Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 142


Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3.

Campbell NG, Shekar A, Aguilar JI, Peng D, Navratna V, Yang D, Morley AN, Duran AM, Galli G, O'Grady B, Ramachandran R, Sutcliffe JS, Sitte HH, Erreger K, Meiler J, Stockner T, Bellan LM, Matthies HJG, Gouaux E, Mchaourab HS, Galli A.

Proc Natl Acad Sci U S A. 2019 Feb 12. pii: 201816247. doi: 10.1073/pnas.1816247116. [Epub ahead of print]


Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol-4,5-bisphosphate independent manner.

Das AK, Kudlacek O, Baumgart F, Jaentsch K, Stockner T, Sitte HH, Schütz GJ.

J Biol Chem. 2019 Jan 31. pii: jbc.RA118.006178. doi: 10.1074/jbc.RA118.006178. [Epub ahead of print]


Stereochemistry of phase-1 metabolites of mephedrone determines their effectiveness as releasers at the serotonin transporter.

Mayer FP, Cintulova D, Pittrich DA, Wimmer L, Luethi D, Holy M, Jaentsch K, Tischberger S, Gmeiner G, Hoener MC, Liechti ME, Mihovilovic MD, Sitte HH.

Neuropharmacology. 2019 Jan 2;148:199-209. doi: 10.1016/j.neuropharm.2018.12.032. [Epub ahead of print]


Dephosphorylation of human dopamine transporter at threonine 48 by protein phosphatase PP1/2A upregulates transport velocity.

Yang JW, Larson G, Konrad L, Shetty M, Holy M, Jäntsch K, Kastein M, Heo S, Erdem FA, Lubec G, Vaughan RA, Sitte HH, Foster JD.

J Biol Chem. 2018 Dec 26. pii: jbc.RA118.005251. doi: 10.1074/jbc.RA118.005251. [Epub ahead of print]


Isolation of synaptic vesicles from genetically engineered cultured neurons.

McKenzie C, Spanova M, Johnson A, Kainrath S, Zheden V, Sitte HH, Janovjak H.

J Neurosci Methods. 2019 Jan 15;312:114-121. doi: 10.1016/j.jneumeth.2018.11.018. Epub 2018 Nov 26.


Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter.

Fraser-Spears R, Krause-Heuer AM, Basiouny M, Mayer FP, Manishimwe R, Wyatt NA, Dobrowolski JC, Roberts MP, Greguric I, Kumar N, Koek W, Sitte HH, Callaghan PD, Fraser BH, Daws LC.

Eur J Pharmacol. 2019 Jan 5;842:351-364. doi: 10.1016/j.ejphar.2018.10.028. Epub 2018 Oct 25.


Neuropharmacology of Synthetic Cathinones.

Baumann MH, Walters HM, Niello M, Sitte HH.

Handb Exp Pharmacol. 2018 Nov 8. doi: 10.1007/164_2018_178. [Epub ahead of print]


The synthetic cathinones, butylone and pentylone, are stimulants that act as dopamine transporter blockers but 5-HT transporter substrates.

Saha K, Li Y, Holy M, Lehner KR, Bukhari MO, Partilla JS, Sandtner W, Sitte HH, Baumann MH.

Psychopharmacology (Berl). 2018 Oct 22. doi: 10.1007/s00213-018-5075-5. [Epub ahead of print]


DARK Classics in Chemical Neuroscience: Aminorex Analogues.

Maier J, Mayer FP, Brandt SD, Sitte HH.

ACS Chem Neurosci. 2018 Oct 17;9(10):2484-2502. doi: 10.1021/acschemneuro.8b00415. Epub 2018 Oct 5.


"Polytox" synthetic cathinone abuse: A potential role for organic cation transporter 3 in combined cathinone-induced efflux.

Mayer FP, Schmid D, Holy M, Daws LC, Sitte HH.

Neurochem Int. 2019 Feb;123:7-12. doi: 10.1016/j.neuint.2018.09.008. Epub 2018 Sep 21.


Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain.

Robson JP, Wagner B, Glitzner E, Heppner FL, Steinkellner T, Khan D, Petritsch C, Pollak DD, Sitte HH, Sibilia M.

