaccines and immunodiagnostic test design.

Vekemans J, Ota MO, Sillah J, Fielding K, Alderson MR, Skeiky YA, Dalemans W, McAdam KP, Lienhardt C, Marchant A.

Infect Immun. 2004 Jan;72(1):381-8.


Cloning and characterization of a gene encoding an immunoglobulin-binding receptor on the cell surface of some members of the family Trypanosomatidae.

Campos-Neto A, Suffia I, Cavassani KA, Jen S, Greeson K, Ovendale P, Silva JS, Reed SG, Skeiky YA.

Infect Immun. 2003 Sep;71(9):5065-76.


A novel method for increasing the expression level of recombinant proteins.

Wang A, Clapper J, Guderian JA, Foy TM, Fanger GR, Retter MW, Skeiky YA.

Protein Expr Purif. 2003 Jul;30(1):124-33.


Prospects for a better vaccine against tuberculosis.

Reed SG, Alderson MR, Dalemans W, Lobet Y, Skeiky YA.

Tuberculosis (Edinb). 2003;83(1-3):213-9. Review.


Dendritic cell (DC)-based protection against an intracellular pathogen is dependent upon DC-derived IL-12 and can be induced by molecularly defined antigens.

Berberich C, Ramírez-Pineda JR, Hambrecht C, Alber G, Skeiky YA, Moll H.

J Immunol. 2003 Mar 15;170(6):3171-9.


Lipoarabinomannan-reactive human secretory immunoglobulin A responses induced by mucosal bacille Calmette-Guérin vaccination.

Brown RM, Cruz O, Brennan M, Gennaro ML, Schlesinger L, Skeiky YA, Hoft DF.

J Infect Dis. 2003 Feb 1;187(3):513-7. Epub 2003 Jan 24.


Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant.

Skeiky YA, Coler RN, Brannon M, Stromberg E, Greeson K, Crane RT, Webb JR, Campos-Neto A, Reed SG.

Vaccine. 2002 Sep 10;20(27-28):3292-303. Erratum in: Vaccine. 2002 Nov 1;20(31-32):3783..


Use of multiepitope polyproteins in serodiagnosis of active tuberculosis.

Houghton RL, Lodes MJ, Dillon DC, Reynolds LD, Day CH, McNeill PD, Hendrickson RC, Skeiky YA, Sampaio DP, Badaro R, Lyashchenko KP, Reed SG.

Clin Diagn Lab Immunol. 2002 Jul;9(4):883-91.


Evaluation of DPPD, a single recombinant Mycobacterium tuberculosis protein as an alternative antigen for the Mantoux test.

Campos-Neto A, Rodrigues-Júnior V, Pedral-Sampaio DB, Netto EM, Ovendale PJ, Coler RN, Skeiky YA, Badaró R, Reed SG.

Tuberculosis (Edinb). 2001;81(5-6):353-8.


Potent stimulation of the innate immune system by a Leishmania brasiliensis recombinant protein.

Borges MM, Campos-Neto A, Sleath P, Grabstein KH, Morrissey PJ, Skeiky YA, Reed SG.

Infect Immun. 2001 Sep;69(9):5270-7.


Serological expression cloning and immunological evaluation of MTB48, a novel Mycobacterium tuberculosis antigen.

Lodes MJ, Dillon DC, Mohamath R, Day CH, Benson DR, Reynolds LD, McNeill P, Sampaio DP, Skeiky YA, Badaro R, Persing DH, Reed SG, Houghton RL.

J Clin Microbiol. 2001 Jul;39(7):2485-93.


Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis.

Moran AJ, Treit JD, Whitney JL, Abomoelak B, Houghton R, Skeiky YA, Sampaio DP, Badaró R, Nano FE.

FEMS Microbiol Lett. 2001 Apr 20;198(1):31-6.


WT1-specific serum antibodies in patients with leukemia.

Gaiger A, Carter L, Greinix H, Carter D, McNeill PD, Houghton RL, Cornellison CD, Vedvick TS, Skeiky YA, Cheever MA.

Clin Cancer Res. 2001 Mar;7(3 Suppl):761s-765s.


The potency and durability of DNA- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge.

