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The promise of assistive technology in institutionalized old age care: economic efficiency, improved working conditions, and better quality of care?

Siren A, Amilon A, Larsen GK, Mehlsen L.

Disabil Rehabil Assist Technol. 2019 Sep 5:1-7. doi: 10.1080/17483107.2019.1659862. [Epub ahead of print]


Skull Fractures Induce Neuroinflammation and Worsen Outcomes after Closed Head Injury in Mice.

Zvejniece L, Stelfa G, Vavers E, Kupats E, Kuka J, Svalbe B, Zvejniece B, Albert-Weissenberger C, Sirén AL, Plesnila N, Dambrova M.

J Neurotrauma. 2019 Nov 8. doi: 10.1089/neu.2019.6524. [Epub ahead of print]


Cognition in adults with Williams syndrome-A 20-year follow-up study.

Sauna-Aho O, Bjelogrlic-Laakso N, Sirén A, Kangasmäki V, Arvio M.

Mol Genet Genomic Med. 2019 Jun;7(6):e695. doi: 10.1002/mgg3.695. Epub 2019 Apr 29.


Cohort Profile: The Danish Longitudinal Study of Ageing (DLSA).

Kjær AA, Siren A, Seestedt MH, Fridberg T, Casier F.

Int J Epidemiol. 2019 Aug 1;48(4):1050-1050g. doi: 10.1093/ije/dyz026. No abstract available.


Engaging Nurses in Future Management Careers: Perspectives on Leadership and Management Competency Development through an Internship Initiative.

Siren A, Gehrs M.

Nurs Leadersh (Tor Ont). 2018 Dec;31(4):36-49. doi: 10.12927/cjnl.2019.25757.


Expanding Urgent Oncofertility Services for Reproductive Age Women Remote from a Tertiary Level Fertility Centre by Use of Telemedicine and an On-site Nurse Navigator.

Zwingerman R, Melenchuk K, McMahon E, Liu KE, Siren A, Laferriere N, Greenblatt EM.

J Cancer Educ. 2019 Feb 28. doi: 10.1007/s13187-019-01490-w. [Epub ahead of print]


How is the formation of microthrombi after traumatic brain injury linked to inflammation?

Albert-Weissenberger C, Hopp S, Nieswandt B, Sirén AL, Kleinschnitz C, Stetter C.

J Neuroimmunol. 2019 Jan 15;326:9-13. doi: 10.1016/j.jneuroim.2018.10.011. Epub 2018 Oct 31. Review.


Modification and Initial Psychometric Evaluation of the Physical Health Attitude Scale for Use in the Canadian Mental Health and Addictions Context.

Siren A, Cleverley K, Strudwick G, Brennenstuhl S.

Issues Ment Health Nurs. 2018 Nov;39(11):946-953. doi: 10.1080/01612840.2018.1475523. Epub 2018 Aug 15.


Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study.

May P, Girard S, Harrer M, Bobbili DR, Schubert J, Wolking S, Becker F, Lachance-Touchette P, Meloche C, Gravel M, Niturad CE, Knaus J, De Kovel C, Toliat M, Polvi A, Iacomino M, Guerrero-López R, Baulac S, Marini C, Thiele H, Altmüller J, Jabbari K, Ruppert AK, Jurkowski W, Lal D, Rusconi R, Cestèle S, Terragni B, Coombs ID, Reid CA, Striano P, Caglayan H, Siren A, Everett K, Møller RS, Hjalgrim H, Muhle H, Helbig I, Kunz WS, Weber YG, Weckhuysen S, Jonghe P, Sisodiya SM, Nabbout R, Franceschetti S, Coppola A, Vari MS, Kasteleijn-Nolst Trenité D, Baykan B, Ozbek U, Bebek N, Klein KM, Rosenow F, Nguyen DK, Dubeau F, Carmant L, Lortie A, Desbiens R, Clément JF, Cieuta-Walti C, Sills GJ, Auce P, Francis B, Johnson MR, Marson AG, Berghuis B, Sander JW, Avbersek A, McCormack M, Cavalleri GL, Delanty N, Depondt C, Krenn M, Zimprich F, Peter S, Nikanorova M, Kraaij R, van Rooij J, Balling R, Ikram MA, Uitterlinden AG, Avanzini G, Schorge S, Petrou S, Mantegazza M, Sander T, LeGuern E, Serratosa JM, Koeleman BPC, Palotie A, Lehesjoki AE, Nothnagel M, Nürnberg P, Maljevic S, Zara F, Cossette P, Krause R, Lerche H; Epicure Consortium; EuroEPINOMICS CoGIE Consortium; EpiPGX Consortium.

