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Epidemiology of Pulmonary Fibrosis: A Cohort Study Using Healthcare Data in Sweden.

Ferrara G, Arnheim-Dahlström L, Bartley K, Janson C, Kirchgässler KU, Levine A, Sköld CM.

Pulm Ther. 2019 Jun;5(1):55-68. doi: 10.1007/s41030-019-0087-9. Epub 2019 Mar 5.


Gender differences at presentation of idiopathic pulmonary fibrosis in Sweden.

Kalafatis D, Gao J, Pesonen I, Carlson L, Sköld CM, Ferrara G.

BMC Pulm Med. 2019 Nov 27;19(1):222. doi: 10.1186/s12890-019-0994-4.


Clinical validation of the Swedish version of Dyspnoea-12 instrument in outpatients with cardiorespiratory disease.

Sundh J, Bornefalk H, Sköld CM, Janson C, Blomberg A, Sandberg J, Bornefalk-Hermansson A, Igelström H, Ekström M.

BMJ Open Respir Res. 2019 Sep 18;6(1):e000418. doi: 10.1136/bmjresp-2019-000418. eCollection 2019.


Dysregulation of the Tryptophan Pathway Evidences Gender Differences in COPD.

Naz S, Bhat M, Ståhl S, Forsslund H, Sköld CM, Wheelock ÅM, Wheelock CE.

Metabolites. 2019 Oct 1;9(10). pii: E212. doi: 10.3390/metabo9100212.


Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis.

Roos Ljungberg K, Joshua V, Skogh T, Eklund A, Sköld CM, Karimi R, Nyrén S, Svärd A, Catrina AI, Kastbom A.

Rheumatology (Oxford). 2020 Apr 1;59(4):852-859. doi: 10.1093/rheumatology/kez377.


Patient journey and treatment patterns in adults with IPF based on health care data in Sweden from 2001 to 2015.

Sköld CM, Arnheim-Dahlström L, Bartley K, Janson C, Kirchgaessler KU, Levine A, Ferrara G.

Respir Med. 2019 Aug;155:72-78. doi: 10.1016/j.rmed.2019.06.001. Epub 2019 Jun 5.


Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma.

Um-Bergström P, Hallberg J, Pourbazargan M, Berggren-Broström E, Ferrara G, Eriksson MJ, Nyrén S, Gao J, Lilja G, Lindén A, Wheelock ÅM, Melén E, Sköld CM.

Respir Res. 2019 May 24;20(1):102. doi: 10.1186/s12931-019-1075-1.


Long-term safety of pirfenidone: results of the prospective, observational PASSPORT study.

Cottin V, Koschel D, Günther A, Albera C, Azuma A, Sköld CM, Tomassetti S, Hormel P, Stauffer JL, Strombom I, Kirchgaessler KU, Maher TM.

ERJ Open Res. 2018 Oct 19;4(4). pii: 00084-2018. doi: 10.1183/23120541.00084-2018. eCollection 2018 Oct.


An LC-MS/MS workflow to characterize 16 regio- and stereoisomeric trihydroxyoctadecenoic acids.

Fuchs D, Hamberg M, Sköld CM, Wheelock ÅM, Wheelock CE.

J Lipid Res. 2018 Oct;59(10):2025-2033. doi: 10.1194/jlr.D087429. Epub 2018 Jul 31.


Delay and inequalities in the treatment of idiopathic pulmonary fibrosis: the case of two Nordic countries.

Pesonen I, Carlson L, Murgia N, Kaarteenaho R, Sköld CM, Myllärniemi M, Ferrara G.

Multidiscip Respir Med. 2018 May 14;13:14. doi: 10.1186/s40248-018-0126-7. eCollection 2018.


The neutrophil-mobilizing cytokine interleukin-26 in the airways of long-term tobacco smokers.

Che KF, Tufvesson E, Tengvall S, Lappi-Blanco E, Kaarteenaho R, Levänen B, Ekberg M, Brauner A, Wheelock ÅM, Bjermer L, Sköld CM, Lindén A.

Clin Sci (Lond). 2018 May 20;132(9):959-983. doi: 10.1042/CS20180057. Print 2018 May 23.


Bronchoalveolar lavage (BAL) cells in idiopathic pulmonary fibrosis express a complex pro-inflammatory, pro-repair, angiogenic activation pattern, likely associated with macrophage iron accumulation.

Lee J, Arisi I, Puxeddu E, Mramba LK, Amicosante M, Swaisgood CM, Pallante M, Brantly ML, Sköld CM, Saltini C.

PLoS One. 2018 Apr 12;13(4):e0194803. doi: 10.1371/journal.pone.0194803. eCollection 2018. Erratum in: PLoS One. 2018 May 17;13(5):e0197794.


