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Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector.

Phelan JP, Kern A, Ramsey ME, Lundt ME, Sharma B, Lin T, Gao L, Norris SJ, Hyde JA, Skare JT, Hu LT.

PLoS Pathog. 2019 May 14;15(5):e1007644. doi: 10.1371/journal.ppat.1007644. eCollection 2019 May.


Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes.

Xie J, Zhi H, Garrigues RJ, Keightley A, Garcia BL, Skare JT.

PLoS Pathog. 2019 Mar 21;15(3):e1007659. doi: 10.1371/journal.ppat.1007659. eCollection 2019 Mar.


The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection.

Zhi H, Xie J, Skare JT.

Front Immunol. 2018 May 7;9:959. doi: 10.3389/fimmu.2018.00959. eCollection 2018.


Detection of Bioluminescent Borrelia burgdorferi from In Vitro Cultivation and During Murine Infection.

Hyde JA, Skare JT.

Methods Mol Biol. 2018;1690:241-257. doi: 10.1007/978-1-4939-7383-5_18.


[It is not harmful to eat fish].

Knutsen HK, Brantsæter AL, Meltzer HM, Haugen M, Skåre JU, Lundebye AK, Frøyland L, Hemre GI, Alexander J.

Tidsskr Nor Laegeforen. 2017 May 23;137(10):688-689. doi: 10.4045/tidsskr.17.0228. eCollection 2017 May. Norwegian. No abstract available.


A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species.

Ramsey ME, Hyde JA, Medina-Perez DN, Lin T, Gao L, Lundt ME, Li X, Norris SJ, Skare JT, Hu LT.

PLoS Pathog. 2017 Feb 17;13(2):e1006225. doi: 10.1371/journal.ppat.1006225. eCollection 2017 Feb.


In Vivo Imaging Demonstrates That Borrelia burgdorferi ospC Is Uniquely Expressed Temporally and Spatially throughout Experimental Infection.

Skare JT, Shaw DK, Trzeciakowski JP, Hyde JA.

PLoS One. 2016 Sep 9;11(9):e0162501. doi: 10.1371/journal.pone.0162501. eCollection 2016.


Biomechanics of Borrelia burgdorferi Vascular Interactions.

Ebady R, Niddam AF, Boczula AE, Kim YR, Gupta N, Tang TT, Odisho T, Zhi H, Simmons CA, Skare JT, Moriarty TJ.

Cell Rep. 2016 Sep 6;16(10):2593-2604. doi: 10.1016/j.celrep.2016.08.013. Epub 2016 Aug 25.


Endocrine effects of real-life mixtures of persistent organic pollutants (POP) in experimental models and wild fish.

Berg V, Kraugerud M, Nourizadeh-Lillabadi R, Olsvik PA, Skåre JU, Alestrøm P, Ropstad E, Zimmer KE, Lyche JL.

J Toxicol Environ Health A. 2016;79(13-15):538-48. doi: 10.1080/15287394.2016.1171980.


Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex.

Garcia BL, Zhi H, Wager B, Höök M, Skare JT.

PLoS Pathog. 2016 Jan 25;12(1):e1005404. doi: 10.1371/journal.ppat.1005404. eCollection 2016 Jan.


BB0744 Affects Tissue Tropism and Spatial Distribution of Borrelia burgdorferi.

Wager B, Shaw DK, Groshong AM, Blevins JS, Skare JT.

Infect Immun. 2015 Sep;83(9):3693-703. doi: 10.1128/IAI.00828-15. Epub 2015 Jul 6.


Human systemic exposure to [¹⁴C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment.

Nohynek GJ, Skare JA, Meuling WJA, Wehmeyer KR, de Bie ATHJ, Vaes WHJ, Dufour EK, Fautz R, Steiling W, Bramante M, Toutain H.

Food Chem Toxicol. 2015 Jul;81:71-80. doi: 10.1016/j.fct.2015.04.003. Epub 2015 Apr 3.


Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines.

Skare JA, Blackburn K, Wu S, Re TA, Duche D, Ringeissen S, Bjerke DL, Srinivasan V, Eisenmann C.

Regul Toxicol Pharmacol. 2015 Apr;71(3):515-28. doi: 10.1016/j.yrtph.2015.01.013. Epub 2015 Feb 7.


The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis.

Zhi H, Weening EH, Barbu EM, Hyde JA, Höök M, Skare JT.

Mol Microbiol. 2015 Apr;96(1):68-83. doi: 10.1111/mmi.12921. Epub 2015 Jan 30.


An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.

Pottenger LH, Andrews LS, Bachman AN, Boogaard PJ, Cadet J, Embry MR, Farmer PB, Himmelstein MW, Jarabek AM, Martin EA, Mauthe RJ, Persaud R, Preston RJ, Schoeny R, Skare J, Swenberg JA, Williams GM, Zeiger E, Zhang F, Kim JH.

Crit Rev Toxicol. 2014 Apr;44(4):348-91. doi: 10.3109/10408444.2013.873768. Epub 2014 Feb 4. Review.


Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination.

