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Items: 1 to 50 of 144

1.

Functional DNA methylation signatures for autism spectrum disorder genomic risk loci: 16p11.2 deletions and CHD8 variants.

Siu MT, Butcher DT, Turinsky AL, Cytrynbaum C, Stavropoulos DJ, Walker S, Caluseriu O, Carter M, Lou Y, Nicolson R, Georgiades S, Szatmari P, Anagnostou E, Scherer SW, Choufani S, Brudno M, Weksberg R.

Clin Epigenetics. 2019 Jul 16;11(1):103. doi: 10.1186/s13148-019-0684-3.

2.

New insights into DNA methylation signatures: SMARCA2 variants in Nicolaides-Baraitser syndrome.

Chater-Diehl E, Ejaz R, Cytrynbaum C, Siu MT, Turinsky A, Choufani S, Goodman SJ, Abdul-Rahman O, Bedford M, Dorrani N, Engleman K, Flores-Daboub J, Genevieve D, Mendoza-Londono R, Meschino W, Perrin L, Safina N, Townshend S, Scherer SW, Anagnostou E, Piton A, Deardorff M, Brudno M, Chitayat D, Weksberg R.

BMC Med Genomics. 2019 Jul 9;12(1):105. doi: 10.1186/s12920-019-0555-y.

3.

Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability.

Ladi E, Everett C, Stivala CE, Daniels BE, Durk MR, Harris SF, Huestis MP, Purkey HE, Staben ST, Augustin M, Blaesse M, Steinbacher S, Eidenschenk C, Pappu R, Siu M.

J Med Chem. 2019 Aug 8;62(15):7032-7041. doi: 10.1021/acs.jmedchem.9b00509. Epub 2019 Jul 29.

PMID:
31283222
4.

CD71+ Population Enriched by HPV-E6 Protein Promotes Cancer Aggressiveness and Radioresistance in Cervical Cancer Cells.

Leung TH, Tang HW, Siu MK, Chan DW, Chan KK, Cheung AN, Ngan HY.

Mol Cancer Res. 2019 Sep;17(9):1867-1880. doi: 10.1158/1541-7786.MCR-19-0068. Epub 2019 Jun 24.

PMID:
31235657
5.

Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades.

Siu MKY, Jiang YX, Wang JJ, Leung THY, Han CY, Tsang BK, Cheung ANY, Ngan HYS, Chan KKL.

Cancers (Basel). 2019 Jun 12;11(6). pii: E813. doi: 10.3390/cancers11060813.

6.

Graptopetalum paraguayense Inhibits Liver Fibrosis by Blocking TGF-β Signaling In Vivo and In Vitro.

Hsu WH, Liao SC, Chyan YJ, Huang KW, Hsu SL, Chen YC, Siu ML, Chang CC, Chung YS, Huang CF.

Int J Mol Sci. 2019 May 27;20(10). pii: E2592. doi: 10.3390/ijms20102592.

7.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.

Zak M, Hanan EJ, Lupardus P, Brown DG, Robinson C, Siu M, Lyssikatos JP, Romero FA, Zhao G, Kellar T, Mendonca R, Ray NC, Goodacre SC, Crackett PH, McLean N, Hurley CA, Yuen PW, Cheng YX, Liu X, Liimatta M, Kohli PB, Nonomiya J, Salmon G, Buckley G, Lloyd J, Gibbons P, Ghilardi N, Kenny JR, Johnson A.

Bioorg Med Chem Lett. 2019 Jun 15;29(12):1522-1531. doi: 10.1016/j.bmcl.2019.04.008. Epub 2019 Apr 4.

PMID:
30981576
8.

High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations.

Giordani L, He GJ, Negroni E, Sakai H, Law JYC, Siu MM, Wan R, Corneau A, Tajbakhsh S, Cheung TH, Le Grand F.

Mol Cell. 2019 May 2;74(3):609-621.e6. doi: 10.1016/j.molcel.2019.02.026. Epub 2019 Mar 25.

