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Items: 1 to 50 of 165

1.

Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity.

Carmona M, de Cubas L, Bautista E, Moral-Blanch M, Medraño-Fernández I, Sitia R, Boronat S, Ayté J, Hidalgo E.

Nat Commun. 2019 Oct 4;10(1):4526. doi: 10.1038/s41467-019-12475-0.

2.

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane.

Bestetti S, Galli M, Sorrentino I, Pinton P, Rimessi A, Sitia R, Medraño-Fernandez I.

Redox Biol. 2020 Jan;28:101326. doi: 10.1016/j.redox.2019.101326. Epub 2019 Sep 12.

3.

Atypical IgM on T cells predict relapse and steroid dependence in idiopathic nephrotic syndrome.

Colucci M, Carsetti R, Rosado MM, Cascioli S, Bruschi M, Candiano G, Corpetti G, Giardino L, Serafinelli J, Giannone C, Ghiggeri GM, Rastaldi MP, Sitia R, Emma F, Vivarelli M.

Kidney Int. 2019 Oct;96(4):971-982. doi: 10.1016/j.kint.2019.04.006. Epub 2019 May 7.

PMID:
31285081
4.

Inadequate BiP availability defines endoplasmic reticulum stress.

Vitale M, Bakunts A, Orsi A, Lari F, Tadè L, Danieli A, Rato C, Valetti C, Sitia R, Raimondi A, Christianson JC, van Anken E.

Elife. 2019 Mar 14;8. pii: e41168. doi: 10.7554/eLife.41168.

5.

Zinc regulates ERp44-dependent protein quality control in the early secretory pathway.

Watanabe S, Amagai Y, Sannino S, Tempio T, Anelli T, Harayama M, Masui S, Sorrentino I, Yamada M, Sitia R, Inaba K.

Nat Commun. 2019 Feb 5;10(1):603. doi: 10.1038/s41467-019-08429-1.

6.

Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways.

Semino C, Carta S, Gattorno M, Sitia R, Rubartelli A.

Cell Death Dis. 2018 Oct 23;9(11):1088. doi: 10.1038/s41419-018-1121-9.

7.

A persulfidation-based mechanism controls aquaporin-8 conductance.

Bestetti S, Medraño-Fernandez I, Galli M, Ghitti M, Bienert GP, Musco G, Orsi A, Rubartelli A, Sitia R.

Sci Adv. 2018 May 2;4(5):eaar5770. doi: 10.1126/sciadv.aar5770. eCollection 2018 May.

8.

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.

Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN.

Cell Rep. 2018 May 1;23(5):1387-1398. doi: 10.1016/j.celrep.2018.04.009.

9.

The unconventional secretion of IL-1β: Handling a dangerous weapon to optimize inflammatory responses.

Sitia R, Rubartelli A.

Semin Cell Dev Biol. 2018 Nov;83:12-21. doi: 10.1016/j.semcdb.2018.03.011. Epub 2018 Apr 5. Review.

PMID:
29571971
10.

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages.

Yoboue ED, Sitia R, Simmen T.

Cell Death Dis. 2018 Feb 28;9(3):331. doi: 10.1038/s41419-017-0033-4. Review.

11.

Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude.

Bakunts A, Orsi A, Vitale M, Cattaneo A, Lari F, Tadè L, Sitia R, Raimondi A, Bachi A, van Anken E.

Elife. 2017 Dec 18;6. pii: e27518. doi: 10.7554/eLife.27518.

12.

A peptide extension dictates IgM assembly.

Pasalic D, Weber B, Giannone C, Anelli T, Müller R, Fagioli C, Felkl M, John C, Mossuto MF, Becker CFW, Sitia R, Buchner J.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8575-E8584. doi: 10.1073/pnas.1701797114. Epub 2017 Sep 27.

13.

Cysteines as Redox Molecular Switches and Targets of Disease.

Fra A, Yoboue ED, Sitia R.

Front Mol Neurosci. 2017 Jun 6;10:167. doi: 10.3389/fnmol.2017.00167. eCollection 2017. Review.

14.

Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?

Carta S, Semino C, Sitia R, Rubartelli A.

Front Immunol. 2017 Apr 4;8:345. doi: 10.3389/fimmu.2017.00345. eCollection 2017.

15.

Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface.

Watanabe S, Harayama M, Kanemura S, Sitia R, Inaba K.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3224-E3232. doi: 10.1073/pnas.1621426114. Epub 2017 Apr 3.

16.

Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway.

Giannone C, Fagioli C, Valetti C, Sitia R, Anelli T.

Sci Rep. 2017 Feb 3;7:41815. doi: 10.1038/srep41815.

17.

Regulation of Calcium Fluxes by GPX8, a Type-II Transmembrane Peroxidase Enriched at the Mitochondria-Associated Endoplasmic Reticulum Membrane.

Yoboue ED, Rimessi A, Anelli T, Pinton P, Sitia R.

Antioxid Redox Signal. 2017 Sep 20;27(9):583-595. doi: 10.1089/ars.2016.6866. Epub 2017 Apr 17.

