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Items: 38


RNA-protein interaction detection in living cells.

Ramanathan M, Majzoub K, Rao DS, Neela PH, Zarnegar BJ, Mondal S, Roth JG, Gai H, Kovalski JR, Siprashvili Z, Palmer TD, Carette JE, Khavari PA.

Nat Methods. 2018 Mar;15(3):207-212. doi: 10.1038/nmeth.4601. Epub 2018 Feb 5.


CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue.

Bao X, Siprashvili Z, Zarnegar BJ, Shenoy RM, Rios EJ, Nady N, Qu K, Mah A, Webster DE, Rubin AJ, Wozniak GG, Tao S, Wysocka J, Khavari PA.

Dev Cell. 2017 Oct 23;43(2):227-239.e5. doi: 10.1016/j.devcel.2017.08.021. Epub 2017 Sep 21.


Novel lincRNA SLINKY is a prognostic biomarker in kidney cancer.

Gong X, Siprashvili Z, Eminaga O, Shen Z, Sato Y, Kume H, Homma Y, Ogawa S, Khavari PA, Pollack JR, Brooks JD.

Oncotarget. 2017 Mar 21;8(12):18657-18669. doi: 10.18632/oncotarget.15703.


Safety and Wound Outcomes Following Genetically Corrected Autologous Epidermal Grafts in Patients With Recessive Dystrophic Epidermolysis Bullosa.

Siprashvili Z, Nguyen NT, Gorell ES, Loutit K, Khuu P, Furukawa LK, Lorenz HP, Leung TH, Keene DR, Rieger KE, Khavari P, Lane AT, Tang JY, Marinkovich MP.

JAMA. 2016 Nov 1;316(17):1808-1817. doi: 10.1001/jama.2016.15588.


The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer.

Siprashvili Z, Webster DE, Johnston D, Shenoy RM, Ungewickell AJ, Bhaduri A, Flockhart R, Zarnegar BJ, Che Y, Meschi F, Puglisi JD, Khavari PA.

Nat Genet. 2016 Jan;48(1):53-8. doi: 10.1038/ng.3452. Epub 2015 Nov 23.


CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.

Sun BK, Boxer LD, Ransohoff JD, Siprashvili Z, Qu K, Lopez-Pajares V, Hollmig ST, Khavari PA.

Genes Dev. 2015 Nov 1;29(21):2225-30. doi: 10.1101/gad.267708.115.


A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation.

Lopez-Pajares V, Qu K, Zhang J, Webster DE, Barajas BC, Siprashvili Z, Zarnegar BJ, Boxer LD, Rios EJ, Tao S, Kretz M, Khavari PA.

Dev Cell. 2015 Mar 23;32(6):693-706. doi: 10.1016/j.devcel.2015.01.028.


Characterization of patients with dystrophic epidermolysis bullosa for collagen VII therapy.

Gorell ES, Nguyen N, Siprashvili Z, Marinkovich MP, Lane AT.

Br J Dermatol. 2015 Sep;173(3):821-3. doi: 10.1111/bjd.13737. Epub 2015 Jul 27. No abstract available.


Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa.

Sebastiano V, Zhen HH, Haddad B, Bashkirova E, Melo SP, Wang P, Leung TL, Siprashvili Z, Tichy A, Li J, Ameen M, Hawkins J, Lee S, Li L, Schwertschkow A, Bauer G, Lisowski L, Kay MA, Kim SK, Lane AT, Wernig M, Oro AE.

Sci Transl Med. 2014 Nov 26;6(264):264ra163. doi: 10.1126/scitranslmed.3009540. Erratum in: Sci Transl Med. 2014 Dec 17;6(267):267er8. Derafshi, Bahareh Haddad [corrected to Haddad, Bahareh].


Advances in skin grafting and treatment of cutaneous wounds.

Sun BK, Siprashvili Z, Khavari PA.

Science. 2014 Nov 21;346(6212):941-5. doi: 10.1126/science.1253836. Review.


Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.

