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Items: 1 to 50 of 143


Effects of different mechanisms on antimicrobial resistance in Acinetobacter baumannii: A strategic system for the screening and activity testing of new antibiotics.

Tsai YK, Liou CH, Lin JC, Fung CP, Chang FY, Siu LK.

Int J Antimicrob Agents. 2020 Jan 30:105918. doi: 10.1016/j.ijantimicag.2020.105918. [Epub ahead of print]


Resistance mechanisms and molecular epidemiology of carbapenem-nonsusceptible Escherichia coli in Taiwan, 2012-2015.

Chang YT, Siu LK, Wang JT, Wu TL, Chen YH, Chuang YC, Lin JC, Lu PL.

Infect Drug Resist. 2019 Jul 16;12:2113-2123. doi: 10.2147/IDR.S208231. eCollection 2019.


Domain 4 of pneumolysin from Streptococcus pneumoniae is a multifunctional domain contributing TLR4 activating and hemolytic activity.

Chiu FF, Leng CH, Ding YJ, Chang JC, Chang LS, Lien SP, Chen HW, Siu LK, Liu SJ.

Biochem Biophys Res Commun. 2019 Oct 1;517(4):596-602. doi: 10.1016/j.bbrc.2019.07.063. Epub 2019 Aug 5.


Appropriate Treatment for Bloodstream Infections Due to Carbapenem-Resistant Klebsiella pneumoniae and Escherichia coli: A Nationwide Multicenter Study in Taiwan.

Lin YT, Su CF, Chuang C, Lin JC, Lu PL, Huang CT, Wang JT, Chuang YC, Siu LK, Fung CP.

Open Forum Infect Dis. 2018 Dec 17;6(2):ofy336. doi: 10.1093/ofid/ofy336. eCollection 2019 Feb.


Klebsiella pneumoniae disassembles host microtubules in lung epithelial cells.

Chua MD, Liou CH, Bogdan AC, Law HT, Yeh KM, Lin JC, Siu LK, Guttman JA.

Cell Microbiol. 2019 Mar;21(3):e12977. doi: 10.1111/cmi.12977. Epub 2018 Nov 22.


Treatment outcome of non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae infections: a multicenter study in Taiwan.

Su CF, Chuang C, Lin YT, Chan YJ, Lin JC, Lu PL, Huang CT, Wang JT, Chuang YC, Siu LK, Fung CP.

Eur J Clin Microbiol Infect Dis. 2018 Apr;37(4):651-659. doi: 10.1007/s10096-017-3156-8. Epub 2017 Dec 14.


The plasmid-mediated fosfomycin resistance determinants and synergy of fosfomycin and meropenem in carbapenem-resistant Klebsiella pneumoniae isolates in Taiwan.

Tseng SP, Wang SF, Ma L, Wang TY, Yang TY, Siu LK, Chuang YC, Lee PS, Wang JT, Wu TL, Lin JC, Lu PL.

J Microbiol Immunol Infect. 2017 Oct;50(5):653-661. doi: 10.1016/j.jmii.2017.03.003. Epub 2017 Jun 28.


First report of OXA-48 carbapenemase-producing Escherichia coli in Taiwan.

Jao YT, Wang WH, Wang A, Siu LK, Lu PL.

J Microbiol Immunol Infect. 2017 Jun;50(3):403-404. doi: 10.1016/j.jmii.2016.12.003. Epub 2017 Jun 20. No abstract available.


Outbreak of imipenem-resistant Acinetobacter baumannii in different wards at a regional hospital related to untrained bedside caregivers.

Wang CH, Li JF, Huang LY, Lin FM, Yang YS, Siu LK, Chang FY, Lin JC.

Am J Infect Control. 2017 Oct 1;45(10):1086-1090. doi: 10.1016/j.ajic.2017.04.016. Epub 2017 May 23.


Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

Chiu SK, Huang LY, Chen H, Tsai YK, Liou CH, Lin JC, Siu LK, Chang FY, Yeh KM.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00391-17. doi: 10.1128/AAC.00391-17. Print 2017 Aug.


Tigecycline resistance among carbapenem-resistant Klebsiella Pneumoniae: Clinical characteristics and expression levels of efflux pump genes.

Chiu SK, Chan MC, Huang LY, Lin YT, Lin JC, Lu PL, Siu LK, Chang FY, Yeh KM.

PLoS One. 2017 Apr 7;12(4):e0175140. doi: 10.1371/journal.pone.0175140. eCollection 2017.


Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of Klebsiella pneumoniae Serotypes K1 and K2.

Siu LK, Tsai YK, Lin JC, Chen TL, Fung CP, Chang FY.

J Clin Microbiol. 2016 Dec;54(12):3018-3021. Epub 2016 Oct 5.


High minimum inhibitory concentration of imipenem as a predictor of fatal outcome in patients with carbapenem non-susceptible Klebsiella pneumoniae.

Wu PF, Chuang C, Su CF, Lin YT, Chan YJ, Wang FD, Chuang YC, Siu LK, Fung CP.

Sci Rep. 2016 Sep 2;6:32665. doi: 10.1038/srep32665.


Effect in virulence of switching conserved homologous capsular polysaccharide genes from Klebsiella pneumoniae serotype K1 into K20.

Lin CL, Chen FH, Huang LY, Chang JC, Chen JH, Tsai YK, Chang FY, Lin JC, Siu LK.

Virulence. 2017 Jul 4;8(5):487-493. doi: 10.1080/21505594.2016.1228508. Epub 2016 Aug 26.


Characterization of Extended-Spectrum β-Lactamase-Carrying Plasmids in Clinical Isolates of Klebsiella pneumoniae from Taiwan.

Chang CY, Lin HJ, Chang LL, Ma L, Siu LK, Tung YC, Lu PL.

Microb Drug Resist. 2017 Jan;23(1):98-106. doi: 10.1089/mdr.2015.0212. Epub 2016 May 5.


Influence of ethanol concentration in the phagocytic function of neutrophils against Klebsiella pneumoniae isolates in an experimental model.

Chiu CH, Wang YC, Yeh KM, Lin JC, Siu LK, Chang FY.

J Microbiol Immunol Infect. 2018 Feb;51(1):64-69. doi: 10.1016/j.jmii.2016.03.004. Epub 2016 Mar 31.


Surface antigens contribute differently to the pathophysiological features in serotype K1 and K2 Klebsiella pneumoniae strains isolated from liver abscesses.

Yeh KM, Chiu SK, Lin CL, Huang LY, Tsai YK, Chang JC, Lin JC, Chang FY, Siu LK.

Gut Pathog. 2016 Feb 13;8:4. doi: 10.1186/s13099-016-0085-5. eCollection 2016.


Quantification and comparison of virulence and characteristics of different variants of carbapenemase-producing Klebsiella pneumoniae clinical isolates from Taiwan and the United States.

Chiang TT, Yang YS, Yeh KM, Chiu SK, Wang NC, Lin TY, Huang LY, Chang FY, Siu LK, Lin JC, Chen JH.

J Microbiol Immunol Infect. 2016 Feb;49(1):83-90. doi: 10.1016/j.jmii.2015.08.011. Epub 2015 Sep 9.


Emergence of OXA-48-Producing Klebsiella pneumoniae in Taiwan.

Ma L, Wang JT, Wu TL, Siu LK, Chuang YC, Lin JC, Lu MC, Lu PL.

PLoS One. 2015 Sep 28;10(9):e0139152. doi: 10.1371/journal.pone.0139152. eCollection 2015. Erratum in: PLoS One. 2015;10(10):e0141179.


A Common Flanking Region in Promiscuous Plasmids Encoding blaNDM-1 in Klebsiella pneumoniae Isolated in Singapore.

Chen YT, Siu LK, Tsai YK, Lin FM, Koh TH, Chen JH.

Microb Drug Resist. 2016 Mar;22(2):109-14. doi: 10.1089/mdr.2015.0132. Epub 2015 Aug 26.


Efficacy of Appropriate Antimicrobial Therapy on the Survival of Patients With Carbapenem Nonsusceptible Klebsiella Pneumoniae Infection: A Multicenter Study in Taiwan.

Lin YT, Chuang C, Su CF, Chan YJ, Wang LS, Huang CT, Chuang YC, Siu LK, Fung CP.

Medicine (Baltimore). 2015 Aug;94(33):e1405. doi: 10.1097/MD.0000000000001405.


Biochemical and Immunological Characterization of Truncated Fragments of the Receptor-Binding Domains of C. difficile Toxin A.

Huang JH, Shen ZQ, Lien SP, Hsiao KN, Leng CH, Chen CC, Siu LK, Chong PC.

PLoS One. 2015 Aug 13;10(8):e0135045. doi: 10.1371/journal.pone.0135045. eCollection 2015.


