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Items: 1 to 50 of 101

1.

Phosphodiesterase 4 inhibition reduces lung fibrosis following targeted type II alveolar epithelial cell injury.

Sisson TH, Christensen PJ, Muraki Y, Dils AJ, Chibucos L, Subbotina N, Tohyama K, Horowitz JC, Matsuo T, Bailie M, Nikam S, Hazama M.

Physiol Rep. 2018 Jun;6(12):e13753. doi: 10.14814/phy2.13753.

2.

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli.

Dodi AE, Ajayi IO, Chang C, Beard M, Ashley SL, Huang SK, Thannickal VJ, Tschumperlin DJ, Sisson TH, Horowitz JC.

Respir Res. 2018 May 10;19(1):91. doi: 10.1186/s12931-018-0801-4.

3.

The influence of MCAT and GPA preadmission academic metrics on interview scores.

Gay SE, Santen SA, Mangrulkar RS, Sisson TH, Ross PT, Zaidi NLB.

Adv Health Sci Educ Theory Pract. 2018 Mar;23(1):151-158. doi: 10.1007/s10459-017-9779-9. Epub 2017 May 13.

PMID:
28501933
4.

Quantifying gas emissions from the "Millennium Eruption" of Paektu volcano, Democratic People's Republic of Korea/China.

Iacovino K, Ju-Song K, Sisson T, Lowenstern J, Kuk-Hun R, Jong-Nam J, Kun-Ho S, Song-Hwan H, Oppenheimer C, Hammond JO, Donovan A, Liu KW, Kum-Ran R.

Sci Adv. 2016 Nov 30;2(11):e1600913. doi: 10.1126/sciadv.1600913. eCollection 2016 Nov.

5.

Fibroblast growth factors and pulmonary fibrosis: it's more complex than it sounds.

Kim KK, Sisson TH, Horowitz JC.

J Pathol. 2017 Jan;241(1):6-9. doi: 10.1002/path.4825. Epub 2016 Nov 29.

6.

Utility of Transbronchial vs Surgical Lung Biopsy in the Diagnosis of Suspected Fibrotic Interstitial Lung Disease.

Sheth JS, Belperio JA, Fishbein MC, Kazerooni EA, Lagstein A, Murray S, Myers JL, Simon RH, Sisson TH, Sundaram B, White ES, Xia M, Zisman D, Flaherty KR.

Chest. 2017 Feb;151(2):389-399. doi: 10.1016/j.chest.2016.09.028. Epub 2016 Oct 8.

7.

Ultrasound Strain Measurements for Evaluating Local Pulmonary Ventilation.

Rubin JM, Horowitz JC, Sisson TH, Kim K, Ortiz LA, Hamilton JD.

Ultrasound Med Biol. 2016 Nov;42(11):2525-2531. doi: 10.1016/j.ultrasmedbio.2016.05.020. Epub 2016 Aug 10.

8.

The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis.

Wheaton AK, Velikoff M, Agarwal M, Loo TT, Horowitz JC, Sisson TH, Kim KK.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1206-17. doi: 10.1152/ajplung.00424.2015. Epub 2016 Apr 22.

9.

Matriptase, Protease-activated Receptor 2, and Idiopathic Pulmonary Fibrosis. Further Evidence for Signaling Pathway Redundancy in this Difficult-to-Treat Disease?

Sisson TH, Spagnolo P.

Am J Respir Crit Care Med. 2016 Apr 15;193(8):816-7. doi: 10.1164/rccm.201512-2319ED. No abstract available.

PMID:
27082530
10.

Ultrasound Strain Measurements for Evaluating Local Pulmonary Ventilation.

Rubin JM, Horowitz JC, Sisson TH, Kim K, Ortiz LA, Hamilton JD.

IEEE Int Ultrason Symp. 2015 Oct;2015. doi: 10.1109/ULTSYM.2015.0181.

11.

Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis.

