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Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host.

Perry WJ, Spraggins JM, Sheldon JR, Grunenwald CM, Heinrichs DE, Cassat JE, Skaar EP, Caprioli RM.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201913991. doi: 10.1073/pnas.1913991116. [Epub ahead of print]


Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism.

Beavers WN, Monteith AJ, Amarnath V, Mernaugh RL, Roberts LJ 2nd, Chazin WJ, Davies SS, Skaar EP.

MBio. 2019 Oct 1;10(5). pii: e01333-19. doi: 10.1128/mBio.01333-19.


The Acinetobacter baumannii Znu system overcomes host-imposed nutrient zinc limitation.

Hesse LE, Lonergan ZR, Beavers WN, Skaar EP.

Infect Immun. 2019 Sep 23. pii: IAI.00746-19. doi: 10.1128/IAI.00746-19. [Epub ahead of print]


Nutrient Zinc at the Host-Pathogen Interface.

Lonergan ZR, Skaar EP.

Trends Biochem Sci. 2019 Jul 17. pii: S0968-0004(19)30143-4. doi: 10.1016/j.tibs.2019.06.010. [Epub ahead of print] Review.


Staphylococcus aureus Coproporphyrinogen III Oxidase Is Required for Aerobic and Anaerobic Heme Synthesis.

Choby JE, Skaar EP.

mSphere. 2019 Jul 10;4(4). pii: e00235-19. doi: 10.1128/mSphere.00235-19.


Mechanistic Insights into the Metal-Dependent Activation of ZnII-Dependent Metallochaperones.

Jordan MR, Wang J, Weiss A, Skaar EP, Capdevila DA, Giedroc DP.

Inorg Chem. 2019 Jun 17. doi: 10.1021/acs.inorgchem.9b01173. [Epub ahead of print]


Control of Metabolite Flux during the Final Steps of Heme b Biosynthesis in Gram-Positive Bacteria.

Celis AI, Choby JE, Kentro J, Skaar EP, DuBois JL.

Biochemistry. 2019 Jun 26. doi: 10.1021/acs.biochem.9b00140. [Epub ahead of print]


Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes.

Di Venanzio G, Flores-Mireles AL, Calix JJ, Haurat MF, Scott NE, Palmer LD, Potter RF, Hibbing ME, Friedman L, Wang B, Dantas G, Skaar EP, Hultgren SJ, Feldman MF.

Nat Commun. 2019 Jun 24;10(1):2763. doi: 10.1038/s41467-019-10706-y.


Misoprostol protects mice against severe Clostridium difficile infection and promotes recovery of the gut microbiota after antibiotic perturbation.

Zackular JP, Kirk L, Trindade BC, Skaar EP, Aronoff DM.

Anaerobe. 2019 Aug;58:89-94. doi: 10.1016/j.anaerobe.2019.06.006. Epub 2019 Jun 17. Review.


Adjunctive transferrin to reduce the emergence of antibiotic resistance in Gram-negative bacteria.

Luna BM, Ershova K, Yan J, Ulhaq A, Nielsen TB, Hsieh S, Pantapalangkoor P, Vanscoy B, Ambrose P, Rudin S, Hujer K, Bonomo RA, Actis L, Skaar EP, Spellberg B.

J Antimicrob Chemother. 2019 Sep 1;74(9):2631-2639. doi: 10.1093/jac/dkz225.


MicroLESA: Integrating Autofluorescence Microscopy, In Situ Micro-Digestions, and Liquid Extraction Surface Analysis for High Spatial Resolution Targeted Proteomic Studies.

Ryan DJ, Patterson NH, Putnam NE, Wilde AD, Weiss A, Perry WJ, Cassat JE, Skaar EP, Caprioli RM, Spraggins JM.

Anal Chem. 2019 Jun 18;91(12):7578-7585. doi: 10.1021/acs.analchem.8b05889. Epub 2019 May 31.


Targeting Mobilization of Ferrous Iron in Pseudomonas aeruginosa Infection with an Iron(II)-Caged LpxC Inhibitor.

Blank BR, Talukder P, Muir RK, Green ER, Skaar EP, Renslo AR.

