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Effects of Dapagliflozin on Symptoms, Function and Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Results from the DAPA-HF Trial.

Kosiborod MN, Jhund P, Docherty KF, Diez M, Petrie MC, Verma S, Nicolau JC, Merkely B, Kitakaze M, DeMets DL, Inzucchi SE, Køeber L, Martinez FA, Ponikowski P, Sabatine MS, Solomon SD, Bengtsson O, Lindholm D, Niklasson A, Sjöstrand M, Langkilde AM, McMurray JJV.

Circulation. 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044138. [Epub ahead of print]


Efficacy and Safety of Dapagliflozin in Heart Failure With Reduced Ejection Fraction According to Age: Insights From DAPA-HF.

Martinez FA, Serenelli M, Nicolau JC, Petrie MC, Chiang CE, Tereshchenko S, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Ponikowski P, Sabatine MS, Demets DL, Dutkiewicz-Piasecka M, Bengtsson O, Sjöstrand M, Langkilde AM, Jhund PS, McMurray JJV.

Circulation. 2019 Nov 17. doi: 10.1161/CIRCULATIONAHA.119.044133. [Epub ahead of print] No abstract available.


Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.

McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Bělohlávek J, Böhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukát A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, O'Meara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjöstrand M, Langkilde AM; DAPA-HF Trial Committees and Investigators.

N Engl J Med. 2019 Sep 19. doi: 10.1056/NEJMoa1911303. [Epub ahead of print]


The Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial: baseline characteristics.

McMurray JJV, DeMets DL, Inzucchi SE, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjöstrand M, Solomon SD; DAPA-HF Committees and Investigators.

Eur J Heart Fail. 2019 Jul 15. doi: 10.1002/ejhf.1548. [Epub ahead of print]


A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF).

McMurray JJV, DeMets DL, Inzucchi SE, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjöstrand M, Solomon SD; DAPA-HF Committees and Investigators.

Eur J Heart Fail. 2019 May;21(5):665-675. doi: 10.1002/ejhf.1432. Epub 2019 Mar 21.


miR-31 regulates energy metabolism and is suppressed in T cells from patients with Sjögren's syndrome.

Johansson A, Nyberg WA, Sjöstrand M, Moruzzi N, Bergman P, Khademi M, Andersson M, Piehl F, Berggren PO, Covacu R, Jagodic M, Espinosa A.

Eur J Immunol. 2019 Feb;49(2):313-322. doi: 10.1002/eji.201747416. Epub 2018 Oct 22.


Towards a palliative care approach in psychiatry: do we need a new definition?

Lindblad A, Helgesson G, Sjöstrand M.

J Med Ethics. 2019 Jan;45(1):26-30. doi: 10.1136/medethics-2018-104944. Epub 2018 Sep 28.


Self-admission in psychiatry: The ethics.

Strand M, Sjöstrand M.

Bioethics. 2019 Jan;33(1):132-137. doi: 10.1111/bioe.12501. Epub 2018 Aug 14.


Skepticism towards the Swedish vision zero for suicide: interviews with 12 psychiatrists.

Karlsson P, Helgesson G, Titelman D, Sjöstrand M, Juth N.

BMC Med Ethics. 2018 Apr 10;19(1):26. doi: 10.1186/s12910-018-0265-6.


Cardiovascular Outcomes According to Urinary Albumin and Kidney Disease in Patients With Type 2 Diabetes at High Cardiovascular Risk: Observations From the SAVOR-TIMI 53 Trial.

Scirica BM, Mosenzon O, Bhatt DL, Udell JA, Steg PG, McGuire DK, Im K, Kanevsky E, Stahre C, Sjöstrand M, Raz I, Braunwald E.

JAMA Cardiol. 2018 Feb 1;3(2):155-163. doi: 10.1001/jamacardio.2017.4228.


Assessment of Saxagliptin Efficacy: Meta-Analysis of 14 Phase 2 and 3 Clinical Trials.

Sjöstrand M, Wei C, Cook W, Johnsson K, Pollack PS, Stahre C, Hirshberg B.

Diabetes Ther. 2017 Jun;8(3):587-599. doi: 10.1007/s13300-017-0261-8. Epub 2017 Apr 21.


Two distinct extracellular RNA signatures released by a single cell type identified by microarray and next-generation sequencing.

Lässer C, Shelke GV, Yeri A, Kim DK, Crescitelli R, Raimondo S, Sjöstrand M, Gho YS, Van Keuren Jensen K, Lötvall J.

