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Items: 1 to 50 of 82

1.

CFTR modulator theratyping: Current status, gaps and future directions.

Clancy JP, Cotton CU, Donaldson SH, Solomon GM, VanDevanter DR, Boyle MP, Gentzsch M, Nick JA, Illek B, Wallenburg JC, Sorscher EJ, Amaral MD, Beekman JM, Naren AP, Bridges RJ, Thomas PJ, Cutting G, Rowe S, Durmowicz AG, Mense M, Boeck KD, Skach W, Penland C, Joseloff E, Bihler H, Mahoney J, Borowitz D, Tuggle KL.

J Cyst Fibros. 2018 Jun 19. pii: S1569-1993(18)30585-X. doi: 10.1016/j.jcf.2018.05.004. [Epub ahead of print] Review.

2.

Patient-Centered Research Priorities for Pulmonary Nontuberculous Mycobacteria (NTM) Infection. An NTM Research Consortium Workshop Report.

Henkle E, Aksamit T, Barker A, Daley CL, Griffith D, Leitman P, Leitman A, Malanga E, Marras TK, Olivier KN, Prevots DR, Prieto D, Quittner AL, Skach W, Walsh JW, Winthrop KL; NTMRC Patient Advisory Panel.

Ann Am Thorac Soc. 2016 Sep;13(9):S379-84. doi: 10.1513/AnnalsATS.201605-387WS.

3.

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

Veit G, Avramescu RG, Chiang AN, Houck SA, Cai Z, Peters KW, Hong JS, Pollard HB, Guggino WB, Balch WE, Skach WR, Cutting GR, Frizzell RA, Sheppard DN, Cyr DM, Sorscher EJ, Brodsky JL, Lukacs GL.

Mol Biol Cell. 2016 Feb 1;27(3):424-33. doi: 10.1091/mbc.E14-04-0935.

4.

The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding.

Patterson MA, Bandyopadhyay A, Devaraneni PK, Woodward J, Rooney L, Yang Z, Skach WR.

J Biol Chem. 2015 Nov 27;290(48):28944-52. doi: 10.1074/jbc.M115.672261. Epub 2015 Aug 7.

5.

Protein folding. Translational tuning optimizes nascent protein folding in cells.

Kim SJ, Yoon JS, Shishido H, Yang Z, Rooney LA, Barral JM, Skach WR.

Science. 2015 Apr 24;348(6233):444-8. doi: 10.1126/science.aaa3974.

6.

Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.

Conti BJ, Devaraneni PK, Yang Z, David LL, Skach WR.

Mol Cell. 2015 Apr 16;58(2):269-83. doi: 10.1016/j.molcel.2015.02.018. Epub 2015 Mar 19.

7.

Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex.

Conti BJ, Elferich J, Yang Z, Shinde U, Skach WR.

Nat Struct Mol Biol. 2014 Mar;21(3):228-35. doi: 10.1038/nsmb.2779. Epub 2014 Feb 23.

8.

Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase.

Matsumura Y, Sakai J, Skach WR.

J Biol Chem. 2013 Oct 25;288(43):31069-79. doi: 10.1074/jbc.M113.479345. Epub 2013 Aug 29.

9.

Mechanisms of CFTR Folding at the Endoplasmic Reticulum.

Kim SJ, Skach WR.

Front Pharmacol. 2012 Dec 13;3:201. doi: 10.3389/fphar.2012.00201. eCollection 2012.

10.

Two-step insertion at the SecY translocon.

Kim SJ, Skach WR.

Nat Struct Mol Biol. 2012 Oct;19(10):975-7. doi: 10.1038/nsmb.2402.

PMID:
23037593
11.

Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activity.

Liu X, O'Donnell N, Landstrom A, Skach WR, Dawson DC.

Biochemistry. 2012 Jun 26;51(25):5113-24. doi: 10.1021/bi300018e. Epub 2012 Jun 15.

12.

Kinetic analysis of ribosome-bound fluorescent proteins reveals an early, stable, cotranslational folding intermediate.

Kelkar DA, Khushoo A, Yang Z, Skach WR.

J Biol Chem. 2012 Jan 20;287(4):2568-78. doi: 10.1074/jbc.M111.318766. Epub 2011 Nov 28.

13.

Epstein-Barr viral BNLF2a protein hijacks the tail-anchored protein insertion machinery to block antigen processing by the transport complex TAP.