ACS Infect Dis. 2019 Aug 9;5(8):1366-1375. doi: 10.1021/acsinfecdis.9b00057. Epub 2019 Jun 11.


Modification of the Gastric Mucosal Microbiota by a Strain-Specific Helicobacter pylori Oncoprotein and Carcinogenic Histologic Phenotype.

Noto JM, Zackular JP, Varga MG, Delgado A, Romero-Gallo J, Scholz MB, Piazuelo MB, Skaar EP, Peek RM Jr.

MBio. 2019 May 28;10(3). pii: e00955-19. doi: 10.1128/mBio.00955-19.


Metals as phagocyte antimicrobial effectors.

Sheldon JR, Skaar EP.

Curr Opin Immunol. 2019 Oct;60:1-9. doi: 10.1016/j.coi.2019.04.002. Epub 2019 May 4. Review.


Total Synthesis of Hinduchelins A-D, Stereochemical Revision of Hinduchelin A, and Biological Evaluation of Natural and Unnatural Analogues.

Childress ES, Garrison AT, Sheldon JR, Skaar EP, Lindsley CW.

J Org Chem. 2019 May 17;84(10):6459-6464. doi: 10.1021/acs.joc.9b00391. Epub 2019 May 8.


Zinc intoxication induces ferroptosis in A549 human lung cells.

Palmer LD, Jordan AT, Maloney KN, Farrow MA, Gutierrez DB, Gant-Branum R, Burns WJ, Romer CE, Tsui T, Allen JL, Beavers WN, Nei YW, Sherrod SD, Lacy DB, Norris JL, McLean JA, Caprioli RM, Skaar EP.

Metallomics. 2019 May 22;11(5):982-993. doi: 10.1039/c8mt00360b.


The Innate Immune Protein S100A9 Protects from T-Helper Cell Type 2-mediated Allergic Airway Inflammation.

Palmer LD, Maloney KN, Boyd KL, Goleniewska AK, Toki S, Maxwell CN, Chazin WJ, Peebles RS Jr, Newcomb DC, Skaar EP.

Am J Respir Cell Mol Biol. 2019 Oct;61(4):459-468. doi: 10.1165/rcmb.2018-0217OC.


Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii.

Wang J, Lonergan ZR, Gonzalez-Gutierrez G, Nairn BL, Maxwell CN, Zhang Y, Andreini C, Karty JA, Chazin WJ, Trinidad JC, Skaar EP, Giedroc DP.

Cell Chem Biol. 2019 May 16;26(5):745-755.e7. doi: 10.1016/j.chembiol.2019.02.011. Epub 2019 Mar 21.


Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic Escherichia coli.

Palmer LD, Skaar EP.

MBio. 2019 Feb 26;10(1). pii: e00115-19. doi: 10.1128/mBio.00115-19.


Manganese Detoxification by MntE Is Critical for Resistance to Oxidative Stress and Virulence of Staphylococcus aureus.

Grunenwald CM, Choby JE, Juttukonda LJ, Beavers WN, Weiss A, Torres VJ, Skaar EP.

MBio. 2019 Feb 26;10(1). pii: e02915-18. doi: 10.1128/mBio.02915-18.


Assessing Acinetobacter baumannii Virulence and Persistence in a Murine Model of Lung Infection.

Palmer LD, Green ER, Sheldon JR, Skaar EP.

Methods Mol Biol. 2019;1946:289-305. doi: 10.1007/978-1-4939-9118-1_26.


An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.

Lonergan ZR, Nairn BL, Wang J, Hsu YP, Hesse LE, Beavers WN, Chazin WJ, Trinidad JC, VanNieuwenhze MS, Giedroc DP, Skaar EP.

Cell Rep. 2019 Feb 19;26(8):2009-2018.e6. doi: 10.1016/j.celrep.2019.01.089.


Apotransferrin in Combination with Ciprofloxacin Slows Bacterial Replication, Prevents Resistance Amplification, and Increases Antimicrobial Regimen Effect.

Ambrose PG, VanScoy BD, Luna BM, Yan J, Ulhaq A, Nielsen TB, Rudin S, Hujer K, Bonomo RA, Actis L, Skaar E, Spellberg B.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e00112-19. doi: 10.1128/AAC.00112-19. Print 2019 May.


