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Items: 1 to 50 of 118

1.

Structural basis for the pathogenesis of Campylobacter jejuni Hcp1, a structural and effector protein of the type six secretion system.

Noreen Z, Jobichen C, Abbasi R, Seetharaman J, Sivaraman J, Bohkhari H.

FEBS J. 2018 Sep 7. doi: 10.1111/febs.14650. [Epub ahead of print]

PMID:
30194714
2.

Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism.

Jobichen C, Tan YC, Prabhakar MT, Nayak D, Biswas D, Pannu NS, Hanski E, Sivaraman J.

Biochem J. 2018 Sep 11;475(17):2847-2860. doi: 10.1042/BCJ20180145.

PMID:
30049896
3.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.

Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. Epub 2018 Jul 5.

PMID:
29976840
4.

Biophysical studies and modelling indicate the binding preference of TAZ WW domain for LATS1 PPxY motif.

Verma A, Lin F, Tan YC, Hidayat MN, Jobichen C, Fan H, Sivaraman J.

Biochem Biophys Res Commun. 2018 Jul 20;502(3):307-312. doi: 10.1016/j.bbrc.2018.05.127. Epub 2018 May 30.

PMID:
29787761
5.

Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1.

Nayak D, Sivaraman J.

J Mol Biol. 2018 Apr 13;430(8):1173-1188. doi: 10.1016/j.jmb.2018.02.016. Epub 2018 Feb 26.

6.

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction.

Verma A, Jing-Song F, Finch-Edmondson ML, Velazquez-Campoy A, Balasegaran S, Sudol M, Sivaraman J.

Oncotarget. 2018 Jan 3;9(8):8068-8080. doi: 10.18632/oncotarget.23909. eCollection 2018 Jan 30.

7.

A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs.

Sivaraman J, Uma G, Langley P, Umapathy M, Venkatesan S, Palanikumar G.

Comput Methods Programs Biomed. 2016 Dec;137:341-351. doi: 10.1016/j.cmpb.2016.10.005. Epub 2016 Oct 11.

PMID:
28110737
8.

Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions.

Husain N, Tulsian NK, Chien WL, Suresh S, Anand GS, Sivaraman J.

Sci Rep. 2016 Nov 15;6:37061. doi: 10.1038/srep37061.

9.

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.

Lim SK, Lu SY, Kang SA, Tan HJ, Li Z, Adrian Wee ZN, Guan JS, Reddy Chichili VP, Sivaraman J, Putti T, Thike AA, Tan PH, Sudol M, Virshup DM, Chan SW, Hong W, Lim YP.

Cancer Res. 2016 Nov 1;76(21):6278-6289. Epub 2016 Aug 30.

10.

Structural basis for exploring the allosteric inhibition of human kidney type glutaminase.

Ramachandran S, Pan CQ, Zimmermann SC, Duvall B, Tsukamoto T, Low BC, Sivaraman J.

Oncotarget. 2016 Sep 6;7(36):57943-57954. doi: 10.18632/oncotarget.10791.

11.

Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria.

Lakshminarayanan R, Tan WX, Aung TT, Goh ET, Muruganantham N, Li J, Chang JY, Dikshit N, Saraswathi P, Lim RR, Kang TS, Balamuralidhar V, Sukumaran B, Verma CS, Sivaraman J, Chaurasia SS, Liu S, Beuerman RW.

Sci Rep. 2016 May 13;6:25905. doi: 10.1038/srep25905.

12.

Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex.

Barnwal B, Jobichen C, Girish VM, Foo CS, Sivaraman J, Kini RM.

Sci Rep. 2016 May 13;6:25935. doi: 10.1038/srep25935.

13.
14.

Structure and mapping of spontaneous mutational sites of PyrR from Mycobacterium tuberculosis.

Ghode P, Ramachandran S, Bifani P, Sivaraman J.

Biochem Biophys Res Commun. 2016 Mar 18;471(4):409-15. doi: 10.1016/j.bbrc.2016.02.071. Epub 2016 Feb 18.

PMID:
26902118
15.

Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis.

Ghode P, Jobichen C, Ramachandran S, Bifani P, Sivaraman J.

