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Items: 1 to 50 of 155

1.

Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Clostridium difficile Colitis while Dysregulating the Inflammatory Response.

Maseda D, Zackular JP, Trindade B, Kirk L, Roxas JL, Rogers LM, Washington MK, Du L, Koyama T, Viswanathan VK, Vedantam G, Schloss PD, Crofford LJ, Skaar EP, Aronoff DM.

MBio. 2019 Jan 8;10(1). pii: e02282-18. doi: 10.1128/mBio.02282-18.

2.

Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection.

Knippel RJ, Zackular JP, Moore JL, Celis AI, Weiss A, Washington MK, DuBois JL, Caprioli RM, Skaar EP.

PLoS Pathog. 2018 Dec 21;14(12):e1007486. doi: 10.1371/journal.ppat.1007486. eCollection 2018 Dec.

3.

Nonconventional Therapeutics against Staphylococcus aureus.

Grunenwald CM, Bennett MR, Skaar EP.

Microbiol Spectr. 2018 Nov;6(6). doi: 10.1128/microbiolspec.GPP3-0047-2018.

PMID:
30547858
4.

Human mAbs to Staphylococcus aureus IsdA Provide Protection Through Both Heme-Blocking and Fc-Mediated Mechanisms.

Bennett MR, Bombardi RG, Kose N, Parrish EH, Nagel MB, Petit RA 3rd, Read TD, Schey KL, Thomsen IP, Skaar EP, Crowe JE Jr.

J Infect Dis. 2018 Nov 29. doi: 10.1093/infdis/jiy635. [Epub ahead of print]

PMID:
30496483
5.

Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus.

Choby JE, Buechi HB, Farrand AJ, Skaar EP, Barber MF.

MBio. 2018 Nov 20;9(6). pii: e01524-18. doi: 10.1128/mBio.01524-18.

6.

Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide.

Juttukonda LJ, Green ER, Lonergan ZR, Heffern MC, Chang CJ, Skaar EP.

Infect Immun. 2018 Dec 19;87(1). pii: e00413-18. doi: 10.1128/IAI.00413-18. Print 2019 Jan.

PMID:
30297527
7.

Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.

Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ Jr, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter R.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10124-10129. doi: 10.1073/pnas.1807613115. Epub 2018 Sep 18.

PMID:
30228116
8.

An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis.

Gutierrez DB, Gant-Branum RL, Romer CE, Farrow MA, Allen JL, Dahal N, Nei YW, Codreanu SG, Jordan AT, Palmer LD, Sherrod SD, McLean JA, Skaar EP, Norris JL, Caprioli RM.

J Proteome Res. 2018 Oct 5;17(10):3396-3408. doi: 10.1021/acs.jproteome.8b00302. Epub 2018 Aug 30.

PMID:
30114907
9.

Correction: Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.

Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ.

PLoS Genet. 2018 Jul 27;14(7):e1007564. doi: 10.1371/journal.pgen.1007564. eCollection 2018 Jul.

10.

The Impact of Dietary Transition Metals on Host-Bacterial Interactions.

Lopez CA, Skaar EP.

Cell Host Microbe. 2018 Jun 13;23(6):737-748. doi: 10.1016/j.chom.2018.05.008. Review.

PMID:
29902439
11.

Drug-Resistant Staphylococcus aureus Strains Reveal Distinct Biochemical Features with Raman Microspectroscopy.

Ayala OD, Wakeman CA, Pence IJ, Gaddy JA, Slaughter JC, Skaar EP, Mahadevan-Jansen A.

ACS Infect Dis. 2018 Aug 10;4(8):1197-1210. doi: 10.1021/acsinfecdis.8b00029. Epub 2018 Jun 25.

PMID:
29845863
12.

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP).

Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M.

Nat Chem Biol. 2018 Jun;14(6):609-617. doi: 10.1038/s41589-018-0060-1. Epub 2018 May 16.

13.

Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions.

Cassat JE, Moore JL, Wilson KJ, Stark Z, Prentice BM, Van de Plas R, Perry WJ, Zhang Y, Virostko J, Colvin DC, Rose KL, Judd AM, Reyzer ML, Spraggins JM, Grunenwald CM, Gore JC, Caprioli RM, Skaar EP.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaan6361. doi: 10.1126/scitranslmed.aan6361.

PMID:
29540616
14.

The role of zinc and nutritional immunity in Clostridium difficile infection.

Zackular JP, Skaar EP.

Gut Microbes. 2018;9(5):469-476. doi: 10.1080/19490976.2018.1448354. Epub 2018 Sep 25.

PMID:
29533126
15.

Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis.

Choby JE, Grunenwald CM, Celis AI, Gerdes SY, DuBois JL, Skaar EP.

MBio. 2018 Feb 6;9(1). pii: e02287-17. doi: 10.1128/mBio.02287-17.

16.

Fur regulation of Staphylococcus aureus heme oxygenases is required for heme homeostasis.

Lojek LJ, Farrand AJ, Weiss A, Skaar EP.

Int J Med Microbiol. 2018 Aug;308(6):582-589. doi: 10.1016/j.ijmm.2018.01.009. Epub 2018 Feb 1.

PMID:
29409696
17.

Crossed Wires: Interspecies Interference Blocks Pathogen Colonization.

Lopez CA, Skaar EP.

Cell Host Microbe. 2017 Dec 13;22(6):721-723. doi: 10.1016/j.chom.2017.11.016.

18.

In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection.

Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12669-12674. doi: 10.1073/pnas.1708747114. Epub 2017 Nov 14.

19.

Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species.

Kinsella RL, Lopez J, Palmer LD, Salinas ND, Skaar EP, Tolia NH, Feldman MF.

J Biol Chem. 2017 Dec 1;292(48):19628-19638. doi: 10.1074/jbc.M117.808394. Epub 2017 Oct 5.

20.

Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP.

Cell Host Microbe. 2017 Oct 11;22(4):531-542.e8. doi: 10.1016/j.chom.2017.08.009. Epub 2017 Sep 21.

21.

Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus.

Peng H, Zhang Y, Palmer LD, Kehl-Fie TE, Skaar EP, Trinidad JC, Giedroc DP.

ACS Infect Dis. 2017 Oct 13;3(10):744-755. doi: 10.1021/acsinfecdis.7b00090. Epub 2017 Sep 6.

22.

Chlamydomonas reinhardtii LFO1 Is an IsdG Family Heme Oxygenase.

Lojek LJ, Farrand AJ, Wisecaver JH, Blaby-Haas CE, Michel BW, Merchant SS, Rokas A, Skaar EP.

mSphere. 2017 Aug 16;2(4). pii: e00176-17. doi: 10.1128/mSphere.00176-17. eCollection 2017 Jul-Aug.

23.

Antibacterial photosensitization through activation of coproporphyrinogen oxidase.

Surdel MC, Horvath DJ Jr, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, Lacy DB, Dailey HA, Skaar EP.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6652-E6659. doi: 10.1073/pnas.1700469114. Epub 2017 Jul 24.

24.

Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus.

Peng H, Shen J, Edmonds KA, Luebke JL, Hickey AK, Palmer LD, Chang FJ, Bruce KA, Kehl-Fie TE, Skaar EP, Giedroc DP.

mSphere. 2017 Jun 21;2(3). pii: e00082-17. doi: 10.1128/mSphere.00082-17. eCollection 2017 May-Jun.

25.

Mechanisms of pyocyanin toxicity and genetic determinants of resistance in Staphylococcus aureus.

Noto MJ, Burns WJ, Beavers WN, Skaar EP.

J Bacteriol. 2017 Jun 12. pii: JB.00221-17. doi: 10.1128/JB.00221-17. [Epub ahead of print]

26.

