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Items: 30

1.

Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.

Schreier JD, Embrey MW, Raheem IT, Barbe G, Campeau LC, Dubost D, McCabe Dunn J, Grobler J, Hartingh TJ, Hazuda DJ, Klein D, Miller MD, Moore KP, Nguyen N, Pajkovic N, Powell DA, Rada V, Sanders JM, Sisko J, Steele TG, Wai J, Walji A, Xu M, Coleman PJ.

Bioorg Med Chem Lett. 2017 May 1;27(9):2038-2046. doi: 10.1016/j.bmcl.2017.02.039. Epub 2017 Feb 20.

PMID:
28285916
2.

[EXOTHERMIC REACTIONS OF PLASTER IMMOBILIZATION – ANALYSIS OF THREE KINDS OF PLASTER BANDAGES].

Antabak A, Brajčinović M, Bradić L, Barišić B, Andabak M, Halužan D, Fuchs N, Haramina T, Ćurković S, Luetić T, Šiško J, Prlić I.

Lijec Vjesn. 2016 Sep-Oct;138(9-10):250-4. Croatian.

PMID:
30148545
3.

[FRONTAL, AXILLARY AND TYMPANIC TEMPERATURE MEASUREMENTS IN CHILDREN].

Antabak A, Sisko J, Romić I, Papes D, Pasini M, Haluzan D, Bogović M, Medancić SS, Cavar S, Luetić T, Fuchs N, Andabak M, Prlić I, Curković S.

Lijec Vjesn. 2016 Jan-Feb;138(1-2):30-3. Croatian.

PMID:
27290811
4.

[PHYSICAL PROPERTIES OF PLASTER BANDAGES].

Antabak A, Barisić B, Andabak M, Bradić L, Brajcinović M, Haramina T, Haluzan D, Fuchs N, Durkovir S, Curković S, Luetić T, Sisko J, Prlić I.

Lijec Vjesn. 2015 Nov-Dec;137(11-12):372-6. Croatian.

PMID:
26975068
5.

Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

Raheem IT, Walji AM, Klein D, Sanders JM, Powell DA, Abeywickrema P, Barbe G, Bennet A, Childers K, Christensen M, Clas SD, Dubost D, Embrey M, Grobler J, Hafey MJ, Hartingh TJ, Hazuda DJ, Kuethe JT, McCabe Dunn J, Miller MD, Moore KP, Nolting A, Pajkovic N, Patel S, Peng Z, Rada V, Rearden P, Schreier JD, Sisko J, Steele TG, Truchon JF, Wai J, Xu M, Coleman PJ.

J Med Chem. 2016 Jan 14;59(1):486. doi: 10.1021/acs.jmedchem.5b01957. Epub 2015 Dec 28. No abstract available.

PMID:
26709958
6.

Medical thermography (digital infrared thermal imaging - DITI) in paediatric forearm fractures - A pilot study.

Ćurković S, Antabak A, Halužan D, Luetić T, Prlić I, Šiško J.

Injury. 2015 Nov;46 Suppl 6:S36-9. doi: 10.1016/j.injury.2015.10.044. Epub 2015 Nov 18.

PMID:
26603613
7.

Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

Raheem IT, Walji AM, Klein D, Sanders JM, Powell DA, Abeywickrema P, Barbe G, Bennet A, Childers K, Christensen M, Clas SD, Dubost D, Embrey M, Grobler J, Hafey MJ, Hartingh TJ, Hazuda DJ, Kuethe JT, McCabe Dunn J, Miller MD, Moore KP, Nolting A, Pajkovic N, Patel S, Peng Z, Rada V, Rearden P, Schreier JD, Sisko J, Steele TG, Truchon JF, Wai J, Xu M, Coleman PJ.

J Med Chem. 2015 Oct 22;58(20):8154-65. doi: 10.1021/acs.jmedchem.5b01037. Epub 2015 Oct 8. Erratum in: J Med Chem. 2016 Jan 14;59(1):486. Childers, Karla [added]; Christensen, Melodie [added]; Kuethe, Jeffrey T. [added]; McCabe Dunn, Jamie [added]; Nolting, Andrew [added]; Peng, Zuihui [corrected].

PMID:
26397965
8.

Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence, and horizontal gene transfer.

