Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 70

1.

The study of Lynch syndrome in a special population reveals a strong founder effect and an unusual mutational mechanism in familial adenomatous polyposis.

Siraj AK, Masoodi T, Bu R, Parvathareddy SK, Siraj S, Alassiri A, Al-Dayel F, Alkuraya FS, Al-Kuraya KS.

Gut. 2020 Jan 10. pii: gutjnl-2019-320511. doi: 10.1136/gutjnl-2019-320511. [Epub ahead of print] No abstract available.

2.

Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region.

Siraj AK, Parvathareddy SK, Bu R, Iqbal K, Siraj S, Masoodi T, Concepcion RM, Ghazwani LO, AlBadawi I, Al-Dayel F, Al-Kuraya KS.

Cancer Cell Int. 2019 Dec 11;19:334. doi: 10.1186/s12935-019-1058-9. eCollection 2019.

3.

APC truncating mutations in Middle Eastern Population: Tankyrase inhibitor is an effective strategy to sensitize APC mutant CRC To 5-FU chemotherapy.

Siraj AK, Kumar Parvathareddy S, Pratheeshkumar P, Padmaja Divya S, Ahmed SO, Melosantos R, Begum R, Concepcion RMJA, Al-Sanea N, Ashari LH, Abduljabbar A, Al-Dayel F, Al-Kuraya KS.

Biomed Pharmacother. 2020 Jan;121:109572. doi: 10.1016/j.biopha.2019.109572. Epub 2019 Nov 5.

4.

Telomerase reverse transcriptase promoter mutations in cancers derived from multiple organ sites among middle eastern population.

Siraj AK, Bu R, Iqbal K, Parvathareddy SK, Siraj N, Siraj S, Diaz MRF, Rala DR, Benito AD, Sabido MA, Al-Rasheed M, Al-Obaisi KAS, Al-Haqawi W, Victoria IG, Al Balawy W, Abedalthagafi M, Wakil SM, Ajarim D, Mohammed S, Alhussain T, Tulbah A, Al-Badawi IA, Al-Dayel F, Al-Kuraya KS.

Genomics. 2020 Mar;112(2):1746-1753. doi: 10.1016/j.ygeno.2019.09.017. Epub 2019 Oct 31.

5.

Evolution and Impact of Subclonal Mutations in Papillary Thyroid Cancer.

Masoodi T, Siraj AK, Siraj S, Azam S, Qadri Z, Parvathareddy SK, Al-Sobhi SS, AlDawish M, Alkuraya FS, Al-Kuraya KS.

Am J Hum Genet. 2019 Nov 7;105(5):959-973. doi: 10.1016/j.ajhg.2019.09.026. Epub 2019 Oct 24.

PMID:
31668701
6.

Whole-Exome Sequencing of Matched Primary and Metastatic Papillary Thyroid Cancer.

Masoodi T, Siraj AK, Siraj S, Azam S, Qadri Z, Albalawy WN, Parvathareddy SK, Al-Sobhi SS, Al-Dayel F, Alkuraya FS, Al-Kuraya KS.

Thyroid. 2020 Jan;30(1):42-56. doi: 10.1089/thy.2019.0052. Epub 2019 Dec 4.

7.

Zamzam water protects cancer cells from chemotherapy-induced apoptosis via mitogen-activated protein kinase-dependent pathway.

Siraj AK, Begum R, Melosantos R, Albalawy W, Abboud J, Siraj N, Al-Kuraya KS.

Biomed Pharmacother. 2019 Oct;118:109376. doi: 10.1016/j.biopha.2019.109376. Epub 2019 Aug 28.

8.

Prognostic significance of DNMT3A alterations in Middle Eastern papillary thyroid carcinoma.

Siraj AK, Pratheeshkumar P, Parvathareddy SK, Bu R, Masoodi T, Iqbal K, Al-Rasheed M, Al-Dayel F, Al-Sobhi SS, Alzahrani AS, Al-Dawish M, Al-Kuraya KS.

Eur J Cancer. 2019 Aug;117:133-144. doi: 10.1016/j.ejca.2019.05.025. Epub 2019 Jul 4.

PMID:
31280122
9.

TGFβ-induced SMAD4-dependent Apoptosis Proceeded by EMT in CRC.

