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Fast and efficient titration of HCMV stocks with a self-excisable BAC cassette by flow cytometry.

Basílio-Queirós D, Venturini L, Sampaio KL, Sinzger C, Mischak-Weissinger EM.

Hum Gene Ther Methods. 2019 Jul 6. doi: 10.1089/hgtb.2019.084. [Epub ahead of print]


Dense bodies of a gH/gL/UL128-131 pentamer repaired Towne strain of human cytomegalovirus induce an enhanced neutralizing antibody response.

Lehmann C, Falk JJ, Büscher N, Penner I, Zimmermann C, Gogesch P, Sinzger C, Plachter B.

J Virol. 2019 Jun 12. pii: JVI.00931-19. doi: 10.1128/JVI.00931-19. [Epub ahead of print]


The N Terminus of Human Cytomegalovirus Glycoprotein O Is Important for Binding to the Cellular Receptor PDGFRα.

Stegmann C, Rothemund F, Laib Sampaio K, Adler B, Sinzger C.

J Virol. 2019 May 15;93(11). pii: e00138-19. doi: 10.1128/JVI.00138-19. Print 2019 Jun 1.


Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34+ Cells.

Theobald SJ, Khailaie S, Meyer-Hermann M, Volk V, Olbrich H, Danisch S, Gerasch L, Schneider A, Sinzger C, Schaudien D, Lienenklaus S, Riese P, Guzman CA, Figueiredo C, von Kaisenberg C, Spineli LM, Glaesener S, Meyer-Bahlburg A, Ganser A, Schmitt M, Mach M, Messerle M, Stripecke R.

Front Immunol. 2018 Nov 22;9:2734. doi: 10.3389/fimmu.2018.02734. eCollection 2018.


Investigating HCMV entry into host cells by STEM tomography.

Abdellatif MEA, Sinzger C, Walther P.

J Struct Biol. 2018 Dec;204(3):406-419. doi: 10.1016/j.jsb.2018.10.007. Epub 2018 Oct 20.


Inhibition of Tetraspanin Functions Impairs Human Papillomavirus and Cytomegalovirus Infections.

Fast LA, Mikuličić S, Fritzen A, Schwickert J, Boukhallouk F, Hochdorfer D, Sinzger C, Suarez H, Monk PN, Yáñez-Mó M, Lieber D, Florin L.

Int J Mol Sci. 2018 Oct 2;19(10). pii: E3007. doi: 10.3390/ijms19103007.


Large-Scale Screening of HCMV-Seropositive Blood Donors Indicates that HCMV Effectively Escapes from Antibodies by Cell-Associated Spread.

Falk JJ, Winkelmann M, Laib Sampaio K, Paal C, Schrezenmeier H, Alt M, Stanton R, Krawczyk A, Lotfi R, Sinzger C.

Viruses. 2018 Sep 14;10(9). pii: E500. doi: 10.3390/v10090500.


Detection of antibody-secreting cells specific for the cytomegalovirus and herpes simplex virus surface antigens.

Alt M, Falk J, Eis-Hübinger AM, Kropff B, Sinzger C, Krawczyk A.

J Immunol Methods. 2018 Nov;462:13-22. doi: 10.1016/j.jim.2018.07.010. Epub 2018 Jul 27.


Identification of Elite Neutralizers With Broad and Potent Neutralizing Activity Against Human Cytomegalovirus (HCMV) in a Population of HCMV-Seropositive Blood Donors.

Falk JJ, Winkelmann M, Stöhr D, Alt M, Schrezenmeier H, Krawczyk A, Lotfi R, Sinzger C.

J Infect Dis. 2018 Aug 14;218(6):876-885. doi: 10.1093/infdis/jiy229.


A TB40/E-derived human cytomegalovirus genome with an intact US-gene region and a self-excisable BAC cassette for immunological research.

Sampaio KL, Weyell A, Subramanian N, Wu Z, Sinzger C.

Biotechniques. 2017 Nov 1;63(5):205-214. doi: 10.2144/000114606.


A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells.

Stegmann C, Hochdorfer D, Lieber D, Subramanian N, Stöhr D, Laib Sampaio K, Sinzger C.

PLoS Pathog. 2017 Apr 12;13(4):e1006273. doi: 10.1371/journal.ppat.1006273. eCollection 2017 Apr.


A Luciferase Gene Driven by an Alphaherpesviral Promoter Also Responds to Immediate Early Antigens of the Betaherpesvirus HCMV, Allowing Comparative Analyses of Different Human Herpesviruses in One Reporter Cell Line.

Maier AK, Jung R, Villinger C, Schubert A, Walther P, Sinzger C, Lieber D.

PLoS One. 2017 Jan 6;12(1):e0169580. doi: 10.1371/journal.pone.0169580. eCollection 2017.


A two-step screening approach for the identification of blood donors with highly and broadly neutralizing capacities against human cytomegalovirus.

Falk JJ, Winkelmann M, Schrezenmeier H, Stöhr D, Sinzger C, Lotfi R.

Transfusion. 2017 Feb;57(2):412-422. doi: 10.1111/trf.13906. Epub 2016 Nov 10.


