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Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia.

Kuttikrishnan S, Siveen KS, Prabhu KS, Khan AQ, Ahmed EI, Akhtar S, Ali TA, Merhi M, Dermime S, Steinhoff M, Uddin S.

Front Oncol. 2019 Jun 19;9:484. doi: 10.3389/fonc.2019.00484. eCollection 2019.


The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer.

Siveen KS, Raza A, Ahmed EI, Khan AQ, Prabhu KS, Kuttikrishnan S, Mateo JM, Zayed H, Rasul K, Azizi F, Dermime S, Steinhoff M, Uddin S.

Cancers (Basel). 2019 May 29;11(6). pii: E746. doi: 10.3390/cancers11060746. Review.


Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.

Ramanjaneya M, Jerobin J, Bettahi I, Bensila M, Aye M, Siveen KS, Sathyapalan T, Skarulis M, Abou-Samra AB, Atkin SL.

Clin Endocrinol (Oxf). 2019 Aug;91(2):278-287. doi: 10.1111/cen.14007. Epub 2019 May 15.


Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.

Akhtar S, Achkar IW, Siveen KS, Kuttikrishnan S, Prabhu KS, Khan AQ, Ahmed EI, Sahir F, Jerobin J, Raza A, Merhi M, Elsabah HM, Taha R, Omri HE, Zayed H, Dermime S, Steinhoff M, Uddin S.

Front Oncol. 2019 Apr 17;9:285. doi: 10.3389/fonc.2019.00285. eCollection 2019.


Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines.

Prabhu KS, Siveen KS, Kuttikrishnan S, Jochebeth A, Ali TA, Elareer NR, Iskandarani A, Quaiyoom Khan A, Merhi M, Dermime S, El-Elimat T, Oberlies NH, Alali FQ, Steinhoff M, Uddin S.

Biomolecules. 2019 Mar 29;9(4). pii: E126. doi: 10.3390/biom9040126.


Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation.

Siveen KS, Prabhu KS, Parray AS, Merhi M, Arredouani A, Chikri M, Uddin S, Dermime S, Mohammad RM, Steinhoff M, Janahi IA, Azizi F.

Sci Rep. 2019 Feb 7;9(1):1554. doi: 10.1038/s41598-018-37469-8.


Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells.

Khan AQ, Siveen KS, Prabhu KS, Kuttikrishnan S, Akhtar S, Shaar A, Raza A, Mraiche F, Dermime S, Uddin S.

Front Oncol. 2018 Oct 2;8:399. doi: 10.3389/fonc.2018.00399. eCollection 2018.


Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia.

Kuttikrishnan S, Siveen KS, Prabhu KS, Khan AQ, Akhtar S, Mateo JM, Merhi M, Taha R, Omri HE, Mraiche F, Dermime S, Uddin S.

Leuk Lymphoma. 2019 Mar;60(3):782-794. doi: 10.1080/10428194.2018.1494270. Epub 2018 Sep 6.


Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines.

Prabhu KS, Siveen KS, Kuttikrishnan S, Iskandarani AN, Khan AQ, Merhi M, Omri HE, Dermime S, El-Elimat T, Oberlies NH, Alali FQ, Uddin S.

Front Pharmacol. 2018 Jul 16;9:720. doi: 10.3389/fphar.2018.00720. eCollection 2018.


Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis.

Halama A, Kulinski M, Dib SS, Zaghlool SB, Siveen KS, Iskandarani A, Zierer J, Prabhu KS, Satheesh NJ, Bhagwat AM, Uddin S, Kastenmüller G, Elemento O, Gross SS, Suhre K.

Cancer Lett. 2018 Aug 28;430:133-147. doi: 10.1016/j.canlet.2018.05.017. Epub 2018 May 17.


Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma.

Shanmugam MK, Ahn KS, Lee JH, Kannaiyan R, Mustafa N, Manu KA, Siveen KS, Sethi G, Chng WJ, Kumar AP.