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC.

Assay Drug Dev Technol. 2017 Apr;15(3):113-119. doi: 10.1089/adt.2016.772. Epub 2017 Apr 5.

27.

A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity.

Garcia YM, Barwinska-Sendra A, Tarrant E, Skaar EP, Waldron KJ, Kehl-Fie TE.

PLoS Pathog. 2017 Jan 19;13(1):e1006125. doi: 10.1371/journal.ppat.1006125. eCollection 2017 Jan.

28.

Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action.

Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan A, Burns W, Poland JC, Romer C, Manier ML, Nei YW, Prentice BM, Rose KL, Hill S, Van de Plas R, Tsui T, Braman NM, Keller MR, Rutherford SA, Lobdell N, Lopez CF, Lacy DB, McLean JA, Wikswo JP, Skaar EP, Caprioli RM.

J Proteome Res. 2017 Mar 3;16(3):1364-1375. doi: 10.1021/acs.jproteome.6b01004. Epub 2017 Feb 9.

PMID:
28088864
29.

RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis.

Noto MJ, Becker KW, Boyd KL, Schmidt AM, Skaar EP.

Infect Immun. 2017 Feb 23;85(3). pii: e00954-16. doi: 10.1128/IAI.00954-16. Print 2017 Mar.

30.

Erratum: Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.

Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP.

Nat Med. 2016 Dec 6;22(12):1502. doi: 10.1038/nm1216-1502d. No abstract available.

31.

TLR9 activation suppresses inflammation in response to Helicobacter pylori infection.

Varga MG, Piazuelo MB, Romero-Gallo J, Delgado AG, Suarez G, Whitaker ME, Krishna US, Patel RV, Skaar EP, Wilson KT, Algood HM, Peek RM Jr.

Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G852-G858. doi: 10.1152/ajpgi.00175.2016. Epub 2016 Oct 6.

32.

Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.

Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP.

Nat Med. 2016 Nov;22(11):1330-1334. doi: 10.1038/nm.4174. Epub 2016 Sep 26. Erratum in: Nat Med. 2016 Dec 6;22(12 ):1502.

33.

A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus.

Choby JE, Mike LA, Mashruwala AA, Dutter BF, Dunman PM, Sulikowski GA, Boyd JM, Skaar EP.

Cell Chem Biol. 2016 Nov 17;23(11):1351-1361. doi: 10.1016/j.chembiol.2016.09.012. Epub 2016 Oct 20.

34.

Acinetobacter baumannii Coordinates Urea Metabolism with Metal Import To Resist Host-Mediated Metal Limitation.

Juttukonda LJ, Chazin WJ, Skaar EP.

MBio. 2016 Sep 27;7(5). pii: e01475-16. doi: 10.1128/mBio.01475-16.

35.

Bacterial Nitric Oxide Synthase Is Required for the Staphylococcus aureus Response to Heme Stress.

Surdel MC, Dutter BF, Sulikowski GA, Skaar EP.

ACS Infect Dis. 2016 Aug 12;2(8):572-8. doi: 10.1021/acsinfecdis.6b00081. Epub 2016 Jul 7.

PMID:
27626297
36.

Transition Metals and Virulence in Bacteria.

Palmer LD, Skaar EP.

Annu Rev Genet. 2016 Nov 23;50:67-91. Epub 2016 Sep 7. Review.

37.

Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.

Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ.

PLoS Genet. 2016 Aug 30;12(8):e1006246. doi: 10.1371/journal.pgen.1006246. eCollection 2016 Aug. Erratum in: PLoS Genet. 2018 Jul 27;14(7):e1007564.

38.

Binding of transition metals to S100 proteins.

Gilston BA, Skaar EP, Chazin WJ.

Sci China Life Sci. 2016 Aug;59(8):792-801. doi: 10.1007/s11427-016-5088-4. Epub 2016 Jul 19. Review.

39.