Biochem Biophys Res Commun. 2015 Nov 20;467(3):577-82. doi: 10.1016/j.bbrc.2015.09.133. Epub 2015 Oct 8.

PMID:
26456658
16.

Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination.

Nayak D, Sivaraman J.

Oncotarget. 2015 Oct 27;6(33):34342-57. doi: 10.18632/oncotarget.5326.

17.

Structure of AcrH-AopB Chaperone-Translocator Complex Reveals a Role for Membrane Hairpins in Type III Secretion System Translocon Assembly.

Nguyen VS, Jobichen C, Tan KW, Tan YW, Chan SL, Ramesh K, Yuan Y, Hong Y, Seetharaman J, Leung KY, Sivaraman J, Mok YK.

Structure. 2015 Nov 3;23(11):2022-31. doi: 10.1016/j.str.2015.08.014. Epub 2015 Oct 1.

18.

Structural Basis for a Unique ATP Synthase Core Complex from Nanoarcheaum equitans.

Mohanty S, Jobichen C, Chichili VP, Velázquez-Campoy A, Low BC, Hogue CW, Sivaraman J.

J Biol Chem. 2015 Nov 6;290(45):27280-96. doi: 10.1074/jbc.M115.677492. Epub 2015 Sep 14.

19.

Structural basis for the hydrolysis of ATP by a nucleotide binding subunit of an amino acid ABC transporter from Thermus thermophilus.

Devi SK, Chichili VP, Jeyakanthan J, Velmurugan D, Sivaraman J.

J Struct Biol. 2015 Jun;190(3):367-72. doi: 10.1016/j.jsb.2015.04.012. Epub 2015 Apr 24.

PMID:
25916755
20.

Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody.

Gu Y, Tang X, Zhang X, Song C, Zheng M, Wang K, Zhang J, Ng MH, Hew CL, Li S, Xia N, Sivaraman J.

Cell Res. 2015 May;25(5):604-20. doi: 10.1038/cr.2015.34. Epub 2015 Mar 20.

21.

Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei.

Lim YT, Jobichen C, Wong J, Limmathurotsakul D, Li S, Chen Y, Raida M, Srinivasan N, MacAry PA, Sivaraman J, Gan YH.

Sci Rep. 2015 Feb 4;5:8235. doi: 10.1038/srep08235.

22.

Destabilization of interaction between cytokinin signaling intermediates AHP1 and ARR4 modulates Arabidopsis development.

Verma V, Sivaraman J, Srivastava AK, Sadanandom A, Kumar PP.

New Phytol. 2015 Apr;206(2):726-37. doi: 10.1111/nph.13297. Epub 2015 Jan 30.

23.

A disordered region in the EvpP protein from the type VI secretion system of Edwardsiella tarda is essential for EvpC binding.

Hu W, Anand G, Sivaraman J, Leung KY, Mok YK.

PLoS One. 2014 Nov 17;9(11):e110810. doi: 10.1371/journal.pone.0110810. eCollection 2014.

24.

Normal limits of ECG measurements related to atrial activity using a modified limb lead system.

Sivaraman J, Uma G, Venkatesan S, Umapathy M, Dhandapani VE.

Anatol J Cardiol. 2015 Jan;15(1):2-6. doi: 10.5152/akd.2014.5155. Epub 2014 Feb 26.

25.

Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure.

Mukherjee M, Jing-Song F, Ramachandran S, Guy GR, Sivaraman J.

J Biol Chem. 2014 Sep 12;289(37):25611-23. doi: 10.1074/jbc.M114.592840. Epub 2014 Jul 29.

26.

Micelle bound structure and DNA interaction of brevinin-2-related peptide, an antimicrobial peptide derived from frog skin.

Bandyopadhyay S, Ng BY, Chong C, Lim MZ, Gill SK, Lee KH, Sivaraman J, Chatterjee C.

J Pept Sci. 2014 Oct;20(10):811-21. doi: 10.1002/psc.2673. Epub 2014 Jul 17.

PMID:
25044683
27.

Solution structures and model membrane interactions of Ctriporin, an anti-methicillin-resistant Staphylococcus aureus Peptide from Scorpion Venom.

