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Items: 1 to 50 of 115

1.

New insights into transcriptional reprogramming during cellular stress.

Himanen SV, Sistonen L.

J Cell Sci. 2019 Nov 1;132(21). pii: jcs238402. doi: 10.1242/jcs.238402. Review.

PMID:
31676663
2.

Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis.

Baker-Williams AJ, Hashmi F, Budzyński MA, Woodford MR, Gleicher S, Himanen SV, Makedon AM, Friedman D, Cortes S, Namek S, Stetler-Stevenson WG, Bratslavsky G, Bah A, Mollapour M, Sistonen L, Bourboulia D.

Cell Rep. 2019 Aug 13;28(7):1894-1906.e6. doi: 10.1016/j.celrep.2019.07.045.

3.

Tailoring of Proteostasis Networks with Heat Shock Factors.

Joutsen J, Sistonen L.

Cold Spring Harb Perspect Biol. 2019 Apr 1;11(4). pii: a034066. doi: 10.1101/cshperspect.a034066. Review.

PMID:
30420555
4.

Increased HSF1 expression predicts shorter disease-specific survival of prostate cancer patients following radical prostatectomy.

Björk JK, Ahonen I, Mirtti T, Erickson A, Rannikko A, Bützow A, Nordling S, Lundin J, Lundin M, Sistonen L, Nees M, Åkerfelt M.

Oncotarget. 2018 Jul 27;9(58):31200-31213. doi: 10.18632/oncotarget.25756. eCollection 2018 Jul 27.

5.

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.

Kijima T, Prince TL, Tigue ML, Yim KH, Schwartz H, Beebe K, Lee S, Budzynski MA, Williams H, Trepel JB, Sistonen L, Calderwood S, Neckers L.

Sci Rep. 2018 May 3;8(1):6976. doi: 10.1038/s41598-018-25404-w.

6.

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer.

Murillo-Garzón V, Gorroño-Etxebarria I, Åkerfelt M, Puustinen MC, Sistonen L, Nees M, Carton J, Waxman J, Kypta RM.

Nat Commun. 2018 May 1;9(1):1747. doi: 10.1038/s41467-018-04042-w.

7.

The VIII International Congress on Stress Proteins in Biology and Medicine: täynnä henkeä.

Bonorino C, Sistonen L, Eriksson J, Mezger V, Santoro G, Hightower LE.

Cell Stress Chaperones. 2018 Mar;23(2):171-177. doi: 10.1007/s12192-018-0878-1.

8.

Sumoylation of Notch1 represses its target gene expression during cell stress.

Antila CJM, Rraklli V, Blomster HA, Dahlström KM, Salminen TA, Holmberg J, Sistonen L, Sahlgren C.

Cell Death Differ. 2018 Mar;25(3):600-615. doi: 10.1038/s41418-017-0002-6. Epub 2018 Jan 5.

9.

Transcriptional response to stress is pre-wired by promoter and enhancer architecture.

Vihervaara A, Mahat DB, Guertin MJ, Chu T, Danko CG, Lis JT, Sistonen L.

Nat Commun. 2017 Aug 15;8(1):255. doi: 10.1038/s41467-017-00151-0.

10.

Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility.

Budzyński MA, Crul T, Himanen SV, Toth N, Otvos F, Sistonen L, Vigh L.

Cell Stress Chaperones. 2017 Sep;22(5):717-728. doi: 10.1007/s12192-017-0798-5. Epub 2017 May 4.

11.

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins.

Karvinen S, Silvennoinen M, Vainio P, Sistonen L, Koch LG, Britton SL, Kainulainen H.

Exp Gerontol. 2016 Jun 15;79:46-54. doi: 10.1016/j.exger.2016.03.015. Epub 2016 Mar 31.

PMID:
27038700
12.

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.

Jaeger AM, Pemble CW 4th, Sistonen L, Thiele DJ.

Nat Struct Mol Biol. 2016 Feb;23(2):147-54. doi: 10.1038/nsmb.3150. Epub 2016 Jan 4.

13.

Global SUMOylation on active chromatin is an acute heat stress response restricting transcription.

Niskanen EA, Malinen M, Sutinen P, Toropainen S, Paakinaho V, Vihervaara A, Joutsen J, Kaikkonen MU, Sistonen L, Palvimo JJ.

Genome Biol. 2015 Jul 28;16:153. doi: 10.1186/s13059-015-0717-y.

14.

Heat-shock factor 2 is a suppressor of prostate cancer invasion.

Björk JK, Åkerfelt M, Joutsen J, Puustinen MC, Cheng F, Sistonen L, Nees M.

Oncogene. 2016 Apr 7;35(14):1770-84. doi: 10.1038/onc.2015.241. Epub 2015 Jun 29.