PMID:
30922843
9.

Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness.

Shin VY, Chen J, Cheuk IW, Siu MT, Ho CW, Wang X, Jin H, Kwong A.

Cell Death Dis. 2019 Mar 20;10(4):270. doi: 10.1038/s41419-019-1513-5.

10.

Common Antacid Medication-Ranitidine Causing a Rare Serious Adverse Effect.

Weissman S, Siu M, Ferm S, Hassan A.

Cureus. 2018 Nov 12;10(11):e3578. doi: 10.7759/cureus.3578.

11.

Prevalence and clinicians' awareness of psychiatric comorbidities among first-episode schizophrenia.

Siu MW, Chong CS, Lo WT.

Early Interv Psychiatry. 2018 Dec;12(6):1128-1136. doi: 10.1111/eip.12426. Epub 2017 Jun 9.

PMID:
30456864
12.

Correction: Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance.

Siu MK, Abou-Kheir W, Yin JJ, Chang YS, Barrett B, Suau F, Casey O, Chen WY, Fang L, Hynes P, Hsieh YY, Liu YN, Huang J, Kelly K.

Oncotarget. 2018 Aug 17;9(64):32403. doi: 10.18632/oncotarget.26020. eCollection 2018 Aug 17.

13.

Evaluation of a Passive Sampling Method for Long-Term Continuous Monitoring of Volatile Organic Compounds in Urban Environments.

Healy RM, Bennett J, Wang JM, Karellas NS, Wong C, Todd A, Sofowote U, Su Y, Di Federico L, Munoz A, Charland JP, Herod D, Siu M, White L.

Environ Sci Technol. 2018 Sep 18;52(18):10580-10589. doi: 10.1021/acs.est.8b02792. Epub 2018 Aug 30.

PMID:
30119604
14.

Negative symptom dimensions differentially impact on functioning in individuals at-risk for psychosis.

Chang WC, Lee HC, Chan SI, Chiu SY, Lee HM, Chan KW, Wong MC, Chan KL, Yeung WS, Choy LW, Chong SY, Siu MW, Lo TL, Yan WC, Ng MK, Poon LT, Pang PF, Lam WC, Wong YC, Chung WS, Mo YM, Lui SY, Hui LM, Chen EYH.

Schizophr Res. 2018 Dec;202:310-315. doi: 10.1016/j.schres.2018.06.041. Epub 2018 Jun 21. No abstract available.

PMID:
29935882
15.

Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration.

Siu M, Sengupta Ghosh A, Lewcock JW.

J Med Chem. 2018 Sep 27;61(18):8078-8087. doi: 10.1021/acs.jmedchem.8b00370. Epub 2018 Jun 4. Review.

PMID:
29863360
16.

MiR-92 suppresses proliferation and induces apoptosis by targeting EP4/Notch1 axis in gastric cancer.

Shin VY, Siu MT, Liu X, Ng EKO, Kwong A, Chu KM.

Oncotarget. 2018 May 11;9(36):24209-24220. doi: 10.18632/oncotarget.24819. eCollection 2018 May 11.

17.

Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer.

Chan KKL, Siu MKY, Jiang YX, Wang JJ, Leung THY, Ngan HYS.

Cancer Cell Int. 2018 May 1;18:65. doi: 10.1186/s12935-018-0559-2. eCollection 2018.

18.
19.

Human papillomavirus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness.

Leung TH, Tang HW, Siu MK, Chan DW, Chan KK, Cheung AN, Ngan HY.

J Pathol. 2018 Feb;244(2):151-163. doi: 10.1002/path.4991. Epub 2017 Dec 19.

PMID:
28944962
20.

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Patel S, Meilandt WJ, Erickson RI, Chen J, Deshmukh G, Estrada AA, Fuji RN, Gibbons P, Gustafson A, Harris SF, Imperio J, Liu W, Liu X, Liu Y, Lyssikatos JP, Ma C, Yin J, Lewcock JW, Siu M.

