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Items: 45


Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector.

Phelan JP, Kern A, Ramsey ME, Lundt ME, Sharma B, Lin T, Gao L, Norris SJ, Hyde JA, Skare JT, Hu LT.

PLoS Pathog. 2019 May 14;15(5):e1007644. doi: 10.1371/journal.ppat.1007644. eCollection 2019 May.


Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes.

Xie J, Zhi H, Garrigues RJ, Keightley A, Garcia BL, Skare JT.

PLoS Pathog. 2019 Mar 21;15(3):e1007659. doi: 10.1371/journal.ppat.1007659. eCollection 2019 Mar.


The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection.

Zhi H, Xie J, Skare JT.

Front Immunol. 2018 May 7;9:959. doi: 10.3389/fimmu.2018.00959. eCollection 2018.


Detection of Bioluminescent Borrelia burgdorferi from In Vitro Cultivation and During Murine Infection.

Hyde JA, Skare JT.

Methods Mol Biol. 2018;1690:241-257. doi: 10.1007/978-1-4939-7383-5_18.


A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species.

Ramsey ME, Hyde JA, Medina-Perez DN, Lin T, Gao L, Lundt ME, Li X, Norris SJ, Skare JT, Hu LT.

PLoS Pathog. 2017 Feb 17;13(2):e1006225. doi: 10.1371/journal.ppat.1006225. eCollection 2017 Feb.


In Vivo Imaging Demonstrates That Borrelia burgdorferi ospC Is Uniquely Expressed Temporally and Spatially throughout Experimental Infection.

Skare JT, Shaw DK, Trzeciakowski JP, Hyde JA.

PLoS One. 2016 Sep 9;11(9):e0162501. doi: 10.1371/journal.pone.0162501. eCollection 2016.


Biomechanics of Borrelia burgdorferi Vascular Interactions.

Ebady R, Niddam AF, Boczula AE, Kim YR, Gupta N, Tang TT, Odisho T, Zhi H, Simmons CA, Skare JT, Moriarty TJ.

Cell Rep. 2016 Sep 6;16(10):2593-2604. doi: 10.1016/j.celrep.2016.08.013. Epub 2016 Aug 25.


Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex.

Garcia BL, Zhi H, Wager B, Höök M, Skare JT.

PLoS Pathog. 2016 Jan 25;12(1):e1005404. doi: 10.1371/journal.ppat.1005404. eCollection 2016 Jan.


BB0744 Affects Tissue Tropism and Spatial Distribution of Borrelia burgdorferi.

Wager B, Shaw DK, Groshong AM, Blevins JS, Skare JT.

Infect Immun. 2015 Sep;83(9):3693-703. doi: 10.1128/IAI.00828-15. Epub 2015 Jul 6.


The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis.

Zhi H, Weening EH, Barbu EM, Hyde JA, Höök M, Skare JT.

Mol Microbiol. 2015 Apr;96(1):68-83. doi: 10.1111/mmi.12921. Epub 2015 Jan 30.


Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.

Moriarty TJ, Shi M, Lin YP, Ebady R, Zhou H, Odisho T, Hardy PO, Salman-Dilgimen A, Wu J, Weening EH, Skare JT, Kubes P, Leong J, Chaconas G.

Mol Microbiol. 2012 Dec;86(5):1116-31. doi: 10.1111/mmi.12045. Epub 2012 Oct 24.


The BB0646 protein demonstrates lipase and haemolytic activity associated with Borrelia burgdorferi, the aetiological agent of Lyme disease.

Shaw DK, Hyde JA, Skare JT.

Mol Microbiol. 2012 Jan;83(2):319-34. doi: 10.1111/j.1365-2958.2011.07932.x. Epub 2011 Dec 11.


Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity.

Hyde JA, Weening EH, Chang M, Trzeciakowski JP, Höök M, Cirillo JD, Skare JT.

Mol Microbiol. 2011 Oct;82(1):99-113. doi: 10.1111/j.1365-2958.2011.07801.x. Epub 2011 Aug 30.


Genetic transformation of Borrelia burgdorferi.

Hyde JA, Weening EH, Skare JT.

Curr Protoc Microbiol. 2011 Feb;Chapter 12:Unit 12C.4. doi: 10.1002/9780471729259.mc12c04s20.


Invasion of eukaryotic cells by Borrelia burgdorferi requires β(1) integrins and Src kinase activity.

Wu J, Weening EH, Faske JB, Höök M, Skare JT.

Infect Immun. 2011 Mar;79(3):1338-48. doi: 10.1128/IAI.01188-10. Epub 2010 Dec 20.


The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete.

Hyde JA, Shaw DK, Smith Iii R, Trzeciakowski JP, Skare JT.

Mol Microbiol. 2009 Dec;74(6):1344-55. doi: 10.1111/j.1365-2958.2009.06951.x. Epub 2009 Nov 10.


Characterization of a conditional bosR mutant in Borrelia burgdorferi.

Hyde JA, Shaw DK, Smith R 3rd, Trzeciakowski JP, Skare JT.

