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NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity.

Sokolova M, Sjaastad I, Louwe MC, Alfsnes K, Aronsen JM, Zhang L, Haugstad SB, Bendiksen BA, Øgaard J, Bliksøen M, Lien E, Berge RK, Aukrust P, Ranheim T, Yndestad A.

Front Immunol. 2019 Jul 16;10:1621. doi: 10.3389/fimmu.2019.01621. eCollection 2019.


Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding.

McGinley G, Bendiksen BA, Zhang L, Aronsen JM, Nordén ES, Sjaastad I, Espe EKS.

PLoS One. 2019 Jul 5;14(7):e0218874. doi: 10.1371/journal.pone.0218874. eCollection 2019.


The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload.

Mohammadzadeh N, Lunde IG, Andenæs K, Strand ME, Aronsen JM, Skrbic B, Marstein HS, Bandlien C, Nygård S, Gorham J, Sjaastad I, Chakravarti S, Christensen G, Engebretsen KVT, Tønnessen T.

Sci Rep. 2019 Jun 24;9(1):9206. doi: 10.1038/s41598-019-45651-9.


The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP).

Mathiesen SB, Lunde M, Aronsen JM, Romaine A, Kaupang A, Martinsen M, de Souza GA, Nyman TA, Sjaastad I, Christensen G, Carlson CR.

J Biol Chem. 2019 May 31;294(22):8717-8731. doi: 10.1074/jbc.RA118.006423. Epub 2019 Apr 9.


Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes.

Skogestad J, Aronsen JM, Tovsrud N, Wanichawan P, Hougen K, Stokke MK, Carlson CR, Sjaastad I, Sejersted OM, Swift F.

Cardiovasc Res. 2019 Apr 5. pii: cvz087. doi: 10.1093/cvr/cvz087. [Epub ahead of print]


Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia.

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE.

Circ Arrhythm Electrophysiol. 2019 Apr;12(4):e007045. doi: 10.1161/CIRCEP.118.007045.


Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension.

Udjus C, Cero FT, Halvorsen B, Behmen D, Carlson CR, Bendiksen BA, Espe EKS, Sjaastad I, Løberg EM, Yndestad A, Aukrust P, Christensen G, Skjønsberg OH, Larsen KO.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L999-L1012. doi: 10.1152/ajplung.00322.2018. Epub 2019 Mar 25.


Effect on Cardiac Function of Longstanding Juvenile-onset Mixed Connective Tissue Disease: A Controlled Study.

Witczak BN, Hetlevik SO, Sanner H, Barth Z, Schwartz T, Flatø B, Lilleby V, Sjaastad I.

J Rheumatol. 2019 Jul;46(7):739-747. doi: 10.3899/jrheum.180526. Epub 2019 Mar 15.


Cardiomyocyte substructure reverts to an immature phenotype during heart failure.

Lipsett DB, Frisk M, Aronsen JM, Nordén ES, Buonarati OR, Cataliotti A, Hell JW, Sjaastad I, Christensen G, Louch WE.

J Physiol. 2019 Apr;597(7):1833-1853. doi: 10.1113/JP277273. Epub 2019 Feb 27.


Evidence for heterogeneous subsarcolemmal Na+ levels in rat ventricular myocytes.

Skogestad J, Lines GT, Louch WE, Sejersted OM, Sjaastad I, Aronsen JM.

Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H941-H957. doi: 10.1152/ajpheart.00637.2018. Epub 2019 Jan 18.


Cardiorespiratory fitness in long-term juvenile dermatomyositis: a controlled, cross-sectional study of active/inactive disease.

Berntsen KS, Edvardsen E, Hansen BH, Flatø B, Sjaastad I, Sanner H.

Rheumatology (Oxford). 2019 Mar 1;58(3):492-501. doi: 10.1093/rheumatology/key342.


Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation.

Danielsen TK, Manotheepan R, Sadredini M, Leren IS, Edwards AG, Vincent KP, Lehnart SE, Sejersted OM, Sjaastad I, Haugaa KH, Stokke MK.

PLoS One. 2018 Nov 6;13(11):e0207100. doi: 10.1371/journal.pone.0207100. eCollection 2018.


Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes.

Kolstad TR, van den Brink J, MacQuaide N, Lunde PK, Frisk M, Aronsen JM, Norden ES, Cataliotti A, Sjaastad I, Sejersted OM, Edwards AG, Lines GT, Louch WE.