Siraj AK, Pratheeshkumar P, Divya SP, Parvathareddy SK, Bu R, Masoodi T, Kong Y, Thangavel S, Al-Sanea N, Ashari LH, Abduljabbar A, Al-Homoud S, Al-Dayel F, Al-Kuraya KS.

Mol Cancer Ther. 2019 Jul;18(7):1312-1322. doi: 10.1158/1535-7163.MCT-18-1378. Epub 2019 May 3.

PMID:
31053577
10.

Prevalence, spectrum, and founder effect of BRCA1 and BRCA2 mutations in epithelial ovarian cancer from the Middle East.

Siraj AK, Bu R, Iqbal K, Siraj N, Al-Haqawi W, Al-Badawi IA, Parvathareddy SK, Masoodi T, Tulbah A, Al-Dayel F, Al-Kuraya KS.

Hum Mutat. 2019 Jun;40(6):729-733. doi: 10.1002/humu.23736. Epub 2019 Mar 18.

PMID:
30825404
11.

Overexpression of PARP is an independent prognostic marker for poor survival in Middle Eastern breast cancer and its inhibition can be enhanced with embelin co-treatment.

Siraj AK, Pratheeshkumar P, Parvathareddy SK, Divya SP, Al-Dayel F, Tulbah A, Ajarim D, Al-Kuraya KS.

Oncotarget. 2018 Dec 18;9(99):37319-37332. doi: 10.18632/oncotarget.26470. eCollection 2018 Dec 18.

12.

FoxM1 is an independent poor prognostic marker and therapeutic target for advanced Middle Eastern breast cancer.

Siraj AK, Pratheeshkumar P, Parvathareddy SK, Qadri Z, Thangavel S, Ahmed S, Al-Dayel F, Tulbah A, Ajarim D, Al-Kuraya KS.

Oncotarget. 2018 Apr 3;9(25):17466-17482. doi: 10.18632/oncotarget.24739. eCollection 2018 Apr 3.

13.

FoxM1 and β-catenin predicts aggressiveness in Middle Eastern ovarian cancer and their co-targeting impairs the growth of ovarian cancer cells.

Pratheeshkumar P, Divya SP, Parvathareddy SK, Alhoshani NM, Al-Badawi IA, Tulbah A, Al-Dayel F, Siraj AK, Al-Kuraya KS.

Oncotarget. 2017 Dec 16;9(3):3590-3604. doi: 10.18632/oncotarget.23338. eCollection 2018 Jan 9.

14.

Downregulation of SKP2 in Papillary Thyroid Cancer Acts Synergistically With TRAIL on Inducing Apoptosis via ROS.

Pratheeshkumar P, Siraj AK, Divya SP, Parvathareddy SK, Begum R, Melosantos R, Al-Sobhi SS, Al-Dawish M, Al-Dayel F, Al-Kuraya KS.

J Clin Endocrinol Metab. 2018 Apr 1;103(4):1530-1544. doi: 10.1210/jc.2017-02178.

PMID:
29300929
15.

Telomerase reverse transcriptase mutations are independent predictor of disease-free survival in Middle Eastern papillary thyroid cancer.

Bu R, Siraj AK, Divya SP, Kong Y, Parvathareddy SK, Al-Rasheed M, Al-Obaisi KAS, Victoria IG, Al-Sobhi SS, Al-Dawish M, Al-Dayel F, Al-Kuraya KS.

Int J Cancer. 2018 May 15;142(10):2028-2039. doi: 10.1002/ijc.31225. Epub 2017 Dec 29.

16.

Expanding the spectrum of germline variants in cancer.

Siraj AK, Masoodi T, Bu R, Parvathareddy SK, Al-Badawi IA, Al-Sanea N, Ashari LH, Abduljabbar A, Alhomoud S, Al-Sobhi SS, Tulbah A, Ajarim D, Alzoman K, Aljuboury M, Yousef HB, Al-Dawish M, Al-Dayel F, Alkuraya FS, Al-Kuraya KS.

Hum Genet. 2017 Nov;136(11-12):1431-1444. doi: 10.1007/s00439-017-1845-0. Epub 2017 Oct 3.

PMID:
28975465
17.

XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis.

