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Items: 20

1.

Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells.

Barnes EME, Xu Y, Benito A, Herendi L, Siskos AP, Aboagye EO, Nijhuis A, Keun HC.

Br J Cancer. 2020 Mar 10. doi: 10.1038/s41416-020-0777-y. [Epub ahead of print]

PMID:
32152504
2.

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.

Allen SP, Hall B, Castelli LM, Francis L, Woof R, Siskos AP, Kouloura E, Gray E, Thompson AG, Talbot K, Higginbottom A, Myszczynska M, Allen CF, Stopford MJ, Hemingway J, Bauer CS, Webster CP, De Vos KJ, Turner MR, Keun HC, Hautbergue GM, Ferraiuolo L, Shaw PJ.

Brain. 2019 Mar 1;142(3):586-605. doi: 10.1093/brain/awy353.

3.

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.

Limonciel A, van Breda SG, Jiang X, Tredwell GD, Wilmes A, Aschauer L, Siskos AP, Sachinidis A, Keun HC, Kopp-Schneider A, de Kok TM, Kleinjans JCS, Jennings P.

Front Genet. 2018 Dec 3;9:558. doi: 10.3389/fgene.2018.00558. eCollection 2018.

4.

Determinants of the urinary and serum metabolome in children from six European populations.

Lau CE, Siskos AP, Maitre L, Robinson O, Athersuch TJ, Want EJ, Urquiza J, Casas M, Vafeiadi M, Roumeliotaki T, McEachan RRC, Azad R, Haug LS, Meltzer HM, Andrusaityte S, Petraviciene I, Grazuleviciene R, Thomsen C, Wright J, Slama R, Chatzi L, Vrijheid M, Keun HC, Coen M.

BMC Med. 2018 Nov 8;16(1):202. doi: 10.1186/s12916-018-1190-8.

5.

Human Early Life Exposome (HELIX) study: a European population-based exposome cohort.

Maitre L, de Bont J, Casas M, Robinson O, Aasvang GM, Agier L, Andrušaitytė S, Ballester F, Basagaña X, Borràs E, Brochot C, Bustamante M, Carracedo A, de Castro M, Dedele A, Donaire-Gonzalez D, Estivill X, Evandt J, Fossati S, Giorgis-Allemand L, R Gonzalez J, Granum B, Grazuleviciene R, Bjerve Gützkow K, Småstuen Haug L, Hernandez-Ferrer C, Heude B, Ibarluzea J, Julvez J, Karachaliou M, Keun HC, Hjertager Krog N, Lau CE, Leventakou V, Lyon-Caen S, Manzano C, Mason D, McEachan R, Meltzer HM, Petraviciene I, Quentin J, Roumeliotaki T, Sabido E, Saulnier PJ, Siskos AP, Siroux V, Sunyer J, Tamayo I, Urquiza J, Vafeiadi M, van Gent D, Vives-Usano M, Waiblinger D, Warembourg C, Chatzi L, Coen M, van den Hazel P, Nieuwenhuijsen MJ, Slama R, Thomsen C, Wright J, Vrijheid M.

BMJ Open. 2018 Sep 10;8(9):e021311. doi: 10.1136/bmjopen-2017-021311.

6.

Assessment of metabolic phenotypic variability in children's urine using 1H NMR spectroscopy.

Maitre L, Lau CE, Vizcaino E, Robinson O, Casas M, Siskos AP, Want EJ, Athersuch T, Slama R, Vrijheid M, Keun HC, Coen M.

Sci Rep. 2017 Apr 19;7:46082. doi: 10.1038/srep46082.

7.

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases.

Chatziioannou A, Georgiadis P, Hebels DG, Liampa I, Valavanis I, Bergdahl IA, Johansson A, Palli D, Chadeau-Hyam M, Siskos AP, Keun H, Botsivali M, de Kok TM, Pérez AE, Kleinjans JC, Vineis P, Kyrtopoulos SA; EnviroGenomarkers project consortium.

Sci Rep. 2017 Feb 22;7:42870. doi: 10.1038/srep42870.

8.

Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother-child cohort in Crete, Greece.

