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Items: 25


The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity.

Li A, Lu X, Natoli T, Bittker J, Sipes NS, Subramanian A, Auerbach S, Sherr DH, Monti S.

Environ Health Perspect. 2019 Apr;127(4):47002. doi: 10.1289/EHP3986.


Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements.

Hubbard TD, Hsieh JH, Rider CV, Sipes NS, Sedykh A, Collins BJ, Auerbach SS, Xia M, Huang R, Walker NJ, DeVito MJ.

Appl In Vitro Toxicol. 2019 Mar 1;5(1):10-25. doi: 10.1089/aivt.2018.0020. Epub 2019 Mar 9.


Screening for neurotoxic potential of 15 flame retardants using freshwater planarians.

Zhang S, Ireland D, Sipes NS, Behl M, Collins ES.

Neurotoxicol Teratol. 2019 Mar 31;73:54-66. doi: 10.1016/ [Epub ahead of print]


The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High-throughput Transcriptomics and Benchmark Concentration Modeling.

Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS.

Toxicol Sci. 2019 Mar 8. pii: kfz065. doi: 10.1093/toxsci/kfz065. [Epub ahead of print]


Screening for Developmental Neurotoxicity at the National Toxicology Program: The Future Is Here.

Behl M, Ryan K, Hsieh JH, Parham F, Shapiro AJ, Collins BJ, Sipes NS, Birnbaum LS, Bucher JR, Foster PMD, Walker NJ, Paules RS, Tice RR.

Toxicol Sci. 2019 Jan 1;167(1):6-14. doi: 10.1093/toxsci/kfy278.


Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance.

Alzualde A, Behl M, Sipes NS, Hsieh JH, Alday A, Tice RR, Paules RS, Muriana A, Quevedo C.

Neurotoxicol Teratol. 2018 Nov - Dec;70:40-50. doi: 10.1016/ Epub 2018 Oct 9.


Identifying Attributes That Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity Versus In Vivo DrugMatrix Transcriptomic Responses Across 130 Chemicals.

Klaren WD, Ring C, Harris MA, Thompson CM, Borghoff S, Sipes NS, Hsieh JH, Auerbach SS, Rager JE.

Toxicol Sci. 2019 Jan 1;167(1):157-171. doi: 10.1093/toxsci/kfy220.


A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics.

Mav D, Shah RR, Howard BE, Auerbach SS, Bushel PR, Collins JB, Gerhold DL, Judson RS, Karmaus AL, Maull EA, Mendrick DL, Merrick BA, Sipes NS, Svoboda D, Paules RS.

PLoS One. 2018 Feb 20;13(2):e0191105. doi: 10.1371/journal.pone.0191105. eCollection 2018.


Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics.

Wambaugh JF, Hughes MF, Ring CL, MacMillan DK, Ford J, Fennell TR, Black SR, Snyder RW, Sipes NS, Wetmore BA, Westerhout J, Setzer RW, Pearce RG, Simmons JE, Thomas RS.

Toxicol Sci. 2018 May 1;163(1):152-169. doi: 10.1093/toxsci/kfy020.


In vitro to in vivo extrapolation for high throughput prioritization and decision making.

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes NS, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC.

Toxicol In Vitro. 2018 Mar;47:213-227. doi: 10.1016/j.tiv.2017.11.016. Epub 2017 Dec 5. Review.


An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library.

Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS.

Environ Sci Technol. 2017 Sep 19;51(18):10786-10796. doi: 10.1021/acs.est.7b00650. Epub 2017 Sep 6.


httk: R Package for High-Throughput Toxicokinetics.

Pearce RG, Setzer RW, Strope CL, Wambaugh JF, Sipes NS.

J Stat Softw. 2017 Jul 17;79(4):1-26. doi: 10.18637/jss.v079.i04.


Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes.

Leung MC, Phuong J, Baker NC, Sipes NS, Klinefelter GR, Martin MT, McLaurin KW, Setzer RW, Darney SP, Judson RS, Knudsen TB.