J Med Chem. 2017 Oct 12;60(19):8083-8102. doi: 10.1021/acs.jmedchem.7b00843. Epub 2017 Sep 20.

PMID:
28929759
21.

Differential expression of estrogen receptor subtypes and variants in ovarian cancer: effects on cell invasion, proliferation and prognosis.

Chan KKL, Siu MKY, Jiang YX, Wang JJ, Wang Y, Leung THY, Liu SS, Cheung ANY, Ngan HYS.

BMC Cancer. 2017 Aug 31;17(1):606. doi: 10.1186/s12885-017-3601-1.

22.

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.

Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, Maloney J, Gandham VD, Pozniak CD, Wang B, Lee S, Siu M, Patel S, Modrusan Z, Liu X, Rudhard Y, Baca M, Gustafson A, Kaminker J, Carano RAD, Huang EJ, Foreman O, Weimer R, Scearce-Levie K, Lewcock JW.

Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394. doi: 10.1126/scitranslmed.aag0394.

23.

Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis.

Chen WY, Tsai YC, Siu MK, Yeh HL, Chen CL, Yin JJ, Huang J, Liu YN.

Oncogene. 2017 Nov 9;36(45):6213-6224. doi: 10.1038/onc.2017.226. Epub 2017 Jul 10.

PMID:
28692046
24.

Epigenetics of Autism Spectrum Disorder.

Siu MT, Weksberg R.

Adv Exp Med Biol. 2017;978:63-90. doi: 10.1007/978-3-319-53889-1_4. Review.

PMID:
28523541
25.

CHARGE and Kabuki Syndromes: Gene-Specific DNA Methylation Signatures Identify Epigenetic Mechanisms Linking These Clinically Overlapping Conditions.

Butcher DT, Cytrynbaum C, Turinsky AL, Siu MT, Inbar-Feigenberg M, Mendoza-Londono R, Chitayat D, Walker S, Machado J, Caluseriu O, Dupuis L, Grafodatskaya D, Reardon W, Gilbert-Dussardier B, Verloes A, Bilan F, Milunsky JM, Basran R, Papsin B, Stockley TL, Scherer SW, Choufani S, Brudno M, Weksberg R.

Am J Hum Genet. 2017 May 4;100(5):773-788. doi: 10.1016/j.ajhg.2017.04.004.

26.

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.

Larhammar M, Huntwork-Rodriguez S, Jiang Z, Solanoy H, Sengupta Ghosh A, Wang B, Kaminker JS, Huang K, Eastham-Anderson J, Siu M, Modrusan Z, Farley MM, Tessier-Lavigne M, Lewcock JW, Watkins TA.

Elife. 2017 Apr 25;6. pii: e20725. doi: 10.7554/eLife.20725.

27.

Dopamine dependent setting of a circadian oscillator underlying the memory for time of day.

Cain SW, Rawashdeh OA, Siu M, Kim SC, Ralph MR.

Neurobiol Learn Mem. 2017 May;141:78-83. doi: 10.1016/j.nlm.2017.03.015. Epub 2017 Mar 30.

PMID:
28366864
28.

TCF7 is suppressed by the androgen receptor via microRNA-1-mediated downregulation and is involved in the development of resistance to androgen deprivation in prostate cancer.

Siu MK, Chen WY, Tsai HY, Chen HY, Yin JJ, Chen CL, Tsai YC, Liu YN.

Prostate Cancer Prostatic Dis. 2017 Jun;20(2):172-178. doi: 10.1038/pcan.2017.2. Epub 2017 Feb 21.

PMID:
28220803
29.

Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.

Takahashi RH, Halladay JS, Siu M, Chen Y, Hop CE, Khojasteh SC, Ma S.

Drug Metab Dispos. 2017 May;45(5):430-440. doi: 10.1124/dmd.116.074336. Epub 2017 Feb 10.

PMID:
28188299
30.

Implementation of data management and effect on chronic disease coding in a primary care organisation: A parallel cohort observational study.

Greiver M, Wintemute K, Aliarzadeh B, Martin K, Khan S, Jackson D, Leggett J, Lambert-Lanning A, Siu M.

