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Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens.

Kashiwakura J, Okayama Y, Furue M, Kabashima K, Shimada S, Ra C, Siraganian RP, Kawakami Y, Kawakami T.

Allergy Asthma Immunol Res. 2012 Nov;4(6):332-40. doi: 10.4168/aair.2012.4.6.332. Epub 2012 Jun 25.


The transcription factor Zeb2 regulates signaling in mast cells.

Barbu EA, Zhang J, Berenstein EH, Groves JR, Parks LM, Siraganian RP.

J Immunol. 2012 Jun 15;188(12):6278-86. doi: 10.4049/jimmunol.1102660. Epub 2012 May 4.


Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.

de Castro RO, Zhang J, Groves JR, Barbu EA, Siraganian RP.

J Biol Chem. 2012 Mar 9;287(11):8194-204. doi: 10.1074/jbc.M111.326850. Epub 2012 Jan 20.


Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy.

Kashiwakura JC, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide DH, Kawakami Y, Kawakami T.

J Clin Invest. 2012 Jan;122(1):218-28. doi: 10.1172/JCI59072. Epub 2011 Dec 1.


Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants.

Siraganian RP, de Castro RO, Barbu EA, Zhang J.

FEBS Lett. 2010 Dec 15;584(24):4933-40. doi: 10.1016/j.febslet.2010.08.006. Epub 2010 Aug 7. Review.


Tyrosines in the carboxyl terminus regulate Syk kinase activity and function.

de Castro RO, Zhang J, Jamur MC, Oliver C, Siraganian RP.

J Biol Chem. 2010 Aug 20;285(34):26674-84. doi: 10.1074/jbc.M110.134262. Epub 2010 Jun 16.


Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation.

Zhang J, Mendoza M, Guiraldelli MF, Barbu EA, Siraganian RP.

J Immunol. 2010 Jun 15;184(12):7178-85. doi: 10.4049/jimmunol.0904169. Epub 2010 May 7.


The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.

Barbu EA, Zhang J, Siraganian RP.

J Biol Chem. 2010 May 21;285(21):15761-8. doi: 10.1074/jbc.M110.109413. Epub 2010 Mar 24.


FcepsilonRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.

Grodzki AC, Moon KD, Berenstein EH, Siraganian RP.

Mol Immunol. 2009 Aug;46(13):2539-47. doi: 10.1016/j.molimm.2009.05.013. Epub 2009 Jun 21.


IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species.

Sly LM, Kalesnikoff J, Lam V, Wong D, Song C, Omeis S, Chan K, Lee CW, Siraganian RP, Rivera J, Krystal G.

J Immunol. 2008 Sep 15;181(6):3850-60.


The low affinity IgG receptor Fc gamma RIIB contributes to the binding of the mast cell specific antibody, mAb BGD6.

Guiraldelli MF, Berenstein EH, Grodzki AC, Siraganian RP, Jamur MC, Oliver C.

Mol Immunol. 2008 Apr;45(8):2411-8. doi: 10.1016/j.molimm.2007.07.041. Epub 2008 Mar 4.


TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells.

Zhang J, Suzuki K, Hitomi T, Siraganian RP.

J Biol Chem. 2007 Dec 28;282(52):37669-77. Epub 2007 Oct 31.


Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?

Ganguly S, Grodzki C, Sugden D, Møller M, Odom S, Gaildrat P, Gery I, Siraganian RP, Rivera J, Klein DC.

J Biol Chem. 2007 Nov 9;282(45):32758-64. Epub 2007 Aug 29.


Mast cell-specific gangliosides and FcepsilonRI follow the same endocytic pathway from lipid rafts in RBL-2H3 cells.

Oliver C, Fujimura A, Silveira E Souza AM, Orlandini de Castro R, Siraganian RP, Jamur MC.

J Histochem Cytochem. 2007 Apr;55(4):315-25. Epub 2006 Dec 12.


Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells.

Mazzoni A, Siraganian RP, Leifer CA, Segal DM.

J Immunol. 2006 Sep 15;177(6):3577-81.


Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis.

Zudaire E, Martínez A, Garayoa M, Pío R, Kaur G, Woolhiser MR, Metcalfe DD, Hook WA, Siraganian RP, Guise TA, Chirgwin JM, Cuttitta F.

Am J Pathol. 2006 Jan;168(1):280-91.


Identification and characterization of undifferentiated mast cells in mouse bone marrow.

Jamur MC, Grodzki AC, Berenstein EH, Hamawy MM, Siraganian RP, Oliver C.

Blood. 2005 Jun 1;105(11):4282-9. Epub 2005 Feb 17.


Phospholipase D1 regulates high-affinity IgE receptor-induced mast cell degranulation.

Hitomi T, Zhang J, Nicoletti LM, Grodzki AC, Jamur MC, Oliver C, Siraganian RP.