Marques Howarth M, Simpson D, Ngok SP, Nieves B, Chen R, Siprashvili Z, Vaka D, Breese MR, Crompton BD, Alexe G, Hawkins DS, Jacobson D, Brunner AL, West R, Mora J, Stegmaier K, Khavari P, Sweet-Cordero EA.

J Clin Invest. 2014 Dec;124(12):5275-90. doi: 10.1172/JCI72124. Epub 2014 Nov 17.


Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma.

Lee CS, Bhaduri A, Mah A, Johnson WL, Ungewickell A, Aros CJ, Nguyen CB, Rios EJ, Siprashvili Z, Straight A, Kim J, Aasi SZ, Khavari PA.

Nat Genet. 2014 Oct;46(10):1060-2. doi: 10.1038/ng.3091. Epub 2014 Sep 7.


Gene therapy for skin diseases.

Gorell E, Nguyen N, Lane A, Siprashvili Z.

Cold Spring Harb Perspect Med. 2014 Apr 1;4(4):a015149. doi: 10.1101/cshperspect.a015149. Review.


Control of somatic tissue differentiation by the long non-coding RNA TINCR.

Kretz M, Siprashvili Z, Chu C, Webster DE, Zehnder A, Qu K, Lee CS, Flockhart RJ, Groff AF, Chow J, Johnston D, Kim GE, Spitale RC, Flynn RA, Zheng GX, Aiyer S, Raj A, Rinn JL, Chang HY, Khavari PA.

Nature. 2013 Jan 10;493(7431):231-5. doi: 10.1038/nature11661. Epub 2012 Dec 2.


Identification of proteins binding coding and non-coding human RNAs using protein microarrays.

Siprashvili Z, Webster DE, Kretz M, Johnston D, Rinn JL, Chang HY, Khavari PA.

BMC Genomics. 2012 Nov 16;13:633. doi: 10.1186/1471-2164-13-633.


ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation.

Sen GL, Boxer LD, Webster DE, Bussat RT, Qu K, Zarnegar BJ, Johnston D, Siprashvili Z, Khavari PA.

Dev Cell. 2012 Mar 13;22(3):669-77. doi: 10.1016/j.devcel.2011.12.001. Epub 2012 Feb 23.


Suppression of progenitor differentiation requires the long noncoding RNA ANCR.

Kretz M, Webster DE, Flockhart RJ, Lee CS, Zehnder A, Lopez-Pajares V, Qu K, Zheng GX, Chow J, Kim GE, Rinn JL, Chang HY, Siprashvili Z, Khavari PA.

Genes Dev. 2012 Feb 15;26(4):338-43. doi: 10.1101/gad.182121.111. Epub 2012 Feb 2.


Long-term type VII collagen restoration to human epidermolysis bullosa skin tissue.

Siprashvili Z, Nguyen NT, Bezchinsky MY, Marinkovich MP, Lane AT, Khavari PA.

Hum Gene Ther. 2010 Oct;21(10):1299-310. doi: 10.1089/hum.2010.023.


Influence of a nonfragile FHIT transgene on murine tumor susceptibility.

McCorkell KA, Mancini R, Siprashvili Z, Barnoski BL, Iliopoulos D, Siracusa LD, Zanesi N, Croce CM, Fong LY, Druck T, Huebner K.

Cytogenet Genome Res. 2007;118(2-4):196-203.


Intracellular delivery of functional proteins via decoration with transporter peptides.

Siprashvili Z, Reuter JA, Khavari PA.

Mol Ther. 2004 May;9(5):721-8.


Lentivectors for regulated and reversible cutaneous gene delivery.

Siprashvili Z, Khavari PA.

Mol Ther. 2004 Jan;9(1):93-100.


Breaching biological barriers: protein translocation domains as tools for molecular imaging and therapy.

Franc BL, Mandl SJ, Siprashvili Z, Wender P, Contag CH.

Mol Imaging. 2003 Oct;2(4):313-23. Review.


Gene transfer via reversible plasmid condensation with cysteine-flanked, internally spaced arginine-rich peptides.

Siprashvili Z, Scholl FA, Oliver SF, Adams A, Contag CH, Wender PA, Khavari PA.