Ashley SL, Sisson TH, Wheaton AK, Kim KK, Wilke CA, Ajayi IO, Subbotina N, Wang S, Duckett CS, Moore BB, Horowitz JC.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):482-92. doi: 10.1165/rcmb.2015-0148OC.

12.

Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin.

Knippenberg S, Ueberberg B, Maus R, Bohling J, Ding N, Tort Tarres M, Hoymann HG, Jonigk D, Izykowski N, Paton JC, Ogunniyi AD, Lindig S, Bauer M, Welte T, Seeger W, Guenther A, Sisson TH, Gauldie J, Kolb M, Maus UA.

Thorax. 2015 Jul;70(7):636-46. doi: 10.1136/thoraxjnl-2014-206420. Epub 2015 May 11.

PMID:
25964315
13.

Milestones for Internal Medicine Sub-interns.

Santen SA, Seidelman JL, Miller CS, Brownfield ED, Houchens N, Sisson TH, Lypson ML.

Am J Med. 2015 Jul;128(7):790-8.e2. doi: 10.1016/j.amjmed.2015.02.001. Epub 2015 Mar 4.

PMID:
25747349
14.

Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.

Sisson TH, Ajayi IO, Subbotina N, Dodi AE, Rodansky ES, Chibucos LN, Kim KK, Keshamouni VG, White ES, Zhou Y, Higgins PD, Larsen SD, Neubig RR, Horowitz JC.

Am J Pathol. 2015 Apr;185(4):969-86. doi: 10.1016/j.ajpath.2014.12.005. Epub 2015 Feb 11.

15.

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12.

16.

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE Jr, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP.

Am J Respir Crit Care Med. 2014 Jan 15;189(2):214-22. doi: 10.1164/rccm.201306-1141WS.

17.

Animal models of fibrotic lung disease.

B Moore B, Lawson WE, Oury TD, Sisson TH, Raghavendran K, Hogaboam CM.

Am J Respir Cell Mol Biol. 2013 Aug;49(2):167-79. doi: 10.1165/rcmb.2013-0094TR. Review.

18.

X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis.

Ajayi IO, Sisson TH, Higgins PD, Booth AJ, Sagana RL, Huang SK, White ES, King JE, Moore BB, Horowitz JC.

Am J Respir Cell Mol Biol. 2013 Jul;49(1):86-95. doi: 10.1165/rcmb.2012-0224OC.

19.

Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury.

Osterholzer JJ, Olszewski MA, Murdock BJ, Chen GH, Erb-Downward JR, Subbotina N, Browning K, Lin Y, Morey RE, Dayrit JK, Horowitz JC, Simon RH, Sisson TH.

J Immunol. 2013 Apr 1;190(7):3447-57. doi: 10.4049/jimmunol.1200604. Epub 2013 Mar 6.

20.

Increased survivin expression contributes to apoptosis-resistance in IPF fibroblasts.

Sisson TH, Maher TM, Ajayi IO, King JE, Higgins PD, Booth AJ, Sagana RL, Huang SK, White ES, Moore BB, Horowitz JC.

Adv Biosci Biotechnol. 2012 Oct;3(6A):657-664.

21.

Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis.

Naik PK, Bozyk PD, Bentley JK, Popova AP, Birch CM, Wilke CA, Fry CD, White ES, Sisson TH, Tayob N, Carnemolla B, Orecchia P, Flaherty KR, Hershenson MB, Murray S, Martinez FJ, Moore BB; COMET Investigators.

Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15;303(12):L1046-56. doi: 10.1152/ajplung.00139.2012. Epub 2012 Oct 5.

22.

PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury.

Osterholzer JJ, Christensen PJ, Lama V, Horowitz JC, Hattori N, Subbotina N, Cunningham A, Lin Y, Murdock BJ, Morey RE, Olszewski MA, Lawrence DA, Simon RH, Sisson TH.

J Pathol. 2012 Oct;228(2):170-80. doi: 10.1002/path.3992. Epub 2012 Jun 6.

23.

Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis.

