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Items: 33

1.

The Opioid Crisis and the Future of Addiction and Pain Therapeutics.

Coussens NP, Sittampalam GS, Jonson SG, Hall MD, Gorby HE, Tamiz AP, McManus OB, Felder CC, Rasmussen K.

J Pharmacol Exp Ther. 2019 Sep 3. pii: jpet.119.259408. doi: 10.1124/jpet.119.259408. [Epub ahead of print]

2.

Fully Three-Dimensional Bioprinted Skin Equivalent Constructs with Validated Morphology and Barrier Function.

Derr K, Zou J, Luo K, Song MJ, Sittampalam GS, Zhou C, Michael S, Ferrer M, Derr P.

Tissue Eng Part C Methods. 2019 Jun;25(6):334-343. doi: 10.1089/ten.TEC.2018.0318.

3.

Mapping biologically active chemical space to accelerate drug discovery.

Sittampalam GS, Rudnicki DD, Tagle DA, Simeonov A, Austin CP.

Nat Rev Drug Discov. 2019 Feb;18(2):83-84. doi: 10.1038/d41573-018-00007-2. No abstract available.

PMID:
30710133
4.

Metastatic Tumor-in-a-Dish, a Novel Multicellular Organoid to Study Lung Colonization and Predict Therapeutic Response.

Ramamoorthy P, Thomas SM, Kaushik G, Subramaniam D, Chastain KM, Dhar A, Tawfik O, Kasi A, Sun W, Ramalingam S, Gunewardena S, Umar S, Mammen JM, Padhye SB, Weir SJ, Jensen RA, Sittampalam GS, Anant S.

Cancer Res. 2019 Apr 1;79(7):1681-1695. doi: 10.1158/0008-5472.CAN-18-2602. Epub 2019 Jan 23.

PMID:
30674533
5.

Translational in vitro research: integrating 3D drug discovery and development processes into the drug development pipeline.

Kelm JM, Lal-Nag M, Sittampalam GS, Ferrer M.

Drug Discov Today. 2019 Jan;24(1):26-30. doi: 10.1016/j.drudis.2018.07.007. Epub 2018 Jul 30.

PMID:
30071313
6.

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP.

Clin Transl Sci. 2018 Sep;11(5):461-470. doi: 10.1111/cts.12570. Epub 2018 Jul 24. Review.

7.

Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration-Approved Drugs.

Coussens NP, Braisted JC, Peryea T, Sittampalam GS, Simeonov A, Hall MD.

Pharmacol Rev. 2017 Oct;69(4):479-496. doi: 10.1124/pr.117.013755. Review.

8.

Twenty-First Century Diseases: Commonly Rare and Rarely Common?

Daunert S, Sittampalam GS, Goldschmidt-Clermont PJ.

Antioxid Redox Signal. 2017 Sep 20;27(9):511-516. doi: 10.1089/ars.2017.7065. Epub 2017 Jul 5.

9.

The translational science training program at NIH: Introducing early career researchers to the science and operation of translation of basic research to medical interventions.

Gilliland CT, Sittampalam GS, Wang PY, Ryan PE.

Biochem Mol Biol Educ. 2017 Jan 2;45(1):13-24. doi: 10.1002/bmb.20978. Epub 2016 May 26.

10.

Basics of Assay Equipment and Instrumentation for High Throughput Screening.

Jones E, Michael S, Sittampalam GS.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 1 [updated 2016 Apr 2].

11.

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.

Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, Cox K, Austin CP, Simeonov A, Sittampalam GS, Husain S, Franklin N, Wild DJ, Yang JJ, Sutherland JJ, Thomas CJ.

PLoS One. 2015 Jul 15;10(7):e0130796. doi: 10.1371/journal.pone.0130796. eCollection 2015.

12.

Phospho-ERK Assays.

Garbison KE, Heinz BA, Lajiness ME, Weidner JR, Sittampalam GS.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 1 [updated 2015 Jun 25].

13.

A multicenter pilot study examining the role of circulating tumor cells as a blood-based tumor marker in patients with extensive small-cell lung cancer.

Huang CH, Wick JA, Sittampalam GS, Nirmalanandhan VS, Ganti AK, Neupane PC, Williamson SK, Godwin AK, Schmitt S, Smart NJ, Spencer S, Van Veldhuizen PJ.

Front Oncol. 2014 Oct 14;4:271. doi: 10.3389/fonc.2014.00271. eCollection 2014.

14.

Calculations and Instrumentation used for Radioligand Binding Assays.

Kahl SD, Sittampalam GS, Weidner J.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-. No abstract available.
2012 May 1 [updated 2012 Oct 1].

15.

HTS Assay Validation.

Iversen PW, Beck B, Chen YF, Dere W, Devanarayan V, Eastwood BJ, Farmen MW, Iturria SJ, Montrose C, Moore RA, Weidner JR, Sittampalam GS.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 1 [updated 2012 Oct 1].

16.

Impedance-Based Technologies.