Méndez S, Gurunathan S, Kamhawi S, Belkaid Y, Moga MA, Skeiky YA, Campos-Neto A, Reed S, Seder RA, Sacks D.

J Immunol. 2001 Apr 15;166(8):5122-8.


T cell expression cloning of a Mycobacterium tuberculosis gene encoding a protective antigen associated with the early control of infection.

Skeiky YA, Ovendale PJ, Jen S, Alderson MR, Dillon DC, Smith S, Wilson CB, Orme IM, Reed SG, Campos-Neto A.

J Immunol. 2000 Dec 15;165(12):7140-9.


Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10, an immunodiagnostic antigen missing in Mycobacterium bovis BCG.

Dillon DC, Alderson MR, Day CH, Bement T, Campos-Neto A, Skeiky YA, Vedvick T, Badaro R, Reed SG, Houghton R.

J Clin Microbiol. 2000 Sep;38(9):3285-90.


Cloning of a Mycobacterium tuberculosis gene encoding a purifed protein derivative protein that elicits strong tuberculosis-specific delayed-type hypersensitivity.

Coler RN, Skeiky YA, Ovendale PJ, Vedvick TS, Gervassi L, Guderian J, Jen S, Reed SG, Campos-Neto A.

J Infect Dis. 2000 Jul;182(1):224-33. Epub 2000 Jul 6.


Expression cloning of an immunodominant family of Mycobacterium tuberculosis antigens using human CD4(+) T cells.

Alderson MR, Bement T, Day CH, Zhu L, Molesh D, Skeiky YA, Coler R, Lewinsohn DM, Reed SG, Dillon DC.

J Exp Med. 2000 Feb 7;191(3):551-60.


Multiepitope synthetic peptide and recombinant protein for the detection of antibodies to Trypanosoma cruzi in patients with treated or untreated Chagas' disease.

Houghton RL, Benson DR, Reynolds L, McNeill P, Sleath P, Lodes M, Skeiky YA, Badaro R, Krettli AU, Reed SG.

J Infect Dis. 2000 Jan;181(1):325-30.


Cloning, characterization and serological evaluation of K9 and K26: two related hydrophilic antigens of Leishmania chagasi.

Bhatia A, Daifalla NS, Jen S, Badaro R, Reed SG, Skeiky YA.

Mol Biochem Parasitol. 1999 Aug 20;102(2):249-61.


Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis.

Skeiky YA, Lodes MJ, Guderian JA, Mohamath R, Bement T, Alderson MR, Reed SG.

Infect Immun. 1999 Aug;67(8):3998-4007.


Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family.

Dillon DC, Alderson MR, Day CH, Lewinsohn DM, Coler R, Bement T, Campos-Neto A, Skeiky YA, Orme IM, Roberts A, Steen S, Dalemans W, Badaro R, Reed SG.

Infect Immun. 1999 Jun;67(6):2941-50.


A multi-epitope synthetic peptide and recombinant protein for the detection of antibodies to Trypanosoma cruzi in radioimmunoprecipitation-confirmed and consensus-positive sera.

Houghton RL, Benson DR, Reynolds LD, McNeill PD, Sleath PR, Lodes MJ, Skeiky YA, Leiby DA, Badaro R, Reed SG.

J Infect Dis. 1999 May;179(5):1226-34.


LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile.

Skeiky YA, Kennedy M, Kaufman D, Borges MM, Guderian JA, Scholler JK, Ovendale PJ, Picha KS, Morrissey PJ, Grabstein KH, Campos-Neto A, Reed SG.

J Immunol. 1998 Dec 1;161(11):6171-9.


Molecular cloning and immunologic reactivity of a novel low molecular mass antigen of Mycobacterium tuberculosis.

Coler RN, Skeiky YA, Vedvick T, Bement T, Ovendale P, Campos-Neto A, Alderson MR, Reed SG.

J Immunol. 1998 Sep 1;161(5):2356-64.


Molecular cloning, expression, and immunogenicity of MTB12, a novel low-molecular-weight antigen secreted by Mycobacterium tuberculosis.

Webb JR, Vedvick TS, Alderson MR, Guderian JA, Jen SS, Ovendale PJ, Johnson SM, Reed SG, Skeiky YA.

Infect Immun. 1998 Sep;66(9):4208-14.


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