A Phenome-Wide Association Study Uncovers a Pathological Role of Coagulation Factor X during Acinetobacter baumannii Infection.

Choby JE, Monteith AJ, Himmel LE, Margaritis P, Shirey-Rice JK, Pruijssers A, Jerome RN, Pulley J, Skaar EP.

Infect Immun. 2019 Apr 23;87(5). pii: e00031-19. doi: 10.1128/IAI.00031-19. Print 2019 Mar.


S100 Proteins in the Innate Immune Response to Pathogens.

Kozlyuk N, Monteith AJ, Garcia V, Damo SM, Skaar EP, Chazin WJ.

Methods Mol Biol. 2019;1929:275-290. doi: 10.1007/978-1-4939-9030-6_18.


Synthesis of the Siderophore Coelichelin and Its Utility as a Probe in the Study of Bacterial Metal Sensing and Response.

Williams JC, Sheldon JR, Imlay HD, Dutter BF, Draelos MM, Skaar EP, Sulikowski GA.

Org Lett. 2019 Feb 1;21(3):679-682. doi: 10.1021/acs.orglett.8b03857. Epub 2019 Jan 15.


Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Clostridium difficile Colitis while Dysregulating the Inflammatory Response.

Maseda D, Zackular JP, Trindade B, Kirk L, Roxas JL, Rogers LM, Washington MK, Du L, Koyama T, Viswanathan VK, Vedantam G, Schloss PD, Crofford LJ, Skaar EP, Aronoff DM.

MBio. 2019 Jan 8;10(1). pii: e02282-18. doi: 10.1128/mBio.02282-18.


Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection.

Knippel RJ, Zackular JP, Moore JL, Celis AI, Weiss A, Washington MK, DuBois JL, Caprioli RM, Skaar EP.

PLoS Pathog. 2018 Dec 21;14(12):e1007486. doi: 10.1371/journal.ppat.1007486. eCollection 2018 Dec.


Nonconventional Therapeutics against Staphylococcus aureus.

Grunenwald CM, Bennett MR, Skaar EP.

Microbiol Spectr. 2018 Nov;6(6). doi: 10.1128/microbiolspec.GPP3-0047-2018.


Human mAbs to Staphylococcus aureus IsdA Provide Protection Through Both Heme-Blocking and Fc-Mediated Mechanisms.

Bennett MR, Bombardi RG, Kose N, Parrish EH, Nagel MB, Petit RA, Read TD, Schey KL, Thomsen IP, Skaar EP, Crowe JE.

J Infect Dis. 2019 Apr 8;219(8):1264-1273. doi: 10.1093/infdis/jiy635.


Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus.

Choby JE, Buechi HB, Farrand AJ, Skaar EP, Barber MF.

MBio. 2018 Nov 20;9(6). pii: e01524-18. doi: 10.1128/mBio.01524-18.


Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide.

Juttukonda LJ, Green ER, Lonergan ZR, Heffern MC, Chang CJ, Skaar EP.

Infect Immun. 2018 Dec 19;87(1). pii: e00413-18. doi: 10.1128/IAI.00413-18. Print 2019 Jan.


A novel geriatric assessment frailty score predicts 2-year mortality after transcatheter aortic valve implantation.

Skaar E, Eide LSP, Norekvål TM, Ranhoff AH, Nordrehaug JE, Forman DE, Schoenenberger AW, Hufthammer KO, Kuiper KK, Bleie Ø, Packer EJS, Langørgen J, Haaverstad R, Schaufel MA.

Eur Heart J Qual Care Clin Outcomes. 2019 Apr 1;5(2):153-160. doi: 10.1093/ehjqcco/qcy044.


Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.

Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ Jr, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter R.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10124-10129. doi: 10.1073/pnas.1807613115. Epub 2018 Sep 18.


An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis.

Gutierrez DB, Gant-Branum RL, Romer CE, Farrow MA, Allen JL, Dahal N, Nei YW, Codreanu SG, Jordan AT, Palmer LD, Sherrod SD, McLean JA, Skaar EP, Norris JL, Caprioli RM.

