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Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4.

Debrie AS, Mielcarek N, Lecher S, Roux X, Sirard JC, Locht C.

J Immunol. 2019 Nov 15. pii: ji1901102. doi: 10.4049/jimmunol.1901102. [Epub ahead of print]


Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.

Hassane M, Jouan Y, Creusat F, Soulard D, Boisseau C, Gonzalez L, Patin EC, Heuzé-Vourc'h N, Sirard JC, Faveeuw C, Trottein F, Si-Tahar M, Baranek T, Paget C.

Mucosal Immunol. 2019 Oct 18. doi: 10.1038/s41385-019-0212-y. [Epub ahead of print]


Toll-like receptor 4 signaling in hematopoietic-lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01.

Van Maele L, Fougeron D, Cayet D, Chalon A, Piccioli D, Collignon C, Sirard JC, Didierlaurent AM.

Eur J Immunol. 2019 Sep 5. doi: 10.1002/eji.201948234. [Epub ahead of print]


A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume.

Franck S, Fuhrmann-Selter T, Joseph JF, Michelet R, Casilag F, Sirard JC, Wicha SG, Kloft C.

Talanta. 2019 Aug 15;201:253-258. doi: 10.1016/j.talanta.2019.03.098. Epub 2019 Apr 2.


Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir.

Georgel AF, Cayet D, Pizzorno A, Rosa-Calatrava M, Paget C, Sencio V, Dubuisson J, Trottein F, Sirard JC, Carnoy C.

Antiviral Res. 2019 Aug;168:28-35. doi: 10.1016/j.antiviral.2019.05.002. Epub 2019 May 9.


Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia.

Matarazzo L, Casilag F, Porte R, Wallet F, Cayet D, Faveeuw C, Carnoy C, Sirard JC.

Front Immunol. 2019 Apr 9;10:723. doi: 10.3389/fimmu.2019.00723. eCollection 2019.


Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants.

Biedma ME, Cayet D, Tabareau J, Rossi AH, Ivičak-Kocjan K, Moreno G, Errea A, Soulard D, Parisi G, Jerala R, Berguer P, Rumbo M, Sirard JC.

Vaccine. 2019 Jan 21;37(4):652-663. doi: 10.1016/j.vaccine.2018.12.009. Epub 2018 Dec 21.


Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection.

Beshara R, Sencio V, Soulard D, Barthélémy A, Fontaine J, Pinteau T, Deruyter L, Ismail MB, Paget C, Sirard JC, Trottein F, Faveeuw C.

PLoS Pathog. 2018 Oct 29;14(10):e1007360. doi: 10.1371/journal.ppat.1007360. eCollection 2018 Oct.


Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae.

Farhat K, Bodart G, Charlet-Renard C, Desmet CJ, Moutschen M, Beguin Y, Baron F, Melin P, Quatresooz P, Parent AS, Desmecht D, Sirard JC, Salvatori R, Martens H, Geenen VG.

Front Immunol. 2018 Oct 2;9:2175. doi: 10.3389/fimmu.2018.02175. eCollection 2018.


Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation.

Bastaert F, Kheir S, Saint-Criq V, Villeret B, Dang PM, El-Benna J, Sirard JC, Voulhoux R, Sallenave JM.

Front Immunol. 2018 Jul 23;9:1675. doi: 10.3389/fimmu.2018.01675. eCollection 2018.


Compartmentalized Antimicrobial Defenses in Response to Flagellin.

Vijayan A, Rumbo M, Carnoy C, Sirard JC.

Trends Microbiol. 2018 May;26(5):423-435. doi: 10.1016/j.tim.2017.10.008. Epub 2017 Nov 22. Review.


Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.

Sabatel C, Radermecker C, Fievez L, Paulissen G, Chakarov S, Fernandes C, Olivier S, Toussaint M, Pirottin D, Xiao X, Quatresooz P, Sirard JC, Cataldo D, Gillet L, Bouabe H, Desmet CJ, Ginhoux F, Marichal T, Bureau F.

Immunity. 2017 Mar 21;46(3):457-473. doi: 10.1016/j.immuni.2017.02.016.


Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella.

Hiriart Y, Rossi AH, Biedma ME, Errea AJ, Moreno G, Cayet D, Rinaldi J, Blancá B, Sirard JC, Goldbaum F, Berguer P, Rumbo M.

