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Items: 1 to 50 of 84

1.
2.

Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes.

Silva M, Nguyen TH, Philbrook P, Chu M, Sears O, Hatfield S, Abbott RK, Kelsoe G, Sitkovsky MV.

Cell Rep. 2017 Dec 26;21(13):3672-3680. doi: 10.1016/j.celrep.2017.12.014.

3.

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells.

Sethumadhavan S, Silva M, Philbrook P, Nguyen T, Hatfield SM, Ohta A, Sitkovsky MV.

PLoS One. 2017 Nov 20;12(11):e0187314. doi: 10.1371/journal.pone.0187314. eCollection 2017.

4.

Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma.

Ravi D, Beheshti A, Abermil N, Passero F, Sharma J, Coyle M, Kritharis A, Kandela I, Hlatky L, Sitkovsky MV, Mazar A, Gartenhaus RB, Evens AM.

Cancer Res. 2016 Jun 1;76(11):3319-31. doi: 10.1158/0008-5472.CAN-15-2477. Epub 2016 Mar 17.

5.

Immunological mechanisms of the antitumor effects of supplemental oxygenation.

Hatfield SM, Kjaergaard J, Lukashev D, Schreiber TH, Belikoff B, Abbott R, Sethumadhavan S, Philbrook P, Ko K, Cannici R, Thayer M, Rodig S, Kutok JL, Jackson EK, Karger B, Podack ER, Ohta A, Sitkovsky MV.

Sci Transl Med. 2015 Mar 4;7(277):277ra30. doi: 10.1126/scitranslmed.aaa1260.

6.

Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists.

Sitkovsky MV, Hatfield S, Abbott R, Belikoff B, Lukashev D, Ohta A.

Cancer Immunol Res. 2014 Jul;2(7):598-605. doi: 10.1158/2326-6066.CIR-14-0075. Review.

7.

Purinergic signaling during inflammation.

Eltzschig HK, Sitkovsky MV, Robson SC.

N Engl J Med. 2013 Mar 28;368(13):1260. doi: 10.1056/NEJMc1300259. No abstract available.

PMID:
23534573
8.

Purinergic signaling during inflammation.

Eltzschig HK, Sitkovsky MV, Robson SC.

N Engl J Med. 2012 Dec 13;367(24):2322-33. doi: 10.1056/NEJMra1205750. Review. No abstract available.

9.

Genetic deletion of the HIF-1α isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model.

Georgiev P, Belikoff BG, Hatfield S, Ohta A, Sitkovsky MV, Lukashev D.

Eur J Immunol. 2013 Mar;43(3):655-66. doi: 10.1002/eji.201242765. Epub 2013 Jan 31.

10.

In vivo hypoxic preconditioning protects from warm liver ischemia-reperfusion injury through the adenosine A2B receptor.

Choukèr A, Ohta A, Martignoni A, Lukashev D, Zacharia LC, Jackson EK, Schnermann J, Ward JM, Kaufmann I, Klaunberg B, Sitkovsky MV, Thiel M.

Transplantation. 2012 Nov 15;94(9):894-902. doi: 10.1097/TP.0b013e31826a9a46.

11.

Adenosine A2A receptor is involved in cell surface expression of A2B receptor.

Moriyama K, Sitkovsky MV.

J Biol Chem. 2010 Dec 10;285(50):39271-88. doi: 10.1074/jbc.M109.098293. Epub 2010 Oct 6.

12.

Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha.

Paone A, Galli R, Gabellini C, Lukashev D, Starace D, Gorlach A, De Cesaris P, Ziparo E, Del Bufalo D, Sitkovsky MV, Filippini A, Riccioli A.

Neoplasia. 2010 Jul;12(7):539-49.

13.

Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow.

Kojima H, Kobayashi A, Sakurai D, Kanno Y, Hase H, Takahashi R, Totsuka Y, Semenza GL, Sitkovsky MV, Kobata T.

J Immunol. 2010 Jan 1;184(1):154-63. doi: 10.4049/jimmunol.0800167. Epub 2009 Nov 30.

14.

Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists.

Ramanathan M, Luo W, Csóka B, Haskó G, Lukashev D, Sitkovsky MV, Leibovich SJ.

J Leukoc Biol. 2009 Sep;86(3):681-9. doi: 10.1189/jlb.0109021. Epub 2009 May 28.

15.

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response.

Sitkovsky MV.

Trends Immunol. 2009 Mar;30(3):102-8. doi: 10.1016/j.it.2008.12.002. Epub 2009 Feb 7.

PMID:
19201652
16.

Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia.

Sitkovsky MV, Kjaergaard J, Lukashev D, Ohta A.

Clin Cancer Res. 2008 Oct 1;14(19):5947-52. doi: 10.1158/1078-0432.CCR-08-0229. Review.

17.

Damage control by hypoxia-inhibited AK.

Sitkovsky MV.

Blood. 2008 Jun 15;111(12):5424-5. doi: 10.1182/blood-2008-03-143990. No abstract available.

PMID:
18544695
18.

Comparison of Fenestra VC Contrast-enhanced computed tomography imaging with gadopentetate dimeglumine and ferucarbotran magnetic resonance imaging for the in vivo evaluation of murine liver damage after ischemia and reperfusion.

Choukèr A, Lizak M, Schimel D, Helmberger T, Ward JM, Despres D, Kaufmann I, Bruns C, Löhe F, Ohta A, Sitkovsky MV, Klaunberg B, Thiel M.