Infect Immun. 2010 Jan;78(1):265-74. doi: 10.1128/IAI.01018-09. Epub 2009 Oct 26.


A novel fibronectin binding motif in MSCRAMMs targets F3 modules.

Prabhakaran S, Liang X, Skare JT, Potts JR, Höök M.

PLoS One. 2009;4(4):e5412. doi: 10.1371/journal.pone.0005412. Epub 2009 Apr 30.


Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection.

Weening EH, Parveen N, Trzeciakowski JP, Leong JM, Höök M, Skare JT.

Infect Immun. 2008 Dec;76(12):5694-705. doi: 10.1128/IAI.00690-08. Epub 2008 Sep 22.


Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels.

Hyde JA, Trzeciakowski JP, Skare JT.

J Bacteriol. 2007 Jan;189(2):437-45. Epub 2006 Nov 10.


Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi.

Seshu J, Esteve-Gassent MD, Labandeira-Rey M, Kim JH, Trzeciakowski JP, Höök M, Skare JT.

Mol Microbiol. 2006 Mar;59(5):1591-601.


A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi.

Seshu J, Boylan JA, Hyde JA, Swingle KL, Gherardini FC, Skare JT.

Mol Microbiol. 2004 Dec;54(5):1352-63.


Dissolved oxygen levels alter gene expression and antigen profiles in Borrelia burgdorferi.

Seshu J, Boylan JA, Gherardini FC, Skare JT.

Infect Immun. 2004 Mar;72(3):1580-6. Erratum in: Infect Immun. 2004 Apr;72(4):2456.


Analysis of mechanisms associated with loss of infectivity of clonal populations of Borrelia burgdorferi B31MI.

McDowell JV, Sung SY, Labandeira-Rey M, Skare JT, Marconi RT.

Infect Immun. 2001 Jun;69(6):3670-7.


The many faces of Borrelia burgdorferi.

Seshu J, Skare JT.

J Mol Microbiol Biotechnol. 2000 Oct;2(4):463-72. Review.


Cloning and molecular characterization of plasmid-encoded antigens of Borrelia burgdorferi.

Skare JT, Foley DM, Hernandez SR, Moore DC, Blanco DR, Miller JN, Lovett MA.

Infect Immun. 1999 Sep;67(9):4407-17.


Isolation and characterization of the outer membrane of Borrelia hermsii.

Shang ES, Skare JT, Exner MM, Blanco DR, Kagan BL, Miller JN, Lovett MA.

Infect Immun. 1998 Mar;66(3):1082-91.


The Oms66 (p66) protein is a Borrelia burgdorferi porin.

Skare JT, Mirzabekov TA, Shang ES, Blanco DR, Erdjument-Bromage H, Bunikis J, Bergström S, Tempst P, Kagan BL, Miller JN, Lovett MA.

Infect Immun. 1997 Sep;65(9):3654-61.


Sequence analysis and characterization of a 40-kilodalton Borrelia hermsii glycerophosphodiester phosphodiesterase homolog.

Shang ES, Skare JT, Erdjument-Bromage H, Blanco DR, Tempst P, Miller JN, Lovett MA.

J Bacteriol. 1997 Apr;179(7):2238-46.


Recombinant Treponema pallidum rare outer membrane protein 1 (Tromp1) expressed in Escherichia coli has porin activity and surface antigenic exposure.

Blanco DR, Champion CI, Exner MM, Shang ES, Skare JT, Hancock RE, Miller JN, Lovett MA.

J Bacteriol. 1996 Dec;178(23):6685-92.


Porin activity of the native and recombinant outer membrane protein Oms28 of Borrelia burgdorferi.

Skare JT, Champion CI, Mirzabekov TA, Shang ES, Blanco DR, Erdjument-Bromage H, Tempst P, Kagan BL, Miller JN, Lovett MA.

J Bacteriol. 1996 Aug;178(16):4909-18.


Identification of TonB homologs in the family Enterobacteriaceae and evidence for conservation of TonB-dependent energy transduction complexes.

Larsen RA, Myers PS, Skare JT, Seachord CL, Darveau RP, Postle K.

J Bacteriol. 1996 Mar;178(5):1363-73.


Virulent strain associated outer membrane proteins of Borrelia burgdorferi.

Skare JT, Shang ES, Foley DM, Blanco DR, Champion CI, Mirzabekov T, Sokolov Y, Kagan BL, Miller JN, Lovett MA.

J Clin Invest. 1995 Nov;96(5):2380-92.


A 9.0-kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection.

Champion CI, Blanco DR, Skare JT, Haake DA, Giladi M, Foley D, Miller JN, Lovett MA.

Infect Immun. 1994 Jul;62(7):2653-61.


Role of the TonB amino terminus in energy transduction between membranes.

Jaskula JC, Letain TE, Roof SK, Skare JT, Postle K.

J Bacteriol. 1994 Apr;176(8):2326-38.


Evidence for a TonB-dependent energy transduction complex in Escherichia coli.

Skare JT, Postle K.

Mol Microbiol. 1991 Dec;5(12):2883-90.


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