Integration of multi-omics datasets enables molecular classification of COPD.

Li CX, Wheelock CE, Sköld CM, Wheelock ÅM.

Eur Respir J. 2018 May 10;51(5). pii: 1701930. doi: 10.1183/13993003.01930-2017. Print 2018 May.


Interleukin-26 Production in Human Primary Bronchial Epithelial Cells in Response to Viral Stimulation: Modulation by Th17 cytokines.

Che KF, Kaarteenaho R, Lappi-Blanco E, Levänen B, Sun J, Wheelock Å, Palmberg L, Sköld CM, Lindén A.

Mol Med. 2017 Oct;23:247-257. doi: 10.2119/molmed.2016.00064. Epub 2017 Aug 29.


Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia.

Um-Bergström P, Hallberg J, Thunqvist P, Berggren-Broström E, Anderson M, Adenfelt G, Lilja G, Ferrara G, Sköld CM, Melén E.

BMC Pulm Med. 2017 Jun 30;17(1):97. doi: 10.1186/s12890-017-0441-3.


Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD.

Naz S, Kolmert J, Yang M, Reinke SN, Kamleh MA, Snowden S, Heyder T, Levänen B, Erle DJ, Sköld CM, Wheelock ÅM, Wheelock CE.

Eur Respir J. 2017 Jun 22;49(6). pii: 1602322. doi: 10.1183/13993003.02322-2016. Print 2017 Jun.


Measures of bronchodilator response of FEV1, FVC and SVC in a Swedish general population sample aged 50-64 years, the SCAPIS Pilot Study.

Torén K, Bake B, Olin AC, Engström G, Blomberg A, Vikgren J, Hedner J, Brandberg J, Persson HL, Sköld CM, Rosengren A, Bergström G, Janson C.

Int J Chron Obstruct Pulmon Dis. 2017 Mar 22;12:973-980. doi: 10.2147/COPD.S127336. eCollection 2017.


Differences in regional air trapping in current smokers with normal spirometry.

Karimi R, Tornling G, Forsslund H, Mikko M, Wheelock ÅM, Nyrén S, Sköld CM.

Eur Respir J. 2017 Jan 25;49(1). pii: 1600345. doi: 10.1183/13993003.00345-2016. Print 2017 Jan.


Gender differences in the T-cell profiles of the airways in COPD patients associated with clinical phenotypes.

Forsslund H, Yang M, Mikko M, Karimi R, Nyrén S, Engvall B, Grunewald J, Merikallio H, Kaarteenaho R, Wahlström J, Wheelock ÅM, Sköld CM.

Int J Chron Obstruct Pulmon Dis. 2016 Dec 20;12:35-48. doi: 10.2147/COPD.S113625. eCollection 2017.


Translation and validation of the King's Brief Interstitial Lung Disease (K-BILD) questionnaire in French, Italian, Swedish, and Dutch.

Wapenaar M, Patel AS, Birring SS, Domburg RTV, Bakker EW, Vindigni V, Sköld CM, Cottin V, Vancheri C, Wijsenbeek MS.

Chron Respir Dis. 2017 May;14(2):140-150. doi: 10.1177/1479972316674425. Epub 2016 Dec 26.


Treatment of idiopathic pulmonary fibrosis: a position paper from a Nordic expert group.

Sköld CM, Bendstrup E, Myllärniemi M, Gudmundsson G, Sjåheim T, Hilberg O, Altraja A, Kaarteenaho R, Ferrara G.

J Intern Med. 2017 Feb;281(2):149-166. doi: 10.1111/joim.12571. Epub 2016 Nov 13. Review.


A retrospective chart review of pirfenidone-treated patients in Sweden: the REPRIS study.

Sköld CM, Janson C, Elf ÅK, Fiaschi M, Wiklund K, Persson HL.

Eur Clin Respir J. 2016 Jul 18;3:32035. doi: 10.3402/ecrj.v3.32035. eCollection 2016.


Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: a randomised, double-blind, placebo-controlled, phase 2 trial.

Behr J, Bendstrup E, Crestani B, Günther A, Olschewski H, Sköld CM, Wells A, Wuyts W, Koschel D, Kreuter M, Wallaert B, Lin CY, Beck J, Albera C.

Lancet Respir Med. 2016 Jun;4(6):445-53. doi: 10.1016/S2213-2600(16)30044-3. Epub 2016 May 5.


Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.

Balgoma D, Yang M, Sjödin M, Snowden S, Karimi R, Levänen B, Merikallio H, Kaarteenaho R, Palmberg L, Larsson K, Erle DJ, Dahlén SE, Dahlén B, Sköld CM, Wheelock ÅM, Wheelock CE.

