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Items: 1 to 50 of 69

1.

Structure of the Fanconi anaemia monoubiquitin ligase complex.

Shakeel S, Rajendra E, Alcón P, O'Reilly F, Chorev DS, Maslen S, Degliesposti G, Russo CJ, He S, Hill CH, Skehel JM, Scheres SHW, Patel KJ, Rappsilber J, Robinson CV, Passmore LA.

Nature. 2019 Oct 30. doi: 10.1038/s41586-019-1703-4. [Epub ahead of print]

PMID:
31666700
2.

Architecture of the mycobacterial type VII secretion system.

Famelis N, Rivera-Calzada A, Degliesposti G, Wingender M, Mietrach N, Skehel JM, Fernandez-Leiro R, Böttcher B, Schlosser A, Llorca O, Geibel S.

Nature. 2019 Oct 9. doi: 10.1038/s41586-019-1633-1. [Epub ahead of print]

PMID:
31597161
3.

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.

Iacobucci C, Piotrowski C, Aebersold R, Amaral BC, Andrews P, Bernfur K, Borchers C, Brodie NI, Bruce JE, Cao Y, Chaignepain S, Chavez JD, Claverol S, Cox J, Davis T, Degliesposti G, Dong MQ, Edinger N, Emanuelsson C, Gay M, Götze M, Gomes-Neto F, Gozzo FC, Gutierrez C, Haupt C, Heck AJR, Herzog F, Huang L, Hoopmann MR, Kalisman N, Klykov O, Kukačka Z, Liu F, MacCoss MJ, Mechtler K, Mesika R, Moritz RL, Nagaraj N, Nesati V, Neves-Ferreira AGC, Ninnis R, Novák P, O'Reilly FJ, Pelzing M, Petrotchenko E, Piersimoni L, Plasencia M, Pukala T, Rand KD, Rappsilber J, Reichmann D, Sailer C, Sarnowski CP, Scheltema RA, Schmidt C, Schriemer DC, Shi Y, Skehel JM, Slavin M, Sobott F, Solis-Mezarino V, Stephanowitz H, Stengel F, Stieger CE, Trabjerg E, Trnka M, Vilaseca M, Viner R, Xiang Y, Yilmaz S, Zelter A, Ziemianowicz D, Leitner A, Sinz A.

Anal Chem. 2019 Jun 4;91(11):6953-6961. doi: 10.1021/acs.analchem.9b00658. Epub 2019 May 22.

4.

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling.

Fletcher AJ, Vaysburd M, Maslen S, Zeng J, Skehel JM, Towers GJ, James LC.

Cell Host Microbe. 2018 Dec 12;24(6):761-775.e6. doi: 10.1016/j.chom.2018.10.007. Epub 2018 Nov 29.

5.

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.

Bellelli R, Belan O, Pye VE, Clement C, Maslen SL, Skehel JM, Cherepanov P, Almouzni G, Boulton SJ.

Mol Cell. 2018 Oct 4;72(1):112-126.e5. doi: 10.1016/j.molcel.2018.08.043. Epub 2018 Sep 11.

6.

Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O.

Nat Commun. 2018 Jul 31;9(1):3063. doi: 10.1038/s41467-018-05546-1.

7.

Mechanism of parkin activation by PINK1.

Gladkova C, Maslen SL, Skehel JM, Komander D.

Nature. 2018 Jul;559(7714):410-414. doi: 10.1038/s41586-018-0224-x. Epub 2018 Jun 6.

8.

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.

Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O.

Nat Commun. 2018 Apr 16;9(1):1501. doi: 10.1038/s41467-018-03942-1. Erratum in: Nat Commun. 2018 Jul 31;9(1):3063.

9.

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.

Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S.

Mol Cell. 2017 Dec 7;68(5):847-859.e7. doi: 10.1016/j.molcel.2017.10.017.

10.

High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center.

Baños-Mateos S, van Roon AM, Lang UF, Maslen SL, Skehel JM, Lamers MH.

Nat Commun. 2017 Oct 11;8(1):855. doi: 10.1038/s41467-017-00886-w.

11.

The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System.

