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Items: 1 to 50 of 228

1.

The Polyphenolic Composition of Extracts Derived from Different Greek Extra Virgin Olive Oils Is Correlated with Their Antioxidant Potency.

Kouka P, Tsakiri G, Tzortzi D, Dimopoulou S, Sarikaki G, Stathopoulos P, Veskoukis AS, Halabalaki M, Skaltsounis AL, Kouretas D.

Oxid Med Cell Longev. 2019 Mar 20;2019:1870965. doi: 10.1155/2019/1870965. eCollection 2019.

2.

The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models.

Chalatsa I, Arvanitis DA, Koulakiotis NS, Giagini A, Skaltsounis AL, Papadopoulou-Daifoti Z, Tsarbopoulos A, Sanoudou D.

Front Neurosci. 2019 Mar 26;13:249. doi: 10.3389/fnins.2019.00249. eCollection 2019.

3.

Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth.

Efstathiou A, Gaboriaud-Kolar N, Myrianthopoulos V, Vougogiannopoulou K, Subota I, Aicher S, Mikros E, Bastin P, Skaltsounis AL, Soteriadou K, Smirlis D.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e02065-18. doi: 10.1128/AAC.02065-18. Print 2019 Jun.

PMID:
30910902
4.

Investigating and re-evaluating the role of glycogen synthase kinase 3 beta kinase as a molecular target for cardioprotection by using novel pharmacological inhibitors.

Nikolaou PE, Boengler K, Efentakis P, Vouvogiannopoulou K, Zoga A, Gaboriaud-Kolar N, Myrianthopoulos V, Alexakos P, Kostomitsopoulos N, Rerras I, Tsantili-Kakoulidou A, Skaltsounis AL, Papapetropoulos A, Iliodromitis EK, Schulz R, Andreadou I.

Cardiovasc Res. 2019 Jun 1;115(7):1228-1243. doi: 10.1093/cvr/cvz061.

PMID:
30843027
5.

Compounds from Olea europaea and Pistacia lentiscus inhibit oral microbial growth.

Karygianni L, Cecere M, Argyropoulou A, Hellwig E, Skaltsounis AL, Wittmer A, Tchorz JP, Al-Ahmad A.

BMC Complement Altern Med. 2019 Feb 26;19(1):51. doi: 10.1186/s12906-019-2461-4.

6.

Design and synthesis of new substituted pyrazolopyridines with potent antiproliferative activity.

Giannouli V, Lougiakis N, Kostakis IK, Pouli N, Marakos P, Skaltsounis AL, Horne DA, Nam S, Gioti K, Tenta R.

Med Chem. 2019 Feb 22. doi: 10.2174/1573406415666190222130225. [Epub ahead of print]

PMID:
30799794
7.

Mediterranean herb extracts inhibit microbial growth of representative oral microorganisms and biofilm formation of Streptococcus mutans.

Hickl J, Argyropoulou A, Sakavitsi ME, Halabalaki M, Al-Ahmad A, Hellwig E, Aligiannis N, Skaltsounis AL, Wittmer A, Vach K, Karygianni L.

PLoS One. 2018 Dec 12;13(12):e0207574. doi: 10.1371/journal.pone.0207574. eCollection 2018.

8.

Hydroxytyrosol (HT) Analogs Act as Potent Antifungals by Direct Disruption of the Fungal Cell Membrane.

Diallinas G, Rafailidou N, Kalpaktsi I, Komianou AC, Tsouvali V, Zantza I, Mikros E, Skaltsounis AL, Kostakis IK.

Front Microbiol. 2018 Nov 6;9:2624. doi: 10.3389/fmicb.2018.02624. eCollection 2018.

9.

Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.

Efstathiou A, Meira CS, Gaboriaud-Kolar N, Bastos TM, Rocha VPC, Vougogiannopoulou K, Skaltsounis AL, Smirlis D, Soares MBP.

Virulence. 2018;9(1):1658-1668. doi: 10.1080/21505594.2018.1532242.

PMID:
30387370
10.

Rapid isolation and characterization of crocins, picrocrocin, and crocetin from saffron using centrifugal partition chromatography and LC-MS.

Karkoula E, Angelis A, Koulakiotis NS, Gikas E, Halabalaki M, Tsarbopoulos A, Skaltsounis AL.

