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Items: 1 to 50 of 134


Conformational plasticity of the intracellular cavity of GPCR-G-protein complexes leads to G-protein promiscuity and selectivity.

Sandhu M, Touma AM, Dysthe M, Sadler F, Sivaramakrishnan S, Vaidehi N.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11956-11965. doi: 10.1073/pnas.1820944116. Epub 2019 May 28.


Inhibitory potential of Hydroxychavicol on Ehrlich ascites carcinoma model and in silico interaction on cancer targets.

Hemamalini V, Velayutham DPM, Lakshmanan L, Muthusamy K, Sivaramakrishnan S, Premkumar K.

Nat Prod Res. 2018 Nov 23:1-6. doi: 10.1080/14786419.2018.1519819. [Epub ahead of print]


Fabrication of MgO nanostructures and its efficient photocatalytic, antibacterial and anticancer performance.

Karthik K, Dhanuskodi S, Gobinath C, Prabukumar S, Sivaramakrishnan S.

J Photochem Photobiol B. 2019 Jan;190:8-20. doi: 10.1016/j.jphotobiol.2018.11.001. Epub 2018 Nov 12.


Bitopic Inhibition of ATP and Substrate Binding in Ser/Thr Kinases through a Conserved Allosteric Mechanism.

Ma N, Lippert LG, Devamani T, Levy B, Lee S, Sandhu M, Vaidehi N, Sivaramakrishnan S.

Biochemistry. 2018 Nov 13;57(45):6387-6390. doi: 10.1021/acs.biochem.8b00729. Epub 2018 Oct 30.


Engineering Synthetic Myosin Filaments Using DNA Nanotubes.

Sommese RF, Sivaramakrishnan S.

Methods Mol Biol. 2018;1805:93-101. doi: 10.1007/978-1-4939-8556-2_5.


Engaging myosin VI tunes motility, morphology and identity in endocytosis.

Ritt M, Sivaramakrishnan S.

Traffic. 2018 Jun 4. doi: 10.1111/tra.12583. [Epub ahead of print]


One pot green fabrication of metallic silver nanoscale materials using Crescentia cujete L. and assessment of their bactericidal activity.

Prabukumar S, Rajkuberan C, Sathishkumar G, Illaiyaraja M, Sivaramakrishnan S.

IET Nanobiotechnol. 2018 Jun;12(4):505-508. doi: 10.1049/iet-nbt.2017.0209.


Investigation and molecular docking studies of Bassianolide from Lecanicillium lecanii against Plutella xylostella (Lepidoptera: Plutellidae).

Ravindran K, Sivaramakrishnan S, Hussain M, Dash CK, Bamisile BS, Qasim M, Liande W.

Comp Biochem Physiol C Toxicol Pharmacol. 2018 Apr;206-207:65-72. doi: 10.1016/j.cbpc.2018.03.004. Epub 2018 Mar 16. Erratum in: Comp Biochem Physiol C Toxicol Pharmacol. 2018 Nov;213:62-63.


Subharmonic anti-phase dynamics in coupled mode-locked semiconductor lasers.

Sivaramakrishnan S, Winful HG.

Opt Lett. 2017 Dec 1;42(23):4905-4908. doi: 10.1364/OL.42.004905.


Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.

Skinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR, Rosner MR.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13453-13458. doi: 10.1073/pnas.1711543114. Epub 2017 Dec 5.


An operant-based detection method for inferring tinnitus in mice.

Zuo H, Lei D, Sivaramakrishnan S, Howie B, Mulvany J, Bao J.

J Neurosci Methods. 2017 Nov 1;291:227-237. doi: 10.1016/j.jneumeth.2017.08.029. Epub 2017 Aug 31.


Distinct structural mechanisms determine substrate affinity and kinase activity of protein kinase Cα.

Lee S, Devamani T, Song HD, Sandhu M, Larsen A, Sommese R, Jain A, Vaidehi N, Sivaramakrishnan S.

J Biol Chem. 2017 Sep 29;292(39):16300-16309. doi: 10.1074/jbc.M117.804781. Epub 2017 Aug 15.


ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells.

Malik RU, Dysthe M, Ritt M, Sunahara RK, Sivaramakrishnan S.