Elife. 2018 Oct 30;7. pii: e39427. doi: 10.7554/eLife.39427.


Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression.

Røe ÅT, Ruud M, Espe EK, Manfra O, Longobardi S, Aronsen JM, Nordén ES, Husebye T, Kolstad TRS, Cataliotti A, Christensen G, Sejersted OM, Niederer SA, Andersen GØ, Sjaastad I, Louch WE.

Cardiovasc Res. 2019 Mar 15;115(4):752-764. doi: 10.1093/cvr/cvy257.


The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.

Andenæs K, Lunde IG, Mohammadzadeh N, Dahl CP, Aronsen JM, Strand ME, Palmero S, Sjaastad I, Christensen G, Engebretsen KVT, Tønnessen T.

PLoS One. 2018 Jul 27;13(7):e0201422. doi: 10.1371/journal.pone.0201422. eCollection 2018.


Association Between Nailfold Capillary Density and Pulmonary and Cardiac Involvement in Medium to Longstanding Juvenile Dermatomyositis.

Barth Z, Schwartz T, Flatø B, Aaløkken TM, Koller A, Lund MB, Sjaastad I, Sanner H.

Arthritis Care Res (Hoboken). 2019 Apr;71(4):492-497. doi: 10.1002/acr.23687.


A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice.

Melleby AO, Romaine A, Aronsen JM, Veras I, Zhang L, Sjaastad I, Lunde IG, Christensen G.

Cardiovasc Res. 2018 Oct 1;114(12):1680-1690. doi: 10.1093/cvr/cvy141.


Heart failure with preserved ejection fraction.

Røe ÅT, Sjaastad I, Louch WE.

Tidsskr Nor Laegeforen. 2017 Oct 2;137(18). doi: 10.4045/tidsskr.16.1068. Print 2017 Oct 3. Review. English, Norwegian.


Regional Dysfunction After Myocardial Infarction in Rats.

Espe EKS, Aronsen JM, Eriksen M, Sejersted OM, Zhang L, Sjaastad I.

Circ Cardiovasc Imaging. 2017 Sep;10(9). pii: e005997. doi: 10.1161/CIRCIMAGING.116.005997.


Assessment of Microvascular Abnormalities by Nailfold Capillaroscopy in Juvenile Dermatomyositis After Medium- to Long-Term Followup.

Barth Z, Witczak BN, Flatø B, Koller A, Sjaastad I, Sanner H.

Arthritis Care Res (Hoboken). 2018 May;70(5):768-776. doi: 10.1002/acr.23338. Epub 2018 Mar 23.


Overexpression of integrin α11 induces cardiac fibrosis in mice.

Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Bendiksen B, Robinson EL, Aronsen JM, Herum KM, Danielsen HE, Sjaastad I, Christensen G, Gullberg D.

Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.12932. Epub 2017 Aug 30.


PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts.

Meier S, Andressen KW, Aronsen JM, Sjaastad I, Hougen K, Skomedal T, Osnes JB, Qvigstad E, Levy FO, Moltzau LR.

Eur J Pharmacol. 2017 Oct 5;812:174-183. doi: 10.1016/j.ejphar.2017.07.014. Epub 2017 Jul 8.


Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients.

Manner IW, Waldum-Grevbo B, Witczak BN, Bækken M, Øktedalen O, Os I, Schwartz T, Sjaastad I.

Blood Press. 2017 Dec;26(6):332-340. doi: 10.1080/08037051.2017.1346459. Epub 2017 Jul 4.


Compensatory and decompensatory alterations in cardiomyocyte Ca2+ dynamics in hearts with diastolic dysfunction following aortic banding.

Gattoni S, Røe ÅT, Aronsen JM, Sjaastad I, Louch WE, Smith NP, Niederer SA.

J Physiol. 2017 Jun 15;595(12):3867-3889. doi: 10.1113/JP273879. Epub 2017 May 21.


Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.

Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A.

Cell Discov. 2017 May 9;3:17013. doi: 10.1038/celldisc.2017.13. eCollection 2017.


Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice.

Dhondup Y, Sjaastad I, Sandanger Ø, Aronsen JM, Ahmed MS, Attramadal H, Finsen AV, Zhang L, Ranheim T, Alfsnes K, Aukrust P, Christensen G, Yndestad A, Vinge LE.

