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Items: 1 to 50 of 103

1.

Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data.

Hross S, Theis FJ, Sixt M, Hasenauer J.

J R Soc Interface. 2018 Dec 21;15(149):20180600. doi: 10.1098/rsif.2018.0600.

2.

Nuclear positioning facilitates amoeboid migration along the path of least resistance.

Renkawitz J, Kopf A, Stopp J, de Vries I, Driscoll MK, Merrin J, Hauschild R, Welf ES, Danuser G, Fiolka R, Sixt M.

Nature. 2019 Apr;568(7753):546-550. doi: 10.1038/s41586-019-1087-5. Epub 2019 Apr 3.

PMID:
30944468
3.

IgM's exit route.

Reversat A, Sixt M.

J Exp Med. 2018 Dec 3;215(12):2959-2961. doi: 10.1084/jem.20181934. Epub 2018 Nov 20.

4.

Micro-engineered "pillar forests" to study cell migration in complex but controlled 3D environments.

Renkawitz J, Reversat A, Leithner A, Merrin J, Sixt M.

Methods Cell Biol. 2018;147:79-91. doi: 10.1016/bs.mcb.2018.07.004. Epub 2018 Jul 27.

PMID:
30165964
5.

On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility.

Dolati S, Kage F, Mueller J, Müsken M, Kirchner M, Dittmar G, Sixt M, Rottner K, Falcke M.

Mol Biol Cell. 2018 Nov 1;29(22):2674-2686. doi: 10.1091/mbc.E18-02-0082. Epub 2018 Aug 29.

6.

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells.

Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck R, Balmer J, Fiocchi A, Kreutzfeldt M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV.

J Exp Med. 2018 Jul 2;215(7):1869-1890. doi: 10.1084/jem.20170896. Epub 2018 Jun 6.

7.

The cell sets the tone.

Alanko J, Sixt M.

Elife. 2018 Jun 6;7. pii: e37888. doi: 10.7554/eLife.37888.

8.

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells.

Hons M, Kopf A, Hauschild R, Leithner A, Gaertner F, Abe J, Renkawitz J, Stein JV, Sixt M.

Nat Immunol. 2018 Jun;19(6):606-616. doi: 10.1038/s41590-018-0109-z. Epub 2018 May 18.

PMID:
29777221
9.

Lymphatic exosomes promote dendritic cell migration along guidance cues.

Brown M, Johnson LA, Leone DA, Majek P, Vaahtomeri K, Senfter D, Bukosza N, Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong YK, Bennett KL, Kain R, Detmar M, Sixt M, Jackson DG, Kerjaschki D.

J Cell Biol. 2018 Jun 4;217(6):2205-2221. doi: 10.1083/jcb.201612051. Epub 2018 Apr 12.

10.

Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice.

Brown M, Assen FP, Leithner A, Abe J, Schachner H, Asfour G, Bago-Horvath Z, Stein JV, Uhrin P, Sixt M, Kerjaschki D.

Science. 2018 Mar 23;359(6382):1408-1411. doi: 10.1126/science.aal3662.

PMID:
29567714
11.

A Fat Lot of Good for Wound Healing.

Casano AM, Sixt M.

Dev Cell. 2018 Feb 26;44(4):405-406. doi: 10.1016/j.devcel.2018.02.009.

12.

Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration.

Leithner A, Renkawitz J, De Vries I, Hauschild R, Häcker H, Sixt M.

Eur J Immunol. 2018 Jun;48(6):1074-1077. doi: 10.1002/eji.201747358. Epub 2018 Mar 1.

13.

Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.

Gaertner F, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt M, Massberg S.

Cell. 2017 Nov 30;171(6):1368-1382.e23. doi: 10.1016/j.cell.2017.11.001.

14.

Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments.

Spira F, Cuylen-Haering S, Mehta S, Samwer M, Reversat A, Verma A, Oldenbourg R, Sixt M, Gerlich DW.

Elife. 2017 Nov 6;6. pii: e30867. doi: 10.7554/eLife.30867.

15.

Load Adaptation of Lamellipodial Actin Networks.