Sci Rep. 2017 Aug 10;7(1):7749. doi: 10.1038/s41598-017-08029-3.


Rebound from Inhibition: Self-Correction against Neurodegeneration?

Sivaramakrishnan S, Lynch WP.

J Clin Cell Immunol. 2017 Apr;8(2). pii: 492. doi: 10.4172/2155-9899.1000492. Epub 2017 Mar 13.


Actin turnover maintains actin filament homeostasis during cytokinetic ring contraction.

Chew TG, Huang J, Palani S, Sommese R, Kamnev A, Hatano T, Gu Y, Oliferenko S, Sivaramakrishnan S, Balasubramanian MK.

J Cell Biol. 2017 Sep 4;216(9):2657-2667. doi: 10.1083/jcb.201701104. Epub 2017 Jun 27.


Green synthesis of magnetic Fe3O4 nanoparticles using Couroupita guianensis Aubl. fruit extract for their antibacterial and cytotoxicity activities.

Sathishkumar G, Logeshwaran V, Sarathbabu S, Jha PK, Jeyaraj M, Rajkuberan C, Senthilkumar N, Sivaramakrishnan S.

Artif Cells Nanomed Biotechnol. 2018 May;46(3):589-598. doi: 10.1080/21691401.2017.1332635. Epub 2017 May 29.


The DRY motif and the four corners of the cubic ternary complex model.

Rovati GE, Capra V, Shaw VS, Malik RU, Sivaramakrishnan S, Neubig RR.

Cell Signal. 2017 Jul;35:16-23. doi: 10.1016/j.cellsig.2017.03.020. Epub 2017 Mar 24. Review.


Priming GPCR signaling through the synergistic effect of two G proteins.

Gupte TM, Malik RU, Sommese RF, Ritt M, Sivaramakrishnan S.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3756-3761. doi: 10.1073/pnas.1617232114. Epub 2017 Mar 21.


The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators.

Cho JH, Swanson CJ, Chen J, Li A, Lippert LG, Boye SE, Rose K, Sivaramakrishnan S, Chuong CM, Chow RH.

ACS Chem Biol. 2017 Apr 21;12(4):1066-1074. doi: 10.1021/acschembio.6b00883. Epub 2017 Mar 1.


The Role of Regulatory Domains in Maintaining Autoinhibition in the Multidomain Kinase PKCα.

Sommese RF, Ritt M, Swanson CJ, Sivaramakrishnan S.

J Biol Chem. 2017 Feb 17;292(7):2873-2880. doi: 10.1074/jbc.M116.768457. Epub 2017 Jan 3.


Response of three cyprinid fish species to the Scavenger Deterrent Factor produced by the mutualistic bacteria associated with entomopathogenic nematodes.

Raja RK, Aiswarya D, Gulcu B, Raja M, Perumal P, Sivaramakrishnan S, Kaya HK, Hazir S.

J Invertebr Pathol. 2017 Feb;143:40-49. doi: 10.1016/j.jip.2016.11.013. Epub 2016 Nov 29.


Patterning protein complexes on DNA nanostructures using a GFP nanobody.

Sommese RF, Hariadi RF, Kim K, Liu M, Tyska MJ, Sivaramakrishnan S.

Protein Sci. 2016 Nov;25(11):2089-2094. doi: 10.1002/pro.3020. Epub 2016 Aug 31.


Calcium Stimulates Self-Assembly of Protein Kinase C α In Vitro.

Swanson CJ, Sommese RF, Petersen KJ, Ritt M, Karslake J, Thomas DD, Sivaramakrishnan S.

PLoS One. 2016 Oct 5;11(10):e0162331. doi: 10.1371/journal.pone.0162331. eCollection 2016.


G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay.

Semack A, Malik RU, Sivaramakrishnan S.

J Vis Exp. 2016 Sep 10;(115). doi: 10.3791/54696.


L-type calcium channels refine the neural population code of sound level.

Grimsley CA, Green DB, Sivaramakrishnan S.

J Neurophysiol. 2016 Dec 1;116(6):2550-2563. doi: 10.1152/jn.00657.2016. Epub 2016 Sep 7.


Engineering Circular Gliding of Actin Filaments Along Myosin-Patterned DNA Nanotube Rings To Study Long-Term Actin-Myosin Behaviors.