Hum Gene Ther. 2003 Sep 1;14(13):1225-33.


Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression.

Werner NS, Siprashvili Z, Fong LY, Marquitan G, Schröder JK, Bardenheuer W, Seeber S, Huebner K, Schütte J, Opalka B.

Cancer Res. 2000 Jun 1;60(11):2780-5.


Muir-Torre-like syndrome in Fhit-deficient mice.

Fong LY, Fidanza V, Zanesi N, Lock LF, Siracusa LD, Mancini R, Siprashvili Z, Ottey M, Martin SE, Druck T, McCue PA, Croce CM, Huebner K.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4742-7.


The role of deletions at the FRA3B/FHIT locus in carcinogenesis.

Huebner K, Druck T, Siprashvili Z, Croce CM, Kovatich A, McCue PA.

Recent Results Cancer Res. 1998;154:200-15.


Absence or reduction of Fhit expression in most clear cell renal carcinomas.

Hadaczek P, Siprashvili Z, Markiewski M, Domagala W, Druck T, McCue PA, Pekarsky Y, Ohta M, Huebner K, Lubinski J.

Cancer Res. 1998 Jul 15;58(14):2946-51.


Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans.

Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM, Mazo A, Brenner C, Croce CM.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8744-9.


Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.

Pace HC, Garrison PN, Robinson AK, Barnes LD, Draganescu A, Rösler A, Blackburn GM, Siprashvili Z, Croce CM, Huebner K, Brenner C.

Proc Natl Acad Sci U S A. 1998 May 12;95(10):5484-9.


Replacement of Fhit in cancer cells suppresses tumorigenicity.

Siprashvili Z, Sozzi G, Barnes LD, McCue P, Robinson AK, Eryomin V, Sard L, Tagliabue E, Greco A, Fusetti L, Schwartz G, Pierotti MA, Croce CM, Huebner K.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13771-6.


The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.

Huebner K, Hadaczek P, Siprashvili Z, Druck T, Croce CM.

Biochim Biophys Acta. 1997 Jun 7;1332(3):M65-70. Review. No abstract available.


Structure and expression of the human FHIT gene in normal and tumor cells.

Druck T, Hadaczek P, Fu TB, Ohta M, Siprashvili Z, Baffa R, Negrini M, Kastury K, Veronese ML, Rosen D, Rothstein J, McCue P, Cotticelli MG, Inoue H, Croce CM, Huebner K.

Cancer Res. 1997 Feb 1;57(3):504-12.


Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.

Barnes LD, Garrison PN, Siprashvili Z, Guranowski A, Robinson AK, Ingram SW, Croce CM, Ohta M, Huebner K.

Biochemistry. 1996 Sep 10;35(36):11529-35.


The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.

Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K.

Cell. 1996 Feb 23;84(4):587-97.


[Protein engineering of uridine phosphorylase from Escherichia coli K-12. Study of the role of cysteine residues in enzyme function].

Veĭko VP, Siprashvili ZZ, Ratmanova KI, Gul'ko LB, Mironov AA.

Mol Biol (Mosk). 1996 Jan-Feb;30(1):170-6. Russian. No abstract available.


[Study of the role of histidine residues in the function of uridine phosphorylase from Escherichia coli K-12 by protein engineering].

Veĭko VP, Siprashvili ZZ, Ratmanova KI, Gul'ko LB.

Bioorg Khim. 1995 Nov;21(11):834-7. Russian.


[Structure-function organization of uridine phosphorylase from Escherichia coli].

Veĭko VP, Siprashvili ZZ, Ratmanova KI, Gul'ko LB, Mironov AA, Andriukhina RV, Debabov VG.

Dokl Akad Nauk. 1994 Dec;339(6):819-21. Russian. No abstract available.


Isolation, crystallization in the macrogravitation field, preliminary X-ray investigation of uridine phosphorylase from Escherichia coli K-12.

Mikhailov AM, Smirnova EA, Tsuprun VL, Tagunova IV, Vainshtein BK, Linkova EV, Komissarov AA, Siprashvili ZZ, Mironov AS.

Biochem Int. 1992 Mar;26(4):607-15.


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