RNA Biol. 2017 Jan 2;14(1):58-72. doi: 10.1080/15476286.2016.1249092. Epub 2016 Oct 28.


Interleukin-16-producing NK cells and T-cells in the blood of tobacco smokers with and without COPD.

Andersson A, Malmhäll C, Houltz B, Tengvall S, Sjöstrand M, Qvarfordt I, Lindén A, Bossios A.

Int J Chron Obstruct Pulmon Dis. 2016 Sep 15;11:2245-2258. eCollection 2016.


Precursor B Cells Increase in the Lung during Airway Allergic Inflammation: A Role for B Cell-Activating Factor.

Samitas K, Malmhäll C, Rådinger M, Ramos-Ramirez P, Lu Y, Deák T, Semitekolou M, Gaga M, Sjöstrand M, Lötvall J, Bossios A.

PLoS One. 2016 Aug 11;11(8):e0161161. doi: 10.1371/journal.pone.0161161. eCollection 2016.


[Thoughts on the crisis in primary health care].

Sjöstrand M.

Lakartidningen. 2016 Jul 8;113. pii: D4D3. Swedish. No abstract available.


Predisposing Factors for Any and Major Hypoglycemia With Saxagliptin Versus Placebo and Overall: Analysis From the SAVOR-TIMI 53 Trial.

Cahn A, Raz I, Mosenzon O, Leibowitz G, Yanuv I, Rozenberg A, Iqbal N, Hirshberg B, Sjostrand M, Stahre C, Im K, Kanevsky E, Scirica BM, Bhatt DL, Braunwald E.

Diabetes Care. 2016 Aug;39(8):1329-37. doi: 10.2337/dc15-2763. Epub 2016 May 23.


Induction of labor in women with a uterine scar.

Stenson D, Wallstrom T, Sjostrand M, Akerud H, Gemzell-Danielsson K, Wiberg-Itzel E.

J Matern Fetal Neonatal Med. 2016 Oct;29(20):3286-91. doi: 10.3109/14767058.2015.1123242. Epub 2015 Dec 23.


The Expression of BAFF Is Controlled by IRF Transcription Factors.

Sjöstrand M, Johansson A, Aqrawi L, Olsson T, Wahren-Herlenius M, Espinosa A.

J Immunol. 2016 Jan 1;196(1):91-6. doi: 10.4049/jimmunol.1501061. Epub 2015 Nov 20.


Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice.

Morentin Gutierrez P, Gyte A, deSchoolmeester J, Ceuppens P, Swales J, Stacey C, Eriksson JW, Sjöstrand M, Nilsson C, Leighton B.

Br J Pharmacol. 2015 Oct;172(20):4806-16. doi: 10.1111/bph.13251. Epub 2015 Oct 8.


Ethical deliberations about involuntary treatment: interviews with Swedish psychiatrists.

Sjöstrand M, Sandman L, Karlsson P, Helgesson G, Eriksson S, Juth N.

BMC Med Ethics. 2015 May 28;16:37. doi: 10.1186/s12910-015-0029-5.


Conceptions of decision-making capacity in psychiatry: interviews with Swedish psychiatrists.

Sjöstrand M, Karlsson P, Sandman L, Helgesson G, Eriksson S, Juth N.

BMC Med Ethics. 2015 May 21;16:34. doi: 10.1186/s12910-015-0026-8.


MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma.

Eldh M, Olofsson Bagge R, Lässer C, Svanvik J, Sjöstrand M, Mattsson J, Lindnér P, Choi DS, Gho YS, Lötvall J.

BMC Cancer. 2014 Dec 16;14:962. doi: 10.1186/1471-2407-14-962.


Saxagliptin improves glycemic control by modulating postprandial glucagon and C-peptide levels in Chinese patients with type 2 diabetes.

Sjöstrand M, Iqbal N, Lu J, Hirshberg B.

Diabetes Res Clin Pract. 2014 Aug;105(2):185-91. doi: 10.1016/j.diabres.2014.05.006. Epub 2014 May 29.


Interferon beta treatment of multiple sclerosis increases serum interleukin-7.

Lundström W, Hermanrud C, Sjöstrand M, Brauner S, Wahren-Herlenius M, Olsson T, Karrenbauer V, Hillert J, Fogdell-Hahn A.

Mult Scler. 2014 Nov;20(13):1727-36. doi: 10.1177/1352458514532700. Epub 2014 May 12.


Moral differences in deep continuous palliative sedation and euthanasia.