FEBS J. 2018 Sep;285(17):3175-3196. doi: 10.1111/febs.14603. Epub 2018 Aug 4.


The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters.

Maier J, Mayer FP, Luethi D, Holy M, Jäntsch K, Reither H, Hirtler L, Hoener MC, Liechti ME, Pifl C, Brandt SD, Sitte HH.

Neuropharmacology. 2018 Aug;138:282-291. doi: 10.1016/j.neuropharm.2018.06.018. Epub 2018 Jun 23.


Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.

Jayaraman K, Morley AN, Szöllősi D, Wassenaar TA, Sitte HH, Stockner T.

PLoS Comput Biol. 2018 Jun 6;14(6):e1006229. doi: 10.1371/journal.pcbi.1006229. eCollection 2018 Jun.


An unsuspected role for organic cation transporter 3 in the actions of amphetamine.

Mayer FP, Schmid D, Owens WA, Gould GG, Apuschkin M, Kudlacek O, Salzer I, Boehm S, Chiba P, Williams PH, Wu HH, Gether U, Koek W, Daws LC, Sitte HH.

Neuropsychopharmacology. 2018 Nov;43(12):2408-2417. doi: 10.1038/s41386-018-0053-5. Epub 2018 Apr 6.


Flotillin-1 interacts with the serotonin transporter and modulates chronic corticosterone response.

Reisinger SN, Kong E, Molz B, Humberg T, Sideromenos S, Cicvaric A, Steinkellner T, Yang JW, Cabatic M, Monje FJ, Sitte HH, Nichols BJ, Pollak DD.

Genes Brain Behav. 2019 Feb;18(2):e12482. doi: 10.1111/gbb.12482. Epub 2018 May 20.


A kinetic account for amphetamine-induced monoamine release.

Hasenhuetl PS, Bhat S, Mayer FP, Sitte HH, Freissmuth M, Sandtner W.

J Gen Physiol. 2018 Feb 9. pii: jgp.201711915. doi: 10.1085/jgp.201711915. [Epub ahead of print]


A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval.

Kristofova M, Aher YD, Ilic M, Radoman B, Kalaba P, Dragacevic V, Aher NY, Leban J, Korz V, Zanon L, Neuhaus W, Wieder M, Langer T, Urban E, Sitte HH, Hoeger H, Lubec G, Aradska J.

Behav Brain Res. 2018 May 2;343:83-94. doi: 10.1016/j.bbr.2018.01.032. Epub 2018 Feb 1.


Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors.

Kalaba P, Aher NY, Ilić M, Dragačević V, Wieder M, Miklosi AG, Zehl M, Wackerlig J, Roller A, Beryozkina T, Radoman B, Saroja SR, Lindner W, Gonzalez EP, Bakulev V, Leban JJ, Sitte HH, Urban E, Langer T, Lubec G.

J Med Chem. 2017 Nov 22;60(22):9330-9348. doi: 10.1021/acs.jmedchem.7b01313. Epub 2017 Nov 9.


Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family.

Mayer FP, Burchardt NV, Decker AM, Partilla JS, Li Y, McLaughlin G, Kavanagh PV, Sandtner W, Blough BE, Brandt SD, Baumann MH, Sitte HH.

Neuropharmacology. 2018 May 15;134(Pt A):149-157. doi: 10.1016/j.neuropharm.2017.10.006. Epub 2017 Oct 6.


R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity.

Shanmugasundaram B, Aher YD, Aradska J, Ilic M, Daba Feyissa D, Kalaba P, Aher NY, Dragacevic V, Saber Marouf B, Langer T, Sitte HH, Hoeger H, Lubec G, Korz V.

PLoS One. 2017 Jun 23;12(6):e0179675. doi: 10.1371/journal.pone.0179675. eCollection 2017.


Cocaine adulteration.

Kudlacek O, Hofmaier T, Luf A, Mayer FP, Stockner T, Nagy C, Holy M, Freissmuth M, Schmid R, Sitte HH.

J Chem Neuroanat. 2017 Oct;83-84:75-81. doi: 10.1016/j.jchemneu.2017.06.001. Epub 2017 Jun 12. Review.