Sarkadi J, Jankovics M, Kis Z, Skare J, Fodor K, Gonczol E, Visontai I, Vajo Z, Jankovics I.

Arch Virol. 2013 Dec;158(12):2577-81. doi: 10.1007/s00705-013-1754-z. Epub 2013 Jun 15.


Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.

Moriarty TJ, Shi M, Lin YP, Ebady R, Zhou H, Odisho T, Hardy PO, Salman-Dilgimen A, Wu J, Weening EH, Skare JT, Kubes P, Leong J, Chaconas G.

Mol Microbiol. 2012 Dec;86(5):1116-31. doi: 10.1111/mmi.12045. Epub 2012 Oct 24.


Parental exposure to natural mixtures of POPs reduced embryo production and altered gene transcription in zebrafish embryos.

Lyche JL, Grześ IM, Karlsson C, Nourizadeh-Lillabadi R, Berg V, Kristoffersen AB, Skåre JU, Alestrøm P, Ropstad E.

Aquat Toxicol. 2013 Jan 15;126:424-34. doi: 10.1016/j.aquatox.2012.08.019. Epub 2012 Sep 20.


The BB0646 protein demonstrates lipase and haemolytic activity associated with Borrelia burgdorferi, the aetiological agent of Lyme disease.

Shaw DK, Hyde JA, Skare JT.

Mol Microbiol. 2012 Jan;83(2):319-34. doi: 10.1111/j.1365-2958.2011.07932.x. Epub 2011 Dec 11.


Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity.

Hyde JA, Weening EH, Chang M, Trzeciakowski JP, Höök M, Cirillo JD, Skare JT.

Mol Microbiol. 2011 Oct;82(1):99-113. doi: 10.1111/j.1365-2958.2011.07801.x. Epub 2011 Aug 30.


Genetic transformation of Borrelia burgdorferi.

Hyde JA, Weening EH, Skare JT.

Curr Protoc Microbiol. 2011 Feb;Chapter 12:Unit 12C.4. doi: 10.1002/9780471729259.mc12c04s20.


Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling.

Lyche JL, Nourizadeh-Lillabadi R, Karlsson C, Stavik B, Berg V, Skåre JU, Alestrøm P, Ropstad E.

Aquat Toxicol. 2011 Apr;102(3-4):197-204. doi: 10.1016/j.aquatox.2011.01.017. Epub 2011 Feb 26.


Invasion of eukaryotic cells by Borrelia burgdorferi requires β(1) integrins and Src kinase activity.

Wu J, Weening EH, Faske JB, Höök M, Skare JT.

Infect Immun. 2011 Mar;79(3):1338-48. doi: 10.1128/IAI.01188-10. Epub 2010 Dec 20.


Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish.

Lyche JL, Nourizadeh-Lillabadi R, Almaas C, Stavik B, Berg V, Skåre JU, Alestrøm P, Ropstad E.

J Toxicol Environ Health A. 2010;73(15):1032-57. doi: 10.1080/15287394.2010.481618.


The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete.

Hyde JA, Shaw DK, Smith Iii R, Trzeciakowski JP, Skare JT.

Mol Microbiol. 2009 Dec;74(6):1344-55. doi: 10.1111/j.1365-2958.2009.06951.x. Epub 2009 Nov 10.


A review of biomonitoring studies measuring genotoxicity in humans exposed to hair dyes.

Preston RJ, Skare JA, Aardema MJ.

Mutagenesis. 2010 Jan;25(1):17-23. doi: 10.1093/mutage/gep044. Epub 2009 Nov 5. Review.


Characterization of a conditional bosR mutant in Borrelia burgdorferi.

Hyde JA, Shaw DK, Smith R 3rd, Trzeciakowski JP, Skare JT.

Infect Immun. 2010 Jan;78(1):265-74. doi: 10.1128/IAI.01018-09. Epub 2009 Oct 26.


Metabolite screening of aromatic amine hair dyes using in vitro hepatic models.

Skare JA, Hewitt NJ, Doyle E, Powrie R, Elcombe C.

Xenobiotica. 2009 Nov;39(11):811-25. doi: 10.3109/00498250903134443.


Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization.

Jarabek AM, Pottenger LH, Andrews LS, Casciano D, Embry MR, Kim JH, Preston RJ, Reddy MV, Schoeny R, Shuker D, Skare J, Swenberg J, Williams GM, Zeiger E.

Crit Rev Toxicol. 2009;39(8):659-78. doi: 10.1080/10408440903164155. Review.


Persistent organic pollutants and mercury in dead and dying glaucous gulls (Larus hyperboreus) at Bjørnøya (Svalbard).

Sagerup K, Helgason LB, Polder A, Strøm H, Josefsen TD, Skåre JU, Gabrielsen GW.

Sci Total Environ. 2009 Nov 15;407(23):6009-16. doi: 10.1016/j.scitotenv.2009.08.020. Epub 2009 Sep 6.


Separation and analysis of dimethylaniline isomers by supercritical fluid chromatography--electrospray ionization tandem mass spectrometry.

Strife RJ, Mangels ML, Skare JA.