Mueller J, Szep G, Nemethova M, de Vries I, Lieber AD, Winkler C, Kruse K, Small JV, Schmeiser C, Keren K, Hauschild R, Sixt M.

Cell. 2017 Sep 21;171(1):188-200.e16. doi: 10.1016/j.cell.2017.07.051. Epub 2017 Aug 31.

16.

A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity.

Veß A, Blache U, Leitner L, Kurz ARM, Ehrenpfordt A, Sixt M, Posern G.

J Cell Sci. 2017 Jul 1;130(13):2172-2184. doi: 10.1242/jcs.200899. Epub 2017 May 17.

17.

The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.

Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, Kenner L, Villunger A, Sixt M, Kovarik P.

J Clin Invest. 2017 Jun 1;127(6):2051-2065. doi: 10.1172/JCI80631. Epub 2017 May 15.

18.

Locally Triggered Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic Endothelia.

Vaahtomeri K, Brown M, Hauschild R, De Vries I, Leithner AF, Mehling M, Kaufmann WA, Sixt M.

Cell Rep. 2017 May 2;19(5):902-909. doi: 10.1016/j.celrep.2017.04.027.

19.

Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6.

Schwarz J, Bierbaum V, Vaahtomeri K, Hauschild R, Brown M, de Vries I, Leithner A, Reversat A, Merrin J, Tarrant T, Bollenbach T, Sixt M.

Curr Biol. 2017 May 8;27(9):1314-1325. doi: 10.1016/j.cub.2017.04.004. Epub 2017 Apr 27.

20.

The Dynamic Cytokine Niche.

Assen FP, Sixt M.

Immunity. 2017 Apr 18;46(4):519-520. doi: 10.1016/j.immuni.2017.04.006.

21.

FMNL formins boost lamellipodial force generation.

Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Brühmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler HJ, Brakebusch C, Stradal TE, Carlier MF, Sixt M, Käs J, Faix J, Rottner K.

Nat Commun. 2017 Mar 22;8:14832. doi: 10.1038/ncomms14832.

22.

Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion.

Horsthemke M, Bachg AC, Groll K, Moyzio S, Müther B, Hemkemeyer SA, Wedlich-Söldner R, Sixt M, Tacke S, Bähler M, Hanley PJ.

J Biol Chem. 2017 Apr 28;292(17):7258-7273. doi: 10.1074/jbc.M116.766923. Epub 2017 Mar 13.

23.

Cell Migration: Making the Waves.

Müller J, Sixt M.

Curr Biol. 2017 Jan 9;27(1):R24-R25. doi: 10.1016/j.cub.2016.11.035.

24.

Formin' a Nuclear Protection.

Renkawitz J, Sixt M.

Cell. 2016 Dec 1;167(6):1448-1449. doi: 10.1016/j.cell.2016.11.024.

25.

A microfluidic device for measuring cell migration towards substrate-bound and soluble chemokine gradients.

Schwarz J, Bierbaum V, Merrin J, Frank T, Hauschild R, Bollenbach T, Tay S, Sixt M, Mehling M.

Sci Rep. 2016 Nov 7;6:36440. doi: 10.1038/srep36440.

26.

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.

Martins R, Maier J, Gorki AD, Huber KV, Sharif O, Starkl P, Saluzzo S, Quattrone F, Gawish R, Lakovits K, Aichinger MC, Radic-Sarikas B, Lardeau CH, Hladik A, Korosec A, Brown M, Vaahtomeri K, Duggan M, Kerjaschki D, Esterbauer H, Colinge J, Eisenbarth SC, Decker T, Bennett KL, Kubicek S, Sixt M, Superti-Furga G, Knapp S.

Nat Immunol. 2016 Dec;17(12):1361-1372. doi: 10.1038/ni.3590. Epub 2016 Oct 31.

PMID:
27798618
27.

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics.

Salzer E, Cagdas D, Hons M, Mace EM, Garncarz W, Petronczki ÖY, Platzer R, Pfajfer L, Bilic I, Ban SA, Willmann KL, Mukherjee M, Supper V, Hsu HT, Banerjee PP, Sinha P, McClanahan F, Zlabinger GJ, Pickl WF, Gribben JG, Stockinger H, Bennett KL, Huppa JB, Dupré L, Sanal Ö, Jäger U, Sixt M, Tezcan I, Orange JS, Boztug K.