Front Pharmacol. 2018 May 3;9:365. doi: 10.3389/fphar.2018.00365. eCollection 2018.


Embelin: a benzoquinone possesses therapeutic potential for the treatment of human cancer.

Prabhu KS, Achkar IW, Kuttikrishnan S, Akhtar S, Khan AQ, Siveen KS, Uddin S.

Future Med Chem. 2018 Apr 1;10(8):961-976. doi: 10.4155/fmc-2017-0198. Epub 2018 Apr 5. Review.


RAS-mediated oncogenic signaling pathways in human malignancies.

Khan AQ, Kuttikrishnan S, Siveen KS, Prabhu KS, Shanmugakonar M, Al-Naemi HA, Haris M, Dermime S, Uddin S.

Semin Cancer Biol. 2019 Feb;54:1-13. doi: 10.1016/j.semcancer.2018.03.001. Epub 2018 Mar 7. Review.


Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.

Siveen KS, Prabhu KS, Achkar IW, Kuttikrishnan S, Shyam S, Khan AQ, Merhi M, Dermime S, Uddin S.

Mol Cancer. 2018 Feb 19;17(1):31. doi: 10.1186/s12943-018-0788-y. Review.


Corrigendum on "Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer" [Cancer Lett. 363 (1) (2015) 28-36].

Manu KA, Shanmugam MK, Ramachandran L, Li F, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Arfuso F, Kumar AP, Ahn KS, Sethi G.

Cancer Lett. 2018 Apr 28;420:259. doi: 10.1016/j.canlet.2018.01.003. Epub 2018 Jan 17. No abstract available.


Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells.

Prabhu KS, Siveen KS, Kuttikrishnan S, Iskandarani A, Tsakou M, Achkar IW, Therachiyil L, Krishnankutty R, Parray A, Kulinski M, Merhi M, Dermime S, Mohammad RM, Uddin S.

PLoS One. 2017 Jul 13;12(7):e0180895. doi: 10.1371/journal.pone.0180895. eCollection 2017.


Targeting acute myeloid leukemia stem cell signaling by natural products.

Siveen KS, Uddin S, Mohammad RM.

Mol Cancer. 2017 Jan 30;16(1):13. doi: 10.1186/s12943-016-0571-x. Review.


Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges.

Siveen KS, Prabhu K, Krishnankutty R, Kuttikrishnan S, Tsakou M, Alali FQ, Dermime S, Mohammad RM, Uddin S.

Curr Vasc Pharmacol. 2017;15(4):339-351. doi: 10.2174/1570161115666170105124038. Review.


Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer.

Zhang J, Sikka S, Siveen KS, Lee JH, Um JY, Kumar AP, Chinnathambi A, Alharbi SA, Basappa, Rangappa KS, Sethi G, Ahn KS.

Apoptosis. 2017 Jan;22(1):158-168. doi: 10.1007/s10495-016-1313-7.


Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells.

Iskandarani A, Bhat AA, Siveen KS, Prabhu KS, Kuttikrishnan S, Khan MA, Krishnankutty R, Kulinski M, Nasr RR, Mohammad RM, Uddin S.

J Transl Med. 2016 Mar 9;14:69. doi: 10.1186/s12967-016-0823-y.


Phytochemicals in Cancer Prevention and Therapy.

Pratheeshkumar P, Son YO, Korangath P, Manu KA, Siveen KS.

Biomed Res Int. 2015;2015:324021. doi: 10.1155/2015/324021. Epub 2015 Dec 13. No abstract available.


Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model.

Zhang J, Ahn KS, Kim C, Shanmugam MK, Siveen KS, Arfuso F, Samym RP, Deivasigamanim A, Lim LH, Wang L, Goh BC, Kumar AP, Hui KM, Sethi G.

Antioxid Redox Signal. 2016 Apr 10;24(11):575-89. doi: 10.1089/ars.2015.6418. Epub 2016 Jan 26.


Gene Microarray Analyses of Daboia russelli russelli Daboiatoxin Treatment of THP-1 Human Macrophages Infected with Burkholderia pseudomallei.