Eur Respir J. 2016 Jun;47(6):1645-56. doi: 10.1183/13993003.01080-2015. Epub 2016 Mar 10.


Signs of immune activation and local inflammation are present in the bronchial tissue of patients with untreated early rheumatoid arthritis.

Reynisdottir G, Olsen H, Joshua V, Engström M, Forsslund H, Karimi R, Sköld CM, Nyren S, Eklund A, Grunewald J, Catrina AI.

Ann Rheum Dis. 2016 Sep;75(9):1722-7. doi: 10.1136/annrheumdis-2015-208216. Epub 2015 Nov 3.


Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation.

Ytterberg AJ, Joshua V, Reynisdottir G, Tarasova NK, Rutishauser D, Ossipova E, Haj Hensvold A, Eklund A, Sköld CM, Grunewald J, Malmström V, Jakobsson PJ, Rönnelid J, Padyukov L, Zubarev RA, Klareskog L, Catrina AI.

Ann Rheum Dis. 2015 Sep;74(9):1772-7. doi: 10.1136/annrheumdis-2013-204912. Epub 2014 May 9.


Lung cancer-associated myofibroblasts reveal distinctive ultrastructure and function.

Karvonen HM, Lehtonen ST, Sormunen RT, Lappi-Blanco E, Sköld CM, Kaarteenaho RL.

J Thorac Oncol. 2014 May;9(5):664-74. doi: 10.1097/JTO.0000000000000149.


Lung density on high resolution computer tomography (HRCT) reflects degree of inflammation in smokers.

Karimi R, Tornling G, Forsslund H, Mikko M, Wheelock Å, Nyrén S, Sköld CM.

Respir Res. 2014 Feb 24;15:23. doi: 10.1186/1465-9921-15-23.


Structural changes and antibody enrichment in the lungs are early features of anti-citrullinated protein antibody-positive rheumatoid arthritis.

Reynisdottir G, Karimi R, Joshua V, Olsen H, Hensvold AH, Harju A, Engström M, Grunewald J, Nyren S, Eklund A, Klareskog L, Sköld CM, Catrina AI.

Arthritis Rheumatol. 2014 Jan;66(1):31-9. doi: 10.1002/art.38201.


Distribution of T-cell subsets in BAL fluid of patients with mild to moderate COPD depends on current smoking status and not airway obstruction.

Forsslund H, Mikko M, Karimi R, Grunewald J, Wheelock ÅM, Wahlström J, Sköld CM.

Chest. 2014 Apr;145(4):711-722. doi: 10.1378/chest.13-0873.


Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients.

Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM.

J Allergy Clin Immunol. 2013 Mar;131(3):894-903. doi: 10.1016/j.jaci.2012.11.039. Epub 2013 Jan 16.


Gender differences in the bronchoalveolar lavage cell proteome of patients with chronic obstructive pulmonary disease.

Kohler M, Sandberg A, Kjellqvist S, Thomas A, Karimi R, Nyrén S, Eklund A, Thevis M, Sköld CM, Wheelock ÅM.

J Allergy Clin Immunol. 2013 Mar;131(3):743-51. doi: 10.1016/j.jaci.2012.09.024. Epub 2012 Nov 10.


Bronchoalveolar lavage results are independent of season, age, gender and collection site.

Olsen HH, Grunewald J, Tornling G, Sköld CM, Eklund A.

PLoS One. 2012;7(8):e43644. doi: 10.1371/journal.pone.0043644. Epub 2012 Aug 31.


Increased intraepithelial (CD103+) CD8+ T cells in the airways of smokers with and without chronic obstructive pulmonary disease.

Mikko M, Forsslund H, Cui L, Grunewald J, Wheelock AM, Wahlström J, Sköld CM.

Immunobiology. 2013 Feb;218(2):225-31. doi: 10.1016/j.imbio.2012.04.012. Epub 2012 May 4.


Cell recovery in bronchoalveolar lavage fluid in smokers is dependent on cumulative smoking history.

Karimi R, Tornling G, Grunewald J, Eklund A, Sköld CM.

PLoS One. 2012;7(3):e34232. doi: 10.1371/journal.pone.0034232. Epub 2012 Mar 29.


Assessing recent smoking status by measuring exhaled carbon monoxide levels.

Sandberg A, Sköld CM, Grunewald J, Eklund A, Wheelock ÅM.

PLoS One. 2011;6(12):e28864. doi: 10.1371/journal.pone.0028864. Epub 2011 Dec 16.


Limited airway effects in mild asthmatics after exposure to air pollution in a road tunnel.

Larsson BM, Grunewald J, Sköld CM, Lundin A, Sandström T, Eklund A, Svartengren M.