Dopamine and noradrenaline, but not serotonin, in the human claustrum are greatly reduced in patients with Parkinson's disease: possible functional implications.

Sitte HH, Pifl C, Rajput AH, Hörtnagl H, Tong J, Lloyd GK, Kish SJ, Hornykiewicz O.

Eur J Neurosci. 2017 May;45(10):1356. doi: 10.1111/ejn.13573. No abstract available.


Occupancy of the zinc-binding site by transition metals decreases the substrate affinity of the human dopamine transporter by an allosteric mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Apr 28;292(17):7161. doi: 10.1074/jbc.A116.760140. No abstract available.


Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter.

Anderluh A, Hofmaier T, Klotzsch E, Kudlacek O, Stockner T, Sitte HH, Schütz GJ.

Nat Commun. 2017 Jan 19;8:14089. doi: 10.1038/ncomms14089.


Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Mar 10;292(10):4235-4243. doi: 10.1074/jbc.M116.760140. Epub 2017 Jan 17. Erratum in: J Biol Chem. 2017 Apr 28;292(17 ):7161.


Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters.

Mayer FP, Luf A, Nagy C, Holy M, Schmid R, Freissmuth M, Sitte HH.

Curr Top Behav Neurosci. 2017;32:333-350. doi: 10.1007/7854_2016_63. Review.


Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities.

Sweeney CG, Tremblay BP, Stockner T, Sitte HH, Melikian HE.

J Biol Chem. 2017 Jan 27;292(4):1302-1309. doi: 10.1074/jbc.M116.762872. Epub 2016 Dec 16.


Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter.

Seddik A, Geerke DP, Stockner T, Holy M, Kudlacek O, Cozzi NV, Ruoho AE, Sitte HH, Ecker GF.

Mol Inform. 2017 May;36(5-6). doi: 10.1002/minf.201600094. Epub 2016 Nov 8.


The Environment Shapes the Inner Vestibule of LeuT.

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197. eCollection 2016 Nov.


Dopamine and noradrenaline, but not serotonin, in the human claustrum are greatly reduced in patients with Parkinson's disease: possible functional implications.

Sitte HH, Pifl C, Rajput AH, Hörtnagl H, Tong J, Lloyd GK, Kish SJ, Hornykiewicz O.

Eur J Neurosci. 2017 Jan;45(1):192-197. doi: 10.1111/ejn.13435. Epub 2016 Nov 11. Erratum in: Eur J Neurosci. 2017 May;45(10 ):1356.


Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter.

Billesbølle CB, Mortensen JS, Sohail A, Schmidt SG, Shi L, Sitte HH, Gether U, Loland CJ.

Nat Commun. 2016 Sep 28;7:12755. doi: 10.1038/ncomms12755.


Making Sense of: Sensitization in Schizophrenia.

Weidenauer A, Bauer M, Sauerzopf U, Bartova L, Praschak-Rieder N, Sitte HH, Kasper S, Willeit M.

Int J Neuropsychopharmacol. 2016 Dec 31;20(1):1-10. doi: 10.1093/ijnp/pyw081. Print 2017 Jan. Review.


[Guidelines for vaccination of immunocompromised individuals].

Wiedermann U, Sitte HH, Burgmann H, Eser A, Falb P, Holzmann H, Kitchen M, Köller M, Kollaritsch H, Kundi M, Lassmann H, Mutz I, Pickl WF, Riedl E, Sibilia M, Thalhammer F, Tucek B, Zenz W, Zwiauer K.

Wien Klin Wochenschr. 2016 Aug;128 Suppl 4:337-76. doi: 10.1007/s00508-016-1033-6. Epub 2016 Jul 25. German.


Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters.

Mayer FP, Wimmer L, Dillon-Carter O, Partilla JS, Burchardt NV, Mihovilovic MD, Baumann MH, Sitte HH.

Br J Pharmacol. 2016 Sep;173(17):2657-68. doi: 10.1111/bph.13547. Epub 2016 Jul 31.


A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System.