Lancet Neurol. 2018 Aug;17(8):699-708. doi: 10.1016/S1474-4422(18)30215-1. Epub 2018 Jul 17.


Signs indicating dementia in Down, Williams and Fragile X syndromes.

Sauna-Aho O, Bjelogrlic-Laakso N, Siren A, Arvio M.

Mol Genet Genomic Med. 2018 Sep;6(5):855-860. doi: 10.1002/mgg3.430. Epub 2018 Jul 3.


Experiences from harvest-driven conservation: Management of Amazonian river turtles as a common-pool resource.

Harju E, Sirén AH, Salo M.

Ambio. 2018 Apr;47(3):327-339. doi: 10.1007/s13280-017-0943-5. Epub 2017 Sep 22. Review.


Changing and partially successful local institutions for harvest of thatch palm leaves.

Sirén AH.

Ambio. 2017 Nov;46(7):812-824. doi: 10.1007/s13280-017-0917-7. Epub 2017 Apr 18.


Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa.

Hopp S, Nolte MW, Stetter C, Kleinschnitz C, Sirén AL, Albert-Weissenberger C.

J Neuroinflammation. 2017 Feb 20;14(1):39. doi: 10.1186/s12974-017-0815-8.


Combined [(18)F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice.

Israel I, Ohsiek A, Al-Momani E, Albert-Weissenberger C, Stetter C, Mencl S, Buck AK, Kleinschnitz C, Samnick S, Sirén AL.

J Neuroinflammation. 2016 Jun 7;13(1):140. doi: 10.1186/s12974-016-0604-9.


Older Adults and Emerging Digital Service Delivery: A Mixed Methods Study on Information and Communications Technology Use, Skills, and Attitudes.

Siren A, Knudsen SG.

J Aging Soc Policy. 2017 Jan-Feb;29(1):35-50. doi: 10.1080/08959420.2016.1187036. Epub 2016 May 23.


Targeting coagulation factor XII as a novel therapeutic option in brain trauma.

Hopp S, Albert-Weissenberger C, Mencl S, Bieber M, Schuhmann MK, Stetter C, Nieswandt B, Schmidt PM, Monoranu CM, Alafuzoff I, Marklund N, Nolte MW, Sirén AL, Kleinschnitz C.

Ann Neurol. 2016 Jun;79(6):970-82. doi: 10.1002/ana.24655. Epub 2016 Apr 28.


Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.

Hassouna I, Ott C, Wüstefeld L, Offen N, Neher RA, Mitkovski M, Winkler D, Sperling S, Fries L, Goebbels S, Vreja IC, Hagemeyer N, Dittrich M, Rossetti MF, Kröhnert K, Hannke K, Boretius S, Zeug A, Höschen C, Dandekar T, Dere E, Neher E, Rizzoli SO, Nave KA, Sirén AL, Ehrenreich H.

Mol Psychiatry. 2016 Dec;21(12):1752-1767. doi: 10.1038/mp.2015.212. Epub 2016 Jan 26.


Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness.

Schulze M, Fedorchenko O, Zink TG, Knobbe-Thomsen CB, Kraus S, Schwinn S, Beilhack A, Reifenberger G, Monoranu CM, Sirén AL, Jeanclos E, Gohla A.

Oncogene. 2016 Jun 16;35(24):3163-77. doi: 10.1038/onc.2015.376. Epub 2015 Nov 9.


Human Parthenogenetic Embryonic Stem Cell-Derived Neural Stem Cells Express HLA-G and Show Unique Resistance to NK Cell-Mediated Killing.

Schmitt J, Eckardt S, Schlegel PG, Sirén AL, Bruttel VS, McLaughlin KJ, Wischhusen J, Müller AM.

Mol Med. 2015 Mar 23;21:185-96. doi: 10.2119/molmed.2014.00188.


Older drivers' reasons for reducing the overall amount of their driving and for avoiding selected driving situations.

Meng A, Siren A.