Bandyopadhyay S, Junjie RL, Lim B, Sanjeev R, Xin WY, Yee CK, Hui Melodies SM, Yow N, Sivaraman J, Chatterjee C.

Biopolymers. 2014 Dec;101(12):1143-53. doi: 10.1002/bip.22519.

PMID:
24947608
28.

The major cockroach allergen Bla g 4 binds tyramine and octopamine.

Offermann LR, Chan SL, Osinski T, Tan YW, Chew FT, Sivaraman J, Mok YK, Minor W, Chruszcz M.

Mol Immunol. 2014 Jul;60(1):86-94. doi: 10.1016/j.molimm.2014.03.016. Epub 2014 Apr 24.

29.

Novel fluorescent protein from Hydnophora rigida possesses green emission.

Idrees M, Thangavelu K, Sikaroodi M, Smith C, Sivaraman J, Gillevet PM, Bokhari H.

Biochem Biophys Res Commun. 2014 May 23;448(1):33-8. doi: 10.1016/j.bbrc.2014.04.042. Epub 2014 Apr 18.

PMID:
24747076
30.

Induction of ROS-dependent mitochondria-mediated intrinsic apoptosis in MDA-MB-231 cells by glycoprotein from Codium decorticatum.

Thangam R, Senthilkumar D, Suresh V, Sathuvan M, Sivasubramanian S, Pazhanichamy K, Gorlagunta PK, Kannan S, Gunasekaran P, Rengasamy R, Sivaraman J.

J Agric Food Chem. 2014 Apr 16;62(15):3410-21. doi: 10.1021/jf405329e. Epub 2014 Apr 2.

PMID:
24694116
31.

Dimerization of VirD2 binding protein is essential for Agrobacterium induced tumor formation in plants.

Padavannil A, Jobichen C, Qinghua Y, Seetharaman J, Velazquez-Campoy A, Yang L, Pan SQ, Sivaraman J.

PLoS Pathog. 2014 Mar 13;10(3):e1003948. doi: 10.1371/journal.ppat.1003948. eCollection 2014 Mar.

32.

Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).

Thangavelu K, Chong QY, Low BC, Sivaraman J.

Sci Rep. 2014 Jan 23;4:3827. doi: 10.1038/srep03827.

33.

Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes.

Padavannil A, Jobichen C, Mills E, Velazquez-Campoy A, Li M, Leung KY, Mok YK, Rosenshine I, Sivaraman J.

Nat Commun. 2013;4:2546. doi: 10.1038/ncomms3546.

PMID:
24092262
34.

Structural basis for the modulation of the neuronal voltage-gated sodium channel NaV1.6 by calmodulin.

Reddy Chichili VP, Xiao Y, Seetharaman J, Cummins TR, Sivaraman J.

Sci Rep. 2013;3:2435. doi: 10.1038/srep02435.

35.

A method to trap transient and weak interacting protein complexes for structural studies.

Chichili VPR, Kumar V, Sivaraman J.

Intrinsically Disord Proteins. 2013 Apr 1;1(1):e25464. doi: 10.4161/idp.25464. eCollection 2013 Jan-Dec.

36.

Expression, purification, and characterization of cytokinin signaling intermediates: Arabidopsis histidine phosphotransfer protein 1 (AHP1) and AHP2.

Verma V, Sivaraman J, Kumar PP.

Plant Cell Rep. 2013 Jun;32(6):795-805. doi: 10.1007/s00299-013-1424-3. Epub 2013 Mar 24.

PMID:
23525762
37.

Structural basis for the interaction of unstructured neuron specific substrates neuromodulin and neurogranin with Calmodulin.

Kumar V, Chichili VP, Zhong L, Tang X, Velazquez-Campoy A, Sheu FS, Seetharaman J, Gerges NZ, Sivaraman J.

Sci Rep. 2013;3:1392. doi: 10.1038/srep01392.

38.

A novel trans conformation of ligand-free calmodulin.

Kumar V, Chichili VP, Tang X, Sivaraman J.

PLoS One. 2013;8(1):e54834. doi: 10.1371/journal.pone.0054834. Epub 2013 Jan 29.