Horowitz JC, Ajayi IO, Kulasekaran P, Rogers DS, White JB, Townsend SK, White ES, Nho RS, Higgins PD, Huang SK, Sisson TH.

Int J Biochem Cell Biol. 2012 Jan;44(1):158-69. doi: 10.1016/j.biocel.2011.10.011. Epub 2011 Oct 25.

24.

Wells Capital's Todd Sisson on what investors expect from hospitals.

Sisson T.

Healthc Financ Manage. 2011 Aug;65(8):36-8. No abstract available.

PMID:
21866717
25.

Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts by reorganizing protein kinase A signaling.

Okunishi K, Sisson TH, Huang SK, Hogaboam CM, Simon RH, Peters-Golden M.

J Biol Chem. 2011 Sep 16;286(37):32231-43. doi: 10.1074/jbc.M111.235606. Epub 2011 Jul 27.

26.

The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice.

Courey AJ, Horowitz JC, Kim KK, Koh TJ, Novak ML, Subbotina N, Warnock M, Xue B, Cunningham AK, Lin Y, Goldklang MP, Simon RH, Lawrence DA, Sisson TH.

Blood. 2011 Aug 25;118(8):2313-21. doi: 10.1182/blood-2010-12-324574. Epub 2011 Jul 6.

27.

Macrophage-specific expression of urokinase-type plasminogen activator promotes skeletal muscle regeneration.

Novak ML, Bryer SC, Cheng M, Nguyen MH, Conley KL, Cunningham AK, Xue B, Sisson TH, You JS, Hornberger TA, Koh TJ.

J Immunol. 2011 Aug 1;187(3):1448-57. doi: 10.4049/jimmunol.1004091. Epub 2011 Jun 27.

28.

Latent infection by γherpesvirus stimulates profibrotic mediator release from multiple cell types.

Stoolman JS, Vannella KM, Coomes SM, Wilke CA, Sisson TH, Toews GB, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L274-85. doi: 10.1152/ajplung.00028.2010. Epub 2010 Oct 29.

29.

The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice.

Bauman KA, Wettlaufer SH, Okunishi K, Vannella KM, Stoolman JS, Huang SK, Courey AJ, White ES, Hogaboam CM, Simon RH, Toews GB, Sisson TH, Moore BB, Peters-Golden M.

J Clin Invest. 2010 Jun;120(6):1950-60. doi: 10.1172/JCI38369. Epub 2010 May 24.

30.

Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis.

Sisson TH, Mendez M, Choi K, Subbotina N, Courey A, Cunningham A, Dave A, Engelhardt JF, Liu X, White ES, Thannickal VJ, Moore BB, Christensen PJ, Simon RH.

Am J Respir Crit Care Med. 2010 Feb 1;181(3):254-63. doi: 10.1164/rccm.200810-1615OC. Epub 2009 Oct 22.

31.

Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration.

Sisson TH, Nguyen MH, Yu B, Novak ML, Simon RH, Koh TJ.

Blood. 2009 Dec 3;114(24):5052-61. doi: 10.1182/blood-2008-12-196212. Epub 2009 Oct 7.

32.

Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis.

Humphries J, Gossage JA, Modarai B, Burnand KG, Sisson TH, Murdoch C, Smith A.

J Vasc Surg. 2009 Nov;50(5):1127-34. doi: 10.1016/j.jvs.2009.06.047. Epub 2009 Aug 22.

33.

Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model.

Kuramoto E, Nishiuma T, Kobayashi K, Yamamoto M, Kono Y, Funada Y, Kotani Y, Sisson TH, Simon RH, Nishimura Y.

Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L337-46. doi: 10.1152/ajplung.90434.2008. Epub 2008 Dec 19.

34.

The plasminogen activation system in lung disease.

Sisson TH, Simon RH.

Curr Drug Targets. 2007 Sep;8(9):1016-29. Review.

PMID:
17896953
35.

Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis.

Horowitz JC, Rogers DS, Simon RH, Sisson TH, Thannickal VJ.

