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Items: 1 to 50 of 167

1.

Effects of allochthonous dissolved organic matter input on microbial composition and nitrogen-cycling genes at two contrasting estuarine sites.

Happel EM, Markussen T, Teikari JE, Huchaiah V, Alneberg J, Andersson AF, Sivonen K, Middelboe M, Kisand V, Riemann L.

FEMS Microbiol Ecol. 2019 Sep 1;95(9). pii: fiz123. doi: 10.1093/femsec/fiz123.

PMID:
31397876
2.

Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes.

Humisto A, Jokela J, Teigen K, Wahlsten M, Permi P, Sivonen K, Herfindal L.

Biochim Biophys Acta Biomembr. 2019 Aug 1;1861(8):1510-1521. doi: 10.1016/j.bbamem.2019.03.010. Epub 2019 Jun 19.

3.

The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium.

Shishido TK, Jokela J, Humisto A, Suurnäkki S, Wahlsten M, Alvarenga DO, Sivonen K, Fewer DP.

Mar Drugs. 2019 May 7;17(5). pii: E271. doi: 10.3390/md17050271.

4.

Insight into the genome and brackish water adaptation strategies of toxic and bloom-forming Baltic Sea Dolichospermum sp. UHCC 0315.

Teikari JE, Popin RV, Hou S, Wahlsten M, Hess WR, Sivonen K.

Sci Rep. 2019 Mar 20;9(1):4888. doi: 10.1038/s41598-019-40883-1.

5.

Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides.

Mareš J, Hájek J, Urajová P, Kust A, Jokela J, Saurav K, Galica T, Čapková K, Mattila A, Haapaniemi E, Permi P, Mysterud I, Skulberg OM, Karlsen J, Fewer DP, Sivonen K, Tønnesen HH, Hrouzek P.

Appl Environ Microbiol. 2019 Feb 6;85(4). pii: e02675-18. doi: 10.1128/AEM.02675-18. Print 2019 Feb 15.

6.

N-Prenylation of Tryptophan by an Aromatic Prenyltransferase from the Cyanobactin Biosynthetic Pathway.

Dalponte L, Parajuli A, Younger E, Mattila A, Jokela J, Wahlsten M, Leikoski N, Sivonen K, Jarmusch SA, Houssen WE, Fewer DP.

Biochemistry. 2018 Dec 18;57(50):6860-6867. doi: 10.1021/acs.biochem.8b00879. Epub 2018 Dec 3.

PMID:
30452235
7.

Frequency of virus-resistant hosts determines experimental community dynamics.

Coloma S, Gaedke U, Sivonen K, Hiltunen T.

Ecology. 2019 Jan;100(1):e02554. doi: 10.1002/ecy.2554. Epub 2018 Nov 28.

PMID:
30411791
8.

Sphaerocyclamide, a prenylated cyanobactin from the cyanobacterium Sphaerospermopsis sp. LEGE 00249.

Martins J, Leikoski N, Wahlsten M, Azevedo J, Antunes J, Jokela J, Sivonen K, Vasconcelos V, Fewer DP, Leão PN.

Sci Rep. 2018 Sep 28;8(1):14537. doi: 10.1038/s41598-018-32618-5.

9.

Coupling biogeochemical process rates and metagenomic blueprints of coastal bacterial assemblages in the context of environmental change.

Markussen T, Happel EM, Teikari JE, Huchaiah V, Alneberg J, Andersson AF, Sivonen K, Riemann L, Middelboe M, Kisand V.

Environ Microbiol. 2018 Aug;20(8):3083-3099. doi: 10.1111/1462-2920.14371. Epub 2018 Sep 19.

PMID:
30084235
10.

Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis.

Morita M, Hao Y, Jokela JK, Sardar D, Lin Z, Sivonen K, Nair SK, Schmidt EW.

J Am Chem Soc. 2018 May 16;140(19):6044-6048. doi: 10.1021/jacs.8b03137. Epub 2018 May 1.

11.

Discovery of a Pederin Family Compound in a Nonsymbiotic Bloom-Forming Cyanobacterium.

Kust A, Mareš J, Jokela J, Urajová P, Hájek J, Saurav K, Voráčová K, Fewer DP, Haapaniemi E, Permi P, Řeháková K, Sivonen K, Hrouzek P.

ACS Chem Biol. 2018 May 18;13(5):1123-1129. doi: 10.1021/acschembio.7b01048. Epub 2018 May 2.

PMID:
29570981
12.

Comparative Genomics of the Baltic Sea Toxic Cyanobacteria Nodularia spumigena UHCC 0039 and Its Response to Varying Salinity.

Teikari JE, Hou S, Wahlsten M, Hess WR, Sivonen K.