Rivera-Calzada A, Pal M, Muñoz-Hernández H, Luque-Ortega JR, Gil-Carton D, Degliesposti G, Skehel JM, Prodromou C, Pearl LH, Llorca O.

Structure. 2017 Jul 5;25(7):1145-1152.e4. doi: 10.1016/j.str.2017.05.016. Epub 2017 Jun 22.

12.

The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation.

Bandara M, Skehel JM, Kadioglu A, Collinson I, Nobbs AH, Blocker AJ, Jenkinson HF.

Microbes Infect. 2017 Jul - Aug;19(7-8):402-412. doi: 10.1016/j.micinf.2017.04.003. Epub 2017 Apr 27.

13.

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.

Clarke TL, Sanchez-Bailon MP, Chiang K, Reynolds JJ, Herrero-Ruiz J, Bandeiras TM, Matias PM, Maslen SL, Skehel JM, Stewart GS, Davies CC.

Mol Cell. 2017 Mar 2;65(5):900-916.e7. doi: 10.1016/j.molcel.2017.01.019. Epub 2017 Feb 23.

14.

Structure of the Escherichia coli ProQ RNA-binding protein.

Gonzalez GM, Hardwick SW, Maslen SL, Skehel JM, Holmqvist E, Vogel J, Bateman A, Luisi BF, Broadhurst RW.

RNA. 2017 May;23(5):696-711. doi: 10.1261/rna.060343.116. Epub 2017 Feb 13.

15.

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.

Stingele J, Bellelli R, Alte F, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A, Kjær S, Tainer JA, Skehel JM, Groll M, Boulton SJ.

Mol Cell. 2016 Nov 17;64(4):688-703. doi: 10.1016/j.molcel.2016.09.031. Epub 2016 Oct 27.

16.

The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability.

Myers KN, Barone G, Ganesh A, Staples CJ, Howard AE, Beveridge RD, Maslen S, Skehel JM, Collis SJ.

Sci Rep. 2016 Oct 14;6:35548. doi: 10.1038/srep35548.

17.

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response.

Staples CJ, Barone G, Myers KN, Ganesh A, Gibbs-Seymour I, Patil AA, Beveridge RD, Daye C, Beniston R, Maslen S, Ahel I, Skehel JM, Collis SJ.

Cell Rep. 2016 Sep 6;16(10):2565-2575. doi: 10.1016/j.celrep.2016.07.087. Epub 2016 Aug 25.

18.

Composition and Activity of the Non-canonical Gram-positive SecY2 Complex.

Bandara M, Corey RA, Martin R, Skehel JM, Blocker AJ, Jenkinson HF, Collinson I.

J Biol Chem. 2016 Oct 7;291(41):21474-21484. Epub 2016 Aug 22.

19.

Human CDK18 promotes replication stress signaling and genome stability.

Barone G, Staples CJ, Ganesh A, Patterson KW, Bryne DP, Myers KN, Patil AA, Eyers CE, Maslen S, Skehel JM, Eyers PA, Collis SJ.

Nucleic Acids Res. 2016 Oct 14;44(18):8772-8785. Epub 2016 Jul 5.

20.

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins.

Guilliam TA, Jozwiakowski SK, Ehlinger A, Barnes RP, Rudd SG, Bailey LJ, Skehel JM, Eckert KA, Chazin WJ, Doherty AJ.

Nucleic Acids Res. 2015 Jan;43(2):1056-68. doi: 10.1093/nar/gku1321. Epub 2014 Dec 29.

21.

The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling.

Beveridge RD, Staples CJ, Patil AA, Myers KN, Maslen S, Skehel JM, Boulton SJ, Collis SJ.

Cell Cycle. 2014;13(21):3450-9. doi: 10.4161/15384101.2014.956529.

22.

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

Roy R, Durie D, Li H, Liu BQ, Skehel JM, Mauri F, Cuorvo LV, Barbareschi M, Guo L, Holcik M, Seckl MJ, Pardo OE.

Nucleic Acids Res. 2014 Nov 10;42(20):12483-97. doi: 10.1093/nar/gku953. Epub 2014 Oct 16.

23.

Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.

Staples CJ, Myers KN, Beveridge RD, Patil AA, Howard AE, Barone G, Lee AJ, Swanton C, Howell M, Maslen S, Skehel JM, Boulton SJ, Collis SJ.

