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Items: 1 to 50 of 86

1.

Improving homology-directed repair efficiency in human stem cells.

Skarnes WC, Pellegrino E, McDonough JA.

Methods. 2019 Jul 15;164-165:18-28. doi: 10.1016/j.ymeth.2019.06.016. Epub 2019 Jun 16.

PMID:
31216442
2.

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".

Nutter LMJ, Heaney JD, Lloyd KCK, Murray SA, Seavitt JR, Skarnes WC, Teboul L, Brown SDM, Moore M.

Nat Methods. 2018 Apr;15(4):235-236. doi: 10.1038/nmeth.4559. Epub 2018 Mar 30. No abstract available.

PMID:
29600991
3.

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie Helmut Fuchs SM, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Nutter SNLMJ, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A; International Mouse Phenotyping Consortium, Wurst W, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SDM, Adams DJ, Lloyd KCK, McKerlie C, Beaudet AL, Murray MBSA.

Nature. 2017 Nov 16;551(7680):398. doi: 10.1038/nature24643. Epub 2017 Nov 8.

4.

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L; International Mouse Phenotyping Consortium, Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, Beaudet AL, Justice MJ, Seavitt J, Dickinson ME, Wurst W, de Angelis MH, Herault Y, Wakana S, Nutter LMJ, Flenniken AM, McKerlie C, Murray SA, Svenson KL, Braun RE, West DB, Lloyd KCK, Adams DJ, White J, Karp N, Flicek P, Smedley D, Meehan TF, Parkinson HE, Teboul LM, Wells S, Steel KP, Mallon AM, Brown SDM.

Nat Commun. 2017 Oct 12;8(1):886. doi: 10.1038/s41467-017-00595-4.

5.

An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.

Fisher CL, Marks H, Cho LT, Andrews R, Wormald S, Carroll T, Iyer V, Tate P, Rosen B, Stunnenberg HG, Fisher AG, Skarnes WC.

Nucleic Acids Res. 2017 Dec 1;45(21):e174. doi: 10.1093/nar/gkx811.

6.

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N; International Mouse Phenotyping Consortium, Haendel M, Washington N, Mungall CJ, Reynolds CL, Gallegos J, Gailus-Durner V, Sorg T, Pavlovic G, Bower LR, Moore M, Morse I, Gao X, Tocchini-Valentini GP, Obata Y, Cho SY, Seong JK, Seavitt J, Beaudet AL, Dickinson ME, Herault Y, Wurst W, de Angelis MH, Lloyd KCK, Flenniken AM, Nutter LMJ, Newbigging S, McKerlie C, Justice MJ, Murray SA, Svenson KL, Braun RE, White JK, Bradley A, Flicek P, Wells S, Skarnes WC, Adams DJ, Parkinson H, Mallon AM, Brown SDM, Smedley D.

Nat Genet. 2017 Aug;49(8):1231-1238. doi: 10.1038/ng.3901. Epub 2017 Jun 26.

7.

Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries.

Metzakopian E, Strong A, Iyer V, Hodgkins A, Tzelepis K, Antunes L, Friedrich MJ, Kang Q, Davidson T, Lamberth J, Hoffmann C, Davis GD, Vassiliou GS, Skarnes WC, Bradley A.

Sci Rep. 2017 May 22;7(1):2244. doi: 10.1038/s41598-017-01766-5.

8.

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

Yeung ATY, Hale C, Lee AH, Gill EE, Bushell W, Parry-Smith D, Goulding D, Pickard D, Roumeliotis T, Choudhary J, Thomson N, Skarnes WC, Dougan G, Hancock REW.

Nat Commun. 2017 Apr 25;8:15013. doi: 10.1038/ncomms15013.

9.

One-step generation of conditional and reversible gene knockouts.

Andersson-Rolf A, Mustata RC, Merenda A, Kim J, Perera S, Grego T, Andrews K, Tremble K, Silva JC, Fink J, Skarnes WC, Koo BK.

Nat Methods. 2017 Mar;14(3):287-289. doi: 10.1038/nmeth.4156. Epub 2017 Jan 30.

10.

Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells.

Bressan RB, Dewari PS, Kalantzaki M, Gangoso E, Matjusaitis M, Garcia-Diaz C, Blin C, Grant V, Bulstrode H, Gogolok S, Skarnes WC, Pollard SM.

Development. 2017 Feb 15;144(4):635-648. doi: 10.1242/dev.140855. Epub 2017 Jan 17.

11.

High-throughput discovery of novel developmental phenotypes.

Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A; International Mouse Phenotyping Consortium; Jackson Laboratory; Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource Center, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA.

Nature. 2016 Sep 22;537(7621):508-514. doi: 10.1038/nature19356. Epub 2016 Sep 14. Erratum in: Nature. 2017 Nov 16;551(7680):398.

12.

CRISPR-Cas9 enables conditional mutagenesis of challenging loci.

Schick JA, Seisenberger C, Beig J, Bürger A, Iyer V, Maier V, Perera S, Rosen B, Skarnes WC, Wurst W.