Front Microbiol. 2018 Mar 8;9:356. doi: 10.3389/fmicb.2018.00356. eCollection 2018.

13.

Strains of the toxic and bloom-forming Nodularia spumigena (cyanobacteria) can degrade methylphosphonate and release methane.

Teikari JE, Fewer DP, Shrestha R, Hou S, Leikoski N, Mäkelä M, Simojoki A, Hess WR, Sivonen K.

ISME J. 2018 Jun;12(6):1619-1630. doi: 10.1038/s41396-018-0056-6. Epub 2018 Feb 14.

14.

Biosynthesis of microcystin hepatotoxins in the cyanobacterial genus Fischerella.

Heck K, Alvarenga DO, Shishido TK, Varani AM, Dörr FA, Pinto E, Rouhiainen L, Jokela J, Sivonen K, Fiore MF.

Toxicon. 2018 Jan;141:43-50. doi: 10.1016/j.toxicon.2017.10.021. Epub 2017 Nov 27.

PMID:
29154789
15.

The Swinholide Biosynthesis Gene Cluster from a Terrestrial Cyanobacterium, Nostoc sp. Strain UHCC 0450.

Humisto A, Jokela J, Liu L, Wahlsten M, Wang H, Permi P, Machado JP, Antunes A, Fewer DP, Sivonen K.

Appl Environ Microbiol. 2018 Jan 17;84(3). pii: e02321-17. doi: 10.1128/AEM.02321-17. Print 2018 Feb 1.

16.

Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543.

Jokela J, Heinilä LMP, Shishido TK, Wahlsten M, Fewer DP, Fiore MF, Wang H, Haapaniemi E, Permi P, Sivonen K.

Front Microbiol. 2017 Oct 9;8:1963. doi: 10.3389/fmicb.2017.01963. eCollection 2017.

17.

Lipid biomarker signatures as tracers for harmful cyanobacterial blooms in the Baltic Sea.

Bauersachs T, Talbot HM, Sidgwick F, Sivonen K, Schwark L.

PLoS One. 2017 Oct 16;12(10):e0186360. doi: 10.1371/journal.pone.0186360. eCollection 2017.

18.

Simultaneous Production of Anabaenopeptins and Namalides by the Cyanobacterium Nostoc sp. CENA543.

Shishido TK, Jokela J, Fewer DP, Wahlsten M, Fiore MF, Sivonen K.

ACS Chem Biol. 2017 Nov 17;12(11):2746-2755. doi: 10.1021/acschembio.7b00570. Epub 2017 Sep 29.

PMID:
28933529
19.

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants.

Alexandru-Crivac CN, Umeobika C, Leikoski N, Jokela J, Rickaby KA, Grilo AM, Sjö P, Plowright AT, Idress M, Siebs E, Nneoyi-Egbe A, Wahlsten M, Sivonen K, Jaspars M, Trembleau L, Fewer DP, Houssen WE.

Chem Commun (Camb). 2017 Sep 26;53(77):10656-10659. doi: 10.1039/c7cc05913b.

PMID:
28905052
20.

Rearranged Biosynthetic Gene Cluster and Synthesis of Hassallidin E in Planktothrix serta PCC 8927.

Pancrace C, Jokela J, Sassoon N, Ganneau C, Desnos-Ollivier M, Wahlsten M, Humisto A, Calteau A, Bay S, Fewer DP, Sivonen K, Gugger M.

ACS Chem Biol. 2017 Jul 21;12(7):1796-1804. doi: 10.1021/acschembio.7b00093. Epub 2017 May 17.

PMID:
28489343
21.

Genetic Organization of Anabaenopeptin and Spumigin Biosynthetic Gene Clusters in the Cyanobacterium Sphaerospermopsis torques-reginae ITEP-024.

Lima ST, Alvarenga DO, Etchegaray A, Fewer DP, Jokela J, Varani AM, Sanz M, Dörr FA, Pinto E, Sivonen K, Fiore MF.

ACS Chem Biol. 2017 Mar 17;12(3):769-778. doi: 10.1021/acschembio.6b00948. Epub 2017 Jan 26.

PMID:
28085246
22.

Evolving interactions between diazotrophic cyanobacterium and phage mediate nitrogen release and host competitive ability.

Cairns J, Coloma S, Sivonen K, Hiltunen T.

R Soc Open Sci. 2016 Dec 14;3(12):160839. doi: 10.1098/rsos.160839. eCollection 2016 Dec.

23.

Corrigendum: A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.

Parajuli A, Kwak DH, Dalponte L, Leikoski N, Galica T, Umeobika U, Trembleau L, Bent A, Sivonen K, Wahlsten M, Wang H, Rizzi E, De Bellis G, Naismith J, Jaspars M, Liu X, Houssen W, Fewer DP.