Hariadi RF, Appukutty AJ, Sivaramakrishnan S.

ACS Nano. 2016 Sep 27;10(9):8281-8. doi: 10.1021/acsnano.6b01294. Epub 2016 Sep 12.


Substrate Affinity Differentially Influences Protein Kinase C Regulation and Inhibitor Potency.

Sommese RF, Sivaramakrishnan S.

J Biol Chem. 2016 Oct 14;291(42):21963-21970. Epub 2016 Aug 23.


Determination and characterization of destruxin production in Metarhizium anisopliae Tk6 and formulations for Aedes aegypti mosquitoes control at the field level.

Ravindran K, Akutse KS, Sivaramakrishnan S, Wang L.

Toxicon. 2016 Sep 15;120:89-96. doi: 10.1016/j.toxicon.2016.07.016. Epub 2016 Jul 22.


Structural Elements in the Gαs and Gαq C Termini That Mediate Selective G Protein-coupled Receptor (GPCR) Signaling.

Semack A, Sandhu M, Malik RU, Vaidehi N, Sivaramakrishnan S.

J Biol Chem. 2016 Aug 19;291(34):17929-40. doi: 10.1074/jbc.M116.735720. Epub 2016 Jun 21.


Distal Hydrogen-bonding Interactions in Ligand Sensing and Signaling by Mycobacterium tuberculosis DosS.

Basudhar D, Madrona Y, Yukl ET, Sivaramakrishnan S, Nishida CR, Moënne-Loccoz P, Ortiz de Montellano PR.

J Biol Chem. 2016 Jul 29;291(31):16100-11. doi: 10.1074/jbc.M116.724815. Epub 2016 May 27.


Correlation between Activity and Domain Complementation in Adenylyl Cyclase Demonstrated with a Novel Fluorescence Resonance Energy Transfer Sensor.

Ritt M, Sivaramakrishnan S.

Mol Pharmacol. 2016 Apr;89(4):407-12. doi: 10.1124/mol.115.101626. Epub 2016 Jan 22.


Dynamic Coupling and Allosteric Networks in the α Subunit of Heterotrimeric G Proteins.

Yao XQ, Malik RU, Griggs NW, Skjærven L, Traynor JR, Sivaramakrishnan S, Grant BJ.

J Biol Chem. 2016 Feb 26;291(9):4742-53. doi: 10.1074/jbc.M115.702605. Epub 2015 Dec 24.


Dual light field and polarization imaging using CMOS diffractive image sensors.

Jayasuriya S, Sivaramakrishnan S, Chuang E, Guruaribam D, Wang A, Molnar A.

Opt Lett. 2015 May 15;40(10):2433-6. doi: 10.1364/OL.40.002433.


Using Protein Dimers to Maximize the Protein Hybridization Efficiency with Multisite DNA Origami Scaffolds.

Verma V, Mallik L, Hariadi RF, Sivaramakrishnan S, Skiniotis G, Joglekar AP.

PLoS One. 2015 Sep 8;10(9):e0137125. doi: 10.1371/journal.pone.0137125. eCollection 2015.


Synthesis of silver and gold nanoparticles using Jasminum nervosum leaf extract and its larvicidal activity against filarial and arboviral vector Culex quinquefasciatus Say (Diptera: Culicidae).

Lallawmawma H, Sathishkumar G, Sarathbabu S, Ghatak S, Sivaramakrishnan S, Gurusubramanian G, Kumar NS.

Environ Sci Pollut Res Int. 2015 Nov;22(22):17753-68. doi: 10.1007/s11356-015-5001-x. Epub 2015 Jul 9.


Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments.

Hariadi RF, Sommese RF, Adhikari AS, Taylor RE, Sutton S, Spudich JA, Sivaramakrishnan S.

Nat Nanotechnol. 2015 Aug;10(8):696-700. doi: 10.1038/nnano.2015.132. Epub 2015 Jul 6.


Fifteen-minute consultation: A child with toe walking.

Sivaramakrishnan S, Seal A.

Arch Dis Child Educ Pract Ed. 2015 Oct;100(5):238-41. doi: 10.1136/archdischild-2014-307852. Epub 2015 Apr 8. Review.