15.

Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation.

Budzyński MA, Puustinen MC, Joutsen J, Sistonen L.

Mol Cell Biol. 2015 Jul;35(14):2530-40. doi: 10.1128/MCB.00816-14. Epub 2015 May 11.

16.

Cellular stress response cross talk maintains protein and energy homeostasis.

Swan CL, Sistonen L.

EMBO J. 2015 Feb 3;34(3):267-9. doi: 10.15252/embj.201490757. Epub 2015 Jan 2. No abstract available.

17.

Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival.

Elsing AN, Aspelin C, Björk JK, Bergman HA, Himanen SV, Kallio MJ, Roos-Mattjus P, Sistonen L.

J Cell Biol. 2014 Sep 15;206(6):735-49. doi: 10.1083/jcb.201402002. Epub 2014 Sep 8.

18.

Heat shock in the springtime.

Morano KA, Sistonen L, Mezger V.

Cell Stress Chaperones. 2014 Nov;19(6):753-61. doi: 10.1007/s12192-014-0539-y. Epub 2014 Sep 9.

19.

HSF1 at a glance.

Vihervaara A, Sistonen L.

J Cell Sci. 2014 Jan 15;127(Pt 2):261-6. doi: 10.1242/jcs.132605. Review.

20.

Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells.

Vihervaara A, Sergelius C, Vasara J, Blom MA, Elsing AN, Roos-Mattjus P, Sistonen L.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3388-97. doi: 10.1073/pnas.1305275110. Epub 2013 Aug 19.

21.

Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein.

Sundvall M, Korhonen A, Vaparanta K, Anckar J, Halkilahti K, Salah Z, Aqeilan RI, Palvimo JJ, Sistonen L, Elenius K.

J Biol Chem. 2012 Jun 29;287(27):23216-26. doi: 10.1074/jbc.M111.335927. Epub 2012 May 14.

22.

Regulation of HSF1 function in the heat stress response: implications in aging and disease.

Anckar J, Sistonen L.

Annu Rev Biochem. 2011;80:1089-115. doi: 10.1146/annurev-biochem-060809-095203. Review.

PMID:
21417720
23.

Regulation of the members of the mammalian heat shock factor family.

Björk JK, Sistonen L.

FEBS J. 2010 Oct;277(20):4126-39. Review.

24.

Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress.

Ahlskog JK, Björk JK, Elsing AN, Aspelin C, Kallio M, Roos-Mattjus P, Sistonen L.

Mol Cell Biol. 2010 Dec;30(24):5608-20. doi: 10.1128/MCB.01506-09. Epub 2010 Oct 11.

25.

Heat shock transcription factor 1 localizes to sex chromatin during meiotic repression.

Akerfelt M, Vihervaara A, Laiho A, Conter A, Christians ES, Sistonen L, Henriksson E.

J Biol Chem. 2010 Nov 5;285(45):34469-76. doi: 10.1074/jbc.M110.157552. Epub 2010 Aug 27.

26.

miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis.

Björk JK, Sandqvist A, Elsing AN, Kotaja N, Sistonen L.

Development. 2010 Oct;137(19):3177-84. doi: 10.1242/dev.050955. Epub 2010 Aug 19.

27.

Heat shock factors: integrators of cell stress, development and lifespan.

Akerfelt M, Morimoto RI, Sistonen L.

Nat Rev Mol Cell Biol. 2010 Aug;11(8):545-55. doi: 10.1038/nrm2938. Epub 2010 Jul 14. Review.

28.

In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.

Blomster HA, Imanishi SY, Siimes J, Kastu J, Morrice NA, Eriksson JE, Sistonen L.

J Biol Chem. 2010 Jun 18;285(25):19324-9. doi: 10.1074/jbc.M110.106955. Epub 2010 Apr 13.

29.

TransLISA, a novel quantitative, nonradioactive assay for transcription factor DNA-binding analyses.

Vuori KA, Ahlskog JK, Sistonen L, Nikinmaa M.

FEBS J. 2009 Dec;276(24):7366-74. doi: 10.1111/j.1742-4658.2009.07446.x.

30.

Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites.

Blomster HA, Hietakangas V, Wu J, Kouvonen P, Hautaniemi S, Sistonen L.

Mol Cell Proteomics. 2009 Jun;8(6):1382-90. doi: 10.1074/mcp.M800551-MCP200. Epub 2009 Feb 24.

31.

Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.

Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI.

Science. 2009 Feb 20;323(5917):1063-6. doi: 10.1126/science.1165946. Erratum in: Science. 2013 Nov 22;342(6161):931.

32.

Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90alpha expression.