J Cell Sci. 2014 Jul 1;127(Pt 13):2910-9. doi: 10.1242/jcs.147785. Epub 2014 May 9.

24.

Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.

Hořejší Z, Stach L, Flower TG, Joshi D, Flynn H, Skehel JM, O'Reilly NJ, Ogrodowicz RW, Smerdon SJ, Boulton SJ.

Cell Rep. 2014 Apr 10;7(1):19-26. doi: 10.1016/j.celrep.2014.03.013. Epub 2014 Mar 20.

25.

Hekate: software suite for the mass spectrometric analysis and three-dimensional visualization of cross-linked protein samples.

Holding AN, Lamers MH, Stephens E, Skehel JM.

J Proteome Res. 2013 Dec 6;12(12):5923-33. doi: 10.1021/pr4003867. Epub 2013 Oct 4.

26.

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.

Adelman CA, Lolo RL, Birkbak NJ, Murina O, Matsuzaki K, Horejsi Z, Parmar K, Borel V, Skehel JM, Stamp G, D'Andrea A, Sartori AA, Swanton C, Boulton SJ.

Nature. 2013 Oct 17;502(7471):381-4. doi: 10.1038/nature12565. Epub 2013 Sep 4.

27.

MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.

Gari K, León Ortiz AM, Borel V, Flynn H, Skehel JM, Boulton SJ.

Science. 2012 Jul 13;337(6091):243-5. doi: 10.1126/science.1219664. Epub 2012 Jun 7.

28.

Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.

Olivieri A, Collins CR, Hackett F, Withers-Martinez C, Marshall J, Flynn HR, Skehel JM, Blackman MJ.

PLoS Pathog. 2011 Dec;7(12):e1002448. doi: 10.1371/journal.ppat.1002448. Epub 2011 Dec 15. Erratum in: PLoS Pathog. 2012 Feb;8(2). doi:10.1371/annotation/72b02b2e-460a-44f4-bc87-067cfe76bfdb.

29.

Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis.

Matos J, Blanco MG, Maslen S, Skehel JM, West SC.

Cell. 2011 Sep 30;147(1):158-72. doi: 10.1016/j.cell.2011.08.032.

30.

Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease.

Silmon de Monerri NC, Flynn HR, Campos MG, Hackett F, Koussis K, Withers-Martinez C, Skehel JM, Blackman MJ.

Infect Immun. 2011 Mar;79(3):1086-97. doi: 10.1128/IAI.00902-10. Epub 2011 Jan 10.

31.

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

Horejsí Z, Takai H, Adelman CA, Collis SJ, Flynn H, Maslen S, Skehel JM, de Lange T, Boulton SJ.

Mol Cell. 2010 Sep 24;39(6):839-50. doi: 10.1016/j.molcel.2010.08.037.

32.

A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae.

Taschner M, Harreman M, Teng Y, Gill H, Anindya R, Maslen SL, Skehel JM, Waters R, Svejstrup JQ.

Mol Cell Biol. 2010 Jan;30(2):436-46. doi: 10.1128/MCB.00822-09. Epub 2009 Nov 9.

33.

Identification of Holliday junction resolvases from humans and yeast.

Ip SC, Rass U, Blanco MG, Flynn HR, Skehel JM, West SC.

Nature. 2008 Nov 20;456(7220):357-61. doi: 10.1038/nature07470.

PMID:
19020614
34.

FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.

Collis SJ, Ciccia A, Deans AJ, Horejsí Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ.

Mol Cell. 2008 Nov 7;32(3):313-24. doi: 10.1016/j.molcel.2008.10.014.

35.

The discovery and early validation of novel plasma biomarkers in mild-to-moderate Alzheimer's disease patients responding to treatment with rosiglitazone.

Akuffo EL, Davis JB, Fox SM, Gloger IS, Hosford D, Kinsey EE, Jones NA, Nock CM, Roses AD, Saunders AM, Skehel JM, Smith MA, Cutler P.

Biomarkers. 2008 Sep;13(6):618-36. doi: 10.1080/13547500802445199 .

PMID:
18830857
36.