Recombinant lipoprotein-based vaccine candidates against C. difficile infections.

Huang JH, Wu CW, Lien SP, Leng CH, Hsiao KN, Liu SJ, Chen HW, Siu LK, Chong P.

J Biomed Sci. 2015 Aug 7;22:65. doi: 10.1186/s12929-015-0171-x.


Regulator of the mucoid phenotype A gene increases the virulent ability of extended-spectrum beta-lactamase-producing serotype non-K1/K2 Klebsiella pneumonia.

Lin HA, Huang YL, Yeh KM, Siu LK, Lin JC, Chang FY.

J Microbiol Immunol Infect. 2016 Aug;49(4):494-501. doi: 10.1016/j.jmii.2014.08.023. Epub 2014 Nov 1.


A suitable streptomycin-resistant mutant for constructing unmarked in-frame gene deletions using rpsL as a counter-selection marker.

Tsai YK, Liou CH, Lin JC, Ma L, Fung CP, Chang FY, Siu LK.

PLoS One. 2014 Sep 30;9(9):e109258. doi: 10.1371/journal.pone.0109258. eCollection 2014.


Closely related NDM-1-encoding plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan.

Chen CJ, Wu TL, Lu PL, Chen YT, Fung CP, Chuang YC, Lin JC, Siu LK.

PLoS One. 2014 Aug 21;9(8):e104899. doi: 10.1371/journal.pone.0104899. eCollection 2014.


Clinical features of patients with carbapenem nonsusceptible Klebsiella pneumoniae and Escherichia coli in intensive care units: a nationwide multicenter study in Taiwan.

Chang YY, Chuang YC, Siu LK, Wu TL, Lin JC, Lu PL, Wang JT, Wang LS, Lin YT, Huang LJ, Fung CP.

J Microbiol Immunol Infect. 2015 Apr;48(2):219-25. doi: 10.1016/j.jmii.2014.05.010. Epub 2014 Jul 26.


Genotypes and virulence in serotype K2 Klebsiella pneumoniae from liver abscess and non-infectious carriers in Hong Kong, Singapore and Taiwan.

Lin JC, Koh TH, Lee N, Fung CP, Chang FY, Tsai YK, Ip M, Siu LK.

Gut Pathog. 2014 Jun 12;6:21. doi: 10.1186/1757-4749-6-21. eCollection 2014.


Plasmid transferability of KPC into a virulent K2 serotype Klebsiella pneumoniae.

Siu LK, Huang DB, Chiang T.

BMC Infect Dis. 2014 Mar 31;14:176. doi: 10.1186/1471-2334-14-176.


Updated molecular epidemiology of carbapenem-non-susceptible Escherichia coli in Taiwan: first identification of KPC-2 or NDM-1-producing E. coli in Taiwan.

Ma L, Siu LK, Lin JC, Wu TL, Fung CP, Wang JT, Lu PL, Chuang YC.

BMC Infect Dis. 2013 Dec 20;13:599. doi: 10.1186/1471-2334-13-599.


Single or in combination antimicrobial resistance mechanisms of Klebsiella pneumoniae contribute to varied susceptibility to different carbapenems.

Tsai YK, Liou CH, Fung CP, Lin JC, Siu LK.

PLoS One. 2013 Nov 12;8(11):e79640. doi: 10.1371/journal.pone.0079640. eCollection 2013.


First report of NDM-1-producing Acinetobacter baumannii in East Africa.

Revathi G, Siu LK, Lu PL, Huang LY.

Int J Infect Dis. 2013 Dec;17(12):e1255-8. doi: 10.1016/j.ijid.2013.07.016. Epub 2013 Sep 10.


KPC-2-encoding plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan.

Chen YT, Lin JC, Fung CP, Lu PL, Chuang YC, Wu TL, Siu LK.

J Antimicrob Chemother. 2014 Mar;69(3):628-31. doi: 10.1093/jac/dkt409. Epub 2013 Oct 11.


National surveillance study on carbapenem non-susceptible Klebsiella pneumoniae in Taiwan: the emergence and rapid dissemination of KPC-2 carbapenemase.

Chiu SK, Wu TL, Chuang YC, Lin JC, Fung CP, Lu PL, Wang JT, Wang LS, Siu LK, Yeh KM.

PLoS One. 2013 Jul 24;8(7):e69428. doi: 10.1371/journal.pone.0069428. Print 2013.


Copy Number Change of the NDM-1 sequence in a multidrug-resistant Klebsiella pneumoniae clinical isolate.