Wycisk AI, Lin J, Loch S, Hobohm K, Funke J, Wieneke R, Koch J, Skach WR, Mayerhofer PU, Tampé R.

J Biol Chem. 2011 Dec 2;286(48):41402-12. doi: 10.1074/jbc.M111.237784. Epub 2011 Oct 7.

14.

Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex.

Devaraneni PK, Conti B, Matsumura Y, Yang Z, Johnson AE, Skach WR.

Cell. 2011 Jul 8;146(1):134-47. doi: 10.1016/j.cell.2011.06.004.

15.

The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation.

Richards R, Scholz I, Powers C, Skach WR, Früh K.

J Virol. 2011 Sep;85(17):8766-76. doi: 10.1128/JVI.05021-11. Epub 2011 Jun 29.

16.

Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.

Matsumura Y, David LL, Skach WR.

Mol Biol Cell. 2011 Aug 15;22(16):2797-809. doi: 10.1091/mbc.E11-02-0137. Epub 2011 Jun 22.

17.

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems.

Brodsky JL, Skach WR.

Curr Opin Cell Biol. 2011 Aug;23(4):464-75. doi: 10.1016/j.ceb.2011.05.004. Epub 2011 Jun 12. Review.

18.

In vitro methods for CFTR biogenesis.

Matsumura Y, Rooney L, Skach WR.

Methods Mol Biol. 2011;741:233-53. doi: 10.1007/978-1-61779-117-8_16.

PMID:
21594789
19.

CFTR Folding Consortium: methods available for studies of CFTR folding and correction.

Peters KW, Okiyoneda T, Balch WE, Braakman I, Brodsky JL, Guggino WB, Penland CM, Pollard HB, Sorscher EJ, Skach WR, Thomas PJ, Lukacs GL, Frizzell RA.

Methods Mol Biol. 2011;742:335-53. doi: 10.1007/978-1-61779-120-8_20.

20.

Ligand-driven vectorial folding of ribosome-bound human CFTR NBD1.

Khushoo A, Yang Z, Johnson AE, Skach WR.

Mol Cell. 2011 Mar 18;41(6):682-92. doi: 10.1016/j.molcel.2011.02.027.

21.

N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2.

Pratt EB, Tewson P, Bruederle CE, Skach WR, Shyng SL.

J Gen Physiol. 2011 Mar;137(3):299-314. doi: 10.1085/jgp.201010557. Epub 2011 Feb 14.

22.

In vitro incorporation of nonnatural amino acids into protein using tRNA(Cys)-derived opal, ochre, and amber suppressor tRNAs.

Gubbens J, Kim SJ, Yang Z, Johnson AE, Skach WR.

RNA. 2010 Aug;16(8):1660-72. doi: 10.1261/rna.2024810. Epub 2010 Jun 25.

23.

Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex.

Yan FF, Pratt EB, Chen PC, Wang F, Skach WR, David LL, Shyng SL.

Mol Biol Cell. 2010 Jun 15;21(12):1945-54. doi: 10.1091/mbc.E10-02-0116. Epub 2010 Apr 28.

24.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, Sorscher EJ, Okiyoneda T, Yates JR 3rd, Lukacs GL, Frizzell RA, Manning G, Gottesfeld JM, Balch WE.

Nat Chem Biol. 2010 Jan;6(1):25-33. doi: 10.1038/nchembio.275. Epub 2009 Dec 6.

25.

Cellular mechanisms of membrane protein folding.

Skach WR.

Nat Struct Mol Biol. 2009 Jun;16(6):606-12. doi: 10.1038/nsmb.1600.

26.

Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon.

Pitonzo D, Yang Z, Matsumura Y, Johnson AE, Skach WR.

Mol Biol Cell. 2009 Jan;20(2):685-98. doi: 10.1091/mbc.E08-09-0902. Epub 2008 Nov 19.

27.

Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking.

Crane JM, Van Hoek AN, Skach WR, Verkman AS.

Mol Biol Cell. 2008 Aug;19(8):3369-78. doi: 10.1091/mbc.E08-03-0322. Epub 2008 May 21.

28.

Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.

Daniel CJ, Conti B, Johnson AE, Skach WR.

J Biol Chem. 2008 Jul 25;283(30):20864-73. doi: 10.1074/jbc.M803517200. Epub 2008 May 13.

