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Items: 10


Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy.

Kermorvant-Duchemin E, Sapieha P, Sirinyan M, Beauchamp M, Checchin D, Hardy P, Sennlaub F, Lachapelle P, Chemtob S.

Doc Ophthalmol. 2010 Feb;120(1):51-60. doi: 10.1007/s10633-009-9201-x. Epub 2009 Oct 31. Review.


The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.

Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S.

Nat Med. 2008 Oct;14(10):1067-76. doi: 10.1038/nm.1873. Epub 2008 Oct 5.


CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

Combadière C, Feumi C, Raoul W, Keller N, Rodéro M, Pézard A, Lavalette S, Houssier M, Jonet L, Picard E, Debré P, Sirinyan M, Deterre P, Ferroukhi T, Cohen SY, Chauvaud D, Jeanny JC, Chemtob S, Behar-Cohen F, Sennlaub F.

J Clin Invest. 2007 Oct;117(10):2920-8.


Hyperoxic exposure leads to nitrative stress and ensuing microvascular degeneration and diminished brain mass and function in the immature subject.

Sirinyan M, Sennlaub F, Dorfman A, Sapieha P, Gobeil F Jr, Hardy P, Lachapelle P, Chemtob S.

Stroke. 2006 Nov;37(11):2807-15. Epub 2006 Sep 28.


Hypercapnia- and trans-arachidonic acid-induced retinal microvascular degeneration: implications in the genesis of retinopathy of prematurity.

Leduc M, Kermorvant-Duchemin E, Checchin D, Sennlaub F, Sirinyan M, Kooli A, Lachapelle P, Chemtob S.

Semin Perinatol. 2006 Jun;30(3):129-38. Review.


Hypercapnia prevents neovascularization via nitrative stress.

Checchin D, Sennlaub F, Sirinyan M, Brault S, Zhu T, Kermorvant-Duchemin E, Hardy P, Balazy M, Chemtob S.

Free Radic Biol Med. 2006 Feb 1;40(3):543-53. Epub 2005 Nov 14.


Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-alpha and consecutively Tie2 dependent.

Zhu T, Sennlaub F, Beauchamp MH, Fan L, Joyal JS, Checchin D, Nim S, Lachapelle P, Sirinyan M, Hou X, Bossolasco M, Rivard GE, Heveker N, Chemtob S.

Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):744-50. Epub 2006 Jan 26.


Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration.

Kermorvant-Duchemin E, Sennlaub F, Sirinyan M, Brault S, Andelfinger G, Kooli A, Germain S, Ong H, d'Orleans-Juste P, Gobeil F Jr, Zhu T, Boisvert C, Hardy P, Jain K, Falck JR, Balazy M, Chemtob S.

Nat Med. 2005 Dec;11(12):1339-45. Epub 2005 Nov 27.


Dominant role for calpain in thromboxane-induced neuromicrovascular endothelial cytotoxicity.

Quiniou C, Sennlaub F, Beauchamp MH, Checchin D, Lahaie I, Brault S, Gobeil F Jr, Sirinyan M, Kooli A, Hardy P, Pshezhetsky A, Chemtob S.

J Pharmacol Exp Ther. 2006 Feb;316(2):618-27. Epub 2005 Oct 7.


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