J Innov Health Inform. 2016 Oct 12;23(3):843. doi: 10.14236/jhi.v23i3.843.

31.

KLF4 functions as an activator of the androgen receptor through reciprocal feedback.

Siu MK, Suau F, Chen WY, Tsai YC, Tsai HY, Yeh HL, Liu YN.

Oncogenesis. 2016 Dec 19;5(12):e282. doi: 10.1038/oncsis.2016.79.

32.

miR-199a-5p confers tumor-suppressive role in triple-negative breast cancer.

Chen J, Shin VY, Siu MT, Ho JC, Cheuk I, Kwong A.

BMC Cancer. 2016 Nov 14;16(1):887.

33.

Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy.

Zhang Z, Zhang G, Sun Y, Szeto SS, Law HC, Quan Q, Li G, Yu P, Sho E, Siu MK, Lee SM, Chu IK, Wang Y.

Sci Rep. 2016 Nov 14;6:37148. doi: 10.1038/srep37148.

34.

Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6.

Tsai YC, Chen WY, Siu MK, Tsai HY, Yin JJ, Huang J, Liu YN.

Cancer Lett. 2017 Jan 1;384:1-8. doi: 10.1016/j.canlet.2016.10.014. Epub 2016 Oct 13.

PMID:
27746161
35.

Predictors of functioning in people suffering from first-episode psychosis 1 year into entering early intervention service in Hong Kong.

Chong CS, Siu MW, Kwan CH, Chang WC, Lee EH, Chan SK, Hui CL, Tam FY, Chen EY, Lo WT.

Early Interv Psychiatry. 2018 Oct;12(5):828-838. doi: 10.1111/eip.12374. Epub 2016 Oct 12.

PMID:
27731949
36.

Temporal variation in the deposition of polycyclic aromatic compounds in snow in the Athabasca Oil Sands area of Alberta.

Manzano CA, Muir D, Kirk J, Teixeira C, Siu M, Wang X, Charland JP, Schindler D, Kelly E.

Environ Monit Assess. 2016 Sep;188(9):542. doi: 10.1007/s10661-016-5500-3. Epub 2016 Aug 31.

PMID:
27581009
37.

Genome-wide characteristics of de novo mutations in autism.

Yuen RK, Merico D, Cao H, Pellecchia G, Alipanahi B, Thiruvahindrapuram B, Tong X, Sun Y, Cao D, Zhang T, Wu X, Jin X, Zhou Z, Liu X, Nalpathamkalam T, Walker S, Howe JL, Wang Z, MacDonald JR, Chan A, D'Abate L, Deneault E, Siu MT, Tammimies K, Uddin M, Zarrei M, Wang M, Li Y, Wang J, Wang J, Yang H, Bookman M, Bingham J, Gross SS, Loy D, Pletcher M, Marshall CR, Anagnostou E, Zwaigenbaum L, Weksberg R, Fernandez BA, Roberts W, Szatmari P, Glazer D, Frey BJ, Ring RH, Xu X, Scherer SW.

NPJ Genom Med. 2016 Aug 3;1:160271-1602710.

38.

Androgen receptor regulates SRC expression through microRNA-203.

Siu MK, Chen WY, Tsai HY, Yeh HL, Yin JJ, Liu SY, Liu YN.

Oncotarget. 2016 May 3;7(18):25726-41. doi: 10.18632/oncotarget.8366.

39.

Association of EP2 receptor and SLC19A3 in regulating breast cancer metastasis.

Cheuk IW, Shin VY, Siu MT, Tsang JY, Ho JC, Chen J, Tse GM, Wang X, Kwong A.

Am J Cancer Res. 2015 Oct 15;5(11):3389-99. eCollection 2015.

40.

Chemical quality evaluation of Antrodia cinnamomea fruiting bodies using phytomics similarity index analysis.

Chung CH, Yeh SC, Tseng HC, Siu ML, Lee KT.