29.

The expanding role of the ER translocon in membrane protein folding.

Skach WR.

J Cell Biol. 2007 Dec 31;179(7):1333-5. doi: 10.1083/jcb.200711107. Review.

30.
31.

A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization.

Buck TM, Wagner J, Grund S, Skach WR.

Nat Struct Mol Biol. 2007 Aug;14(8):762-9. Epub 2007 Jul 15.

PMID:
17632520
32.

Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.

Wahlman J, DeMartino GN, Skach WR, Bulleid NJ, Brodsky JL, Johnson AE.

Cell. 2007 Jun 1;129(5):943-55.

33.

CFTR: new members join the fold.

Skach WR.

Cell. 2006 Nov 17;127(4):673-5.

34.

Global organization and function of mammalian cytosolic proteasome pools: Implications for PA28 and 19S regulatory complexes.

Shibatani T, Carlson EJ, Larabee F, McCormack AL, Früh K, Skach WR.

Mol Biol Cell. 2006 Dec;17(12):4962-71. Epub 2006 Sep 20.

35.

p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation.

Carlson EJ, Pitonzo D, Skach WR.

EMBO J. 2006 Oct 4;25(19):4557-66. Epub 2006 Sep 14.

36.

Molecular mechanisms of aquaporin biogenesis by the endoplasmic reticulum Sec61 translocon.

Pitonzo D, Skach WR.

Biochim Biophys Acta. 2006 Aug;1758(8):976-88. Epub 2006 May 19. Review.

37.

Uncoupling proteasome peptidase and ATPase activities results in cytosolic release of an ER polytopic protein.

Oberdorf J, Carlson EJ, Skach WR.

J Cell Sci. 2006 Jan 15;119(Pt 2):303-13. Epub 2006 Jan 3.

38.

Aberrant folding of a mutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction.

Chia DJ, Subbian E, Buck TM, Hwa V, Rosenfeld RG, Skach WR, Shinde U, Rotwein P.

J Biol Chem. 2006 Mar 10;281(10):6552-8. Epub 2005 Nov 22. Erratum in: J Biol Chem. 2006 Jun 2;281(22):15592.

39.

Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein.

Sadlish H, Pitonzo D, Johnson AE, Skach WR.

Nat Struct Mol Biol. 2005 Oct;12(10):870-8. Epub 2005 Sep 25.

PMID:
16186821
41.

The cotranslational contacts between ribosome-bound nascent polypeptides and the subunits of the hetero-oligomeric chaperonin TRiC probed by photocross-linking.

Etchells SA, Meyer AS, Yam AY, Roobol A, Miao Y, Shao Y, Carden MJ, Skach WR, Frydman J, Johnson AE.

J Biol Chem. 2005 Jul 29;280(30):28118-26. Epub 2005 May 30.

42.

Reticulocyte lysate as a model system to study endoplasmic reticulum membrane protein degradation.

Carlson E, Bays N, David L, Skach WR.

Methods Mol Biol. 2005;301:185-205.

PMID:
15917633
43.

Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.

Shibatani T, David LL, McCormack AL, Frueh K, Skach WR.

Biochemistry. 2005 Apr 26;44(16):5982-92.

PMID:
15835887
44.

Biogenesis of CFTR and other polytopic membrane proteins: new roles for the ribosome-translocon complex.

Sadlish H, Skach WR.

J Membr Biol. 2004 Dec;202(3):115-26. Review.

PMID:
15798900
45.
46.

Evidence for stabilization of aquaporin-2 folding mutants by N-linked glycosylation in endoplasmic reticulum.

Buck TM, Eledge J, Skach WR.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1292-9. Epub 2004 Jul 14.

47.

Molecular mechanism of P-glycoprotein assembly into cellular membranes.

Anthony V, Skach WR.

Curr Protein Pept Sci. 2002 Oct;3(5):485-501. Review.

PMID:
12369997
48.
49.

In vitro reconstitution of CFTR biogenesis and degradation.

Oberdorf J, Skach WR.

Methods Mol Med. 2002;70:295-310. No abstract available.

PMID:
11917531
50.

Redundancy of mammalian proteasome beta subunit function during endoplasmic reticulum associated degradation.

Oberdorf J, Carlson EJ, Skach WR.

Biochemistry. 2001 Nov 6;40(44):13397-405.

PMID:
11683650

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