Environ Health Perspect. 2016 Jul;124(7):1050-61. doi: 10.1289/ehp.1510385. Epub 2015 Dec 11.


Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes.

Pei Y, Peng J, Behl M, Sipes NS, Shockley KR, Rao MS, Tice RR, Zeng X.

Brain Res. 2016 May 1;1638(Pt A):57-73. doi: 10.1016/j.brainres.2015.07.048. Epub 2015 Aug 5.


Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses.

Rotroff DM, Martin MT, Dix DJ, Filer DL, Houck KA, Knudsen TB, Sipes NS, Reif DM, Xia M, Huang R, Judson RS.

Environ Sci Technol. 2014;48(15):8706-16. doi: 10.1021/es502676e. Epub 2014 Jul 10.


Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells.

Rotroff DM, Dix DJ, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Reif DM, Richard AM, Sipes NS, Abassi YA, Jin C, Stampfl M, Judson RS.

Chem Res Toxicol. 2013 Jul 15;26(7):1097-107. doi: 10.1021/tx400117y. Epub 2013 Jun 10.


Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays.

Sipes NS, Martin MT, Kothiya P, Reif DM, Judson RS, Richard AM, Houck KA, Dix DJ, Kavlock RJ, Knudsen TB.

Chem Res Toxicol. 2013 Jun 17;26(6):878-95. doi: 10.1021/tx400021f. Epub 2013 May 16.


Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.

Dix DJ, Houck KA, Judson RS, Kleinstreuer NC, Knudsen TB, Martin MT, Reif DM, Richard AM, Shah I, Sipes NS, Kavlock RJ.

Toxicol Sci. 2012 Dec;130(2):440-1; author reply 442-3. doi: 10.1093/toxsci/kfs281. Epub 2012 Sep 14. No abstract available.


Zebrafish: as an integrative model for twenty-first century toxicity testing.

Sipes NS, Padilla S, Knudsen TB.

Birth Defects Res C Embryo Today. 2011 Sep;93(3):256-67. doi: 10.1002/bdrc.20214. Review.


Cdc42 regulates extracellular matrix remodeling in three dimensions.

Sipes NS, Feng Y, Guo F, Lee HO, Chou FS, Cheng J, Mulloy J, Zheng Y.

J Biol Chem. 2011 Oct 21;286(42):36469-77. doi: 10.1074/jbc.M111.283176. Epub 2011 Aug 31.


Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.

Sipes NS, Martin MT, Reif DM, Kleinstreuer NC, Judson RS, Singh AV, Chandler KJ, Dix DJ, Kavlock RJ, Knudsen TB.

Toxicol Sci. 2011 Nov;124(1):109-27. doi: 10.1093/toxsci/kfr220. Epub 2011 Aug 26.


Environmental impact on vascular development predicted by high-throughput screening.

Kleinstreuer NC, Judson RS, Reif DM, Sipes NS, Singh AV, Chandler KJ, Dewoskin R, Dix DJ, Kavlock RJ, Knudsen TB.

Environ Health Perspect. 2011 Nov;119(11):1596-603. doi: 10.1289/ehp.1103412. Epub 2011 Jul 25.


Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay.

Chandler KJ, Barrier M, Jeffay S, Nichols HP, Kleinstreuer NC, Singh AV, Reif DM, Sipes NS, Judson RS, Dix DJ, Kavlock R, Hunter ES 3rd, Knudsen TB.

PLoS One. 2011;6(6):e18540. doi: 10.1371/journal.pone.0018540. Epub 2011 Jun 7.


Activity profiles of 309 ToxCastâ„¢ chemicals evaluated across 292 biochemical targets.

Knudsen TB, Houck KA, Sipes NS, Singh AV, Judson RS, Martin MT, Weissman A, Kleinstreuer NC, Mortensen HM, Reif DM, Rabinowitz JR, Setzer RW, Richard AM, Dix DJ, Kavlock RJ.

Toxicology. 2011 Mar 28;282(1-2):1-15. doi: 10.1016/j.tox.2010.12.010. Epub 2011 Jan 18.


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