Hussain AR, Siraj AK, Ahmed M, Bu R, Pratheeshkumar P, Alrashed AM, Qadri Z, Ajarim D, Al-Dayel F, Beg S, Al-Kuraya KS.

BMC Cancer. 2017 Sep 11;17(1):640. doi: 10.1186/s12885-017-3627-4.

18.

Response to Yehia et al.

Siraj AK, Masoodi T, Alkuraya FS, Al-Kuraya KS.

Am J Hum Genet. 2017 Mar 2;100(3):564-565. doi: 10.1016/j.ajhg.2017.01.022. No abstract available.

19.

MED12 is recurrently mutated in Middle Eastern colorectal cancer.

Siraj AK, Masoodi T, Bu R, Pratheeshkumar P, Al-Sanea N, Ashari LH, Abduljabbar A, Alhomoud S, Al-Dayel F, Alkuraya FS, Al-Kuraya KS.

Gut. 2018 Apr;67(4):663-671. doi: 10.1136/gutjnl-2016-313334. Epub 2017 Feb 9.

20.

Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis.

Siraj AK, Masoodi T, Bu R, Beg S, Al-Sobhi SS, Al-Dayel F, Al-Dawish M, Alkuraya FS, Al-Kuraya KS.

Am J Hum Genet. 2016 Jun 2;98(6):1170-1180. doi: 10.1016/j.ajhg.2016.04.014. Epub 2016 May 26.

21.

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis.

Bu R, Siraj AK, Al-Obaisi KA, Beg S, Al Hazmi M, Ajarim D, Tulbah A, Al-Dayel F, Al-Kuraya KS.

Int J Cancer. 2016 Sep 1;139(5):1091-7. doi: 10.1002/ijc.30143. Epub 2016 May 3.

22.

Reply to specific gene patterns and molecular pathways related to human carcinogenesis in different populations among various geographic locations.

Siraj AK, Beg S, Al-Kuraya KS.

Cancer. 2016 Apr 1;122(7):1135-7. doi: 10.1002/cncr.29904. Epub 2016 Feb 5. No abstract available.

23.

ALK alteration is a frequent event in aggressive breast cancers.

Siraj AK, Beg S, Jehan Z, Prabhakaran S, Ahmed M, R Hussain A, Al-Dayel F, Tulbah A, Ajarim D, Al-Kuraya KS.

Breast Cancer Res. 2015 Sep 17;17:127. doi: 10.1186/s13058-015-0610-3.

24.

Molecular markers and pathway analysis of colorectal carcinoma in the Middle East.

Beg S, Siraj AK, Prabhakaran S, Bu R, Al-Rasheed M, Sultana M, Qadri Z, Al-Assiri M, Sairafi R, Al-Dayel F, Al-Sanea N, Uddin S, Al-Kuraya KS.

Cancer. 2015 Nov 1;121(21):3799-808. doi: 10.1002/cncr.29580. Epub 2015 Jul 28.

25.

Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells.

Ahmed M, Hussain AR, Siraj AK, Uddin S, Al-Sanea N, Al-Dayel F, Al-Assiri M, Beg S, Al-Kuraya KS.

Mol Cancer. 2015 Jul 10;14:131. doi: 10.1186/s12943-015-0406-1.

26.

Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian Cancer.

Hussain AR, Al-Romaizan M, Ahmed M, Thangavel S, Al-Dayel F, Beg S, Uddin S, Siraj AK, Al-Kuraya KS.

Mol Med. 2015 May 26;21:466-78. doi: 10.2119/molmed.2014.00238.

27.

PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma.

Beg S, Siraj AK, Jehan Z, Prabakaran S, Al-Sobhi SS, Al-Dawish M, Al-Dayel F, Al-Kuraya KS.

Br J Cancer. 2015 Jun 9;112(12):1938-43. doi: 10.1038/bjc.2015.169. Epub 2015 May 19.

28.

Loss of PTEN expression is associated with aggressive behavior and poor prognosis in Middle Eastern triple-negative breast cancer.

Beg S, Siraj AK, Prabhakaran S, Jehan Z, Ajarim D, Al-Dayel F, Tulbah A, Al-Kuraya KS.

Breast Cancer Res Treat. 2015 Jun;151(3):541-53. doi: 10.1007/s10549-015-3430-3. Epub 2015 May 16.

PMID:
25981902
29.