Sci Rep. 2016 Sep 1;6:32326. doi: 10.1038/srep32326.

13.

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.

Coelho PA, Bury L, Shahbazi MN, Liakath-Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC, Zernicka-Goetz M, Glover DM.

Open Biol. 2015 Dec;5(12):150209. doi: 10.1098/rsob.150209.

14.

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.

Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1728-48. doi: 10.1016/j.bbamcr.2015.10.014. Epub 2015 Oct 31.

15.

Off-target mutations are rare in Cas9-modified mice.

Iyer V, Shen B, Zhang W, Hodgkins A, Keane T, Huang X, Skarnes WC.

Nat Methods. 2015 Jun;12(6):479. doi: 10.1038/nmeth.3408. No abstract available.

PMID:
26020497
16.

Is mouse embryonic stem cell technology obsolete?

Skarnes WC.

Genome Biol. 2015 May 27;16:109. doi: 10.1186/s13059-015-0673-6.

17.

WGE: a CRISPR database for genome engineering.

Hodgkins A, Farne A, Perera S, Grego T, Parry-Smith DJ, Skarnes WC, Iyer V.

Bioinformatics. 2015 Sep 15;31(18):3078-80. doi: 10.1093/bioinformatics/btv308. Epub 2015 May 14.

18.

Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.

Yeung AT, Hale C, Xia J, Tate PH, Goulding D, Keane JA, Mukhopadhyay S, Forrester L, Billker O, Skarnes WC, Hancock RE, Dougan G.

Sci Rep. 2015 Mar 10;5:8908. doi: 10.1038/srep08908.

19.

ZFP57 and the Targeted Maintenance of Postfertilization Genomic Imprints.

Takahashi N, Gray D, Strogantsev R, Noon A, Delahaye C, Skarnes WC, Tate PH, Ferguson-Smith AC.

Cold Spring Harb Symp Quant Biol. 2015;80:177-87. doi: 10.1101/sqb.2015.80.027466. Review.

PMID:
27325708
20.

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

Shen B, Zhang W, Zhang J, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC.

Nat Methods. 2014 Apr;11(4):399-402. doi: 10.1038/nmeth.2857. Epub 2014 Mar 2.

PMID:
24584192
21.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.

Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H.

Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9. doi: 10.1093/nar/gkt977. Epub 2013 Nov 4.

22.

Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.

Ryder E, Gleeson D, Sethi D, Vyas S, Miklejewska E, Dalvi P, Habib B, Cook R, Hardy M, Jhaveri K, Bottomley J, Wardle-Jones H, Bussell JN, Houghton R, Salisbury J, Skarnes WC; Sanger Mouse Genetics Project, Ramirez-Solis R.

Mamm Genome. 2013 Aug;24(7-8):286-94. doi: 10.1007/s00335-013-9467-x. Epub 2013 Aug 4.

23.

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC; Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP.

Cell. 2013 Jul 18;154(2):452-64. doi: 10.1016/j.cell.2013.06.022.

24.

Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans.

Mallon AM, Iyer V, Melvin D, Morgan H, Parkinson H, Brown SD, Flicek P, Skarnes WC.

Mamm Genome. 2012 Oct;23(9-10):641-52. doi: 10.1007/s00335-012-9428-9. Epub 2012 Sep 19.

25.

The mammalian gene function resource: the International Knockout Mouse Consortium.

Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W.

Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12.

26.

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

Ayadi A, Birling MC, Bottomley J, Bussell J, Fuchs H, Fray M, Gailus-Durner V, Greenaway S, Houghton R, Karp N, Leblanc S, Lengger C, Maier H, Mallon AM, Marschall S, Melvin D, Morgan H, Pavlovic G, Ryder E, Skarnes WC, Selloum M, Ramirez-Solis R, Sorg T, Teboul L, Vasseur L, Walling A, Weaver T, Wells S, White JK, Bradley A, Adams DJ, Steel KP, Hrabě de Angelis M, Brown SD, Herault Y.

Mamm Genome. 2012 Oct;23(9-10):600-10. doi: 10.1007/s00335-012-9418-y. Epub 2012 Sep 9. Review.

27.

Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines.

Davis MP, Abreu-Goodger C, van Dongen S, Lu D, Tate PH, Bartonicek N, Kutter C, Liu P, Skarnes WC, Enright AJ, Dunham I.

PLoS One. 2012;7(8):e41762. doi: 10.1371/journal.pone.0041762. Epub 2012 Aug 17.

28.

MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs.

Lu D, Davis MP, Abreu-Goodger C, Wang W, Campos LS, Siede J, Vigorito E, Skarnes WC, Dunham I, Enright AJ, Liu P.

PLoS One. 2012;7(8):e40938. doi: 10.1371/journal.pone.0040938. Epub 2012 Aug 17.

29.

Building and sharing resources. Interview by Krystie Nybo.

Skarnes WC.

Biotechniques. 2012 May;52(5):299. doi: 10.2144/000113846. No abstract available.