Weyand NJ, Wertheimer AM, Hobbs TR, Sisko JL, Taku NA, Gregston LD, Clary S, Higashi DL, Biais N, Brown LM, Planer SL, Legasse AW, Axthelm MK, Wong SW, So M.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3059-64. doi: 10.1073/pnas.1217420110. Epub 2013 Feb 4.

9.

Synthesis of fused dihydropyrano(furano)pyridines via [4 + 2]-cycloaddition of 5-alkenoxy substituted oxazoles.

Goodman SN, Mans DM, Sisko J, Yin H.

Org Lett. 2012 Mar 16;14(6):1604-7. doi: 10.1021/ol300351v. Epub 2012 Mar 7.

PMID:
22397735
10.

N. elongata produces type IV pili that mediate interspecies gene transfer with N. gonorrhoeae.

Higashi DL, Biais N, Weyand NJ, Agellon A, Sisko JL, Brown LM, So M.

PLoS One. 2011;6(6):e21373. doi: 10.1371/journal.pone.0021373. Epub 2011 Jun 22.

11.

Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.

Su DS, Lim JJ, Tinney E, Tucker TJ, Saggar S, Sisko JT, Wan BL, Young MB, Anderson KD, Rudd D, Munshi V, Bahnck C, Felock PJ, Lu M, Lai MT, Touch S, Moyer G, Distefano DJ, Flynn JA, Liang Y, Sanchez R, Perlow-Poehnelt R, Miller M, Vacca JP, Williams TM, Anthony NJ.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4328-32. doi: 10.1016/j.bmcl.2010.06.083. Epub 2010 Jun 17.

PMID:
20609585
12.

Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.

Tucker TJ, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey G, Liu M, Miller M, Moyer G, Munshi V, Perlow-Poehnelt R, Prasad S, Reid JC, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y.

J Med Chem. 2008 Oct 23;51(20):6503-11. doi: 10.1021/jm800856c. Epub 2008 Oct 1.

PMID:
18826204
13.

The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.

Tucker TJ, Saggar S, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey G, Liu M, Miller M, Moyer G, Munshi V, Perlow-Poehnelt R, Prasad S, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y.

Bioorg Med Chem Lett. 2008 May 1;18(9):2959-66. doi: 10.1016/j.bmcl.2008.03.064. Epub 2008 Mar 25.

PMID:
18396399
14.

Multifunctional analysis of Chlamydia-specific genes in a yeast expression system.

Sisko JL, Spaeth K, Kumar Y, Valdivia RH.

Mol Microbiol. 2006 Apr;60(1):51-66.

15.

Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.

Sisko JT, Tucker TJ, Bilodeau MT, Buser CA, Ciecko PA, Coll KE, Fernandes C, Gibbs JB, Koester TJ, Kohl N, Lynch JJ, Mao X, McLoughlin D, Miller-Stein CM, Rodman LD, Rickert KW, Sepp-Lorenzino L, Shipman JM, Thomas KA, Wong BK, Hartman GD.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1146-50. Epub 2005 Dec 20.

PMID:
16368234
16.

The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.

Tucker TJ, Abrams MT, Buser CA, Davide JP, Ellis-Hutchings M, Fernandes C, Gibbs JB, Graham SL, Hartman GD, Huber HE, Liu D, Lobell RB, Lumma WC, Robinson RG, Sisko JT, Smith AM.

Bioorg Med Chem Lett. 2002 Aug 5;12(15):2027-30.

PMID:
12113834
17.

Sustained activation of p38 mitogen-activated protein kinase contributes to the vascular response to injury.

Ju H, Nerurkar S, Sauermelch CF, Olzinski AR, Mirabile R, Zimmerman D, Lee JC, Adams J, Sisko J, Berova M, Willette RN.

J Pharmacol Exp Ther. 2002 Apr;301(1):15-20.

PMID:
11907152
18.

Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction.

Behr TM, Nerurkar SS, Nelson AH, Coatney RW, Woods TN, Sulpizio A, Chandra S, Brooks DP, Kumar S, Lee JC, Ohlstein EH, Angermann CE, Adams JL, Sisko J, Sackner-Bernstein JD, Willette RN.

Circulation. 2001 Sep 11;104(11):1292-8.

PMID:
11551882
19.

Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation.