Angew Chem Int Ed Engl. 2017 Jan 9;56(2):433. doi: 10.1002/anie.201609949. No abstract available.

PMID:
28045232
24.

Newly isolated Nodularia phage influences cyanobacterial community dynamics.

Coloma SE, Dienstbier A, Bamford DH, Sivonen K, Roine E, Hiltunen T.

Environ Microbiol. 2017 Jan;19(1):273-286. doi: 10.1111/1462-2920.13601. Epub 2017 Jan 23.

PMID:
27878952
25.

Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.

Howieson VM, Tran E, Hoegl A, Fam HL, Fu J, Sivonen K, Li XX, Auclair K, Saliba KJ.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7146-7152. Print 2016 Dec.

26.

The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ('Penicillium islandicum').

Schafhauser T, Kirchner N, Kulik A, Huijbers MM, Flor L, Caradec T, Fewer DP, Gross H, Jacques P, Jahn L, Jokela J, Leclère V, Ludwig-Müller J, Sivonen K, van Berkel WJ, Weber T, Wohlleben W, van Pée KH.

Environ Microbiol. 2016 Nov;18(11):3728-3741. doi: 10.1111/1462-2920.13294. Epub 2016 Jun 27.

PMID:
26954535
27.

A liquid chromatography-mass spectrometric method for the detection of cyclic β-amino fatty acid lipopeptides.

Urajová P, Hájek J, Wahlsten M, Jokela J, Galica T, Fewer DP, Kust A, Zapomělová-Kozlíková E, Delawská K, Sivonen K, Kopecký J, Hrouzek P.

J Chromatogr A. 2016 Mar 18;1438:76-83. doi: 10.1016/j.chroma.2016.02.013. Epub 2016 Feb 15.

PMID:
26893022
28.

A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.

Parajuli A, Kwak DH, Dalponte L, Leikoski N, Galica T, Umeobika U, Trembleau L, Bent A, Sivonen K, Wahlsten M, Wang H, Rizzi E, De Bellis G, Naismith J, Jaspars M, Liu X, Houssen W, Fewer DP.

Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3596-9. doi: 10.1002/anie.201509920. Epub 2016 Feb 5. Erratum in: Angew Chem Int Ed Engl. 2017 Jan 9;56(2):433.

29.

Genomic insights into the distribution, genetic diversity and evolution of polyketide synthases and nonribosomal peptide synthetases.

Wang H, Sivonen K, Fewer DP.

Curr Opin Genet Dev. 2015 Dec;35:79-85. doi: 10.1016/j.gde.2015.10.004. Epub 2015 Nov 21. Review.

PMID:
26605685
30.

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria.

Shishido TK, Jokela J, Kolehmainen CT, Fewer DP, Wahlsten M, Wang H, Rouhiainen L, Rizzi E, De Bellis G, Permi P, Sivonen K.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13669-74. doi: 10.1073/pnas.1510432112. Epub 2015 Oct 16.

31.
32.

Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria.

Dittmann E, Gugger M, Sivonen K, Fewer DP.

Trends Microbiol. 2015 Oct;23(10):642-652. doi: 10.1016/j.tim.2015.07.008. Review.

PMID:
26433696
33.

Cyanobacteria as a Source for Novel Anti-Leukemic Compounds.

Humisto A, Herfindal L, Jokela J, Karkman A, Bjørnstad R, Choudhury RR, Sivonen K.

Curr Pharm Biotechnol. 2016;17(1):78-91.

PMID:
26306745
34.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

35.

Draft genome sequence of Talaromyces islandicus ("Penicillium islandicum") WF-38-12, a neglected mold with significant biotechnological potential.

Schafhauser T, Wibberg D, Rückert C, Winkler A, Flor L, van Pée KH, Fewer DP, Sivonen K, Jahn L, Ludwig-Müller J, Caradec T, Jacques P, Huijbers MM, van Berkel WJ, Weber T, Wohlleben W, Kalinowski J.

J Biotechnol. 2015 Oct 10;211:101-2. doi: 10.1016/j.jbiotec.2015.07.004. Epub 2015 Jul 18.

PMID:
26197417
36.

Transcriptomic and Proteomic Profiling of Anabaena sp. Strain 90 under Inorganic Phosphorus Stress.

Teikari J, Österholm J, Kopf M, Battchikova N, Wahlsten M, Aro EM, Hess WR, Sivonen K.

Appl Environ Microbiol. 2015 Aug;81(15):5212-22. doi: 10.1128/AEM.01062-15. Epub 2015 May 29.

37.

Antifungal compounds from cyanobacteria.