J Sep Sci. 2018 Nov;41(22):4105-4114. doi: 10.1002/jssc.201800516. Epub 2018 Oct 10.

PMID:
30232839
11.

Antioxidant effects of an olive oil total polyphenolic fraction from a Greek Olea europaea variety in different cell cultures.

Kouka P, Chatzieffraimidi GA, Raftis G, Stagos D, Angelis A, Stathopoulos P, Xynos N, Skaltsounis AL, Tsatsakis AM, Kouretas D.

Phytomedicine. 2018 Aug 1;47:135-142. doi: 10.1016/j.phymed.2018.04.054. Epub 2018 May 8.

PMID:
30166098
12.

UHPLC-HRMS-based tissue untargeted metabolomics study of naringin and hesperidin after dietary supplementation in chickens.

Baira E, Dagla I, Siapi E, Zoumpoulakis P, Simitzis P, Goliomytis M, Deligeorgis SG, Skaltsounis AL, Gikas E.

Food Chem. 2018 Dec 15;269:276-285. doi: 10.1016/j.foodchem.2018.06.146. Epub 2018 Jul 2.

PMID:
30100435
13.

The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides.

Malliou F, Andreadou I, Gonzalez FJ, Lazou A, Xepapadaki E, Vallianou I, Lambrinidis G, Mikros E, Marselos M, Skaltsounis AL, Konstandi M.

J Nutr Biochem. 2018 Sep;59:17-28. doi: 10.1016/j.jnutbio.2018.05.013. Epub 2018 Jun 5.

PMID:
29960113
14.

Trans-crocin 4 is not hydrolyzed to crocetin following i.p. administration in mice, while it shows penetration through the blood brain barrier.

Karkoula E, Lemonakis N, Kokras N, Dalla C, Gikas E, Skaltsounis AL, Tsarbopoulos A.

Fitoterapia. 2018 Sep;129:62-72. doi: 10.1016/j.fitote.2018.06.012. Epub 2018 Jun 18.

PMID:
29920295
15.

Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources-The MediHealth Project.

Waltenberger B, Halabalaki M, Schwaiger S, Adamopoulos N, Allouche N, Fiebich BL, Hermans N, Jansen-Dürr P, Kesternich V, Pieters L, Schönbichler S, Skaltsounis AL, Tran H, Trougakos IP, Viljoen A, Wolfender JL, Wolfrum C, Xynos N, Stuppner H.

Molecules. 2018 May 6;23(5). pii: E1097. doi: 10.3390/molecules23051097.

16.

Natural alkaloids intervening the insulin pathway: new hopes for anti-diabetic agents?

Christodoulou MI, Tchoumtchoua J, Skaltsounis AL, Scorilas A, Halabalaki M.

Curr Med Chem. 2018 Apr 30. doi: 10.2174/0929867325666180430152618. [Epub ahead of print]

PMID:
29714135
17.

Identification of Novel Melanin Synthesis Inhibitors From Crataegus pycnoloba Using an in Vivo Zebrafish Phenotypic Assay.

Agalou A, Thrapsianiotis M, Angelis A, Papakyriakou A, Skaltsounis AL, Aligiannis N, Beis D.

Front Pharmacol. 2018 Mar 26;9:265. doi: 10.3389/fphar.2018.00265. eCollection 2018.

18.

Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights.

Cheimonidi C, Samara P, Polychronopoulos P, Tsakiri EN, Nikou T, Myrianthopoulos V, Sakellaropoulos T, Zoumpourlis V, Mikros E, Papassideri I, Argyropoulou A, Halabalaki M, Alexopoulos LG, Skaltsounis AL, Tsitsilonis OE, Aligiannis NN, Trougakos IP.

Redox Biol. 2018 Jun;16:169-178. doi: 10.1016/j.redox.2018.02.015. Epub 2018 Mar 1.

19.

Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events.

Tsakiri EN, Terpos E, Papanagnou ED, Kastritis E, Brieudes V, Halabalaki M, Bagratuni T, Florea BI, Overkleeft HS, Scorrano L, Skaltsounis AL, Dimopoulos MA, Trougakos IP.

Sci Rep. 2017 Dec 19;7(1):17802. doi: 10.1038/s41598-017-17596-4.

20.

Bioavailability of Terpenes and Postprandial Effect on Human Antioxidant Potential. An Open-Label Study in Healthy Subjects.