Wong B, Lumma WC, Smith AM, Sisko JT, Wright SD, Cai TQ.

J Leukoc Biol. 2001 Jun;69(6):959-62.

PMID:
11404382
20.

2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.

Trotter BW, Quigley AG, Lumma WC, Sisko JT, Walsh ES, Hamann CS, Robinson RG, Bhimnathwala H, Kolodin DG, Zheng W, Buser CA, Huber HE, Lobell RB, Kohl NE, Williams TM, Graham SL, Dinsmore CJ.

Bioorg Med Chem Lett. 2001 Apr 9;11(7):865-9.

PMID:
11294379
21.

Unexpected reactivity of Imidazo[2,1-b]thiazolines with organometallic reagents.

Sisko J, Kassick AJ, Shetzline SB.

Org Lett. 2000 Sep 7;2(18):2877-80.

PMID:
10964388
22.

An investigation of imidazole and oxazole syntheses using aryl-substituted TosMIC reagents.

Sisko J, Kassick AJ, Mellinger M, Filan JJ, Allen A, Olsen MA.

J Org Chem. 2000 Mar 10;65(5):1516-24.

PMID:
10814116
23.

Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.

Tucker TJ, Brady SF, Lumma WC, Lewis SD, Gardell SJ, Naylor-Olsen AM, Yan Y, Sisko JT, Stauffer KJ, Lucas BJ, Lynch JJ, Cook JJ, Stranieri MT, Holahan MA, Lyle EA, Baskin EP, Chen IW, Dancheck KB, Krueger JA, Cooper CM, Vacca JP.

J Med Chem. 1998 Aug 13;41(17):3210-9.

PMID:
9703466
24.

Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: rapid structure-activity studies by solid-phase synthesis.

Lumma WC Jr, Witherup KM, Tucker TJ, Brady SF, Sisko JT, Naylor-Olsen AM, Lewis SD, Lucas BJ, Vacca JP.

J Med Chem. 1998 Mar 26;41(7):1011-3.

PMID:
9544200
25.

Characterization of the two-step pathway for inhibition of thrombin by alpha-ketoamide transition state analogs.

Lewis SD, Lucas BJ, Brady SF, Sisko JT, Cutrona KJ, Sanderson PE, Freidinger RM, Mao SS, Gardell SJ, Shafer JA.

J Biol Chem. 1998 Feb 27;273(9):4843-54.

26.

Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position.

Tucker TJ, Lumma WC, Lewis SD, Gardell SJ, Lucas BJ, Sisko JT, Lynch JJ, Lyle EA, Baskin EP, Woltmann RF, Appleby SD, Chen IW, Dancheck KB, Naylor-Olsen AM, Krueger JA, Cooper CM, Vacca JP.

J Med Chem. 1997 Oct 24;40(22):3687-93.

PMID:
9357536
27.

Inhibition of thrombin by peptides containing Lysyl-alpha-keto carbonyl derivatives.

Lewis SD, Ng AS, Lyle EA, Mellott MJ, Appleby SD, Brady SF, Stauffer KJ, Sisko JT, Mao SS, Veber DF, et al.

Thromb Haemost. 1995 Oct;74(4):1107-12.

PMID:
8560421
28.

Amide and alpha-keto carbonyl inhibitors of thrombin based on arginine and lysine: synthesis, stability and biological characterization.

Brady SF, Sisko JT, Stauffer KJ, Colton CD, Qiu H, Lewis SD, Ng AS, Shafer JA, Bogusky MJ, Veber DF, et al.

Bioorg Med Chem. 1995 Aug;3(8):1063-78.

PMID:
7582980
29.

Synthesis and solution conformation of c(D-Trp-D-Cys(SO3-Na+)-Pro-D-Val-Leu), a potent endothelin-A receptor antagonist.

Bogusky MJ, Brady SF, Sisko JT, Nutt RF, Smith GM.

Int J Pept Protein Res. 1993 Aug;42(2):194-203.

PMID:
8407113
30.

NMR and molecular modeling characterization of RGD containing peptides.

Bogusky MJ, Naylor AM, Pitzenberger SM, Nutt RF, Brady SF, Colton CD, Sisko JT, Anderson PS, Veber DF.

Int J Pept Protein Res. 1992 Jan;39(1):63-76.

PMID:
1634331

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