Mediators Inflamm. 2017;2017:9450439. doi: 10.1155/2017/9450439. Epub 2017 Apr 11.


Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids.

Johansen IB, Sandblom E, Skov PV, Gräns A, Ekström A, Lunde IG, Vindas MA, Zhang L, Höglund E, Frisk M, Sjaastad I, Nilsson GE, Øverli Ø.

J Exp Biol. 2017 Jul 15;220(Pt 14):2545-2553. doi: 10.1242/jeb.135046. Epub 2017 May 5.


Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy.

Røe ÅT, Aronsen JM, Skårdal K, Hamdani N, Linke WA, Danielsen HE, Sejersted OM, Sjaastad I, Louch WE.

Cardiovasc Res. 2017 Aug 1;113(10):1161-1172. doi: 10.1093/cvr/cvx087.


Submaximal Exercise Capacity in Juvenile Dermatomyositis after Longterm Disease: The Contribution of Muscle, Lung, and Heart Involvement.

Berntsen KS, Tollisen A, Schwartz T, Kirkhus E, Aaløkken TM, Lund MB, Flatø B, Sjaastad I, Sanner H.

J Rheumatol. 2017 Jun;44(6):827-834. doi: 10.3899/jrheum.160997. Epub 2017 Apr 1.


Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis.

Ottesen AH, Carlson CR, Louch WE, Dahl MB, Sandbu RA, Johansen RF, Jarstadmarken H, Bjørås M, Høiseth AD, Brynildsen J, Sjaastad I, Stridsberg M, Omland T, Christensen G, Røsjø H.

Circ Heart Fail. 2017 Feb;10(2). pii: e003675. doi: 10.1161/CIRCHEARTFAILURE.116.003675.


Noninvasive stratification of postinfarction rats based on the degree of cardiac dysfunction using magnetic resonance imaging and echocardiography.

Aronsen JM, Espe EKS, Skårdal K, Hasic A, Zhang L, Sjaastad I.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H932-H942. doi: 10.1152/ajpheart.00668.2016. Epub 2017 Feb 10.


NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P, Yndestad A, Aukrust P, Bjørås M, Finsen AV.

Cell Rep. 2017 Jan 3;18(1):82-92. doi: 10.1016/j.celrep.2016.12.009.


The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.

Thienpont B, Aronsen JM, Robinson EL, Okkenhaug H, Loche E, Ferrini A, Brien P, Alkass K, Tomasso A, Agrawal A, Bergmann O, Sjaastad I, Reik W, Roderick HL.

J Clin Invest. 2017 Jan 3;127(1):335-348. doi: 10.1172/JCI88353. Epub 2016 Nov 28.


The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling.

Melleby AO, Strand ME, Romaine A, Herum KM, Skrbic B, Dahl CP, Sjaastad I, Fiane AE, Filmus J, Christensen G, Lunde IG.

PLoS One. 2016 Oct 21;11(10):e0165079. doi: 10.1371/journal.pone.0165079. eCollection 2016.


Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies.

Schwartz T, Diederichsen LP, Lundberg IE, Sjaastad I, Sanner H.

RMD Open. 2016 Sep 27;2(2):e000291. eCollection 2016. Review.


A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data.

Espe EKS, Skårdal K, Aronsen JM, Zhang L, Sjaastad I.

Magn Reson Med. 2017 Sep;78(3):1199-1207. doi: 10.1002/mrm.26486. Epub 2016 Oct 3.


Exercise training increases protein O-GlcNAcylation in rat skeletal muscle.

Hortemo KH, Lunde PK, Anonsen JH, Kvaløy H, Munkvik M, Rehn TA, Sjaastad I, Lunde IG, Aronsen JM, Sejersted OM.

Physiol Rep. 2016 Sep;4(18). pii: e12896.


Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure.

Dhondup Y, Ueland T, Dahl CP, Askevold ET, Sandanger Ø, Fiane A, Ohm IK, Sjaastad I, Finsen AV, Wæhre A, Gullestad L, Aukrust P, Yndestad A, Vinge LE.

J Card Fail. 2016 Oct;22(10):823-8. doi: 10.1016/j.cardfail.2016.06.013. Epub 2016 Jun 24.


Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance.

Logantha SJ, Stokke MK, Atkinson AJ, Kharche SR, Parveen S, Saeed Y, Sjaastad I, Sejersted OM, Dobrzynski H.