Perumal Samy R, Manikandan J, Pachiappan A, Ooi EE, Aw LT, Stiles BG, Franco OL, Kandasamy M, Mathi KM, Rane G, Siveen KS, Arunachalam C, Zayed ME, Alharbi SA, Kumar AP, Sethi G, Lim LH, Chow VT.

Curr Mol Med. 2015;15(10):961-74.


Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model.

Selvi RB, Swaminathan A, Chatterjee S, Shanmugam MK, Li F, Ramakrishnan GB, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Basha J, Bhat A, Vasudevan M, Dharmarajan A, Sethi G, Kundu TK.

Oncotarget. 2015 Dec 22;6(41):43806-18. doi: 10.18632/oncotarget.6245.


Analysis of the intricate relationship between chronic inflammation and cancer.

Chai EZ, Siveen KS, Shanmugam MK, Arfuso F, Sethi G.

Biochem J. 2015 May 15;468(1):1-15. doi: 10.1042/BJ20141337. Review.


Isorhamnetin augments the anti-tumor effect of capecitabine through the negative regulation of NF-κB signaling cascade in gastric cancer.

Manu KA, Shanmugam MK, Ramachandran L, Li F, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Arfuso F, Kumar AP, Ahn KS, Sethi G.

Cancer Lett. 2015 Jul 10;363(1):28-36. doi: 10.1016/j.canlet.2015.03.033. Epub 2015 Mar 28. Erratum in: Cancer Lett. 2018 Jan 13;:.


Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.

Bishayee A, Haskell Y, Do C, Siveen KS, Mohandas N, Sethi G, Stoner GD.

Crit Rev Food Sci Nutr. 2016 Jul 26;56(10):1753-75. doi: 10.1080/10408398.2014.982243. Review.


Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers.

Li F, Shanmugam MK, Siveen KS, Wang F, Ong TH, Loo SY, Swamy MM, Mandal S, Kumar AP, Goh BC, Kundu T, Ahn KS, Wang LZ, Hui KM, Sethi G.

Oncotarget. 2015 Mar 10;6(7):5147-63.


microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer.

Goh JN, Loo SY, Datta A, Siveen KS, Yap WN, Cai W, Shin EM, Wang C, Kim JE, Chan M, Dharmarajan AM, Lee AS, Lobie PE, Yap CT, Kumar AP.

Biol Rev Camb Philos Soc. 2016 May;91(2):409-28. doi: 10.1111/brv.12176. Epub 2015 Jan 28. Review.


Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3.

Dai X, Ahn KS, Kim C, Siveen KS, Ong TH, Shanmugam MK, Li F, Shi J, Kumar AP, Wang LZ, Goh BC, Magae J, Hui KM, Sethi G.

Mol Oncol. 2015 Apr;9(4):818-33. doi: 10.1016/j.molonc.2014.12.008. Epub 2015 Jan 5.


Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review.

Mastron JK, Siveen KS, Sethi G, Bishayee A.

Anticancer Drugs. 2015 Jun;26(5):475-86. doi: 10.1097/CAD.0000000000000211. Review.


Novel synthetic coumarins that targets NF-κB in Hepatocellular carcinoma.

Neelgundmath M, Dinesh KR, Mohan CD, Li F, Dai X, Siveen KS, Paricharak S, Mason DJ, Fuchs JE, Sethi G, Bender A, Rangappa KS, Kotresh O, Basappa.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):893-7. doi: 10.1016/j.bmcl.2014.12.065. Epub 2014 Dec 30.


Novel phospholipase A2 inhibitors from python serum are potent peptide antibiotics.

Samy RP, Thwin MM, Stiles BG, Satyanarayana-Jois S, Chinnathambi A, Zayed ME, Alharbi SA, Siveen KS, Sikka S, Kumar AP, Sethi G, Lim LH.

Biochimie. 2015 Apr;111:30-44. doi: 10.1016/j.biochi.2015.01.003. Epub 2015 Jan 9.


Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives.

Parikh NR, Mandal A, Bhatia D, Siveen KS, Sethi G, Bishayee A.

Phytochem Rev. 2014 Dec;13(4):793-810.


Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.

Siveen KS, Nguyen AH, Lee JH, Li F, Singh SS, Kumar AP, Low G, Jha S, Tergaonkar V, Ahn KS, Sethi G.

Br J Cancer. 2014 Sep 23;111(7):1327-37. doi: 10.1038/bjc.2014.422. Epub 2014 Aug 7.


Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model.

Shanmugam MK, Rajendran P, Li F, Kim C, Sikka S, Siveen KS, Kumar AP, Ahn KS, Sethi G.

Mol Carcinog. 2015 Oct;54(10):971-85. doi: 10.1002/mc.22166. Epub 2014 May 3.


Y-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model.

Siveen KS, Ahn KS, Ong TH, Shanmugam MK, Li F, Yap WN, Kumar AP, Fong CW, Tergaonkar V, Hui KM, Sethi G.

Oncotarget. 2014 Apr 15;5(7):1897-911.


Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.

Siveen KS, Sikka S, Surana R, Dai X, Zhang J, Kumar AP, Tan BK, Sethi G, Bishayee A.

Biochim Biophys Acta. 2014 Apr;1845(2):136-54. doi: 10.1016/j.bbcan.2013.12.005. Epub 2014 Jan 2. Review.


Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products.

Manu KA, Shanmugam MK, Li F, Chen L, Siveen KS, Ahn KS, Kumar AP, Sethi G.

J Mol Med (Berl). 2014 Mar;92(3):267-76.


An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins.

Subramaniam A, Loo SY, Rajendran P, Manu KA, Perumal E, Li F, Shanmugam MK, Siveen KS, Park JI, Ahn KS, Hui KM, Kumar AP, Sethi G.

Apoptosis. 2013 Oct;18(10):1175-87. doi: 10.1007/s10495-013-0851-5.


Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma.

Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G.

PLoS One. 2013;8(3):e57015. doi: 10.1371/journal.pone.0057015. Epub 2013 Mar 5.


Inhibition of B16F-10 melanoma-induced lung metastasis in C57BL/6 mice by Aerva lanata via induction of apoptosis.

Siveen KS, Kuttan G.

Integr Cancer Ther. 2013 Jan;12(1):81-92. doi: 10.1177/1534735412443853. Epub 2012 Nov 26.


Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.

Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, Sethi G.

J Biol Chem. 2012 Nov 2;287(45):38028-40. doi: 10.1074/jbc.M112.388702. Epub 2012 Sep 19. Erratum in: J Biol Chem. 2013 Jun 28;288(26):18777.


Modulation of humoral immune responses and inhibition of proinflammatory cytokines and nitric oxide production by 10-methoxycanthin-6-one.

Siveen KS, Kuttan G.

Immunopharmacol Immunotoxicol. 2012 Feb;34(1):116-25. doi: 10.3109/08923973.2011.586703.


Effect of Aerva lanata on cell-mediated immune responses and cytotoxic T-lymphocyte generation in normal and tumor-bearing mice.

Siveen KS, Kuttan G.

J Immunotoxicol. 2012 Jan-Mar;9(1):25-33. doi: 10.3109/1547691X.2011.609191. Epub 2011 Nov 30.


Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice.

Siveen KS, Kuttan G.

Can J Physiol Pharmacol. 2011 Oct;89(10):691-703. doi: 10.1139/y11-067. Epub 2011 Sep 9.


Augmentation of humoral and cell mediated immune responses by Thujone.

Siveen KS, Kuttan G.

Int Immunopharmacol. 2011 Dec;11(12):1967-75. doi: 10.1016/j.intimp.2011.08.006. Epub 2011 Aug 30.


Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers.

Preethi KC, Siveen KS, Kuttan R, Kuttan G.

Asian Pac J Cancer Prev. 2010;11(6):1773-9.

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