J Appl Gerontol. 2015 Apr;34(3):NP62-82. doi: 10.1177/0733464812463433. Epub 2012 Nov 5.


Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke.

Zerche M, Weissenborn K, Ott C, Dere E, Asif AR, Worthmann H, Hassouna I, Rentzsch K, Tryc AB, Dahm L, Steiner J, Binder L, Wiltfang J, Sirén AL, Stöcker W, Ehrenreich H.

Stroke. 2015 May;46(5):1180-6. doi: 10.1161/STROKEAHA.114.008323. Epub 2015 Mar 12.


Role of the kallikrein-kinin system in traumatic brain injury.

Albert-Weissenberger C, Mencl S, Hopp S, Kleinschnitz C, Sirén AL.

Front Cell Neurosci. 2014 Nov 3;8:345. doi: 10.3389/fncel.2014.00345. eCollection 2014. Review.


Experimental heart failure causes depression-like behavior together with differential regulation of inflammatory and structural genes in the brain.

Frey A, Popp S, Post A, Langer S, Lehmann M, Hofmann U, Sirén AL, Hommers L, Schmitt A, Strekalova T, Ertl G, Lesch KP, Frantz S.

Front Behav Neurosci. 2014 Oct 31;8:376. doi: 10.3389/fnbeh.2014.00376. eCollection 2014.


C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation.

Albert-Weissenberger C, Mencl S, Schuhmann MK, Salur I, Göb E, Langhauser F, Hopp S, Hennig N, Meuth SG, Nolte MW, Sirén AL, Kleinschnitz C.

Front Cell Neurosci. 2014 Sep 9;8:269. doi: 10.3389/fncel.2014.00269. eCollection 2014.


FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation.

Mencl S, Hennig N, Hopp S, Schuhmann MK, Albert-Weissenberger C, Sirén AL, Kleinschnitz C.

J Neuroimmunol. 2014 Sep 15;274(1-2):125-31. doi: 10.1016/j.jneuroim.2014.07.010. Epub 2014 Jul 22.


Neurobehavioral and cytotoxic effects of vanadium during oligodendrocyte maturation: a protective role for erythropoietin.

Mustapha O, Oke B, Offen N, Sirén AL, Olopade J.

Environ Toxicol Pharmacol. 2014 Jul;38(1):98-111. doi: 10.1016/j.etap.2014.05.001. Epub 2014 May 10.


X-exome sequencing in Finnish families with intellectual disability--four novel mutations and two novel syndromic phenotypes.

Philips AK, Sirén A, Avela K, Somer M, Peippo M, Ahvenainen M, Doagu F, Arvio M, Kääriäinen H, Van Esch H, Froyen G, Haas SA, Hu H, Kalscheuer VM, Järvelä I.

Orphanet J Rare Dis. 2014 Apr 11;9:49. doi: 10.1186/1750-1172-9-49.


Driving Cessation Anno 2010: Which Older Drivers Give Up Their License and Why? Evidence From Denmark.

Siren A, Haustein S.

J Appl Gerontol. 2016 Jan;35(1):18-38. doi: 10.1177/0733464814521690. Epub 2014 Feb 12.


Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.

Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL.

Mol Med. 2013 Nov 8;19:399-408. doi: 10.2119/molmed.2013.00136.


A new locus for familial temporal lobe epilepsy on chromosome 3q.

Chahine L, Abou-Khalil B, Siren A, Andermann F, Hedera P, Ge Q, Andermann E, Pandolfo M.

Epilepsy Res. 2013 Oct;106(3):338-44. doi: 10.1016/j.eplepsyres.2013.07.007. Epub 2013 Aug 14.


Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.

Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H.

Mol Psychiatry. 2014 Oct;19(10):1143-9. doi: 10.1038/mp.2013.110. Epub 2013 Sep 3.


Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells.

Wolber W, Ahmad R, Choi SW, Eckardt S, McLaughlin KJ, Schmitt J, Geis C, Heckmann M, Sirén AL, Müller AM.

Cell Med. 2013 Jun 13;5(1):29-42. doi: 10.3727/215517913X666468. eCollection 2013 Aug 10.


An experimental protocol for in vivo imaging of neuronal structural plasticity with 2-photon microscopy in mice.