Mass spectrometric compatibility of Deep Purple and SYPRO Ruby total protein stains for high-throughput proteomics using large-format two-dimensional gel electrophoresis.

Nock CM, Ball MS, White IR, Skehel JM, Bill L, Karuso P.

Rapid Commun Mass Spectrom. 2008;22(6):881-6. doi: 10.1002/rcm.3483.

PMID:
18293286
37.

Bovine complex I is a complex of 45 different subunits.

Carroll J, Fearnley IM, Skehel JM, Shannon RJ, Hirst J, Walker JE.

J Biol Chem. 2006 Oct 27;281(43):32724-7. Epub 2006 Sep 1.

38.

The post-translational modifications of the nuclear encoded subunits of complex I from bovine heart mitochondria.

Carroll J, Fearnley IM, Skehel JM, Runswick MJ, Shannon RJ, Hirst J, Walker JE.

Mol Cell Proteomics. 2005 May;4(5):693-9. Epub 2005 Feb 22.

39.

A statistical comparison of silver and SYPRO Ruby staining for proteomic analysis.

White IR, Pickford R, Wood J, Skehel JM, Gangadharan B, Cutler P.

Electrophoresis. 2004 Sep;25(17):3048-54.

PMID:
15349947
40.

Preparation of extracts from animal tissues.

Skehel JM.

Methods Mol Biol. 2004;244:15-20. No abstract available.

PMID:
14970538
41.

Proteomic analysis of rat kidney cortex following treatment with gentamicin.

Charlwood J, Skehel JM, King N, Camilleri P, Lord P, Bugelski P, Atif U.

J Proteome Res. 2002 Jan-Feb;1(1):73-82.

PMID:
12643529
42.

Analysis of N-linked oligosaccharides: progress towards the characterisation of glycoprotein-linked carbohydrates.

Charlwood J, Bryant D, Skehel JM, Camilleri P.

Biomol Eng. 2001 Nov;18(5):229-40. Review.

PMID:
11911090
43.

Immobilisation of antibodies in gels allows the improved release and identification of glycans.

Charlwood J, Skehel JM, Camilleri P.

Proteomics. 2001 Feb;1(2):275-84.

PMID:
11680874
44.

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

Charlwood J, Dingwall C, Matico R, Hussain I, Johanson K, Moore S, Powell DJ, Skehel JM, Ratcliffe S, Clarke B, Trill J, Sweitzer S, Camilleri P.

J Biol Chem. 2001 May 18;276(20):16739-48. Epub 2001 Jan 30.

45.

Phenotyping apolipoprotein E*3-leiden transgenic mice by two-dimensional polyacrylamide gel electrophoresis and mass spectrometric identification.

Skehel JM, Schneider K, Murphy N, Graham A, Benson GM, Cutler P, Camilleri P.

Electrophoresis. 2000 Jul;21(12):2540-5.

PMID:
10939469
46.

Analysis of N-linked oligosaccharides released from glycoproteins separated by two-dimensional gel electrophoresis.

Charlwood J, Skehel JM, Camilleri P.

Anal Biochem. 2000 Aug 15;284(1):49-59.

PMID:
10933855
47.

An integrated proteomic approach to studying glomerular nephrotoxicity.

Cutler P, Bell DJ, Birrell HC, Connelly JC, Connor SC, Holmes E, Mitchell BC, Monté SY, Neville BA, Pickford R, Polley S, Schneider K, Skehel JM.

Electrophoresis. 1999 Dec;20(18):3647-58.

PMID:
10612292
48.
49.

The ATPase inhibitor protein from bovine heart mitochondria: the minimal inhibitory sequence.

van Raaij MJ, Orriss GL, Montgomery MG, Runswick MJ, Fearnley IM, Skehel JM, Walker JE.

Biochemistry. 1996 Dec 10;35(49):15618-25.

PMID:
8961923
50.

The F1F0-ATPase complex from bovine heart mitochondria: the molar ratio of the subunits in the stalk region linking the F1 and F0 domains.

Collinson IR, Skehel JM, Fearnley IM, Runswick MJ, Walker JE.

Biochemistry. 1996 Sep 24;35(38):12640-6.

PMID:
8823202

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