Aher YD, Subramaniyan S, Shanmugasundaram B, Sase A, Saroja SR, Holy M, Höger H, Beryozkina T, Sitte HH, Leban JJ, Lubec G.

Front Behav Neurosci. 2016 Feb 22;10:20. doi: 10.3389/fnbeh.2016.00020. eCollection 2016.


Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers.

McLaughlin G, Morris N, Kavanagh PV, Dowling G, Power JD, Twamley B, O'Brien J, Talbot B, Sitte HH, Brandt SD.

Drug Test Anal. 2017 Mar;9(3):369-377. doi: 10.1002/dta.1945. Epub 2016 Jan 26.


Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1719-22. doi: 10.1002/anie.201508755. Epub 2015 Dec 22.


Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters.

Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang YW, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH.

Mol Pharmacol. 2016 Jan;89(1):165-75. doi: 10.1124/mol.115.101394. Epub 2015 Oct 30.


Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.

Li Y, Hasenhuetl PS, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2015 Dec 25;290(52):31069-76. doi: 10.1074/jbc.M115.688275. Epub 2015 Oct 26.


Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site.

Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T.

PLoS Comput Biol. 2015 Oct 20;11(10):e1004551. doi: 10.1371/journal.pcbi.1004551. eCollection 2015 Oct.


A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes.

Sase A, Aher YD, Saroja SR, Ganesan MK, Sase S, Holy M, Höger H, Bakulev V, Ecker GF, Langer T, Sitte HH, Leban J, Lubec G.

Neuropharmacology. 2016 Mar;102:186-96. doi: 10.1016/j.neuropharm.2015.07.039. Epub 2015 Sep 25.


The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze.

Karabacak Y, Sase S, Aher YD, Sase A, Saroja SR, Cicvaric A, Höger H, Berger M, Bakulev V, Sitte HH, Leban J, Monje FJ, Lubec G.

Front Behav Neurosci. 2015 Aug 19;9:215. doi: 10.3389/fnbeh.2015.00215. eCollection 2015.


Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH.

J Neurosci. 2015 May 27;35(21):8258-71. doi: 10.1523/JNEUROSCI.4034-14.2015. Erratum in: J Neurosci. 2015 Aug 19;35(33):11762.


Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W.

Mol Pharmacol. 2015 Jul;88(1):12-8. doi: 10.1124/mol.115.099036. Epub 2015 Apr 14.


A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.

Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2015 May 22;290(21):13263-78. doi: 10.1074/jbc.M115.641357. Epub 2015 Apr 13.


Reduced default mode network suppression during a working memory task in remitted major depression.

Bartova L, Meyer BM, Diers K, Rabl U, Scharinger C, Popovic A, Pail G, Kalcher K, Boubela RN, Huemer J, Mandorfer D, Windischberger C, Sitte HH, Kasper S, Praschak-Rieder N, Moser E, Brocke B, Pezawas L.

J Psychiatr Res. 2015 May;64:9-18. doi: 10.1016/j.jpsychires.2015.02.025. Epub 2015 Mar 6.


Cooperativity between individual transporter protomers: new data fuelling old complexes.

Sitte HH, Schütz GJ, Freissmuth M.

J Neurochem. 2015 Apr;133(2):163-6. doi: 10.1111/jnc.13086. Epub 2015 Mar 15.


A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1).

Jurik A, Zdrazil B, Holy M, Stockner T, Sitte HH, Ecker GF.

J Med Chem. 2015 Mar 12;58(5):2149-58. doi: 10.1021/jm5015428. Epub 2015 Feb 26.


Amphetamines, new psychoactive drugs and the monoamine transporter cycle.

Sitte HH, Freissmuth M.

Trends Pharmacol Sci. 2015 Jan;36(1):41-50. doi: 10.1016/ Epub 2014 Dec 23. Review.


'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function.

Saha K, Partilla JS, Lehner KR, Seddik A, Stockner T, Holy M, Sandtner W, Ecker GF, Sitte HH, Baumann MH.

Neuropsychopharmacology. 2015 May;40(6):1321-31. doi: 10.1038/npp.2014.325. Epub 2014 Dec 15.

Supplemental Content

Loading ...
Support Center