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Items: 16

1.

Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma.

Zhao F, Evans K, Xiao C, DeVito N, Theivanthiran B, Holtzhausen A, Siska PJ, Blobe GC, Hanks BA.

Cancer Immunol Res. 2018 Sep 12. doi: 10.1158/2326-6066.CIR-18-0086. [Epub ahead of print]

PMID:
30209062
2.

Immunometabolism in cancer at a glance.

Singer K, Cheng WC, Kreutz M, Ho PC, Siska PJ.

Dis Model Mech. 2018 Aug 2;11(8). pii: dmm034272. doi: 10.1242/dmm.034272. Review.

3.

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.

Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP.

Oncogene. 2018 Sep;37(36):5007-5019. doi: 10.1038/s41388-018-0307-z. Epub 2018 May 23.

4.

The Peripheral and Intratumoral Immune Cell Landscape in Cancer Patients: A Proxy for Tumor Biology and a Tool for Outcome Prediction.

Schnell A, Schmidl C, Herr W, Siska PJ.

Biomedicines. 2018 Feb 24;6(1). pii: E25. doi: 10.3390/biomedicines6010025. Review.

5.

Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.

Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC.

JCI Insight. 2017 Jun 15;2(12). pii: 93411. doi: 10.1172/jci.insight.93411. [Epub ahead of print]

6.

Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling.

Siska PJ, Johnpulle RAN, Zhou A, Bordeaux J, Kim JY, Dabbas B, Dakappagari N, Rathmell JC, Rathmell WK, Morgans AK, Balko JM, Johnson DB.

Oncoimmunology. 2017 Mar 20;6(4):e1305535. doi: 10.1080/2162402X.2017.1305535. eCollection 2017.

7.

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment.

Renner K, Singer K, Koehl GE, Geissler EK, Peter K, Siska PJ, Kreutz M.

Front Immunol. 2017 Mar 8;8:248. doi: 10.3389/fimmu.2017.00248. eCollection 2017. Review.

8.

Strategies to overcome therapeutic resistance in renal cell carcinoma.

Siska PJ, Beckermann KE, Rathmell WK, Haake SM.

Urol Oncol. 2017 Mar;35(3):102-110. doi: 10.1016/j.urolonc.2016.12.002. Epub 2017 Jan 11. Review.

9.

Metabolic Signaling Drives IFN-γ.

Siska PJ, Rathmell JC.

Cell Metab. 2016 Nov 8;24(5):651-652. doi: 10.1016/j.cmet.2016.10.018.

10.

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.

Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC.

Nat Immunol. 2016 Dec;17(12):1459-1466. doi: 10.1038/ni.3577. Epub 2016 Oct 3.

11.

Nutrients and the microenvironment to feed a T cell army.

Johnson MO, Siska PJ, Contreras DC, Rathmell JC.

Semin Immunol. 2016 Oct;28(5):505-513. doi: 10.1016/j.smim.2016.09.003. Epub 2016 Oct 3. Review.

12.

Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes.

Siska PJ, Kim B, Ji X, Hoeksema MD, Massion PP, Beckermann KE, Wu J, Chi JT, Hong J, Rathmell JC.

J Immunol Methods. 2016 Nov;438:51-58. doi: 10.1016/j.jim.2016.08.013. Epub 2016 Sep 2.

13.

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.

Siska PJ, van der Windt GJ, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC.

J Immunol. 2016 Sep 15;197(6):2532-40. doi: 10.4049/jimmunol.1502464. Epub 2016 Aug 10.

14.

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC.

Cell Metab. 2016 Apr 12;23(4):649-62. doi: 10.1016/j.cmet.2016.03.008.

15.

PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1.

Siska PJ, Rathmell JC.

Mol Cell. 2015 Jun 4;58(5):711-2. doi: 10.1016/j.molcel.2015.05.025.

16.

T cell metabolic fitness in antitumor immunity.

Siska PJ, Rathmell JC.

Trends Immunol. 2015 Apr;36(4):257-64. doi: 10.1016/j.it.2015.02.007. Epub 2015 Mar 12. Review.

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