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Items: 30

1.

Retinal blood oxygen saturation and aqueous humour biomarkers in early diabetic retinopathy.

Tayyari F, Khuu LA, Sivak JM, Flanagan JG, Singer S, Brent MH, Hudson C.

Acta Ophthalmol. 2019 Aug;97(5):e673-e679. doi: 10.1111/aos.14016. Epub 2019 Jan 28.

PMID:
30690929
2.

All roads lead to glaucoma: Induced retinal injury cascades contribute to a common neurodegenerative outcome.

Alqawlaq S, Flanagan JG, Sivak JM.

Exp Eye Res. 2019 Jun;183:88-97. doi: 10.1016/j.exer.2018.11.005. Epub 2018 Nov 14. Review.

PMID:
30447198
3.

Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia.

Wang DS, Kaneshwaran K, Lei G, Mostafa F, Wang J, Lecker I, Avramescu S, Xie YF, Chan NK, Fernandez-Escobar A, Woo J, Chan D, Ramsey AJ, Sivak JM, Lee CJ, Bonin RP, Orser BA.

Anesthesiology. 2018 Sep;129(3):477-489. doi: 10.1097/ALN.0000000000002311.

PMID:
29889105
4.

Conserved characteristics of ocular refractive development - Did the eye evolve once?

Sivak JG, Sivak JM.

Exp Eye Res. 2019 Jun;183:84-87. doi: 10.1016/j.exer.2018.05.007. Epub 2018 May 16. Review.

PMID:
29758190
5.

The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury.

Guo X, Jiang Q, Tuccitto A, Chan D, Alqawlaq S, Won GJ, Sivak JM.

Neurobiol Dis. 2018 May;113:59-69. doi: 10.1016/j.nbd.2018.02.004. Epub 2018 Feb 10.

PMID:
29438738
6.

The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.

Adams CM, Anderson K, Artman G 3rd, Bizec JC, Cepeda R, Elliott J, Fassbender E, Ghosh M, Hanks S, Hardegger LA, Hosagrahara VP, Jaffee B, Jendza K, Ji N, Johnson L, Lee W, Liu D, Liu F, Long D, Ma F, Mainolfi N, Meredith EL, Miranda K, Peng Y, Poor S, Powers J, Qiu Y, Rao C, Shen S, Sivak JM, Solovay C, Tarsa P, Woolfenden A, Zhang C, Zhang Y.

J Med Chem. 2018 Feb 22;61(4):1622-1635. doi: 10.1021/acs.jmedchem.7b01731. Epub 2018 Feb 5.

PMID:
29400470
7.

Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury.

Livne-Bar I, Wei J, Liu HH, Alqawlaq S, Won GJ, Tuccitto A, Gronert K, Flanagan JG, Sivak JM.

J Clin Invest. 2017 Dec 1;127(12):4403-4414. doi: 10.1172/JCI77398. Epub 2017 Nov 6.

8.

Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult.

Voorhees AP, Jan NJ, Austin ME, Flanagan JG, Sivak JM, Bilonick RA, Sigal IA.

Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5336-5346. doi: 10.1167/iovs.17-22015.

9.

Aqueous humor endothelin-1 and total retinal blood flow in patients with non-proliferative diabetic retinopathy.

Khuu LA, Tayyari F, Sivak JM, Flanagan JG, Singer S, Brent MH, Huang D, Tan O, Hudson C.

Eye (Lond). 2017 Oct;31(10):1443-1450. doi: 10.1038/eye.2017.74. Epub 2017 May 26.

10.

Diabetes impairs arterio-venous specification in engineered vascular tissues in a perivascular cell recruitment-dependent manner.

Altalhi W, Sun X, Sivak JM, Husain M, Nunes SS.

Biomaterials. 2017 Mar;119:23-32. doi: 10.1016/j.biomaterials.2016.12.003. Epub 2016 Dec 8.

PMID:
27988406
11.

Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis.

Livne-Bar I, Lam S, Chan D, Guo X, Askar I, Nahirnyj A, Flanagan JG, Sivak JM.

Cell Death Dis. 2016 Sep 29;7(9):e2386. doi: 10.1038/cddis.2016.277.

12.

Aqueous humour concentrations of TGF-β, PLGF and FGF-1 and total retinal blood flow in patients with early non-proliferative diabetic retinopathy.

Khuu LA, Tayyari F, Sivak JM, Flanagan JG, Singer S, Brent MH, Huang D, Tan O, Hudson C.