Papada E, Gioxari A, Brieudes V, Amerikanou C, Halabalaki M, Skaltsounis AL, Smyrnioudis I, Kaliora AC.

Mol Nutr Food Res. 2018 Feb;62(3). doi: 10.1002/mnfr.201700751. Epub 2017 Dec 29.

PMID:
29171157
21.

Alteration in the liver metabolome of rats with metabolic syndrome after treatment with Hydroxytyrosol. A Mass Spectrometry And Nuclear Magnetic Resonance - based metabolomics study.

Dagla I, Benaki D, Baira E, Lemonakis N, Poudyal H, Brown L, Tsarbopoulos A, Skaltsounis AL, Mikros E, Gikas E.

Talanta. 2018 Feb 1;178:246-257. doi: 10.1016/j.talanta.2017.09.029. Epub 2017 Sep 11.

PMID:
29136819
22.
23.

Isolation of natural products with anti-ageing activity from the fruits of Platanus orientalis.

Chatzigeorgiou S, Thai QD, Tchoumtchoua J, Tallas K, Tsakiri EN, Papassideri I, Halabalaki M, Skaltsounis AL, Trougakos IP.

Phytomedicine. 2017 Sep 15;33:53-61. doi: 10.1016/j.phymed.2017.07.009. Epub 2017 Jul 31.

PMID:
28887920
24.

Assessment of the antioxidant activity of an olive oil total polyphenolic fraction and hydroxytyrosol from a Greek Olea europea variety in endothelial cells and myoblasts.

Kouka P, Priftis A, Stagos D, Angelis A, Stathopoulos P, Xinos N, Skaltsounis AL, Mamoulakis C, Tsatsakis AM, Spandidos DA, Kouretas D.

Int J Mol Med. 2017 Sep;40(3):703-712. doi: 10.3892/ijmm.2017.3078. Epub 2017 Jul 20.

25.

Enzymatic tailoring of oleuropein from Olea europaea leaves and product identification by HRMS/MS spectrometry.

Nikolaivits E, Termentzi A, Skaltsounis AL, Fokialakis N, Topakas E.

J Biotechnol. 2017 Jul 10;253:48-54. doi: 10.1016/j.jbiotec.2017.05.020. Epub 2017 May 30.

PMID:
28576392
26.

New semi-synthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo.

Samara P, Christoforidou N, Lemus C, Argyropoulou A, Ioannou K, Vougogiannopoulou K, Aligiannis N, Paronis E, Gaboriaud-Kolar N, Tsitsilonis O, Skaltsounis AL.

Eur J Med Chem. 2017 Sep 8;137:11-29. doi: 10.1016/j.ejmech.2017.05.029. Epub 2017 May 12.

PMID:
28551177
27.

Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.

Chaita E, Lambrinidis G, Cheimonidi C, Agalou A, Beis D, Trougakos I, Mikros E, Skaltsounis AL, Aligiannis N.

Molecules. 2017 Mar 23;22(4). pii: E514. doi: 10.3390/molecules22040514.

28.

An integrated process for the recovery of high added-value compounds from olive oil using solid support free liquid-liquid extraction and chromatography techniques.

Angelis A, Hamzaoui M, Aligiannis N, Nikou T, Michailidis D, Gerolimatos P, Termentzi A, Hubert J, Halabalaki M, Renault JH, Skaltsounis AL.

J Chromatogr A. 2017 Mar 31;1491:126-136. doi: 10.1016/j.chroma.2017.02.046. Epub 2017 Feb 22.

PMID:
28256253
29.

The Indirubin Derivative 6-Bromoindirubin-3'-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects.

Tsakiri EN, Gaboriaud-Kolar N, Iliaki KK, Tchoumtchoua J, Papanagnou ED, Chatzigeorgiou S, Tallas KD, Mikros E, Halabalaki M, Skaltsounis AL, Trougakos IP.

Antioxid Redox Signal. 2017 Nov 10;27(14):1027-1047. doi: 10.1089/ars.2016.6910. Epub 2017 May 16.

30.

Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.

Svouraki A, Garscha U, Kouloura E, Pace S, Pergola C, Krauth V, Rossi A, Sautebin L, Halabalaki M, Werz O, Gaboriaud-Kolar N, Skaltsounis AL.