39.

Linkers in the structural biology of protein-protein interactions.

Reddy Chichili VP, Kumar V, Sivaraman J.

Protein Sci. 2013 Feb;22(2):153-67. doi: 10.1002/pro.2206. Epub 2013 Jan 8. Review.

40.

Model membrane interaction and DNA-binding of antimicrobial peptide Lasioglossin II derived from bee venom.

Bandyopadhyay S, Lee M, Sivaraman J, Chatterjee C.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):1-6. doi: 10.1016/j.bbrc.2012.11.015. Epub 2012 Nov 14.

PMID:
23159628
41.

Identification and structural characterization of a new three-finger toxin hemachatoxin from Hemachatus haemachatus venom.

Girish VM, Kumar S, Joseph L, Jobichen C, Kini RM, Sivaraman J.

PLoS One. 2012;7(10):e48112. doi: 10.1371/journal.pone.0048112. Epub 2012 Oct 29.

42.

Crystal structure of Der f 7, a dust mite allergen from Dermatophagoides farinae.

Tan KW, Jobichen C, Ong TC, Gao YF, Tiong YS, Wong KN, Chew FT, Sivaraman J, Mok YK.

PLoS One. 2012;7(9):e44850. doi: 10.1371/journal.pone.0044850. Epub 2012 Sep 6.

43.

NMR structure of Carcinoscorpius rotundicauda thioredoxin-related protein 16 and its role in regulating transcription factor NF-κB activity.

Giri PK, Jing-Song F, Shanmugam MK, Ding JL, Sethi G, Swaminathan K, Sivaraman J.

J Biol Chem. 2012 Aug 24;287(35):29417-28. doi: 10.1074/jbc.M112.379859. Epub 2012 Jul 3.

44.

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.

Thangavelu K, Pan CQ, Karlberg T, Balaji G, Uttamchandani M, Suresh V, Schüler H, Low BC, Sivaraman J.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7705-10. doi: 10.1073/pnas.1116573109. Epub 2012 Apr 26.

45.

Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin.

Mukherjee M, Chow SY, Yusoff P, Seetharaman J, Ng C, Sinniah S, Koh XW, Asgar NF, Li D, Yim D, Jackson RA, Yew J, Qian J, Iyu A, Lim YP, Zhou X, Sze SK, Guy GR, Sivaraman J.

EMBO J. 2012 Mar 7;31(5):1308-19. doi: 10.1038/emboj.2011.496. Epub 2012 Jan 17.

46.

A conformational switch in the active site of BT_2972, a methyltransferase from an antibiotic resistant pathogen B. thetaiotaomicron.

Kumar V, Sivaraman J.

PLoS One. 2011;6(11):e27543. doi: 10.1371/journal.pone.0027543. Epub 2011 Nov 28.

47.

Purification, crystallization and diffraction studies of the methyltransferases BT_2972 and BVU_3255 from antibiotic-resistant pathogens of the genus Bacteroides from the human intestine.

Kumar V, Mallika N, Sivaraman J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1359-62. doi: 10.1107/S1744309111031812. Epub 2011 Oct 27.

48.

Two-component PhoB-PhoR regulatory system and ferric uptake regulator sense phosphate and iron to control virulence genes in type III and VI secretion systems of Edwardsiella tarda.

Chakraborty S, Sivaraman J, Leung KY, Mok YK.

J Biol Chem. 2011 Nov 11;286(45):39417-30. doi: 10.1074/jbc.M111.295188. Epub 2011 Sep 27.

49.

Structural characterization of BVU_3255, a methyltransferase from human intestine antibiotic resistant pathogen Bacteroides vulgatus.

Kumar V, Sivaraman J.

J Struct Biol. 2011 Dec;176(3):409-13. doi: 10.1016/j.jsb.2011.08.007. Epub 2011 Aug 22.

PMID:
21872662
50.

Novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus.

Tran BN, Chen L, Liu Y, Wu J, Velázquez-Campoy A, Sivaraman J, Hew CL.

J Virol. 2011 Sep;85(17):9159-66. doi: 10.1128/JVI.02219-10. Epub 2011 Jun 29.

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