J Food Drug Anal. 2016 Jan;24(1):173-178. doi: 10.1016/j.jfda.2015.01.008. Epub 2015 Apr 21.

41.

NSD1 mutations generate a genome-wide DNA methylation signature.

Choufani S, Cytrynbaum C, Chung BH, Turinsky AL, Grafodatskaya D, Chen YA, Cohen AS, Dupuis L, Butcher DT, Siu MT, Luk HM, Lo IF, Lam ST, Caluseriu O, Stavropoulos DJ, Reardon W, Mendoza-Londono R, Brudno M, Gibson WT, Chitayat D, Weksberg R.

Nat Commun. 2015 Dec 22;6:10207. doi: 10.1038/ncomms10207.

42.

Air toxics in Canada measured by the National Air Pollution Surveillance (NAPS) program and their relation to ambient air quality guidelines.

Galarneau E, Wang D, Dabek-Zlotorzynska E, Siu M, Celo V, Tardif M, Harnish D, Jiang Y.

J Air Waste Manag Assoc. 2016 Feb;66(2):184-200. doi: 10.1080/10962247.2015.1096863.

PMID:
26447858
43.

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).

Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW.

J Med Chem. 2015 Oct 22;58(20):8182-99. doi: 10.1021/acs.jmedchem.5b01072. Epub 2015 Oct 2.

PMID:
26431428
44.

Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors.

Diaz D, Dambach D, Siu M, Hunt K, Thomas A, Lyssikatos J, Liu X, Lewin-Koh S, McCray B, Ford K.

Toxicol Mech Methods. 2015;25(6):478-86. Epub 2015 Aug 14.

PMID:
26275124
45.

p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.

Siu MK, Kong DS, Ngai SY, Chan HY, Jiang L, Wong ES, Liu SS, Chan KK, Ngan HY, Cheung AN.

PLoS One. 2015 Jul 28;10(7):e0133467. doi: 10.1371/journal.pone.0133467. eCollection 2015.

46.

Comprehensive spectrum of BRCA1 and BRCA2 deleterious mutations in breast cancer in Asian countries.

Kwong A, Shin VY, Ho JC, Kang E, Nakamura S, Teo SH, Lee AS, Sng JH, Ginsburg OM, Kurian AW, Weitzel JN, Siu MT, Law FB, Chan TL, Narod SA, Ford JM, Ma ES, Kim SW.

J Med Genet. 2016 Jan;53(1):15-23. doi: 10.1136/jmedgenet-2015-103132. Epub 2015 Jul 17. Review.

47.

FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling.

Mak VC, Wong OG, Siu MK, Wong ES, Ng WY, Wong RW, Chan KK, Ngan HY, Cheung AN.

Am J Pathol. 2015 Jul;185(7):2038-48. doi: 10.1016/j.ajpath.2015.03.011.

PMID:
26093985
48.

Stimulus characteristics affect assessment of pupil defects in amblyopia.

Law CL, Siu M, Modica P, Backus B.

Optom Vis Sci. 2015 May;92(5):551-8. doi: 10.1097/OPX.0000000000000576.

PMID:
25875680
49.

Assessing polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in air across Latin American countries using polyurethane foam disk passive air samplers.

Schuster JK, Harner T, Fillmann G, Ahrens L, Altamirano JC, Aristizábal B, Bastos W, Castillo LE, Cortés J, Fentanes O, Gusev A, Hernandez M, Ibarra MV, Lana NB, Lee SC, Martínez AP, Miglioranza KS, Puerta AP, Segovia F, Siu M, Tominaga MY.

Environ Sci Technol. 2015 Mar 17;49(6):3680-6. doi: 10.1021/es506071n. Epub 2015 Mar 2.

PMID:
25686404
50.

Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway.

Siu MK, Tsai YC, Chang YS, Yin JJ, Suau F, Chen WY, Liu YN.

Oncogene. 2015 Sep 3;34(36):4767-76. doi: 10.1038/onc.2014.414. Epub 2014 Dec 22.

PMID:
25531317

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