Juth N, Lindblad A, Lynöe N, Sjöstrand M, Helgesson G.

BMJ Support Palliat Care. 2013 Jun;3(2):203-6. doi: 10.1136/bmjspcare-2012-000431. Epub 2013 Mar 7. Review.


Assessment of beta-cell function in young patients with type 2 diabetes: arginine-stimulated insulin secretion may reflect beta-cell reserve.

Sjostrand M, Carlson K, Arnqvist HJ, Gudbjörnsdottir S, Landin-Olsson M, Lindmark S, Nyström L, Svensson MK, Eriksson JW, Bolinder J.

J Intern Med. 2014 Jan;275(1):39-48.


MicroRNA-155 is essential for T(H)2-mediated allergen-induced eosinophilic inflammation in the lung.

Malmhäll C, Alawieh S, Lu Y, Sjöstrand M, Bossios A, Eldh M, Rådinger M.

J Allergy Clin Immunol. 2014 May;133(5):1429-38, 1438.e1-7. doi: 10.1016/j.jaci.2013.11.008. Epub 2013 Dec 24.


Paternalism in the name of autonomy.

Sjöstrand M, Eriksson S, Juth N, Helgesson G.

J Med Philos. 2013 Dec;38(6):710-24. doi: 10.1093/jmp/jht049. Epub 2013 Oct 24.


Increase in net activity of serine proteinases but not gelatinases after local endotoxin exposure in the peripheral airways of healthy subjects.

Smith ME, Bozinovski S, Malmhäll C, Sjöstrand M, Glader P, Venge P, Hiemstra PS, Anderson GP, Lindén A, Qvarfordt I.

PLoS One. 2013 Sep 23;8(9):e75032. doi: 10.1371/journal.pone.0075032. eCollection 2013.


Authenticity and psychiatric disorder: does autonomy of personal preferences matter?

Sjöstrand M, Juth N.

Med Health Care Philos. 2014 Feb;17(1):115-22. doi: 10.1007/s11019-013-9509-x.


Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.

Sjöstrand M, Ambrosi A, Brauner S, Sullivan J, Malin S, Kuchroo VK, Espinosa A, Wahren-Herlenius M.

J Immunol. 2013 Oct 1;191(7):3753-63. doi: 10.4049/jimmunol.1202341. Epub 2013 Aug 23.


The selective phosphodiesterase-5 inhibitor tadalafil induces microvascular and metabolic effects in type 2 diabetic postmenopausal females.

Murdolo G, Sjöstrand M, Strindberg L, Lönnroth P, Jansson PA.

J Clin Endocrinol Metab. 2013 Jan;98(1):245-54. doi: 10.1210/jc.2012-1830. Epub 2012 Nov 1.


Pharmacodynamic effects of the oral glucokinase activator AZD6370 after single doses in healthy volunteers assessed with euglycaemic clamp.

Sjöstrand M, Ericsson H, Hartford M, Norjavaara E, Eriksson JW.

Diabetes Obes Metab. 2013 Jan;15(1):35-41. doi: 10.1111/j.1463-1326.2012.01672.x. Epub 2012 Sep 9.


Immunophenotyping of circulating T helper cells argues for multiple functions and plasticity of T cells in vivo in humans--possible role in asthma.

Malmhäll C, Bossios A, Rådinger M, Sjöstrand M, Lu Y, Lundbäck B, Lötvall J.

PLoS One. 2012;7(6):e40012. doi: 10.1371/journal.pone.0040012. Epub 2012 Jun 29.


Glucokinase activators AZD6370 and AZD1656 do not affect the central counterregulatory response to hypoglycemia in healthy males.

Norjavaara E, Ericsson H, Sjöberg F, Leonsson-Zachrisson M, Sjöstrand M, Morrow LA, Hompesch M.

J Clin Endocrinol Metab. 2012 Sep;97(9):3319-25. doi: 10.1210/jc.2012-1496. Epub 2012 Jun 21.


Repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase pathways.

Cui ZH, Rådinger M, Sjöstrand M, Lötvall J.

Clin Transl Allergy. 2012 Mar 22;2:7. doi: 10.1186/2045-7022-2-7.


The launch of Journal of Extracellular Vesicles (JEV), the official journal of the International Society for Extracellular Vesicles - about microvesicles, exosomes, ectosomes and other extracellular vesicles.

Lötvall J, Rajendran L, Gho YS, Thery C, Wauben M, Raposo G, Sjöstrand M, Taylor D, Telemo E, Breakefield XO.