J Chromatogr A. 2009 Oct 9;1216(41):6970-3. doi: 10.1016/j.chroma.2009.07.043. Epub 2009 Jul 30.


Dermal penetration and metabolism of p-aminophenol and p-phenylenediamine: application of the EpiDerm human reconstructed epidermis model.

Hu T, Bailey RE, Morrall SW, Aardema MJ, Stanley LA, Skare JA.

Toxicol Lett. 2009 Jul 24;188(2):119-29. doi: 10.1016/j.toxlet.2009.03.019. Epub 2009 Mar 31.


A novel fibronectin binding motif in MSCRAMMs targets F3 modules.

Prabhakaran S, Liang X, Skare JT, Potts JR, Höök M.

PLoS One. 2009;4(4):e5412. doi: 10.1371/journal.pone.0005412. Epub 2009 Apr 30.


Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP).

Nourizadeh-Lillabadi R, Lyche JL, Almaas C, Stavik B, Moe SJ, Aleksandersen M, Berg V, Jakobsen KS, Stenseth NC, Skåre JU, Alestrøm P, Ropstad E.

J Toxicol Environ Health A. 2009;72(3-4):112-30. doi: 10.1080/15287390802537255.


Skin metabolism of aminophenols: human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo.

Goebel C, Hewitt NJ, Kunze G, Wenker M, Hein DW, Beck H, Skare J.

Toxicol Appl Pharmacol. 2009 Feb 15;235(1):114-23. doi: 10.1016/j.taap.2008.11.014. Epub 2008 Nov 28.


Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection.

Weening EH, Parveen N, Trzeciakowski JP, Leong JM, Höök M, Skare JT.

Infect Immun. 2008 Dec;76(12):5694-705. doi: 10.1128/IAI.00690-08. Epub 2008 Sep 22.


Estrogenic effects of selected hydroxy polychlorinated biphenyl congeners in primary culture of Atlantic Salmon (Salmo salar) hepatocytes.

Braathen M, Mortensen AS, Sandvik M, Skåre JU, Arukwe A.

Arch Environ Contam Toxicol. 2009 Jan;56(1):111-22. doi: 10.1007/s00244-008-9163-0. Epub 2008 Apr 15.


Reply: letter to the editor in response to Morton et al. (2007) Carcinogenesis, 28, 1759-1764.

Bailey JE, Skare JA.

Carcinogenesis. 2008 Sep;29(9):1851. doi: 10.1093/carcin/bgn022. Epub 2008 Jan 24. No abstract available.


Clinical and pathologic features of lineage 2 West Nile virus infections in birds of prey in Hungary.

Erdélyi K, Ursu K, Ferenczi E, Szeredi L, Rátz F, Skáre J, Bakonyi T.

Vector Borne Zoonotic Dis. 2007 Summer;7(2):181-8.


Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels.

Hyde JA, Trzeciakowski JP, Skare JT.

J Bacteriol. 2007 Jan;189(2):437-45. Epub 2006 Nov 10.


Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi.

Seshu J, Esteve-Gassent MD, Labandeira-Rey M, Kim JH, Trzeciakowski JP, Höök M, Skare JT.

Mol Microbiol. 2006 Mar;59(5):1591-601.


A new eriophyid mite-borne membrane-enveloped virus-like complex isolated from plants.

Skare JM, Wijkamp I, Denham I, Rezende JA, Kitajima EW, Park JW, Desvoyes B, Rush CM, Michels G, Scholthof KB, Scholthof HB.

Virology. 2006 Apr 10;347(2):343-53. Epub 2006 Jan 10.


Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004.

Sander M, Cadet J, Casciano DA, Galloway SM, Marnett LJ, Novak RF, Pettit SD, Preston RJ, Skare JA, Williams GM, Van Houten B, Gollapudi BB.

Toxicol Appl Pharmacol. 2005 Oct 1;208(1):1-20.


Lack of evidence for metabolism of p-phenylenediamine by human hepatic cytochrome P450 enzymes.

Stanley LA, Skare JA, Doyle E, Powrie R, D'Angelo D, Elcombe CR.

Toxicology. 2005 Jun 1;210(2-3):147-57.


A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi.

Seshu J, Boylan JA, Hyde JA, Swingle KL, Gherardini FC, Skare JT.

Mol Microbiol. 2004 Dec;54(5):1352-63.


Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye.

Nohynek GJ, Skare JA, Meuling WJ, Hein DW, De Bie AT, Toutain H.

Food Chem Toxicol. 2004 Nov;42(11):1885-91.


Dissolved oxygen levels alter gene expression and antigen profiles in Borrelia burgdorferi.

Seshu J, Boylan JA, Gherardini FC, Skare JT.

Infect Immun. 2004 Mar;72(3):1580-6. Erratum in: Infect Immun. 2004 Apr;72(4):2456.


Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays.

Ojaimi C, Brooks C, Casjens S, Rosa P, Elias A, Barbour A, Jasinskas A, Benach J, Katona L, Radolf J, Caimano M, Skare J, Swingle K, Akins D, Schwartz I.

Infect Immun. 2003 Apr;71(4):1689-705.

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