Front Physiol. 2016 Jun 2;7:197. doi: 10.3389/fphys.2016.00197. eCollection 2016.


Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis.

Frisk M, Ruud M, Espe EK, Aronsen JM, Røe ÅT, Zhang L, Norseng PA, Sejersted OM, Christensen GA, Sjaastad I, Louch WE.

Cardiovasc Res. 2016 Oct;112(1):443-51. doi: 10.1093/cvr/cvw111. Epub 2016 May 25.


Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.

Manotheepan R, Danielsen TK, Sadredini M, Anderson ME, Carlson CR, Lehnart SE, Sjaastad I, Stokke MK.

Cardiovasc Res. 2016 Aug 1;111(3):295-306. doi: 10.1093/cvr/cvw095. Epub 2016 May 8.


Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure.

Sadredini M, Danielsen TK, Aronsen JM, Manotheepan R, Hougen K, Sjaastad I, Stokke MK.

PLoS One. 2016 Apr 20;11(4):e0153887. doi: 10.1371/journal.pone.0153887. eCollection 2016.


Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance.

Skårdal K, Espe EK, Zhang L, Aronsen JM, Sjaastad I.

PLoS One. 2016 Mar 1;11(3):e0150536. doi: 10.1371/journal.pone.0150536. eCollection 2016.


Cardiomyocyte Ca2+ dynamics: clinical perspectives.

Aronsen JM, Louch WE, Sjaastad I.

Scand Cardiovasc J. 2016;50(2):65-77. doi: 10.3109/14017431.2015.1136079. Epub 2016 Feb 7. Review.


Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman.

Hafver TL, Hodne K, Wanichawan P, Aronsen JM, Dalhus B, Lunde PK, Lunde M, Martinsen M, Enger UH, Fuller W, Sjaastad I, Louch WE, Sejersted OM, Carlson CR.

J Biol Chem. 2016 Feb 26;291(9):4561-79. doi: 10.1074/jbc.M115.677898. Epub 2015 Dec 14.


In juvenile dermatomyositis, heart rate variability is reduced, and associated with both cardiac dysfunction and markers of inflammation: a cross-sectional study median 13.5 years after symptom onset.

Barth Z, Nomeland Witczak B, Schwartz T, Gjesdal K, Flatø B, Koller A, Sanner H, Sjaastad I.

Rheumatology (Oxford). 2016 Mar;55(3):535-43. doi: 10.1093/rheumatology/kev376. Epub 2015 Oct 24.


Effects of haloperidol and aripiprazole on the human mesolimbic motivational system: A pharmacological fMRI study.

Bolstad I, Andreassen OA, Groote I, Server A, Sjaastad I, Kapur S, Jensen J.

Eur Neuropsychopharmacol. 2015 Dec;25(12):2252-61. doi: 10.1016/j.euroneuro.2015.09.016. Epub 2015 Oct 9.


Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.

Dhondup Y, Sjaastad I, Scott H, Sandanger Ø, Zhang L, Haugstad SB, Aronsen JM, Ranheim T, Holmen SD, Alfsnes K, Ahmed MS, Attramadal H, Gullestad L, Aukrust P, Christensen G, Yndestad A, Vinge LE.

PLoS One. 2015 Oct 13;10(10):e0139715. doi: 10.1371/journal.pone.0139715. eCollection 2015.


Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice.

Strand ME, Aronsen JM, Braathen B, Sjaastad I, Kvaløy H, Tønnessen T, Christensen G, Lunde IG.

J Mol Cell Cardiol. 2015 Nov;88:133-44. doi: 10.1016/j.yjmcc.2015.10.003. Epub 2015 Oct 9.


Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.

Zoccarato A, Surdo NC, Aronsen JM, Fields LA, Mancuso L, Dodoni G, Stangherlin A, Livie C, Jiang H, Sin YY, Gesellchen F, Terrin A, Baillie GS, Nicklin SA, Graham D, Szabo-Fresnais N, Krall J, Vandeput F, Movsesian M, Furlan L, Corsetti V, Hamilton G, Lefkimmiatis K, Sjaastad I, Zaccolo M.

Circ Res. 2015 Sep 25;117(8):707-19. doi: 10.1161/CIRCRESAHA.114.305892. Epub 2015 Aug 4.


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