PMID:
28129698
18.

Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by ¹H HR-MAS NMR Metabolomics.

Tavel L, Fontana F, Garcia Manteiga JM, Mari S, Mariani E, Caneva E, Sitia R, Camnasio F, Marcatti M, Cenci S, Musco G.

Int J Mol Sci. 2016 Oct 31;17(11). pii: E1814.

19.

AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.

Bertolotti M, Farinelli G, Galli M, Aiuti A, Sitia R.

J Leukoc Biol. 2016 Nov;100(5):1071-1079. Epub 2016 Jun 2.

PMID:
27256569
20.

Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.

Yang K, Li DF, Wang X, Liang J, Sitia R, Wang CC, Wang X.

Structure. 2016 Oct 4;24(10):1755-1765. doi: 10.1016/j.str.2016.08.002. Epub 2016 Sep 15.

21.

Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival.

Medraño-Fernandez I, Bestetti S, Bertolotti M, Bienert GP, Bottino C, Laforenza U, Rubartelli A, Sitia R.

Antioxid Redox Signal. 2016 Jun 20;24(18):1031-44. doi: 10.1089/ars.2016.6636. Epub 2016 Apr 19.

22.

Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish.

Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP.

Free Radic Biol Med. 2016 May;94:157-60. doi: 10.1016/j.freeradbiomed.2016.02.030. Epub 2016 Feb 27.

PMID:
26928585
23.

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

Ronzoni R, Berardelli R, Medicina D, Sitia R, Gooptu B, Fra AM.

Hum Mol Genet. 2016 Feb 15;25(4):642-50. doi: 10.1093/hmg/ddv501. Epub 2015 Dec 8.

PMID:
26647313
24.

Biochemical nature of Russell Bodies.

Mossuto MF, Ami D, Anelli T, Fagioli C, Doglia SM, Sitia R.

Sci Rep. 2015 Jul 30;5:12585. doi: 10.1038/srep12585.

25.

Proteostasis and "redoxtasis" in the secretory pathway: Tales of tails from ERp44 and immunoglobulins.

Anelli T, Sannino S, Sitia R.

Free Radic Biol Med. 2015 Jun;83:323-30. doi: 10.1016/j.freeradbiomed.2015.02.020. Epub 2015 Mar 2. Review.

PMID:
25744412
26.

Sialylation of N-linked glycans influences the immunomodulatory effects of IgM on T cells.

Colucci M, Stöckmann H, Butera A, Masotti A, Baldassarre A, Giorda E, Petrini S, Rudd PM, Sitia R, Emma F, Vivarelli M.

J Immunol. 2015 Jan 1;194(1):151-7. doi: 10.4049/jimmunol.1402025. Epub 2014 Nov 24.

27.

A dynamic study of protein secretion and aggregation in the secretory pathway.

Mossuto MF, Sannino S, Mazza D, Fagioli C, Vitale M, Yoboue ED, Sitia R, Anelli T.

PLoS One. 2014 Oct 3;9(10):e108496. doi: 10.1371/journal.pone.0108496. eCollection 2014.

28.

Progressive quality control of secretory proteins in the early secretory compartment by ERp44.

Sannino S, Anelli T, Cortini M, Masui S, Degano M, Fagioli C, Inaba K, Sitia R.

J Cell Sci. 2014 Oct 1;127(Pt 19):4260-9. doi: 10.1242/jcs.153239. Epub 2014 Aug 5.

29.

Different redox sensitivity of endoplasmic reticulum associated degradation clients suggests a novel role for disulphide bonds in secretory proteins.

Medraño-Fernandez I, Fagioli C, Mezghrani A, Otsu M, Sitia R.

Biochem Cell Biol. 2014 Apr;92(2):113-8. doi: 10.1139/bcb-2013-0090. Epub 2014 Feb 4.

PMID:
24697695
30.

A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses.

van Anken E, Orsi A, Sitia R.

Eur J Immunol. 2014 Mar;44(3):641-5. doi: 10.1002/eji.201444461. Epub 2014 Feb 20.

31.

MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity.

Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari NL, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S.

J Bone Miner Res. 2014 Feb;29(2):290-303. doi: 10.1002/jbmr.2090.

32.

Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway.

Kakihana T, Araki K, Vavassori S, Iemura S, Cortini M, Fagioli C, Natsume T, Sitia R, Nagata K.

J Biol Chem. 2013 Oct 11;288(41):29586-94. doi: 10.1074/jbc.M113.467845. Epub 2013 Aug 26.

33.

Response to Marinelli and Marchissio.

Bertolotti M, Bestetti S, Medrano-Fernandez I, Sitia R.

Antioxid Redox Signal. 2013 Sep 10;19(8):897. doi: 10.1089/ars.2013.5505rs. No abstract available.

PMID:
23952014
34.

Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding.

Wang L, Zhang L, Niu Y, Sitia R, Wang CC.

Antioxid Redox Signal. 2014 Feb 1;20(4):545-56. doi: 10.1089/ars.2013.5236. Epub 2013 Sep 17.

35.