Respir Med. 2010 Dec;104(12):1912-8. doi: 10.1016/j.rmed.2010.06.014. Epub 2010 Jul 10.


Remodeling in asthma and COPD--differences and similarities.

Sköld CM.

Clin Respir J. 2010 May;4 Suppl 1:20-7. doi: 10.1111/j.1752-699X.2010.00193.x. Review.


Health effects of a subway environment in healthy volunteers.

Klepczyńska Nyström A, Svartengren M, Grunewald J, Pousette C, Rödin I, Lundin A, Sköld CM, Eklund A, Larsson BM.

Eur Respir J. 2010 Aug;36(2):240-8. doi: 10.1183/09031936.00099909. Epub 2009 Dec 23.


Agonist-specific patterns of beta 2-adrenoceptor responses in human airway cells during prolonged exposure.

Düringer C, Grundström G, Gürcan E, Dainty IA, Lawson M, Korn SH, Jerre A, Håkansson HF, Wieslander E, Fredriksson K, Sköld CM, Löfdahl M, Löfdahl CG, Nicholls DJ, Silberstein DS.

Br J Pharmacol. 2009 Sep;158(1):169-79. doi: 10.1111/j.1476-5381.2009.00262.x. Epub 2009 Jun 22.


PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts.

Togo S, Liu X, Wang X, Sugiura H, Kamio K, Kawasaki S, Kobayashi T, Ertl RF, Ahn Y, Holz O, Magnussen H, Fredriksson K, Skold CM, Rennard SI.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. doi: 10.1152/ajplung.00508.2007. Epub 2009 Mar 20.


Eosinophil cationic protein stimulates migration of human lung fibroblasts in vitro.

Zagai U, Lundahl J, Klominek J, Venge P, Sköld CM.

Scand J Immunol. 2009 Apr;69(4):381-6. doi: 10.1111/j.1365-3083.2009.02233.x.


Increased levels of nerve growth factor in the airways of patients with sarcoidosis.

Dagnell C, Grunewald J, Idali F, Wikén M, Kemi C, Sköld CM, Planck A, Newman LS, Eklund A, Olgart Höglund C.

J Intern Med. 2008 Nov;264(5):463-71. doi: 10.1111/j.1365-2796.2008.01988.x. Epub 2008 Sep 6.


Increased intraepithelial T-cells in stable COPD.

Löfdahl MJ, Roos-Engstrand E, Pourazar J, Bucht A, Dahlen B, Elmberger G, Blomberg A, Sköld CM.

Respir Med. 2008 Dec;102(12):1812-8. doi: 10.1016/j.rmed.2008.06.013. Epub 2008 Aug 15.


Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms.

Togo S, Holz O, Liu X, Sugiura H, Kamio K, Wang X, Kawasaki S, Ahn Y, Fredriksson K, Skold CM, Mueller KC, Branscheid D, Welker L, Watz H, Magnussen H, Rennard SI.

Am J Respir Crit Care Med. 2008 Aug 1;178(3):248-60. doi: 10.1164/rccm.200706-929OC. Epub 2008 May 8.


Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells.

Makrygiannakis D, Hermansson M, Ulfgren AK, Nicholas AP, Zendman AJ, Eklund A, Grunewald J, Skold CM, Klareskog L, Catrina AI.

Ann Rheum Dis. 2008 Oct;67(10):1488-92. doi: 10.1136/ard.2007.075192. Epub 2008 Apr 15.


Detection of Chlamydia pneumoniae on cytospin preparations from bronchoalveolar lavage in COPD patients and in lung tissue from advanced emphysema.

Brandén E, Gnarpe J, Hillerdal G, Orre L, Sköld CM, Löfdahl M, Koyi H, Tornling G.

Int J Chron Obstruct Pulmon Dis. 2007;2(4):643-50.


Human T cells stimulate fibroblast-mediated degradation of extracellular matrix in vitro.

Mikko M, Fredriksson K, Wahlström J, Eriksson P, Grunewald J, Sköld CM.

Clin Exp Immunol. 2008 Feb;151(2):317-25. Epub 2007 Dec 6.


Creatine supplementation and physical training in patients with COPD: a double blind, placebo-controlled study.

Faager G, Söderlund K, Sköld CM, Rundgren S, Tollbäck A, Jakobsson P.

Int J Chron Obstruct Pulmon Dis. 2006;1(4):445-53.


Effects of neurotrophins on human bronchial smooth muscle cell migration and matrix metalloproteinase-9 secretion.

Dagnell C, Kemi C, Klominek J, Eriksson P, Sköld CM, Eklund A, Grunewald J, Olgart Höglund C.

Transl Res. 2007 Nov;150(5):303-10. Epub 2007 May 29.


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