Nat Immunol. 2016 Dec;17(12):1352-1360. doi: 10.1038/ni.3575. Epub 2016 Oct 24.

28.

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes.

Leithner A, Eichner A, Müller J, Reversat A, Brown M, Schwarz J, Merrin J, de Gorter DJ, Schur F, Bayerl J, de Vries I, Wieser S, Hauschild R, Lai FP, Moser M, Kerjaschki D, Rottner K, Small JV, Stradal TE, Sixt M.

Nat Cell Biol. 2016 Nov;18(11):1253-1259. doi: 10.1038/ncb3426. Epub 2016 Oct 24.

PMID:
27775702
29.

A Radical Break: Restraining Neutrophil Migration.

Renkawitz J, Sixt M.

Dev Cell. 2016 Sep 12;38(5):448-50. doi: 10.1016/j.devcel.2016.08.017.

30.

Focal Adhesion-Independent Cell Migration.

Paluch EK, Aspalter IM, Sixt M.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:469-490. Epub 2016 Aug 4. Review.

PMID:
27501447
31.

Quantitative Analysis of Dendritic Cell Haptotaxis.

Schwarz J, Sixt M.

Methods Enzymol. 2016;570:567-81. doi: 10.1016/bs.mie.2015.11.004. Epub 2015 Dec 24.

PMID:
26921962
32.

Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels.

Russo E, Teijeira A, Vaahtomeri K, Willrodt AH, Bloch JS, Nitschké M, Santambrogio L, Kerjaschki D, Sixt M, Halin C.

Cell Rep. 2016 Feb 23;14(7):1723-1734. doi: 10.1016/j.celrep.2016.01.048. Epub 2016 Feb 11.

33.

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition.

Kiermaier E, Moussion C, Veldkamp CT, Gerardy-Schahn R, de Vries I, Williams LG, Chaffee GR, Phillips AJ, Freiberger F, Imre R, Taleski D, Payne RJ, Braun A, Förster R, Mechtler K, Mühlenhoff M, Volkman BF, Sixt M.

Science. 2016 Jan 8;351(6269):186-90. doi: 10.1126/science.aad0512. Epub 2015 Dec 10.

34.

Editorial overview: Cell adhesion and migration.

Sixt M, Raz E.

Curr Opin Cell Biol. 2015 Oct;36:iv-vi. doi: 10.1016/j.ceb.2015.09.004. Epub 2015 Oct 11. No abstract available.

PMID:
26459173
35.

Navigating in tissue mazes: chemoattractant interpretation in complex environments.

Sarris M, Sixt M.

Curr Opin Cell Biol. 2015 Oct;36:93-102. doi: 10.1016/j.ceb.2015.08.001. Epub 2015 Sep 7. Review.

36.

IMMUNOLOGY. Fragmented communication between immune cells.

Kiermaier E, Sixt M.

Science. 2015 Sep 4;349(6252):1055-6. doi: 10.1126/science.aad0867. No abstract available.

PMID:
26339015
37.

Corrigendum: Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells.

Chabaud M, Heuzé ML, Bretou M, Vargas P, Maiuri P, Solanes P, Maurin M, Terriac E, Le Berre M, Lankar D, Piolot T, Adelstein RS, Zhang Y, Sixt M, Jacobelli J, Bénichou O, Voituriez R, Piel M, Lennon-Duménil AM.

Nat Commun. 2015 Aug 14;6:8122. doi: 10.1038/ncomms9122. No abstract available.

38.

Neuromuscular electrical stimulation leads to physiological gains enhancing postural balance in the pre-frail elderly.

Mignardot JB, Deschamps T, Le Goff CG, Roumier FX, Duclay J, Martin A, Sixt M, Pousson M, Cornu C.

Physiol Rep. 2015 Jul;3(7). pii: e12471. doi: 10.14814/phy2.12471.

39.

Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.