Garbison KE, Heinz BA, Lajiness ME, Weidner JR, Sittampalam GS.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 1.

17.

Stretching mechanotransduction from the lung to the lab: approaches and physiological relevance in drug discovery.

Schmitt S, Hendricks P, Weir J, Somasundaram R, Sittampalam GS, Nirmalanandhan VS.

Assay Drug Dev Technol. 2012 Apr;10(2):137-47. doi: 10.1089/adt.2011.418. Epub 2012 Feb 21. Review.

PMID:
22352900
18.

Impact of high-throughput screening in biomedical research.

Macarron R, Banks MN, Bojanic D, Burns DJ, Cirovic DA, Garyantes T, Green DV, Hertzberg RP, Janzen WP, Paslay JW, Schopfer U, Sittampalam GS.

Nat Rev Drug Discov. 2011 Mar;10(3):188-95. doi: 10.1038/nrd3368. Review.

PMID:
21358738
19.

Activity of anticancer agents in a three-dimensional cell culture model.

Nirmalanandhan VS, Duren A, Hendricks P, Vielhauer G, Sittampalam GS.

Assay Drug Dev Technol. 2010 Oct;8(5):581-90. doi: 10.1089/adt.2010.0276. Epub 2010 Jul 27.

PMID:
20662735
20.

Stem cells in drug discovery, tissue engineering, and regenerative medicine: emerging opportunities and challenges.

Nirmalanandhan VS, Sittampalam GS.

J Biomol Screen. 2009 Aug;14(7):755-68. doi: 10.1177/1087057109336591. Epub 2009 Aug 12. Review.

PMID:
19675315
21.

A comparison of assay performance measures in screening assays: signal window, Z' factor, and assay variability ratio.

Iversen PW, Eastwood BJ, Sittampalam GS, Cox KL.

J Biomol Screen. 2006 Apr;11(3):247-52. Epub 2006 Feb 20.

PMID:
16490779
22.

Bioimaging in drug discovery sciences.

Sittampalam GS, Westmore M.

Anal Bioanal Chem. 2003 Nov;377(6):953-4. Epub 2003 Oct 16. No abstract available.

PMID:
14564446
23.

Conceptual and statistical issues in the validation of analytic dilution assays for pharmaceutical applications.

Smith WC, Sittampalam GS.

J Biopharm Stat. 1998 Nov;8(4):509-32. Review.

PMID:
9855031
24.

High-throughput screening: advances in assay technologies.

Sittampalam GS, Kahl SD, Janzen WP.

Curr Opin Chem Biol. 1997 Oct;1(3):384-91. Review.

PMID:
9667878
25.

Synthesis and characterization of insulin-fluorescein derivatives for bioanalytical applications.

Hentz NG, Richardson JM, Sportsman JR, Daijo J, Sittampalam GS.

Anal Chem. 1997 Dec 15;69(24):4994-5000.

PMID:
9414613
26.

Application of experimental design techniques to optimize a competitive ELISA.

Sittampalam GS, Smith WC, Miyakawa TW, Smith DR, McMorris C.

J Immunol Methods. 1996 Apr 19;190(2):151-61.

PMID:
8621950
27.

Separation of antibody-antigen complexes by capillary zone electrophoresis, isoelectric focusing and high-performance size-exclusion chromatography.

Nielsen RG, Rickard EC, Santa PF, Sharknas DA, Sittampalam GS.

J Chromatogr. 1991 Feb 8;539(1):177-85.

PMID:
2013611
28.

Application of free-solution capillary electrophoresis to the analytical scale separation of proteins and peptides.

Grossman PD, Colburn JC, Lauer HH, Nielsen RG, Riggin RM, Sittampalam GS, Rickard EC.

Anal Chem. 1989 Jun 1;61(11):1186-94.

PMID:
2757205
29.

Capillary zone electrophoresis of insulin and growth hormone.

Nielsen RG, Sittampalam GS, Rickard EC.

Anal Biochem. 1989 Feb 15;177(1):20-6.

PMID:
2662817
30.

Visualization of multiple protein bands on the same nitrocellulose membrane by double immunoblotting.

Poor ML, Santa PF, Sittampalam GS.

Anal Biochem. 1988 Nov 15;175(1):191-5.

PMID:
2469351
31.

Protein assays for monoclonal antibodies.

Rickard EC, Sittampalam GS, Clodfelter DK.

Biotechniques. 1988 Nov-Dec;6(10):982-92.

PMID:
3273400
32.

Evaluation of amino acid analysis as reference method to quantitate highly purified proteins.

Sittampalam GS, Ellis RM, Miner DJ, Rickard EC, Clodfelter DK.

J Assoc Off Anal Chem. 1988 Jul-Aug;71(4):833-8.

PMID:
3047099
33.

Recommendations for establishment of reference standards for recombinant-DNA-derived proteins and polypeptides.

Atkins LM, Miner DJ, Sittampalam GS, Wentling CD.

J Assoc Off Anal Chem. 1987 Jul-Aug;70(4):610-7.

PMID:
3305473

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