Blood. 2004 Dec 15;104(13):4122-8. Epub 2004 Aug 31.


Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.

Zhang J, Chiang YJ, Hodes RJ, Siraganian RP.

J Immunol. 2004 Aug 1;173(3):1811-8.


Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.

Suzuki-Inoue K, Wilde JI, Andrews RK, Auger JM, Siraganian RP, Sekiya F, Rhee SG, Watson SP.

Biochem J. 2004 Mar 15;378(Pt 3):1023-9.


Alterations in granule matrix and cell surface of focal adhesion kinase-deficient mast cells.

Vial D, Oliver C, Jamur MC, Pastor MV, da Silva Trindade E, Berenstein E, Zhang J, Siraganian RP.

J Immunol. 2003 Dec 1;171(11):6178-86.


Mast cell signal transduction from the high-affinity IgE receptor.

Siraganian RP.

Curr Opin Immunol. 2003 Dec;15(6):639-46. Review.


Protein tyrosine kinase Syk in mast cell signaling.

Siraganian RP, Zhang J, Suzuki K, Sada K.

Mol Immunol. 2002 Sep;38(16-18):1229-33. Review.


The adapter molecule Gab2 regulates Fc epsilon RI-mediated signal transduction in mast cells.

Xie ZH, Ambudkar I, Siraganian RP.

J Immunol. 2002 May 1;168(9):4682-91.


Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival.

Kalesnikoff J, Huber M, Lam V, Damen JE, Zhang J, Siraganian RP, Krystal G.

Immunity. 2001 Jun;14(6):801-11.


Activated Cdc42/Rac reconstitutes Fcepsilon RI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells.

Hong-Geller E, Holowka D, Siraganian RP, Baird B, Cerione RA.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1154-9.


Identification and isolation of rat bone marrow-derived mast cells using the mast cell-specific monoclonal antibody AA4.

Jamur MC, Grodzki AC, Moreno AN, de Mello Lde F, Pastor MV, Berenstein EH, Siraganian RP, Oliver C.

J Histochem Cytochem. 2001 Feb;49(2):219-28.


Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.

Field KA, Apgar JR, Hong-Geller E, Siraganian RP, Baird B, Holowka D.

Mol Biol Cell. 2000 Oct;11(10):3661-73.


Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.

Kawakami Y, Kitaura J, Hartman SE, Lowell CA, Siraganian RP, Kawakami T.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7423-8.


The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1.

Arudchandran R, Brown MJ, Peirce MJ, Song JS, Zhang J, Siraganian RP, Blank U, Rivera J.

J Exp Med. 2000 Jan 3;191(1):47-60.


Point mutation of a tyrosine in the linker region of Syk results in a gain of function.

Sada K, Zhang J, Siraganian RP.

J Immunol. 2000 Jan 1;164(1):338-44.


A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling.

Latour S, Zhang J, Siraganian RP, Veillette A.

EMBO J. 1998 May 1;17(9):2584-95.


Immunomagnetic isolation of rat bone marrow-derived and peritoneal mast cells.

Jamur MC, Grodzki AC, Moreno AN, Swaim WD, Siraganian RP, Oliver C.

J Histochem Cytochem. 1997 Dec;45(12):1715-22.


Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcepsilonRI signaling.

Okazaki H, Zhang J, Hamawy MM, Siraganian RP.

J Biol Chem. 1997 Dec 19;272(51):32443-7.


The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31).

Sagawa K, Kimura T, Swieter M, Siraganian RP.

J Biol Chem. 1997 Dec 5;272(49):31086-91.


Reconstitution of high affinity IgE receptor-mediated secretion by transfecting protein tyrosine kinase pp125FAK.

Hamawy MM, Swieter M, Mergenhagen SE, Siraganian RP.

J Biol Chem. 1997 Nov 28;272(48):30498-503.


Fc epsilon RI aggregation induces tyrosine phosphorylation of a novel 72 kDa protein downstream of Syk.

Hamawy MM, Fischler C, Zhang J, Siraganian RP.

Biochem Biophys Res Commun. 1997 Oct 29;239(3):670-5.


Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor.

Kimura T, Zhang J, Sagawa K, Sakaguchi K, Appella E, Siraganian RP.

J Immunol. 1997 Nov 1;159(9):4426-34.


Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31).

Sagawa K, Swaim W, Zhang J, Unsworth E, Siraganian RP.

J Biol Chem. 1997 May 16;272(20):13412-8.


Immunocytochemical identification of immature rat peritoneal mast cells using a monoclonal antibody specific for rat mast cells.

Faraco CD, Vugman I, Siraganian RP, Jamur MC, Oliver C.

Acta Histochem. 1997 Mar;99(1):23-7.


Large scale isolation of intact rat basophilic leukemia (RBL-2H3) cells.

Hamawy MM, Siraganian RP.

J Immunol Methods. 1997 Feb 14;201(1):11-4.


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