Huang TW, Chen TL, Chen YT, Lauderdale TL, Liao TL, Lee YT, Chen CP, Liu YM, Lin AC, Chang YH, Wu KM, Kirby R, Lai JF, Tan MC, Siu LK, Chang CM, Fung CP, Tsai SF.

PLoS One. 2013 Apr 29;8(4):e62774. doi: 10.1371/journal.pone.0062774. Print 2013.


Klebsiella pneumoniae liver abscesses--authors' reply.

Siu LK, Chang FY.

Lancet Infect Dis. 2013 May;13(5):393. doi: 10.1016/S1473-3099(13)70084-7. No abstract available.


Identification of vancomycin-resistant enterococci clones and inter-hospital spread during an outbreak in Taiwan.

Lee SC, Wu MS, Shih HJ, Huang SH, Chiou MJ, See LC, Siu LK.

BMC Infect Dis. 2013 Apr 4;13:163. doi: 10.1186/1471-2334-13-163.


Clinical features and risk factors of mortality for bacteremia due to community-onset healthcare-associated methicillin-resistant S. aureus.

Lee SC, Lee CW, Shih HJ, Chiou MJ, See LC, Siu LK.

Diagn Microbiol Infect Dis. 2013 May;76(1):86-92. doi: 10.1016/j.diagmicrobio.2013.01.017. Epub 2013 Feb 16.


Influence of early daptomycin therapy on treatment outcome of meticillin-resistant Staphylococcus aureus bacteraemia with high vancomycin minimum inhibitory concentrations.

Cheng CW, Hsu PC, Yang CC, Chang HJ, Siu LK, Wu TL, Huang CT, Lee MH.

Int J Antimicrob Agents. 2013 Mar;41(3):293-4. doi: 10.1016/j.ijantimicag.2012.10.019. Epub 2013 Jan 9. No abstract available.


Sequence of closely related plasmids encoding bla(NDM-1) in two unrelated Klebsiella pneumoniae isolates in Singapore.

Chen YT, Lin AC, Siu LK, Koh TH.

PLoS One. 2012;7(11):e48737. doi: 10.1371/journal.pone.0048737. Epub 2012 Nov 6.


Klebsiella pneumoniae liver abscess: a new invasive syndrome.

Siu LK, Yeh KM, Lin JC, Fung CP, Chang FY.

Lancet Infect Dis. 2012 Nov;12(11):881-7. doi: 10.1016/S1473-3099(12)70205-0. Review.


Klebsiella pneumoniae in gastrointestinal tract and pyogenic liver abscess.

Fung CP, Lin YT, Lin JC, Chen TL, Yeh KM, Chang FY, Chuang HC, Wu HS, Tseng CP, Siu LK.

Emerg Infect Dis. 2012 Aug;18(8):1322-5. doi: 10.3201/eid1808.111053.


Induction of alloimmune tolerance in heart transplantation through gene silencing of TLR adaptors.

Zhang X, Beduhn M, Zheng X, Lian D, Chen D, Li R, Siu LK, Marleau A, French PW, Ichim TE, Min WP.

Am J Transplant. 2012 Oct;12(10):2675-88. doi: 10.1111/j.1600-6143.2012.04196.x. Epub 2012 Jul 23.


Molecular epidemiology and clinical characteristics of hetero-resistant vancomycin intermediate Staphylococcus aureus bacteremia in a Taiwan Medical Center.

Lin SY, Chen TC, Chen FJ, Chen YH, Lin YI, Siu LK, Lu PL.

J Microbiol Immunol Infect. 2012 Dec;45(6):435-41. doi: 10.1016/j.jmii.2012.05.004. Epub 2012 Jun 30.


Virulence and plasmid transferability of KPC Klebsiella pneumoniae at the Veterans Affairs Healthcare System of New Jersey.

Siu LK, Lin JC, Gomez E, Eng R, Chiang T.

Microb Drug Resist. 2012 Aug;18(4):380-4. doi: 10.1089/mdr.2011.0241. Epub 2012 Apr 25.


Increasing opsonizing and killing effect of serum from patients with recurrent K1 Klebsiella pneumoniae liver abscess.

Yeh FC, Yeh KM, Siu LK, Fung CP, Yang YS, Lin JC, Chang FY.

J Microbiol Immunol Infect. 2012 Apr;45(2):141-6. doi: 10.1016/j.jmii.2011.12.006. Epub 2012 Mar 21.

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