A pH-regulated quality control cycle for surveillance of secretory protein assembly.

Vavassori S, Cortini M, Masui S, Sannino S, Anelli T, Caserta IR, Fagioli C, Mossuto MF, Fornili A, van Anken E, Degano M, Inaba K, Sitia R.

Mol Cell. 2013 Jun 27;50(6):783-92. doi: 10.1016/j.molcel.2013.04.016. Epub 2013 May 16.

36.

Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability?

Bertolotti M, Bestetti S, García-Manteiga JM, Medraño-Fernandez I, Dal Mas A, Malosio ML, Sitia R.

Antioxid Redox Signal. 2013 Nov 1;19(13):1447-51. doi: 10.1089/ars.2013.5330. Epub 2013 Sep 18.

37.

Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum.

Benham AM, van Lith M, Sitia R, Braakman I.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110403. doi: 10.1098/rstb.2011.0403. Print 2013 May 5.

38.

Plasma cells require autophagy for sustainable immunoglobulin production.

Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S.

Nat Immunol. 2013 Mar;14(3):298-305. doi: 10.1038/ni.2524. Epub 2013 Jan 27.

PMID:
23354484
39.

Iron increases the susceptibility of multiple myeloma cells to bortezomib.

Campanella A, Santambrogio P, Fontana F, Frenquelli M, Cenci S, Marcatti M, Sitia R, Tonon G, Camaschella C.

Haematologica. 2013 Jun;98(6):971-9. doi: 10.3324/haematol.2012.074872. Epub 2012 Dec 14.

40.

Pivotal Advance: Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors.

Cenci S, Oliva L, Cerruti F, Milan E, Bianchi G, Raule M, Mezghrani A, Pasqualetto E, Sitia R, Cascio P.

J Leukoc Biol. 2012 Nov;92(5):921-31. doi: 10.1189/jlb.1011497. Epub 2012 Jun 8.

PMID:
22685320
41.

Production of H₂O₂ in the endoplasmic reticulum promotes in vivo disulfide bond formation.

Margittai É, Löw P, Stiller I, Greco A, Garcia-Manteiga JM, Pengo N, Benedetti A, Sitia R, Bánhegyi G.

Antioxid Redox Signal. 2012 May 15;16(10):1088-99. doi: 10.1089/ars.2011.4221.

PMID:
22369093
42.

On the redox control of B lymphocyte differentiation and function.

Bertolotti M, Sitia R, Rubartelli A.

Antioxid Redox Signal. 2012 May 15;16(10):1139-49. doi: 10.1089/ars.2011.4252. Epub 2012 Feb 24. Review.

PMID:
22229488
43.

Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative folding.

Kakihana T, Nagata K, Sitia R.

Antioxid Redox Signal. 2012 Apr 15;16(8):763-71. doi: 10.1089/ars.2011.4238. Epub 2012 Jan 25. Review.

PMID:
22146055
44.

Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM).

Anelli T, Bergamelli L, Margittai E, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R, Sitia R.

Antioxid Redox Signal. 2012 May 15;16(10):1077-87. doi: 10.1089/ars.2011.4004. Epub 2011 Oct 19.

PMID:
21854214
45.

Metabolomics of B to plasma cell differentiation.

Garcia-Manteiga JM, Mari S, Godejohann M, Spraul M, Napoli C, Cenci S, Musco G, Sitia R.

J Proteome Res. 2011 Sep 2;10(9):4165-76. doi: 10.1021/pr200328f. Epub 2011 Jul 29.

PMID:
21744784
46.

Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction.

Quaglio E, Restelli E, Garofoli A, Dossena S, De Luigi A, Tagliavacca L, Imperiale D, Migheli A, Salmona M, Sitia R, Forloni G, Chiesa R.

PLoS One. 2011 Apr 29;6(4):e19339. doi: 10.1371/journal.pone.0019339.

47.

Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).

Masui S, Vavassori S, Fagioli C, Sitia R, Inaba K.

J Biol Chem. 2011 May 6;286(18):16261-71. doi: 10.1074/jbc.M111.231357. Epub 2011 Mar 11.

48.

Proteostenosis and plasma cell pathophysiology.

Cenci S, van Anken E, Sitia R.

Curr Opin Cell Biol. 2011 Apr;23(2):216-22. doi: 10.1016/j.ceb.2010.11.004. Epub 2010 Dec 18. Review.

PMID:
21169004
49.

From antibodies to adiponectin: role of ERp44 in sizing and timing protein secretion.

Cortini M, Sitia R.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:39-47. doi: 10.1111/j.1463-1326.2010.01272.x. Review.

PMID:
21029299
50.

A new fluorogenic peptide determines proteasome activity in single cells.

Urru SA, Veglianese P, De Luigi A, Fumagalli E, Erba E, Gonella Diaza R, Carrà A, Davoli E, Borsello T, Forloni G, Pengo N, Monzani E, Cascio P, Cenci S, Sitia R, Salmona M.

J Med Chem. 2010 Oct 28;53(20):7452-60. doi: 10.1021/jm100362x.

PMID:
20883027

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