30.

BioMart as an integration solution for the International Knockout Mouse Consortium.

Oakley DJ, Iyer V, Skarnes WC, Smedley D.

Database (Oxford). 2011 Sep 18;2011:bar028. doi: 10.1093/database/bar028. Print 2011.

31.

A conditional knockout resource for the genome-wide study of mouse gene function.

Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A.

Nature. 2011 Jun 15;474(7351):337-42. doi: 10.1038/nature10163.

32.

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.

Migliorini D, Bogaerts S, Defever D, Vyas R, Denecker G, Radaelli E, Zwolinska A, Depaepe V, Hochepied T, Skarnes WC, Marine JC.

J Clin Invest. 2011 Apr;121(4):1329-43. doi: 10.1172/JCI45784. Epub 2011 Mar 14.

33.

Bi-allelic gene targeting in mouse embryonic stem cells.

Tate PH, Skarnes WC.

Methods. 2011 Apr;53(4):331-8. doi: 10.1016/j.ymeth.2010.12.025. Epub 2011 Feb 1.

34.

Dual RMCE for efficient re-engineering of mouse mutant alleles.

Osterwalder M, Galli A, Rosen B, Skarnes WC, Zeller R, Lopez-Rios J.

Nat Methods. 2010 Nov;7(11):893-5. doi: 10.1038/nmeth.1521. Epub 2010 Oct 17.

35.

The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium.

Ringwald M, Iyer V, Mason JC, Stone KR, Tadepally HD, Kadin JA, Bult CJ, Eppig JT, Oakley DJ, Briois S, Stupka E, Maselli V, Smedley D, Liu S, Hansen J, Baldock R, Hicks GG, Skarnes WC.

Nucleic Acids Res. 2011 Jan;39(Database issue):D849-55. doi: 10.1093/nar/gkq879. Epub 2010 Oct 6.

36.

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

Landeira D, Sauer S, Poot R, Dvorkina M, Mazzarella L, Jørgensen HF, Pereira CF, Leleu M, Piccolo FM, Spivakov M, Brookes E, Pombo A, Fisher C, Skarnes WC, Snoek T, Bezstarosti K, Demmers J, Klose RJ, Casanova M, Tavares L, Brockdorff N, Merkenschlager M, Fisher AG.

Nat Cell Biol. 2010 Jun;12(6):618-24. doi: 10.1038/ncb2065. Epub 2010 May 16.

37.

Floxin, a resource for genetically engineering mouse ESCs.

Singla V, Hunkapiller J, Santos N, Seol AD, Norman AR, Wakenight P, Skarnes WC, Reiter JF.

Nat Methods. 2010 Jan;7(1):50-2. doi: 10.1038/nmeth.1406. Epub 2009 Dec 6.

38.

Agouti C57BL/6N embryonic stem cells for mouse genetic resources.

Pettitt SJ, Liang Q, Rairdan XY, Moran JL, Prosser HM, Beier DR, Lloyd KC, Bradley A, Skarnes WC.

Nat Methods. 2009 Jul;6(7):493-5. doi: 10.1038/nmeth.1342. Epub 2009 Jun 14.

39.

Gene trapping in mouse embryonic stem cells.

Brennan J, Skarnes WC.

Methods Mol Biol. 2008;461:133-48. doi: 10.1007/978-1-60327-483-8_9. Review. No abstract available.

PMID:
19030794
40.

Extensive genomic copy number variation in embryonic stem cells.

Liang Q, Conte N, Skarnes WC, Bradley A.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17453-6. doi: 10.1073/pnas.0805638105. Epub 2008 Nov 6.

41.

ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a.

Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6656-61. doi: 10.1073/pnas.0801802105. Epub 2008 Apr 30.

42.

Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.

Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR.

PLoS One. 2007 Jul 18;2(7):e617.

43.

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.

Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D642-8.

44.

Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.

Reiter JF, Skarnes WC.

Genes Dev. 2006 Jan 1;20(1):22-7. Epub 2005 Dec 15.

45.

Two ways to trap a gene in mice.

Skarnes WC.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13001-2. Epub 2005 Sep 6. No abstract available.

46.

JAM-A expression during embryonic development.

Parris JJ, Cooke VG, Skarnes WC, Duncan MK, Naik UP.

Dev Dyn. 2005 Aug;233(4):1517-24.

47.
48.

Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neurons.

Henion TR, Raitcheva D, Grosholz R, Biellmann F, Skarnes WC, Hennet T, Schwarting GA.

J Neurosci. 2005 Feb 23;25(8):1894-903.

49.

The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.

Ren J, Shi M, Liu R, Yang QH, Johnson T, Skarnes WC, Du C.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):565-70. Epub 2005 Jan 7.

50.

Polybromo protein BAF180 functions in mammalian cardiac chamber maturation.

Wang Z, Zhai W, Richardson JA, Olson EN, Meneses JJ, Firpo MT, Kang C, Skarnes WC, Tjian R.

Genes Dev. 2004 Dec 15;18(24):3106-16.

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