J Proteome Res. 2018 Oct 5;17(10):3396-3408. doi: 10.1021/acs.jproteome.8b00302. Epub 2018 Aug 30.


Correction: Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.

Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ.

PLoS Genet. 2018 Jul 27;14(7):e1007564. doi: 10.1371/journal.pgen.1007564. eCollection 2018 Jul.


The Impact of Dietary Transition Metals on Host-Bacterial Interactions.

Lopez CA, Skaar EP.

Cell Host Microbe. 2018 Jun 13;23(6):737-748. doi: 10.1016/j.chom.2018.05.008. Review.


Drug-Resistant Staphylococcus aureus Strains Reveal Distinct Biochemical Features with Raman Microspectroscopy.

Ayala OD, Wakeman CA, Pence IJ, Gaddy JA, Slaughter JC, Skaar EP, Mahadevan-Jansen A.

ACS Infect Dis. 2018 Aug 10;4(8):1197-1210. doi: 10.1021/acsinfecdis.8b00029. Epub 2018 Jun 25.


Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP).

Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M.

Nat Chem Biol. 2018 Jun;14(6):609-617. doi: 10.1038/s41589-018-0060-1. Epub 2018 May 16.


Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions.

Cassat JE, Moore JL, Wilson KJ, Stark Z, Prentice BM, Van de Plas R, Perry WJ, Zhang Y, Virostko J, Colvin DC, Rose KL, Judd AM, Reyzer ML, Spraggins JM, Grunenwald CM, Gore JC, Caprioli RM, Skaar EP.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaan6361. doi: 10.1126/scitranslmed.aan6361.


The role of zinc and nutritional immunity in Clostridium difficile infection.

Zackular JP, Skaar EP.

Gut Microbes. 2018;9(5):469-476. doi: 10.1080/19490976.2018.1448354. Epub 2018 Sep 25.


Understanding cardiovascular physiology of ageing.

Flaatten H, Skaar E, Joynt GM.

Intensive Care Med. 2018 Jun;44(6):932-935. doi: 10.1007/s00134-018-5119-7. Epub 2018 Mar 9. No abstract available.


Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis.

Choby JE, Grunenwald CM, Celis AI, Gerdes SY, DuBois JL, Skaar EP.

MBio. 2018 Feb 6;9(1). pii: e02287-17. doi: 10.1128/mBio.02287-17.


Fur regulation of Staphylococcus aureus heme oxygenases is required for heme homeostasis.

Lojek LJ, Farrand AJ, Weiss A, Skaar EP.

Int J Med Microbiol. 2018 Aug;308(6):582-589. doi: 10.1016/j.ijmm.2018.01.009. Epub 2018 Feb 1.


Crossed Wires: Interspecies Interference Blocks Pathogen Colonization.

Lopez CA, Skaar EP.

Cell Host Microbe. 2017 Dec 13;22(6):721-723. doi: 10.1016/j.chom.2017.11.016.


In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection.

Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12669-12674. doi: 10.1073/pnas.1708747114. Epub 2017 Nov 14.


Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species.

Kinsella RL, Lopez J, Palmer LD, Salinas ND, Skaar EP, Tolia NH, Feldman MF.

J Biol Chem. 2017 Dec 1;292(48):19628-19638. doi: 10.1074/jbc.M117.808394. Epub 2017 Oct 5.


Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP.

Cell Host Microbe. 2017 Oct 11;22(4):531-542.e8. doi: 10.1016/j.chom.2017.08.009. Epub 2017 Sep 21.


Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus.

Peng H, Zhang Y, Palmer LD, Kehl-Fie TE, Skaar EP, Trinidad JC, Giedroc DP.

ACS Infect Dis. 2017 Oct 13;3(10):744-755. doi: 10.1021/acsinfecdis.7b00090. Epub 2017 Sep 6.


Chlamydomonas reinhardtii LFO1 Is an IsdG Family Heme Oxygenase.

Lojek LJ, Farrand AJ, Wisecaver JH, Blaby-Haas CE, Michel BW, Merchant SS, Rokas A, Skaar EP.

mSphere. 2017 Aug 16;2(4). pii: e00176-17. doi: 10.1128/mSphere.00176-17. eCollection 2017 Jul-Aug.

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