Metchat A, Akerfelt M, Bierkamp C, Delsinne V, Sistonen L, Alexandre H, Christians ES.

J Biol Chem. 2009 Apr 3;284(14):9521-8. doi: 10.1074/jbc.M808819200. Epub 2009 Jan 21.

33.

Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli.

Sandqvist A, Björk JK, Akerfelt M, Chitikova Z, Grichine A, Vourc'h C, Jolly C, Salminen TA, Nymalm Y, Sistonen L.

Mol Biol Cell. 2009 Mar;20(5):1340-7. doi: 10.1091/mbc.E08-08-0864. Epub 2009 Jan 7.

34.

Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2.

Akerfelt M, Henriksson E, Laiho A, Vihervaara A, Rautoma K, Kotaja N, Sistonen L.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11224-9. doi: 10.1073/pnas.0800620105. Epub 2008 Aug 5.

35.

SUMO: getting it on.

Anckar J, Sistonen L.

Biochem Soc Trans. 2007 Dec;35(Pt 6):1409-13. Review.

PMID:
18031233
36.

Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells: correlation with HLA-B27 misfolding.

Sahlberg AS, Penttinen MA, Heiskanen KM, Colbert RA, Sistonen L, Granfors K.

Arthritis Rheum. 2007 Aug;56(8):2652-62.

37.

Heat shock factors at a crossroad between stress and development.

Akerfelt M, Trouillet D, Mezger V, Sistonen L.

Ann N Y Acad Sci. 2007 Oct;1113:15-27. Epub 2007 May 4. Review.

PMID:
17483205
38.

Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line.

Nagy E, Balogi Z, Gombos I, Akerfelt M, Björkbom A, Balogh G, Török Z, Maslyanko A, Fiszer-Kierzkowska A, Lisowska K, Slotte PJ, Sistonen L, Horváth I, Vígh L.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7945-50. Epub 2007 Apr 30.

39.

Fever-like hyperthermia controls T Lymphocyte persistence by inducing degradation of cellular FLIPshort.

Meinander A, Söderström TS, Kaunisto A, Poukkula M, Sistonen L, Eriksson JE.

J Immunol. 2007 Mar 15;178(6):3944-53.

40.

Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1.

Ostling P, Björk JK, Roos-Mattjus P, Mezger V, Sistonen L.

J Biol Chem. 2007 Mar 9;282(10):7077-86. Epub 2007 Jan 9.

41.

Heat shock factor 1 as a coordinator of stress and developmental pathways.

Anckar J, Sistonen L.

Adv Exp Med Biol. 2007;594:78-88. Review.

PMID:
17205677
42.

Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression.

Chang Y, Ostling P, Akerfelt M, Trouillet D, Rallu M, Gitton Y, El Fatimy R, Fardeau V, Le Crom S, Morange M, Sistonen L, Mezger V.

Genes Dev. 2006 Apr 1;20(7):836-47.

43.

Clustering of heat-shock factors.

Björk JK, Sistonen L.

Biochem J. 2006 Apr 1;395(1):e5-6.

44.

Inhibition of DNA binding by differential sumoylation of heat shock factors.

Anckar J, Hietakangas V, Denessiouk K, Thiele DJ, Johnson MS, Sistonen L.

Mol Cell Biol. 2006 Feb;26(3):955-64.

45.

PDSM, a motif for phosphorylation-dependent SUMO modification.

Hietakangas V, Anckar J, Blomster HA, Fujimoto M, Palvimo JJ, Nakai A, Sistonen L.

Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):45-50. Epub 2005 Dec 21.

46.

Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail.

Poukkula M, Kaunisto A, Hietakangas V, Denessiouk K, Katajamäki T, Johnson MS, Sistonen L, Eriksson JE.

J Biol Chem. 2005 Jul 22;280(29):27345-55. Epub 2005 May 10.

47.

CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization.

Concannon CG, FitzGerald U, Holmberg CI, Szegezdi E, Sistonen L, Samali A.

Cell Stress Chaperones. 2005 Spring;10(1):59-65.

48.

Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: dependency on glutamic acid at position 45 in the B pocket of HLA-B27.

Penttinen MA, Heiskanen KM, Mohapatra R, DeLay ML, Colbert RA, Sistonen L, Granfors K.

Arthritis Rheum. 2004 Jul;50(7):2255-63.

49.

The ubiquitin-proteasome pathway.

Roos-Mattjus P, Sistonen L.

Ann Med. 2004;36(4):285-95. Review.

PMID:
15224655
50.

Nuclear stress granules: the awakening of a sleeping beauty?

Sandqvist A, Sistonen L.

J Cell Biol. 2004 Jan 5;164(1):15-7. Review.

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