J Nat Prod. 2017 Mar 24;80(3):699-706. doi: 10.1021/acs.jnatprod.6b01008. Epub 2017 Feb 27.

PMID:
28240894
31.

The LC-MS-based metabolomics of hydroxytyrosol administration in rats reveals amelioration of the metabolic syndrome.

Lemonakis N, Poudyal H, Halabalaki M, Brown L, Tsarbopoulos A, Skaltsounis AL, Gikas E.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 15;1041-1042:45-59. doi: 10.1016/j.jchromb.2016.12.020. Epub 2016 Dec 15.

PMID:
28012379
32.

Synthesis and antiproliferative activity of new pyrazolo[3,4-c]pyridines.

Gavriil ES, Lougiakis N, Pouli N, Marakos P, Skaltsounis AL, Nam S, Jove R, Horne D, Gioti K, Pratsinis H, Kletsas D, Tenta R.

Med Chem. 2016 Dec 13. [Epub ahead of print]

PMID:
27978787
33.

Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme.

Daniilides K, Lougiakis N, Evangelidis T, Kostakis IK, Pouli N, Marakos P, Mikros E, Skaltsounis AL, Bach S, Baratte B, Ruchaud S, Karamani V, Papafotika A, Christoforidis S, Argyros O, Kouvari E, Tamvakopoulos C.

Anticancer Agents Med Chem. 2017;17(7):990-1002. doi: 10.2174/1871520616666161207143450.

PMID:
27928955
34.

Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties.

Angelis A, Hubert J, Aligiannis N, Michalea R, Abedini A, Nuzillard JM, Gangloff SC, Skaltsounis AL, Renault JH.

Molecules. 2016 Nov 21;21(11). pii: E1586.

35.

Post-acquisition spectral stitching. An alternative approach for data processing in untargeted metabolomics by UHPLC-ESI(-)-HRMS.

Baira E, Siapi E, Zoumpoulakis P, Stelios G D, Skaltsounis AL, Gikas E.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 15;1047:106-114. doi: 10.1016/j.jchromb.2016.10.030. Epub 2016 Oct 24.

PMID:
27825627
36.

Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines.

Gaboriaud-Kolar N, Myrianthopoulos V, Vougogiannopoulou K, Gerolymatos P, Horne DA, Jove R, Mikros E, Nam S, Skaltsounis AL.

J Nat Prod. 2016 Oct 28;79(10):2464-2471. Epub 2016 Oct 11.

PMID:
27726390
37.

The discovery of new cytotoxic pyrazolopyridine derivatives.

Giannouli V, Lougiakis N, Kostakis IK, Pouli N, Marakos P, Skaltsounis AL, Nam S, Jove R, Horne D, Tenta R, Pratsinis H, Kletsas D.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5229-5233. doi: 10.1016/j.bmcl.2016.09.056. Epub 2016 Sep 24.

PMID:
27720292
38.

Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides.

Faqueti LG, Brieudes V, Halabalaki M, Skaltsounis AL, Nascimento LF, Barros WM, Santos AR, Biavatti MW.

J Ethnopharmacol. 2016 Dec 24;194:369-377. doi: 10.1016/j.jep.2016.09.025. Epub 2016 Sep 12.

PMID:
27633406
39.

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.

Myrianthopoulos V, Gaboriaud-Kolar N, Tallant C, Hall ML, Grigoriou S, Brownlee PM, Fedorov O, Rogers C, Heidenreich D, Wanior M, Drosos N, Mexia N, Savitsky P, Bagratuni T, Kastritis E, Terpos E, Filippakopoulos P, Müller S, Skaltsounis AL, Downs JA, Knapp S, Mikros E.

J Med Chem. 2016 Oct 13;59(19):8787-8803. Epub 2016 Sep 27.

40.

Quality profile determination of Chios mastic gum essential oil and detection of adulteration in mastic oil products with the application of chiral and non-chiral GC-MS analysis.

Paraschos S, Magiatis P, Gikas E, Smyrnioudis I, Skaltsounis AL.

Fitoterapia. 2016 Oct;114:12-17. doi: 10.1016/j.fitote.2016.08.003. Epub 2016 Aug 8.

PMID:
27514656
41.

The leishmanicidal activity of oleuropein is selectively regulated through inflammation- and oxidative stress-related genes.

Kyriazis ID, Koutsoni OS, Aligiannis N, Karampetsou K, Skaltsounis AL, Dotsika E.