Stetter C, Hirschberg M, Nieswandt B, Ernestus RI, Heckmann M, Sirén AL.

Exp Transl Stroke Med. 2013 Jul 10;5(1):9. doi: 10.1186/2040-7378-5-9.


Ischemic stroke and traumatic brain injury: the role of the kallikrein-kinin system.

Albert-Weißenberger C, Sirén AL, Kleinschnitz C.

Prog Neurobiol. 2013 Feb-Mar;101-102:65-82. doi: 10.1016/j.pneurobio.2012.11.004. Epub 2012 Dec 27. Review.


Cognitive problems, self-rated changes in driving skills, driving-related discomfort and self-regulation of driving in old drivers.

Meng A, Siren A.

Accid Anal Prev. 2012 Nov;49:322-9. doi: 10.1016/j.aap.2012.01.023. Epub 2012 Feb 12.


Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.

EPICURE Consortium; EMINet Consortium, Steffens M, Leu C, Ruppert AK, Zara F, Striano P, Robbiano A, Capovilla G, Tinuper P, Gambardella A, Bianchi A, La Neve A, Crichiutti G, de Kovel CG, Kasteleijn-Nolst Trenité D, de Haan GJ, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Steinhoff BJ, Kleefuß-Lie AA, Kunz WS, Surges R, Elger CE, Muhle H, von Spiczak S, Ostertag P, Helbig I, Stephani U, Møller RS, Hjalgrim H, Dibbens LM, Bellows S, Oliver K, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C, Guerrini R, Lehesjoki AE, Siren A, Guipponi M, Malafosse A, Thomas P, Nabbout R, Baulac S, Leguern E, Guerrero R, Serratosa JM, Reif PS, Rosenow F, Mörzinger M, Feucht M, Zimprich F, Kapser C, Schankin CJ, Suls A, Smets K, De Jonghe P, Jordanova A, Caglayan H, Yapici Z, Yalcin DA, Baykan B, Bebek N, Ozbek U, Gieger C, Wichmann HE, Balschun T, Ellinghaus D, Franke A, Meesters C, Becker T, Wienker TF, Hempelmann A, Schulz H, Rüschendorf F, Leber M, Pauck SM, Trucks H, Toliat MR, Nürnberg P, Avanzini G, Koeleman BP, Sander T.

Hum Mol Genet. 2012 Dec 15;21(24):5359-72. doi: 10.1093/hmg/dds373. Epub 2012 Sep 4.


The relationship between ventricular dilatation, neuropathological and neurobehavioural changes in hydrocephalic rats.

Olopade FE, Shokunbi MT, Sirén AL.

Fluids Barriers CNS. 2012 Sep 1;9(1):19. doi: 10.1186/2045-8118-9-19.


Functional neuronal cells generated by human parthenogenetic stem cells.

Ahmad R, Wolber W, Eckardt S, Koch P, Schmitt J, Semechkin R, Geis C, Heckmann M, Brüstle O, McLaughlin JK, Sirén AL, Müller AM.

PLoS One. 2012;7(8):e42800. doi: 10.1371/journal.pone.0042800. Epub 2012 Aug 6.


Ectopic expression of neurogenin 2 alone is sufficient to induce differentiation of embryonic stem cells into mature neurons.

Thoma EC, Wischmeyer E, Offen N, Maurus K, Sirén AL, Schartl M, Wagner TU.

PLoS One. 2012;7(6):e38651. doi: 10.1371/journal.pone.0038651. Epub 2012 Jun 13.


Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.

Albert-Weissenberger C, Stetter C, Meuth SG, Göbel K, Bader M, Sirén AL, Kleinschnitz C.

J Cereb Blood Flow Metab. 2012 Sep;32(9):1747-56. doi: 10.1038/jcbfm.2012.62. Epub 2012 May 9.


Focal brain trauma in the cryogenic lesion model in mice.

Raslan F, Albert-Weißenberger C, Ernestus RI, Kleinschnitz C, Sirén AL.

Exp Transl Stroke Med. 2012 Apr 5;4:6. doi: 10.1186/2040-7378-4-6.


An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice.

Albert-Weißenberger C, Várrallyay C, Raslan F, Kleinschnitz C, Sirén AL.

Exp Transl Stroke Med. 2012 Feb 2;4:1. doi: 10.1186/2040-7378-4-1.