Cellular chirality arising from the self-organization of the actin cytoskeleton.

Tee YH, Shemesh T, Thiagarajan V, Hariadi RF, Anderson KL, Page C, Volkmann N, Hanein D, Sivaramakrishnan S, Kozlov MM, Bershadsky AD.

Nat Cell Biol. 2015 Apr;17(4):445-57. doi: 10.1038/ncb3137. Epub 2015 Mar 23.


Direct observation of interfacial Au atoms on TiO₂ in three dimensions.

Gao W, Sivaramakrishnan S, Wen J, Zuo JM.

Nano Lett. 2015 Apr 8;15(4):2548-54. doi: 10.1021/acs.nanolett.5b00682. Epub 2015 Mar 17.


The C2 Domain and Altered ATP-Binding Loop Phosphorylation at Ser³⁵⁹ Mediate the Redox-Dependent Increase in Protein Kinase C-δ Activity.

Gong J, Yao Y, Zhang P, Udayasuryan B, Komissarova EV, Chen J, Sivaramakrishnan S, Van Eyk JE, Steinberg SF.

Mol Cell Biol. 2015 May;35(10):1727-40. doi: 10.1128/MCB.01436-14. Epub 2015 Mar 9.


Tuning myosin-driven sorting on cellular actin networks.

Hariadi RF, Sommese RF, Sivaramakrishnan S.

Elife. 2015 Mar 4;4. doi: 10.7554/eLife.05472.


Microwave-assisted synthesis of CdO-ZnO nanocomposite and its antibacterial activity against human pathogens.

Karthik K, Dhanuskodi S, Gobinath C, Sivaramakrishnan S.

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 15;139:7-12. doi: 10.1016/j.saa.2014.11.079. Epub 2014 Dec 1.


Antibacterial and cytotoxic potential of silver nanoparticles synthesized using latex of Calotropis gigantea L.

Rajkuberan C, Sudha K, Sathishkumar G, Sivaramakrishnan S.

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 5;136 Pt B:924-30. doi: 10.1016/j.saa.2014.09.115. Epub 2014 Oct 5.


A method for multiprotein assembly in cells reveals independent action of kinesins in complex.

Norris SR, Soppina V, Dizaji AS, Schimert KI, Sept D, Cai D, Sivaramakrishnan S, Verhey KJ.

J Cell Biol. 2014 Nov 10;207(3):393-406. doi: 10.1083/jcb.201407086. Epub 2014 Nov 3.


Optofluidic lasers with a single molecular layer of gain.

Chen Q, Ritt M, Sivaramakrishnan S, Sun Y, Fan X.

Lab Chip. 2014 Dec 21;14(24):4590-5. doi: 10.1039/c4lc00872c. Epub 2014 Oct 14.


Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.

Li Y, Davey RA, Sivaramakrishnan S, Lynch WP.

J Neurophysiol. 2014 Aug 1;112(3):683-704. doi: 10.1152/jn.00227.2014. Epub 2014 May 14.


Optimization of reaction conditions to fabricate nano-silver using Couroupita guianensis Aubl. (leaf & fruit) and its enhanced larvicidal effect.

Vimala RT, Sathishkumar G, Sivaramakrishnan S.

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 25;135:110-5. doi: 10.1016/j.saa.2014.06.009. Epub 2014 Jun 27.


Harnessing the unique structural properties of isolated α-helices.

Swanson CJ, Sivaramakrishnan S.

J Biol Chem. 2014 Sep 12;289(37):25460-7. doi: 10.1074/jbc.R114.583906. Epub 2014 Jul 24.


Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity.

Baker GJ, Chockley P, Yadav VN, Doherty R, Ritt M, Sivaramakrishnan S, Castro MG, Lowenstein PR.

Cancer Res. 2014 Sep 15;74(18):5079-90. doi: 10.1158/0008-5472.CAN-14-1203. Epub 2014 Jul 18.


Conserved modular domains team up to latch-open active protein kinase Cα.

Swanson CJ, Ritt M, Wang W, Lang MJ, Narayan A, Tesmer JJ, Westfall M, Sivaramakrishnan S.

J Biol Chem. 2014 Jun 20;289(25):17812-29. doi: 10.1074/jbc.M113.534750. Epub 2014 Apr 30.

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