Parasit Vectors. 2016 Aug 9;9(1):441. doi: 10.1186/s13071-016-1701-4.

42.

Bioactivity-guided identification of antimicrobial metabolites in Alnus glutinosa bark and optimization of oregonin purification by Centrifugal Partition Chromatography.

Abedini A, Chollet S, Angelis A, Borie N, Nuzillard JM, Skaltsounis AL, Reynaud R, Gangloff SC, Renault JH, Hubert J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Sep 1;1029-1030:121-127. doi: 10.1016/j.jchromb.2016.07.021. Epub 2016 Jul 11.

PMID:
27428455
43.

In Vitro Dermo-Cosmetic Evaluation of Bark Extracts from Common Temperate Trees.

Hubert J, Angelis A, Aligiannis N, Rosalia M, Abedini A, Bakiri A, Reynaud R, Nuzillard JM, Gangloff SC, Skaltsounis AL, Renault JH.

Planta Med. 2016 Oct;82(15):1351-1358. Epub 2016 Jun 28.

PMID:
27352384
44.

A novel bioanalytical method based on UHPLC-HRMS/MS for the quantification of oleuropein in human serum. Application to a pharmacokinetic study.

Lemonakis N, Mougios V, Halabalaki M, Skaltsounis AL, Gikas E.

Biomed Chromatogr. 2016 Dec;30(12):2016-2023. doi: 10.1002/bmc.3779. Epub 2016 Jul 24.

PMID:
27301548
45.

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.

Durieu E, Prina E, Leclercq O, Oumata N, Gaboriaud-Kolar N, Vougogiannopoulou K, Aulner N, Defontaine A, No JH, Ruchaud S, Skaltsounis AL, Galons H, Späth GF, Meijer L, Rachidi N.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2822-33. doi: 10.1128/AAC.00021-16. Print 2016 May.

46.

Screening of Panamanian Plants for Cosmetic Properties, and HPLC-Based Identification of Constituents with Antioxidant and UV-B Protecting Activities.

Guldbrandsen N, De Mieri M, Gupta M, Liakou E, Pratsinis H, Kletsas D, Chaita E, Aligiannis N, Skaltsounis AL, Hamburger M.

Sci Pharm. 2014 Oct 15;83(1):177-90. doi: 10.3797/scipharm.1409-12. Print 2015 Jan-Mar.

47.

Natural Antimicrobials and Oral Microorganisms: A Systematic Review on Herbal Interventions for the Eradication of Multispecies Oral Biofilms.

Karygianni L, Al-Ahmad A, Argyropoulou A, Hellwig E, Anderson AC, Skaltsounis AL.

Front Microbiol. 2016 Jan 14;6:1529. doi: 10.3389/fmicb.2015.01529. eCollection 2015. Review.

48.

Synthesis and Pharmacological Evaluation of Novel Adenine-Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents.

Lougiakis N, Papapetropoulos A, Gikas E, Toumpas S, Efentakis P, Wedmann R, Zoga A, Zhou Z, Iliodromitis EK, Skaltsounis AL, Filipovic MR, Pouli N, Marakos P, Andreadou I.

J Med Chem. 2016 Mar 10;59(5):1776-90. doi: 10.1021/acs.jmedchem.5b01223. Epub 2016 Feb 8.

PMID:
26809888
49.

Estrogenic activity of isoflavonoids from the stem bark of the tropical tree Amphimas pterocarpoides, a source of traditional medicines.

Tchoumtchoua J, Makropoulou M, Ateba SB, Boulaka A, Halabalaki M, Lambrinidis G, Meligova AK, Mbanya JC, Mikros E, Skaltsounis AL, Mitsiou DJ, Njamen D, Alexis MN.

J Steroid Biochem Mol Biol. 2016 Apr;158:138-148. doi: 10.1016/j.jsbmb.2015.12.015. Epub 2015 Dec 17.

PMID:
26706281
50.

Optimization of parameters affecting signal intensity in an LTQ-orbitrap in negative ion mode: A design of experiments approach.

Lemonakis N, Skaltsounis AL, Tsarbopoulos A, Gikas E.

Talanta. 2016 Jan 15;147:402-9. doi: 10.1016/j.talanta.2015.10.009. Epub 2015 Oct 8.

PMID:
26592625

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