Protein Sci. 2017 May;26(5):1049-1059. doi: 10.1002/pro.3151. Epub 2017 Mar 16.


Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model.

Iraporda C, Romanin DE, Bengoa AA, Errea AJ, Cayet D, Foligné B, Sirard JC, Garrote GL, Abraham AG, Rumbo M.

Front Immunol. 2016 Dec 27;7:651. doi: 10.3389/fimmu.2016.00651. eCollection 2016.


Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections.

Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F, Paget C.

Mucosal Immunol. 2017 Jul;10(4):1056-1068. doi: 10.1038/mi.2016.113. Epub 2017 Jan 4.


Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.

Porte R, Van Maele L, Muñoz-Wolf N, Foligné B, Dumoutier L, Tabareau J, Cayet D, Gosset P, Jonckheere N, Van Seuningen I, Chabalgoity JA, Simonet M, Lamkanfi M, Renauld JC, Sirard JC, Carnoy C.

Infect Immun. 2017 Jan 26;85(2). pii: e00806-16. doi: 10.1128/IAI.00806-16. Print 2017 Feb.


Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.

Errea A, Cayet D, Marchetti P, Tang C, Kluza J, Offermanns S, Sirard JC, Rumbo M.

PLoS One. 2016 Nov 15;11(11):e0163694. doi: 10.1371/journal.pone.0163694. eCollection 2016.


Characterization of the protective immune response to Yersinia pseudotuberculosis infection in mice vaccinated with an LcrV-secreting strain of Lactococcus lactis.

Daniel C, Titecat M, Poiret S, Cayet D, Boutillier D, Simonet M, Sirard JC, Lemaître N, Sebbane F.

Vaccine. 2016 Nov 11;34(47):5762-5767. doi: 10.1016/j.vaccine.2016.09.060. Epub 2016 Oct 11.


Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.

Muñoz-Wolf N, Rial A, Fougeron D, Tabareau J, Sirard JC, Chabalgoity JA.

Future Microbiol. 2016 Sep;11:1167-77. doi: 10.2217/fmb-2016-0045. Epub 2016 Aug 22.


A Toll-Like Receptor 5 Agonist Improves the Efficacy of Antibiotics in Treatment of Primary and Influenza Virus-Associated Pneumococcal Mouse Infections.

Porte R, Fougeron D, Muñoz-Wolf N, Tabareau J, Georgel AF, Wallet F, Paget C, Trottein F, Chabalgoity JA, Carnoy C, Sirard JC.

Antimicrob Agents Chemother. 2015 Oct;59(10):6064-72. doi: 10.1128/AAC.01210-15. Epub 2015 Jul 20.


Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells.

Iraporda C, Errea A, Romanin DE, Cayet D, Pereyra E, Pignataro O, Sirard JC, Garrote GL, Abraham AG, Rumbo M.

Immunobiology. 2015 Oct;220(10):1161-9. doi: 10.1016/j.imbio.2015.06.004. Epub 2015 Jun 10.


Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract.

Fougeron D, Van Maele L, Songhet P, Cayet D, Hot D, Van Rooijen N, Mollenkopf HJ, Hardt WD, Benecke AG, Sirard JC.

Vaccine. 2015 Jun 26;33(29):3331-41. doi: 10.1016/j.vaccine.2015.05.022. Epub 2015 May 21.


Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells.

Goubard A, Loïez C, Abe J, Fichel C, Herwegh S, Faveeuw C, Porte R, Cayet D, Sebbane F, Penet S, Foligné B, Desreumaux P, Saito H, Sirard JC, Simonet M, Carnoy C.

Infect Immun. 2015 May;83(5):2053-64. doi: 10.1128/IAI.02339-14. Epub 2015 Mar 9.


Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5.

Matusiak M, Van Opdenbosch N, Vande Walle L, Sirard JC, Kanneganti TD, Lamkanfi M.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1541-6. doi: 10.1073/pnas.1417945112. Epub 2015 Jan 20.


Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection.

Van Maele L, Carnoy C, Cayet D, Ivanov S, Porte R, Deruy E, Chabalgoity JA, Renauld JC, Eberl G, Benecke AG, Trottein F, Faveeuw C, Sirard JC.