Shishido TK, Humisto A, Jokela J, Liu L, Wahlsten M, Tamrakar A, Fewer DP, Permi P, Andreote AP, Fiore MF, Sivonen K.

Mar Drugs. 2015 Apr 13;13(4):2124-40. doi: 10.3390/md13042124.

38.

Draft genome sequence of calothrix strain 336/3, a novel h2-producing cyanobacterium isolated from a finnish lake.

Isojärvi J, Shunmugam S, Sivonen K, Allahverdiyeva Y, Aro EM, Battchikova N.

Genome Announc. 2015 Jan 22;3(1). pii: e01474-14. doi: 10.1128/genomeA.01474-14.

39.

Identification of geosmin and 2-methylisoborneol in cyanobacteria and molecular detection methods for the producers of these compounds.

Suurnäkki S, Gomez-Saez GV, Rantala-Ylinen A, Jokela J, Fewer DP, Sivonen K.

Water Res. 2015 Jan 1;68:56-66.

PMID:
25462716
40.

Anatoxin-a producing Tychonema (Cyanobacteria) in European waterbodies.

Shams S, Capelli C, Cerasino L, Ballot A, Dietrich DR, Sivonen K, Salmaso N.

Water Res. 2015 Feb 1;69:68-79. doi: 10.1016/j.watres.2014.11.006. Epub 2014 Nov 18.

PMID:
25437339
41.

Pseudoaeruginosins, nonribosomal peptides in Nodularia spumigena.

Liu L, Budnjo A, Jokela J, Haug BE, Fewer DP, Wahlsten M, Rouhiainen L, Permi P, Fossen T, Sivonen K.

ACS Chem Biol. 2015 Mar 20;10(3):725-33. doi: 10.1021/cb5004306. Epub 2014 Dec 5.

PMID:
25419633
42.

Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria.

Calteau A, Fewer DP, Latifi A, Coursin T, Laurent T, Jokela J, Kerfeld CA, Sivonen K, Piel J, Gugger M.

BMC Genomics. 2014 Nov 18;15:977. doi: 10.1186/1471-2164-15-977.

43.

4-Methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides.

Liu L, Jokela J, Herfindal L, Wahlsten M, Sinkkonen J, Permi P, Fewer DP, Døskeland SO, Sivonen K.

ACS Chem Biol. 2014 Nov 21;9(11):2646-55. doi: 10.1021/cb500436p. Epub 2014 Sep 25.

PMID:
25203327
44.

Reply to Sasso et al.: Distribution and phylogeny of nonribosomal peptide and polyketide biosynthetic pathways in eukaryotes.

Wang H, Fewer DP, Holm L, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3947. doi: 10.1073/pnas.1413343111. Epub 2014 Sep 2. No abstract available.

45.

Nostosins, Trypsin Inhibitors Isolated from the Terrestrial Cyanobacterium Nostoc sp. Strain FSN.

Liu L, Jokela J, Wahlsten M, Nowruzi B, Permi P, Zhang YZ, Xhaard H, Fewer DP, Sivonen K.

J Nat Prod. 2014 Aug 22;77(8):1784-90. doi: 10.1021/np500106w.

PMID:
25069058
46.

Hydrogen photoproduction by immobilized n2-fixing cyanobacteria: understanding the role of the uptake hydrogenase in the long-term process.

Kosourov S, Leino H, Murukesan G, Lynch F, Sivonen K, Tsygankov AA, Aro EM, Allahverdiyeva Y.

Appl Environ Microbiol. 2014 Sep;80(18):5807-17. doi: 10.1128/AEM.01776-14. Epub 2014 Jul 11.

47.

Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes.

Wang H, Fewer DP, Holm L, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9259-64. doi: 10.1073/pnas.1401734111. Epub 2014 Jun 9.

48.

Secondary metabolite from Nostoc XPORK14A inhibits photosynthesis and growth of Synechocystis PCC 6803.

Shunmugam S, Jokela J, Wahlsten M, Battchikova N, Ateeq ur Rehman, Vass I, Karonen M, Sinkkonen J, Permi P, Sivonen K, Aro EM, Allahverdiyeva Y.

Plant Cell Environ. 2014 Jun;37(6):1371-81.

PMID:
24895757
49.

Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway.

Vestola J, Shishido TK, Jokela J, Fewer DP, Aitio O, Permi P, Wahlsten M, Wang H, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1909-17. doi: 10.1073/pnas.1320913111. Epub 2014 Apr 17.

50.

Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.

Liu L, Herfindal L, Jokela J, Shishido TK, Wahlsten M, Døskeland SO, Sivonen K.

Mar Drugs. 2014 Apr 3;12(4):2036-53. doi: 10.3390/md12042036.

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