Veldkamp CT, Kiermaier E, Gabel-Eissens SJ, Gillitzer ML, Lippner DR, DiSilvio FA, Mueller CJ, Wantuch PL, Chaffee GR, Famiglietti MW, Zgoba DM, Bailey AA, Bah Y, Engebretson SJ, Graupner DR, Lackner ER, LaRosa VD, Medeiros T, Olson ML, Phillips AJ, Pyles H, Richard AM, Schoeller SJ, Touzeau B, Williams LG, Sixt M, Peterson FC.

Biochemistry. 2015 Jul 14;54(27):4163-6. doi: 10.1021/acs.biochem.5b00560. Epub 2015 Jul 6.

40.

Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells.

Chabaud M, Heuzé ML, Bretou M, Vargas P, Maiuri P, Solanes P, Maurin M, Terriac E, Le Berre M, Lankar D, Piolot T, Adelstein RS, Zhang Y, Sixt M, Jacobelli J, Bénichou O, Voituriez R, Piel M, Lennon-Duménil AM.

Nat Commun. 2015 Jun 25;6:7526. doi: 10.1038/ncomms8526. Erratum in: Nat Commun. 2015;6:8122.

41.

The serotonin receptor 5-HT₇R regulates the morphology and migratory properties of dendritic cells.

Holst K, Guseva D, Schindler S, Sixt M, Braun A, Chopra H, Pabst O, Ponimaskin E.

J Cell Sci. 2015 Aug 1;128(15):2866-80. doi: 10.1242/jcs.167999. Epub 2015 Jun 19.

42.

Actin flows mediate a universal coupling between cell speed and cell persistence.

Maiuri P, Rupprecht JF, Wieser S, Ruprecht V, Bénichou O, Carpi N, Coppey M, De Beco S, Gov N, Heisenberg CP, Lage Crespo C, Lautenschlaeger F, Le Berre M, Lennon-Dumenil AM, Raab M, Thiam HR, Piel M, Sixt M, Voituriez R.

Cell. 2015 Apr 9;161(2):374-86. doi: 10.1016/j.cell.2015.01.056. Epub 2015 Mar 19.

43.

The lymph node filter revealed.

Hons M, Sixt M.

Nat Immunol. 2015 Apr;16(4):338-40. doi: 10.1038/ni.3126. No abstract available.

PMID:
25789676
44.

A novel Cre recombinase reporter mouse strain facilitates selective and efficient infection of primary immune cells with adenoviral vectors.

Heger K, Kober M, Rieß D, Drees C, de Vries I, Bertossi A, Roers A, Sixt M, Schmidt-Supprian M.

Eur J Immunol. 2015 Jun;45(6):1614-20. doi: 10.1002/eji.201545457. Epub 2015 Apr 17.

45.

Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.

Ruprecht V, Wieser S, Callan-Jones A, Smutny M, Morita H, Sako K, Barone V, Ritsch-Marte M, Sixt M, Voituriez R, Heisenberg CP.

Cell. 2015 Feb 12;160(4):673-685. doi: 10.1016/j.cell.2015.01.008.

46.

Physiology: Relax and come in.

Vaahtomeri K, Sixt M.

Nature. 2014 Oct 23;514(7523):441-2. doi: 10.1038/514441a. No abstract available.

PMID:
25341781
47.

New paradigms in the establishment and maintenance of gradients during directed cell migration.

Majumdar R, Sixt M, Parent CA.

Curr Opin Cell Biol. 2014 Oct;30:33-40. doi: 10.1016/j.ceb.2014.05.010. Epub 2014 Jun 22. Review.

48.

Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects.

Stoler-Barak L, Moussion C, Shezen E, Hatzav M, Sixt M, Alon R.

PLoS One. 2014 Jan 22;9(1):e85699. doi: 10.1371/journal.pone.0085699. eCollection 2014.

49.

A miR-155-dependent microRNA hierarchy in dendritic cell maturation and macrophage activation.

Dueck A, Eichner A, Sixt M, Meister G.

FEBS Lett. 2014 Feb 14;588(4):632-40. doi: 10.1016/j.febslet.2014.01.009. Epub 2014 Jan 18.

50.

Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.

Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt M, Strobl H.

Eur J Immunol. 2014 Feb;44(2):553-60. doi: 10.1002/eji.201343681. Epub 2013 Dec 2.

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