Role of X-Linked Inhibitor of Apoptosis as a Prognostic Marker and Therapeutic Target in Papillary Thyroid Carcinoma.

Hussain AR, Bu R, Ahmed M, Jehan Z, Beg S, Al-Sobhi S, Al-Dayel F, Siraj AK, Uddin S, Al-Kuraya KS.

J Clin Endocrinol Metab. 2015 Jul;100(7):E974-85. doi: 10.1210/jc.2014-4356. Epub 2015 May 14.

PMID:
25974735
30.

Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer.

Siraj AK, Prabhakaran S, Bavi P, Bu R, Beg S, Hazmi MA, Al-Rasheed M, Al-Assiri M, Sairafi R, Al-Dayel F, Al-Sanea N, Uddin S, Al-Kuraya KS.

Cancer. 2015 Jun 1;121(11):1762-71. doi: 10.1002/cncr.29288. Epub 2015 Feb 24.

31.

A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma.

Siraj AK, Bu R, Prabhakaran S, Bavi P, Beg S, Al Hazmi M, Al-Rasheed M, Alobaisi K, Al-Dayel F, AlManea H, Al-Sanea N, Uddin S, Al-Kuraya KS.

Mol Cancer. 2014 Jul 8;13:168. doi: 10.1186/1476-4598-13-168.

32.

Clinico-pathological significance of TNF alpha-induced protein3 (TNFAIP3) in Middle Eastern colorectal carcinoma.

Bavi P, Abubaker J, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Uddin S, Siraj AK, Al-Kuraya KS.

Clin Epigenetics. 2011 Aug;2(2):417-8. doi: 10.1007/s13148-011-0049-z. Epub 2011 Jul 14. No abstract available.

33.

Colorectal cancer risk is not associated with increased levels of homozygosity in Saudi Arabia.

Siraj AK, Khalak HG, Sultana M, Al-Rasheed M, Bavi P, Al-Sanea N, Al-Dayel F, Uddin S, Alkuraya FS, Al-Kuraya KS.

Genet Med. 2013;14(8):720-728. doi: 10.1038/gim.2012.27. Epub 2012 Apr 5.

PMID:
22481135
34.

Role of leptin and its receptors in the pathogenesis of thyroid cancer.

Uddin S, Hussain AR, Siraj AK, Khan OS, Bavi PP, Al-Kuraya KS.

Int J Clin Exp Pathol. 2011;4(7):637-43. Epub 2011 Oct 3. Review.

35.

Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.

Uddin S, Ahmed M, Hussain A, Abubaker J, Al-Sanea N, AbdulJabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Jehan Z, Bavi P, Siraj AK, Al-Kuraya KS.

Am J Pathol. 2011 Feb;178(2):537-47. doi: 10.1016/j.ajpath.2010.10.020.

36.

Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis.

Siraj AK, Hussain AR, Al-Rasheed M, Ahmed M, Bavi P, Alsobhi SA, Al-Nuaim A, Uddin S, Al-Kuraya K.

J Clin Endocrinol Metab. 2011 Jan;96(1):E215-24. doi: 10.1210/jc.2010-0790. Epub 2010 Oct 6.

PMID:
20926535
37.

Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma.

Uddin S, Bavi P, Siraj AK, Ahmed M, Al-Rasheed M, Hussain AR, Ahmed M, Amin T, Alzahrani A, Al-Dayel F, Abubaker J, Bu R, Al-Kuraya KS.

Endocr Relat Cancer. 2010 Feb 18;17(1):191-202. doi: 10.1677/ERC-09-0153. Print 2010 Mar.

PMID:
20008098
38.

RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.

Siraj AK, Al-Rasheed M, Ibrahim M, Siddiqui K, Al-Dayel F, Al-Sanea O, Uddin S, Al-Kuraya K.

J Endocrinol Invest. 2008 Oct;31(10):893-9.

PMID:
19092295
39.

Distinct gene expression profiles: nodal versus extranodal diffuse large B-cell lymphoma.

Jehan Z, Siraj AK, Abubaker J, Ruiz C, Simon R, Sultana M, Uddin S, Bavi P, Hussain A, Razack S, Ezzat A, Al-Dayel F, Sauter G, Al-Kuraya KS.