Am J Respir Cell Mol Biol. 2008 Jan;38(1):78-87. Epub 2007 Jul 26.

36.

Plasminogen-mediated activation and release of hepatocyte growth factor from extracellular matrix.

Matsuoka H, Sisson TH, Nishiuma T, Simon RH.

Am J Respir Cell Mol Biol. 2006 Dec;35(6):705-13. Epub 2006 Jul 13.

37.

Expression of the reverse tetracycline-transactivator gene causes emphysema-like changes in mice.

Sisson TH, Hansen JM, Shah M, Hanson KE, Du M, Ling T, Simon RH, Christensen PJ.

Am J Respir Cell Mol Biol. 2006 May;34(5):552-60. Epub 2006 Jan 13.

38.

Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration.

Koh TJ, Bryer SC, Pucci AM, Sisson TH.

Am J Physiol Cell Physiol. 2005 Jul;289(1):C217-23. Epub 2005 Feb 16.

39.

Cell specific control of coagulation and fibrinolysis within the lung.

Sisson TH, Simon RH.

Thromb Haemost. 2004 Sep;92(3):435-7. Review. No abstract available.

PMID:
15351836
40.

Plasminogen activator inhibitor-1 impairs alveolar epithelial repair by binding to vitronectin.

Lazar MH, Christensen PJ, Du M, Yu B, Subbotina NM, Hanson KE, Hansen JM, White ES, Simon RH, Sisson TH.

Am J Respir Cell Mol Biol. 2004 Dec;31(6):672-8. Epub 2004 Aug 12.

41.

Localization of plasminogen activator activity within normal and injured lungs by in situ zymography.

Nishiuma T, Sisson TH, Subbotina N, Simon RH.

Am J Respir Cell Mol Biol. 2004 Nov;31(5):552-8. Epub 2004 Jul 29.

PMID:
15284078
42.

The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism.

Hattori N, Mizuno S, Yoshida Y, Chin K, Mishima M, Sisson TH, Simon RH, Nakamura T, Miyake M.

Am J Pathol. 2004 Mar;164(3):1091-8.

43.

Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1.

Chuang-Tsai S, Sisson TH, Hattori N, Tsai CG, Subbotina NM, Hanson KE, Simon RH.

Am J Pathol. 2003 Aug;163(2):445-52.

44.

A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia.

Kim KK, Flaherty KR, Long Q, Hattori N, Sisson TH, Colby TV, Travis WD, Martinez FJ, Murray S, Simon RH.

Mol Med. 2003 Jan-Feb;9(1-2):52-6.

45.

Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice.

Sisson TH, Hanson KE, Subbotina N, Patwardhan A, Hattori N, Simon RH.

Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L1023-32.

46.

Age and sex effects on the pharmacokinetics of linezolid.

Sisson TL, Jungbluth GL, Hopkins NK.

Eur J Clin Pharmacol. 2002 Jan;57(11):793-7.

PMID:
11868801
47.

Linezolid absolute bioavailability and the effect of food on oral bioavailability.

Welshman IR, Sisson TA, Jungbluth GL, Stalker DJ, Hopkins NK.

Biopharm Drug Dispos. 2001 Apr;22(3):91-7.

PMID:
11745911
48.

Lack of pharmacokinetic interaction between the antimigraine compound, almotriptan, and propranolol in healthy volunteers.

Fleishaker JC, Sisson TA, Carel BJ, Azie NE.

Cephalalgia. 2001 Feb;21(1):61-5.

PMID:
11298665
49.

Aerogeophysical measurements of collapse-prone hydrothermally altered zones at Mount Rainier volcano.

Finn CA, Sisson TW, Deszcz-Pan M.

Nature. 2001 Feb 1;409(6820):600-3.

PMID:
11214315
50.

Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice.

Hattori N, Degen JL, Sisson TH, Liu H, Moore BB, Pandrangi RG, Simon RH, Drew AF.

J Clin Invest. 2000 Dec;106(11):1341-50.

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