J Infect Dis. 2014 Aug 1;210(3):493-503. doi: 10.1093/infdis/jiu106. Epub 2014 Feb 26.


Transgenic mouse model harboring the transcriptional fusion ccl20-luciferase as a novel reporter of pro-inflammatory response.

Crispo M, Van Maele L, Tabareau J, Cayet D, Errea A, Ferreira AM, Rumbo M, Sirard JC.

PLoS One. 2013 Nov 12;8(11):e78447. doi: 10.1371/journal.pone.0078447. eCollection 2013.


NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.

Felmy B, Songhet P, Slack EM, Müller AJ, Kremer M, Van Maele L, Cayet D, Heikenwalder M, Sirard JC, Hardt WD.

PLoS One. 2013 Oct 15;8(10):e77204. doi: 10.1371/journal.pone.0077204. eCollection 2013.


Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.

Van Maele L, Fougeron D, Janot L, Didierlaurent A, Cayet D, Tabareau J, Rumbo M, Corvo-Chamaillard S, Boulenouar S, Jeffs S, Vande Walle L, Lamkanfi M, Lemoine Y, Erard F, Hot D, Hussell T, Ryffel B, Benecke AG, Sirard JC.

Mucosal Immunol. 2014 May;7(3):489-500. doi: 10.1038/mi.2013.66. Epub 2013 Sep 25.


Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection.

Moreno G, Errea A, Van Maele L, Roberts R, Léger H, Sirard JC, Benecke A, Rumbo M, Hozbor D.

Microbes Infect. 2013 Sep-Oct;15(10-11):708-18. doi: 10.1016/j.micinf.2013.06.010. Epub 2013 Jun 28.


The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon.

Knudsen ML, Johansson DX, Kostic L, Nordström EK, Tegerstedt K, Pasetto A, Applequist SE, Ljungberg K, Sirard JC, Liljeström P.

PLoS One. 2013 Jun 13;8(6):e65964. doi: 10.1371/journal.pone.0065964. Print 2013.


Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.

Ivanov S, Renneson J, Fontaine J, Barthelemy A, Paget C, Fernandez EM, Blanc F, De Trez C, Van Maele L, Dumoutier L, Huerre MR, Eberl G, Si-Tahar M, Gosset P, Renauld JC, Sirard JC, Faveeuw C, Trottein F.

J Virol. 2013 Jun;87(12):6911-24. doi: 10.1128/JVI.02943-12. Epub 2013 Apr 17.


Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune response.

Derbise A, Pierre F, Merchez M, Pradel E, Laouami S, Ricard I, Sirard JC, Fritz J, Lemaître N, Akinbi H, Boneca IG, Sebbane F.

J Infect Dis. 2013 May 15;207(10):1535-43. doi: 10.1093/infdis/jit057. Epub 2013 Feb 12.


In vivo germination of Bacillus anthracis spores during murine cutaneous infection.

Corre JP, Piris-Gimenez A, Moya-Nilges M, Jouvion G, Fouet A, Glomski IJ, Mock M, Sirard JC, Goossens PL.

J Infect Dis. 2013 Feb 1;207(3):450-7. doi: 10.1093/infdis/jis686. Epub 2012 Nov 12.


Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide.

Ivanov S, Fontaine J, Paget C, Macho Fernandez E, Van Maele L, Renneson J, Maillet I, Wolf NM, Rial A, Léger H, Ryffel B, Frisch B, Chabalgoity JA, Sirard JC, Benecke A, Faveeuw C, Trottein F.

J Infect Dis. 2012 Sep 1;206(5):723-34. doi: 10.1093/infdis/jis413. Epub 2012 Jun 21.


Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity.

Marqués JM, Rial A, Muñoz N, Pellay FX, Van Maele L, Léger H, Camou T, Sirard JC, Benecke A, Chabalgoity JA.

Immunobiology. 2012 Apr;217(4):420-9. doi: 10.1016/j.imbio.2011.10.012. Epub 2011 Nov 23.


IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality.

Dumoutier L, de Heusch M, Orabona C, Satoh-Takayama N, Eberl G, Sirard JC, Di Santo JP, Renauld JC.

Eur J Immunol. 2011 Apr;41(4):1075-85. doi: 10.1002/eji.201040878. Epub 2011 Mar 14.


IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium.

Songhet P, Barthel M, Röhn TA, Van Maele L, Cayet D, Sirard JC, Bachmann M, Kopf M, Hardt WD.

PLoS One. 2010 Nov 23;5(11):e13804. doi: 10.1371/journal.pone.0013804.


The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea.

Endt K, Stecher B, Chaffron S, Slack E, Tchitchek N, Benecke A, Van Maele L, Sirard JC, Mueller AJ, Heikenwalder M, Macpherson AJ, Strugnell R, von Mering C, Hardt WD.

PLoS Pathog. 2010 Sep 9;6(9):e1001097. doi: 10.1371/journal.ppat.1001097.


Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection.

Muñoz N, Van Maele L, Marqués JM, Rial A, Sirard JC, Chabalgoity JA.

Infect Immun. 2010 Oct;78(10):4226-33. doi: 10.1128/IAI.00224-10. Epub 2010 Jul 19.


TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.

Van Maele L, Carnoy C, Cayet D, Songhet P, Dumoutier L, Ferrero I, Janot L, Erard F, Bertout J, Leger H, Sebbane F, Benecke A, Renauld JC, Hardt WD, Ryffel B, Sirard JC.

J Immunol. 2010 Jul 15;185(2):1177-85. doi: 10.4049/jimmunol.1000115. Epub 2010 Jun 21.


The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells.

Beauvillain C, Meloni F, Sirard JC, Blanchard S, Jarry U, Scotet M, Magistrelli G, Delneste Y, Barnaba V, Jeannin P.

J Hepatol. 2010 May;52(5):644-51. doi: 10.1016/j.jhep.2009.11.031. Epub 2010 Mar 4.


Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.

Janot L, Sirard JC, Secher T, Noulin N, Fick L, Akira S, Uematsu S, Didierlaurent A, Hussell T, Ryffel B, Erard F.

Eur J Immunol. 2009 Jun;39(6):1587-96. doi: 10.1002/eji.200838907.


Toll-like receptor 5- and lymphotoxin beta receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics.

Sirard JC, Didierlaurent A, Cayet D, Sierro F, Rumbo M.

Biochim Biophys Acta. 2009 May;1789(5):386-94. doi: 10.1016/j.bbagrm.2009.03.001. Epub 2009 Mar 20.


Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.

Dessein R, Gironella M, Vignal C, Peyrin-Biroulet L, Sokol H, Secher T, Lacas-Gervais S, Gratadoux JJ, Lafont F, Dagorn JC, Ryffel B, Akira S, Langella P, Nùñez G, Sirard JC, Iovanna J, Simonet M, Chamaillard M.

Gut. 2009 Jun;58(6):771-6. doi: 10.1136/gut.2008.168443. Epub 2009 Jan 27.


Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity.

Nempont C, Cayet D, Rumbo M, Bompard C, Villeret V, Sirard JC.

J Immunol. 2008 Aug 1;181(3):2036-43.


Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.

Didierlaurent A, Goulding J, Patel S, Snelgrove R, Low L, Bebien M, Lawrence T, van Rijt LS, Lambrecht BN, Sirard JC, Hussell T.

J Exp Med. 2008 Feb 18;205(2):323-9. doi: 10.1084/jem.20070891. Epub 2008 Jan 28.


Nod-like receptors: cytosolic watchdogs for immunity against pathogens.

Sirard JC, Vignal C, Dessein R, Chamaillard M.

PLoS Pathog. 2007 Dec 28;3(12):e152. doi: 10.1371/journal.ppat.0030152. Review.


Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells.

Guo A, Lasaro MA, Sirard JC, Kraehenbühl JP, Schifferli DM.

Microbiology. 2007 Apr;153(Pt 4):1059-69.


A key role of dendritic cells in probiotic functionality.

Foligne B, Zoumpopoulou G, Dewulf J, Ben Younes A, Chareyre F, Sirard JC, Pot B, Grangette C.

PLoS One. 2007 Mar 21;2(3):e313.


Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.

Luu RA, Gurnani K, Dudani R, Kammara R, van Faassen H, Sirard JC, Krishnan L, Sad S.

J Immunol. 2006 Aug 1;177(3):1516-25.

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