Oncology. 2008;75(1-2):71-80. doi: 10.1159/000155144. Epub 2008 Sep 12.

PMID:
18784434
40.

Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers.

Uddin S, Siraj AK, Al-Rasheed M, Ahmed M, Bu R, Myers JN, Al-Nuaim A, Al-Sobhi S, Al-Dayel F, Bavi P, Hussain AR, Al-Kuraya KS.

J Clin Endocrinol Metab. 2008 Oct;93(10):4088-97. doi: 10.1210/jc.2008-0503. Epub 2008 Aug 5.

PMID:
18682509
41.

Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.

Siraj AK, Ibrahim M, Al-Rasheed M, Abubaker J, Bu R, Siddiqui SU, Al-Dayel F, Al-Sanea O, Al-Nuaim A, Uddin S, Al-Kuraya K.

BMC Med Genet. 2008 Jul 5;9:61. doi: 10.1186/1471-2350-9-61.

42.

Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population.

Al-Dayel F, Al-Rasheed M, Ibrahim M, Bu R, Bavi P, Abubaker J, Al-Jomah N, Mohamed GH, Moorji A, Uddin S, Siraj AK, Al-Kuraya K.

Leuk Lymphoma. 2008 Jan;49(1):122-9. doi: 10.1080/10428190701704605.

PMID:
18203021
43.

Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population.

Abubaker J, Bavi P, Al-Harbi S, Ibrahim M, Siraj AK, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Uddin S, Al-Kuraya KS.

Oncogene. 2008 Jun 5;27(25):3539-45. doi: 10.1038/sj.onc.1211013. Epub 2008 Jan 14.

PMID:
18193083
44.

Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways.

Bavi PP, Abubaker JA, Jehan ZD, Al-Jomah NA, Siraj AK, Al-Harbi SR, Atizado VL, Abduljabbar AS, Alhomoud SJ, Ashari LH, Al-Dayel FH, Uddin S, Al-Kuraya KS, Alsanea NA.

Saudi Med J. 2008 Jan;29(1):75-80.

PMID:
18176677
45.

Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East.

Siraj AK, Ibrahim M, Al-Rasheed M, Bu R, Bavi P, Jehan Z, Abubaker J, Murad W, Al-Dayel F, Ezzat A, El-Solh H, Uddin S, Al-Kuraya K.

Ann Hematol. 2007 Dec;86(12):887-95. Epub 2007 Aug 22.

PMID:
17712558
46.

Genome-wide expression analysis of Middle Eastern papillary thyroid cancer reveals c-MET as a novel target for cancer therapy.

Siraj AK, Bavi P, Abubaker J, Jehan Z, Sultana M, Al-Dayel F, Al-Nuaim A, Alzahrani A, Ahmed M, Al-Sanea O, Uddin S, Al-Kuraya KS.

J Pathol. 2007 Oct;213(2):190-9.

PMID:
17703498
47.

PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma.

Abubaker J, Bavi PP, Al-Harbi S, Siraj AK, Al-Dayel F, Uddin S, Al-Kuraya K.

Leukemia. 2007 Nov;21(11):2368-70. Epub 2007 Jul 26. No abstract available.

PMID:
17657213
48.

Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells.

Hussain AR, Al-Jomah NA, Siraj AK, Manogaran P, Al-Hussein K, Abubaker J, Platanias LC, Al-Kuraya KS, Uddin S.

Cancer Res. 2007 Apr 15;67(8):3888-97.

49.

Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival.

Uddin S, Hussain AR, Siraj AK, Manogaran PS, Al-Jomah NA, Moorji A, Atizado V, Al-Dayel F, Belgaumi A, El-Solh H, Ezzat A, Bavi P, Al-Kuraya KS.

Blood. 2006 Dec 15;108(13):4178-86. Epub 2006 Aug 31.

PMID:
16946303
50.

HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer.

Al-Kuraya K, Novotny H, Bavi P, Siraj AK, Uddin S, Ezzat A, Sanea NA, Al-Dayel F, Al-Mana H, Sheikh SS, Mirlacher M, Tapia C, Simon R, Sauter G, Terracciano L, Tornillo L.

J Clin Pathol. 2007 Jul;60(7):768-72. Epub 2006 Aug 1.

Supplemental Content

Loading ...
Support Center