CtaM Is Required for Menaquinol Oxidase aa3 Function in Staphylococcus aureus.

Hammer ND, Schurig-Briccio LA, Gerdes SY, Gennis RB, Skaar EP.

MBio. 2016 Jul 12;7(4). pii: e00823-16. doi: 10.1128/mBio.00823-16.

40.

Neutrophil-generated oxidative stress and protein damage in Staphylococcus aureus.

Beavers WN, Skaar EP.

Pathog Dis. 2016 Aug;74(6). pii: ftw060. doi: 10.1093/femspd/ftw060. Epub 2016 Jun 27. Review.

41.

Repurposing the Nonsteroidal Anti-inflammatory Drug Diflunisal as an Osteoprotective, Antivirulence Therapy for Staphylococcus aureus Osteomyelitis.

Hendrix AS, Spoonmore TJ, Wilde AD, Putnam NE, Hammer ND, Snyder DJ, Guelcher SA, Skaar EP, Cassat JE.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5322-30. doi: 10.1128/AAC.00834-16. Print 2016 Sep.

42.

The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction.

Wakeman CA, Moore JL, Noto MJ, Zhang Y, Singleton MD, Prentice BM, Gilston BA, Doster RS, Gaddy JA, Chazin WJ, Caprioli RM, Skaar EP.

Nat Commun. 2016 Jun 15;7:11951. doi: 10.1038/ncomms11951.

43.

The Response of Acinetobacter baumannii to Zinc Starvation.

Nairn BL, Lonergan ZR, Wang J, Braymer JJ, Zhang Y, Calcutt MW, Lisher JP, Gilston BA, Chazin WJ, de Crécy-Lagard V, Giedroc DP, Skaar EP.

Cell Host Microbe. 2016 Jun 8;19(6):826-36. doi: 10.1016/j.chom.2016.05.007.

44.

Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration.

Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M.

Cell Host Microbe. 2016 Jun 8;19(6):814-25. doi: 10.1016/j.chom.2016.05.005.

45.

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system.

Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM.

Oncogene. 2016 Dec 1;35(48):6262-6269. doi: 10.1038/onc.2016.158. Epub 2016 May 9.

46.

Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis.

Spraggins JM, Rizzo DG, Moore JL, Noto MJ, Skaar EP, Caprioli RM.

Proteomics. 2016 Jun;16(11-12):1678-89. doi: 10.1002/pmic.201600003. Epub 2016 May 10.

47.

Heme Synthesis and Acquisition in Bacterial Pathogens.

Choby JE, Skaar EP.

J Mol Biol. 2016 Aug 28;428(17):3408-28. doi: 10.1016/j.jmb.2016.03.018. Epub 2016 Mar 24. Review.

48.

Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphylococcus aureus.

Dutter BF, Mike LA, Reid PR, Chong KM, Ramos-Hunter SJ, Skaar EP, Sulikowski GA.

ACS Chem Biol. 2016 May 20;11(5):1354-61. doi: 10.1021/acschembio.5b00934. Epub 2016 Mar 4.

49.

Medically Relevant Acinetobacter Species Require a Type II Secretion System and Specific Membrane-Associated Chaperones for the Export of Multiple Substrates and Full Virulence.

Harding CM, Kinsella RL, Palmer LD, Skaar EP, Feldman MF.

PLoS Pathog. 2016 Jan 14;12(1):e1005391. doi: 10.1371/journal.ppat.1005391. eCollection 2016 Jan.

50.

Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection.

Wilde AD, Snyder DJ, Putnam NE, Valentino MD, Hammer ND, Lonergan ZR, Hinger SA, Aysanoa EE, Blanchard C, Dunman PM, Wasserman GA, Chen J, Shopsin B, Gilmore MS, Skaar EP, Cassat JE.

PLoS Pathog. 2015 Dec 18;11(12):e1005341. doi: 10.1371/journal.ppat.1005341. eCollection 2015 Dec.

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