Acta Ophthalmol. 2017 May;95(3):e206-e211. doi: 10.1111/aos.13230. Epub 2016 Sep 28.

13.

Biomechanical insult switches PEA-15 activity to uncouple its anti-apoptotic function and promote erk mediated tissue remodeling.

Exler RE, Guo X, Chan D, Livne-Bar I, Vicic N, Flanagan JG, Sivak JM.

Exp Cell Res. 2016 Jan 15;340(2):283-94. doi: 10.1016/j.yexcr.2015.11.023. Epub 2015 Nov 23.

PMID:
26615958
14.

Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.

Meredith EL, Mainolfi N, Poor S, Qiu Y, Miranda K, Powers J, Liu D, Ma F, Solovay C, Rao C, Johnson L, Ji N, Artman G, Hardegger L, Hanks S, Shen S, Woolfenden A, Fassbender E, Sivak JM, Zhang Y, Long D, Cepeda R, Liu F, Hosagrahara VP, Lee W, Tarsa P, Anderson K, Elliott J, Jaffee B.

J Med Chem. 2015 Dec 10;58(23):9273-86. doi: 10.1021/acs.jmedchem.5b01227. Epub 2015 Nov 30.

PMID:
26568411
15.
16.

Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: towards non-invasive glaucoma gene therapy.

Alqawlaq S, Sivak JM, Huzil JT, Ivanova MV, Flanagan JG, Beazely MA, Foldvari M.

Nanomedicine. 2014 Nov;10(8):1637-47. doi: 10.1016/j.nano.2014.05.010. Epub 2014 Jun 4.

PMID:
24905400
17.

PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina.

Guo X, Dason ES, Zanon-Moreno V, Jiang Q, Nahirnyj A, Chan D, Flanagan JG, Sivak JM.

Am J Pathol. 2014 Apr;184(4):1017-1029. doi: 10.1016/j.ajpath.2013.12.012. Epub 2014 Feb 5.

PMID:
24508229
18.

ROS detoxification and proinflammatory cytokines are linked by p38 MAPK signaling in a model of mature astrocyte activation.

Nahirnyj A, Livne-Bar I, Guo X, Sivak JM.

PLoS One. 2013 Dec 23;8(12):e83049. doi: 10.1371/journal.pone.0083049. eCollection 2013.

19.

An effective prodrug strategy to selectively enhance ocular exposure of a cannabinoid receptor (CB1/2) agonist.

Mainolfi N, Powers J, Amin J, Long D, Lee W, McLaughlin ME, Jaffee B, Brain C, Elliott J, Sivak JM.

J Med Chem. 2013 Jul 11;56(13):5464-72. doi: 10.1021/jm4004939. Epub 2013 Jun 19.

PMID:
23738526
20.

The aging eye: common degenerative mechanisms between the Alzheimer's brain and retinal disease.

Sivak JM.

Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):871-80. doi: 10.1167/iovs.12-10827. Review.

PMID:
23364356
21.

Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation.

Yuen DA, Zhang Y, Thai K, Spring C, Chan L, Guo X, Advani A, Sivak JM, Gilbert RE.

Stem Cells Transl Med. 2012 Dec;1(12):921-6. doi: 10.5966/sctm.2012-0026. Epub 2012 Nov 26.

22.

Proteomics analyses of human optic nerve head astrocytes following biomechanical strain.

Rogers RS, Dharsee M, Ackloo S, Sivak JM, Flanagan JG.

Mol Cell Proteomics. 2012 Feb;11(2):M111.012302. doi: 10.1074/mcp.M111.012302. Epub 2011 Nov 29.

23.

Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization.

Sivak JM, Ostriker AC, Woolfenden A, Demirs J, Cepeda R, Long D, Anderson K, Jaffee B.

J Biol Chem. 2011 Dec 30;286(52):44965-75. doi: 10.1074/jbc.M111.294967. Epub 2011 Nov 9.

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Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface.

West-Mays JA, Sivak JM, Papagiotas SS, Kim J, Nottoli T, Williams T, Fini ME.

Differentiation. 2003 Apr;71(3):206-16.

28.

Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells.

Surgucheva IG, Sivak JM, Fini ME, Palazzo RE, Surguchov AP.

Arch Biochem Biophys. 2003 Feb 1;410(1):167-76.

PMID:
12559990
29.

MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology.

Sivak JM, Fini ME.

Prog Retin Eye Res. 2002 Jan;21(1):1-14. Review.

PMID:
11906808

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