J Extracell Vesicles. 2012 Apr 16;1. doi: 10.3402/jev.v1i0.18514. eCollection 2012. No abstract available.


Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells.

Ekström K, Valadi H, Sjöstrand M, Malmhäll C, Bossios A, Eldh M, Lötvall J.

J Extracell Vesicles. 2012 Apr 16;1. doi: 10.3402/jev.v1i0.18389. eCollection 2012.


Autonomy-based arguments against physician-assisted suicide and euthanasia: a critique.

Sjöstrand M, Helgesson G, Eriksson S, Juth N.

Med Health Care Philos. 2013 May;16(2):225-30. doi: 10.1007/s11019-011-9365-5.


Atropine improves insulin sensitivity in both lean and abdominally obese subjects.

Svensson MK, Jansson PA, Persson AL, Sjöstrand M, Eriksson JW.

J Clin Endocrinol Metab. 2011 Nov;96(11):E1843-7. doi: 10.1210/jc.2011-0669. Epub 2011 Aug 24.


Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.

Lu Y, Malmhäll C, Sjöstrand M, Rådinger M, O'Neil SE, Lötvall J, Bossios A.

PLoS One. 2011;6(5):e19889. doi: 10.1371/journal.pone.0019889. Epub 2011 May 19.


Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages.

Lässer C, Alikhani VS, Ekström K, Eldh M, Paredes PT, Bossios A, Sjöstrand M, Gabrielsson S, Lötvall J, Valadi H.

J Transl Med. 2011 Jan 14;9:9. doi: 10.1186/1479-5876-9-9.


Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA.

Eldh M, Ekström K, Valadi H, Sjöstrand M, Olsson B, Jernås M, Lötvall J.

PLoS One. 2010 Dec 17;5(12):e15353. doi: 10.1371/journal.pone.0015353.


RNA-containing exosomes in human nasal secretions.

Lässer C, O'Neil SE, Ekerljung L, Ekström K, Sjöstrand M, Lötvall J.

Am J Rhinol Allergy. 2011 Mar-Apr;25(2):89-93. doi: 10.2500/ajra.2011.25.3573. Epub 2010 Dec 17.


Effects of tobacco smoke on IL-16 in CD8+ cells from human airways and blood: a key role for oxygen free radicals?

Andersson A, Bossios A, Malmhäll C, Sjöstrand M, Eldh M, Eldh BM, Glader P, Andersson B, Qvarfordt I, Riise GC, Lindén A.

Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L43-55. doi: 10.1152/ajplung.00387.2009. Epub 2010 Oct 29.


Local proliferation and mobilization of CCR3(+)  CD34(+) eosinophil-lineage-committed cells in the lung.

Rådinger M, Bossios A, Sjöstrand M, Lu Y, Malmhäll C, Dahlborn AK, Lee JJ, Lötvall J.

Immunology. 2011 Jan;132(1):144-54. doi: 10.1111/j.1365-2567.2010.03349.x. Epub 2010 Sep 28.


European Association for Palliative Care (EAPC) framework for palliative sedation: an ethical discussion.

Juth N, Lindblad A, Lynöe N, Sjöstrand M, Helgesson G.

BMC Palliat Care. 2010 Sep 13;9:20. doi: 10.1186/1472-684X-9-20.


Tadalafil increases muscle capillary recruitment and forearm glucose uptake in women with type 2 diabetes.

Jansson PA, Murdolo G, Sjögren L, Nyström B, Sjöstrand M, Strindberg L, Lönnroth P.

Diabetologia. 2010 Oct;53(10):2205-8. doi: 10.1007/s00125-010-1819-4. Epub 2010 Jun 10.


Repeated measurements of 11β-HSD-1 activity in subcutaneous adipose tissue from lean, abdominally obese, and type 2 diabetes subjects--no change following a mixed meal.

Sjöstrand M, Jansson PA, Palming J, de Schoolmeester J, Gill D, Rees A, Sjögren L, Persson T, Eriksson JW.

Horm Metab Res. 2010 Oct;42(11):798-802. doi: 10.1055/s-0030-1254134. Epub 2010 May 31.


New production of eosinophils and the corresponding TH1/TH2 balance in the lungs after allergen exposure in BALB/c and C57BL/6 mice.

Lu Y, Sjöstrand M, Malmhäll C, Rådinger M, Jeurink P, Lötvall J, Bossios A.

Scand J Immunol. 2010 Mar;71(3):176-85. doi: 10.1111/j.1365-3083.2009.02363.x.

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