Perng W, Oken E, Roumeliotaki T, Sood D, Siskos AP, Chalkiadaki G, Dermitzaki E, Vafeiadi M, Kyrtopoulos S, Kogevinas M, Keun HC, Chatzi L.

Obes Sci Pract. 2016 Dec;2(4):471-476. doi: 10.1002/osp4.65. Epub 2016 Oct 21.

9.

CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.

Sood D, Johnson N, Jain P, Siskos AP, Bennett M, Gilham C, Busana MC, Peto J, Dos-Santos-Silva I, Keun HC, Fletcher O.

Br J Cancer. 2017 Jan;116(3):382-388. doi: 10.1038/bjc.2016.432. Epub 2017 Jan 10.

10.

Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma.

Siskos AP, Jain P, Römisch-Margl W, Bennett M, Achaintre D, Asad Y, Marney L, Richardson L, Koulman A, Griffin JL, Raynaud F, Scalbert A, Adamski J, Prehn C, Keun HC.

Anal Chem. 2017 Jan 3;89(1):656-665. doi: 10.1021/acs.analchem.6b02930. Epub 2016 Dec 13.

11.

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.

Valbuena GN, Rizzardini M, Cimini S, Siskos AP, Bendotti C, Cantoni L, Keun HC.

Mol Neurobiol. 2016 May;53(4):2222-40. doi: 10.1007/s12035-015-9165-7. Epub 2015 May 12.

12.

Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention.

Miller JA, Pappan K, Thompson PA, Want EJ, Siskos AP, Keun HC, Wulff J, Hu C, Lang JE, Chow HH.

Cancer Prev Res (Phila). 2015 Jan;8(1):86-93. doi: 10.1158/1940-6207.CAPR-14-0100. Epub 2014 Nov 11.

13.

Transarterial embolization with sorafenib in animal livers: a pharmacokinetics study.

Chatziioannou AN, Siskos AP, Loxas D, Kavatzas N, Agrogiannis G, Fokas D, Malagari K, Kostomitsopoulos NG, Tsigkou O, Tamvakopoulos C.

J Vasc Interv Radiol. 2013 Nov;24(11):1657-63.e1. doi: 10.1016/j.jvir.2013.08.007. Epub 2013 Sep 21.

PMID:
24060438
14.

Peptide and protein drugs: the study of their metabolism and catabolism by mass spectrometry.

Katsila T, Siskos AP, Tamvakopoulos C.

Mass Spectrom Rev. 2012 Jan-Feb;31(1):110-33. doi: 10.1002/mas.20340. Epub 2011 Jun 22. Review.

PMID:
21698655
15.

Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis.

Anderson R, Franch A, Castell M, Perez-Cano FJ, Bräuer R, Pohlers D, Gajda M, Siskos AP, Katsila T, Tamvakopoulos C, Rauchhaus U, Panzner S, Kinne RW.

Arthritis Res Ther. 2010;12(4):R147. doi: 10.1186/ar3089. Epub 2010 Jul 19.

16.

Simultaneous absolute quantification of the glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 in mouse plasma by LC/ESI-MS/MS: preclinical evaluation of DP-IV inhibitors.

Siskos AP, Katsila T, Balafas E, Kostomitsopoulos N, Tamvakopoulos C.

J Proteome Res. 2009 Jul;8(7):3487-96. doi: 10.1021/pr900155h.

PMID:
19425608
17.

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

Baerga-Ortiz A, Popovic B, Siskos AP, O'Hare HM, Spiteller D, Williams MG, Campillo N, Spencer JB, Leadlay PF.

Chem Biol. 2006 Mar;13(3):277-85.

18.

Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.

Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF.

Chem Biol. 2005 Oct;12(10):1145-53.

19.

Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry.

Hong H, Appleyard AN, Siskos AP, Garcia-Bernardo J, Staunton J, Leadlay PF.

FEBS J. 2005 May;272(10):2373-87.

20.

Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea.

Weissman KJ, Hong H, Oliynyk M, Siskos AP, Leadlay PF.

Chembiochem. 2004 Jan 3;5(1):116-25.

PMID:
14695521

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