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Items: 10

1.

Matching pH values for antibody stabilization and crystallization suggest rationale for accelerated development of biotherapeutic drugs.

Sjuts H, Schreuder H, Engel CK, Bussemer T, Gokarn Y.

Drug Dev Res. 2019 Nov 23. doi: 10.1002/ddr.21624. [Epub ahead of print]

PMID:
31758731
2.

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.

Sjuts H, Vargiu AV, Kwasny SM, Nguyen ST, Kim HS, Ding X, Ornik AR, Ruggerone P, Bowlin TL, Nikaido H, Pos KM, Opperman TJ.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3509-14. doi: 10.1073/pnas.1602472113. Epub 2016 Mar 14.

3.

Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification.

Payne KA, Fisher K, Sjuts H, Dunstan MS, Bellina B, Johannissen L, Barran P, Hay S, Rigby SE, Leys D.

J Biol Chem. 2015 Nov 13;290(46):27572-81. doi: 10.1074/jbc.M115.685693. Epub 2015 Sep 16.

4.

Structures of the methyltransferase component of Desulfitobacterium hafniense DCB-2 O-demethylase shed light on methyltetrahydrofolate formation.

Sjuts H, Dunstan MS, Fisher K, Leys D.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1900-8. doi: 10.1107/S1399004715013061. Epub 2015 Aug 25.

PMID:
26327380
5.

Correction to Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.

Klingler FM, Wichelhaus TA, Frank D, Cuesta-Bernal J, El-Delik J, Müller HF, Sjuts H, Göttig S, Koenigs A, Pos KM, Pogoryelov D, Proschak E.

J Med Chem. 2015 Aug 13;58(15):6320. doi: 10.1021/acs.jmedchem.5b01097. Epub 2015 Jul 30. No abstract available.

PMID:
26225625
6.

Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.

Klingler FM, Wichelhaus TA, Frank D, Cuesta-Bernal J, El-Delik J, Müller HF, Sjuts H, Göttig S, Koenigs A, Pos KM, Pogoryelov D, Proschak E.

J Med Chem. 2015 Apr 23;58(8):3626-30. doi: 10.1021/jm501844d. Epub 2015 Apr 13. Erratum in: J Med Chem. 2015 Aug 13;58(15):6320.

PMID:
25815530
7.

Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation.

Payne KA, Quezada CP, Fisher K, Dunstan MS, Collins FA, Sjuts H, Levy C, Hay S, Rigby SE, Leys D.

Nature. 2015 Jan 22;517(7535):513-516. doi: 10.1038/nature13901. Epub 2014 Oct 19.

8.

Structure of the cobalamin-binding protein of a putative O-demethylase from Desulfitobacterium hafniense DCB-2.

Sjuts H, Dunstan MS, Fisher K, Leys D.

Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1609-16. doi: 10.1107/S0907444913011323. Epub 2013 Jul 20.

9.

Heterologous expression, purification and cofactor reconstitution of the reductive dehalogenase PceA from Dehalobacter restrictus.

Sjuts H, Fisher K, Dunstan MS, Rigby SE, Leys D.

Protein Expr Purif. 2012 Oct;85(2):224-9. doi: 10.1016/j.pep.2012.08.007. Epub 2012 Aug 23.

PMID:
22940504
10.

Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin.

Meyer D, Neumann P, Koers E, Sjuts H, Lüdtke S, Sheldrick GM, Ficner R, Tittmann K.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10867-72. doi: 10.1073/pnas.1201280109. Epub 2012 Jun 22.

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