Cognitive screening of older drivers does not produce safety benefits.

Siren A, Meng A.

Accid Anal Prev. 2012 Mar;45:634-8. doi: 10.1016/j.aap.2011.09.032. Epub 2011 Oct 5.


Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies.

EPICURE Consortium, Leu C, de Kovel CG, Zara F, Striano P, Pezzella M, Robbiano A, Bianchi A, Bisulli F, Coppola A, Giallonardo AT, Beccaria F, Trenité DK, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Kleefuss-Lie AA, Hallman K, Kunz WS, Elger CE, Muhle H, Stephani U, Møller RS, Hjalgrim H, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C, Guerrini R, Lehesjoki AE, Siren A, Nabbout R, Baulac S, Leguern E, Serratosa JM, Rosenow F, Feucht M, Unterberger I, Covanis A, Suls A, Weckhuysen S, Kaneva R, Caglayan H, Turkdogan D, Baykan B, Bebek N, Ozbek U, Hempelmann A, Schulz H, Rüschendorf F, Trucks H, Nürnberg P, Avanzini G, Koeleman BP, Sander T.

Epilepsia. 2012 Feb;53(2):308-18. doi: 10.1111/j.1528-1167.2011.03379.x. Epub 2012 Jan 13.


Shared loci for migraine and epilepsy on chromosomes 14q12-q23 and 12q24.2-q24.3.

Polvi A, Siren A, Kallela M, Rantala H, Artto V, Sobel EM, Palotie A, Lehesjoki AE, Wessman M.

Neurology. 2012 Jan 17;78(3):202-9. doi: 10.1212/WNL.0b013e31823fcd87. Epub 2012 Jan 4.


Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition.

Geis C, Weishaupt A, Hallermann S, Grünewald B, Wessig C, Wultsch T, Reif A, Byts N, Beck M, Jablonka S, Boettger MK, Üçeyler N, Fouquet W, Gerlach M, Meinck HM, Sirén AL, Sigrist SJ, Toyka KV, Heckmann M, Sommer C.

Brain. 2010 Nov;133(11):3166-80. doi: 10.1093/brain/awq253. Epub 2010 Sep 30.


Experimental traumatic brain injury.

Albert-Weissenberger C, Sirén AL.

Exp Transl Stroke Med. 2010 Aug 13;2(1):16. doi: 10.1186/2040-7378-2-16.


Erythropoietin: not just about erythropoiesis.

Ghezzi P, Bernaudin M, Bianchi R, Blomgren K, Brines M, Campana W, Cavaletti G, Cerami A, Chopp M, Coleman T, Digicaylioglu M, Ehrenreich H, Erbayraktar S, Erbayraktar Z, Gassmann M, Genc S, Gokmen N, Grasso G, Juul S, Lipton SA, Hand CC, Latini R, Lauria G, Leist M, Newton SS, Petit E, Probert L, Sfacteria A, Siren AL, Talan M, Thiemermann C, Westenbrink D, Yaqoob M, Zhu C.

Lancet. 2010 Jun 19;375(9732):2142. doi: 10.1016/S0140-6736(10)60992-0. No abstract available. Erratum in: Lancet. 2010 Aug 7;376(9739):418. Bernaudinb, Myriam [corrected to Bernaudin, Myrian]; Bianchic, Roberto [corrected to Bianchi, Roberto].


Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.

Raslan F, Schwarz T, Meuth SG, Austinat M, Bader M, Renné T, Roosen K, Stoll G, Sirén AL, Kleinschnitz C.

J Cereb Blood Flow Metab. 2010 Aug;30(8):1477-86. doi: 10.1038/jcbfm.2010.28. Epub 2010 Mar 3.


Whole-genome linkage scan for epilepsy-related photosensitivity: a mega-analysis.

de Kovel CG, Pinto D, Tauer U, Lorenz S, Muhle H, Leu C, Neubauer BA, Hempelmann A, Callenbach PM, Scheffer IE, Berkovic SF, Rudolf G, Striano P, Siren A, Baykan B, Sander T, Lindhout D, Kasteleijn-Nolst Trenité DG, Stephani U, Koeleman BP.

Epilepsy Res. 2010 May;89(2-3):286-94. doi: 10.1016/j.eplepsyres.2010.01.013. Epub 2010 Feb 12.


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