Invest Radiol. 2008 Feb;43(2):77-91. doi: 10.1097/RLI.0b013e318155aa2e.

PMID:
18197060
19.

Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway.

Choukèr A, Thiel M, Lukashev D, Ward JM, Kaufmann I, Apasov S, Sitkovsky MV, Ohta A.

Mol Med. 2008 Mar-Apr;14(3-4):116-23.

20.

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.

Thiel M, Caldwell CC, Kreth S, Kuboki S, Chen P, Smith P, Ohta A, Lentsch AB, Lukashev D, Sitkovsky MV.

PLoS One. 2007 Sep 5;2(9):e853.

21.

The 'danger' sensors that STOP the immune response: the A2 adenosine receptors?

Sitkovsky MV, Ohta A.

Trends Immunol. 2005 Jun;26(6):299-304.

PMID:
15922945
22.

Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury.

Thiel M, Chouker A, Ohta A, Jackson E, Caldwell C, Smith P, Lukashev D, Bittmann I, Sitkovsky MV.

PLoS Biol. 2005 Jun;3(6):e174. Epub 2005 May 3.

23.

Hypoxia-inducible factor 1alpha-deficient chimeric mice as a model to study abnormal B lymphocyte development and autoimmunity.

Kojima H, Jones BT, Chen J, Cascalho M, Sitkovsky MV.

Methods Enzymol. 2004;381:218-29. No abstract available.

PMID:
15063678
24.

Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.

Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M.

Annu Rev Immunol. 2004;22:657-82. Review.

PMID:
15032592
25.

Immunomodulatory and neuroprotective effects of inosine.

Haskó G, Sitkovsky MV, Szabó C.

Trends Pharmacol Sci. 2004 Mar;25(3):152-7. Review. No abstract available.

PMID:
15019271
26.
27.

Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo.

Gomez G, Sitkovsky MV.

Blood. 2003 Dec 15;102(13):4472-8. Epub 2003 Aug 28.

PMID:
12947007
28.

HIF-1 alpha deficiency perturbs T and B cell functions.

Kojima H, Sitkovsky MV, Cascalho M.

Curr Pharm Des. 2003;9(23):1827-32. Review.

PMID:
12871187
29.

Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs.

Lukashev DE, Smith PT, Caldwell CC, Ohta A, Apasov SG, Sitkovsky MV.

Biochem Pharmacol. 2003 Jun 15;65(12):2081-90.

PMID:
12787889
30.
31.

A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen.

Lukashev DE, Caldwell CC, Chen P, Apasov SG, Margulies DH, Sitkovsky MV.

J Recept Signal Transduct Res. 2003 Feb;23(1):33-52.

PMID:
12680588
32.
33.

Targeting G protein-coupled A2a adenosine receptors to engineer inflammation in vivo.

Gomez G, Sitkovsky MV.

Int J Biochem Cell Biol. 2003 Apr;35(4):410-4. Review.

PMID:
12565702
34.

Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice.

Kojima H, Gu H, Nomura S, Caldwell CC, Kobata T, Carmeliet P, Semenza GL, Sitkovsky MV.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2170-4.

35.

Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions.

Caldwell CC, Kojima H, Lukashev D, Armstrong J, Farber M, Apasov SG, Sitkovsky MV.

J Immunol. 2001 Dec 1;167(11):6140-9.

36.

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling.

Apasov SG, Blackburn MR, Kellems RE, Smith PT, Sitkovsky MV.

J Clin Invest. 2001 Jul;108(1):131-41.

37.

Purification and Recognition of Recombinant Mouse P2X(1) Receptors Expressed in a Baculovirus System.

Chen L, Hardwick JP, McPhie P, Sitkovsky MV, Jacobson KA.

Drug Dev Res. 2000 Sep 1;51(1):7-19. Epub 2000 Oct 16.

38.

Study of A(2A) adenosine receptor gene deficient mice reveals that adenosine analogue CGS 21680 possesses no A(2A) receptor-unrelated lymphotoxicity.

Apasov SG, Chen JF, Smith PT, Schwarzschild MA, Fink JS, Sitkovsky MV.

Br J Pharmacol. 2000 Sep;131(1):43-50.

39.
40.

Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation?

Redegeld FA, Caldwell CC, Sitkovsky MV.

Trends Pharmacol Sci. 1999 Nov;20(11):453-9. Review.

PMID:
10542445
43.

Extracellular purines and their receptors in immunoregulation. Review of recent advances.

Sitkovsky MV.

Nihon Ika Daigaku Zasshi. 1998 Oct;65(5):351-7. Review.

PMID:
9808987
44.

Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells.

Koshiba M, Kojima H, Huang S, Apasov S, Sitkovsky MV.

J Biol Chem. 1997 Oct 10;272(41):25881-9.

46.

Leukocyte function-associated antigen-1-dependent lysis of Fas+ (CD95+/Apo-1+) innocent bystanders by antigen-specific CD8+ CTL.

Kojima H, Eshima K, Takayama H, Sitkovsky MV.

J Immunol. 1997 Sep 15;159(6):2728-34.

PMID:
9300693
47.
48.

Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes.

Koshiba M, Apasov S, Sverdlov V, Chen P, Erb L, Turner JT, Weisman GA, Sitkovsky MV.

Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):831-6.

50.

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