Importance of Highly Conserved Peptide Sites of Human Cytomegalovirus gO for Formation of the gH/gL/gO Complex.

Stegmann C, Abdellatif MEA, Laib Sampaio K, Walther P, Sinzger C.

J Virol. 2016 Dec 16;91(1). pii: e01339-16. doi: 10.1128/JVI.01339-16. Print 2017 Jan 1.


Generation of a Gaussia luciferase-expressing endotheliotropic cytomegalovirus for screening approaches and mutant analyses.

Falk JJ, Laib Sampaio K, Stegmann C, Lieber D, Kropff B, Mach M, Sinzger C.

J Virol Methods. 2016 Sep;235:182-189. doi: 10.1016/j.jviromet.2016.06.008. Epub 2016 Jun 17.


Tetraspanin CD151 Promotes Initial Events in Human Cytomegalovirus Infection.

Hochdorfer D, Florin L, Sinzger C, Lieber D.

J Virol. 2016 Jun 24;90(14):6430-42. doi: 10.1128/JVI.00145-16. Print 2016 Jul 15.


The contribution of pUL74 to growth of human cytomegalovirus is masked in the presence of RL13 and UL128 expression.

Laib Sampaio K, Stegmann C, Brizic I, Adler B, Stanton RJ, Sinzger C.

J Gen Virol. 2016 Aug;97(8):1917-27. doi: 10.1099/jgv.0.000475. Epub 2016 Apr 6.


The Cellular Proteins Grb2 and DDX3 Are Increased upon Human Cytomegalovirus Infection and Act in a Proviral Fashion.

Cavignac Y, Lieber D, Laib Sampaio K, Madlung J, Lamkemeyer T, Jahn G, Nordheim A, Sinzger C.

PLoS One. 2015 Jun 29;10(6):e0131614. doi: 10.1371/journal.pone.0131614. eCollection 2015.


Natural killer cells can inhibit the transmission of human cytomegalovirus in cell culture by using mechanisms from innate and adaptive immune responses.

Wu Z, Sinzger C, Reichel JJ, Just M, Mertens T.

J Virol. 2015 Mar;89(5):2906-17. doi: 10.1128/JVI.03489-14. Epub 2014 Dec 24.


Cytomegalovirus infection impairs immunosuppressive and antimicrobial effector functions of human multipotent mesenchymal stromal cells.

Meisel R, Heseler K, Nau J, Schmidt SK, Leineweber M, Pudelko S, Wenning J, Zimmermann A, Hengel H, Sinzger C, Degistirici Ö, Sorg RV, Däubener W.

Mediators Inflamm. 2014;2014:898630. doi: 10.1155/2014/898630. Epub 2014 Mar 23.


Distinct properties of human cytomegalovirus strains and the appropriate choice of strains for particular studies.

Frascaroli G, Sinzger C.

Methods Mol Biol. 2014;1119:29-46. doi: 10.1007/978-1-62703-788-4_3.


A permanently growing human endothelial cell line supports productive infection with human cytomegalovirus under conditional cell growth arrest.

Lieber D, Hochdorfer D, Stoehr D, Schubert A, Lotfi R, May T, Wirth D, Sinzger C.

Biotechniques. 2015 Sep 1;59(3):127-36. doi: 10.2144/000114326. eCollection 2015 Sep.


Applications for a dual fluorescent human cytomegalovirus in the analysis of viral entry.

Sampaio KL, Jahn G, Sinzger C.

Methods Mol Biol. 2013;1064:201-9. doi: 10.1007/978-1-62703-601-6_14.


Cytomegalovirus impairs the induction of indoleamine 2,3-dioxygenase mediated antimicrobial and immunoregulatory effects in human fibroblasts.

Heseler K, Schmidt SK, Spekker K, Sinzger C, Sorg RV, Quambusch M, Zimmermann A, Meisel R, Däubener W.

PLoS One. 2013 May 15;8(5):e64442. doi: 10.1371/journal.pone.0064442. Print 2013.


Human cytomegalovirus-induced NKG2C(hi) CD57(hi) natural killer cells are effectors dependent on humoral antiviral immunity.

Wu Z, Sinzger C, Frascaroli G, Reichel J, Bayer C, Wang L, Schirmbeck R, Mertens T.

J Virol. 2013 Jul;87(13):7717-25. doi: 10.1128/JVI.01096-13. Epub 2013 May 1.


Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner.

Haspot F, Lavault A, Sinzger C, Laib Sampaio K, Stierhof YD, Pilet P, Bressolette-Bodin C, Halary F.

PLoS One. 2012;7(4):e34795. doi: 10.1371/journal.pone.0034795. Epub 2012 Apr 9.


Mutational mapping of pUL131A of human cytomegalovirus emphasizes its central role for endothelial cell tropism.

Schuessler A, Sampaio KL, Straschewski S, Sinzger C.

J Virol. 2012 Jan;86(1):504-12. doi: 10.1128/JVI.05354-11. Epub 2011 Oct 26.


UL74 of human cytomegalovirus reduces the inhibitory effect of gH-specific and gB-specific antibodies.

Jiang XJ, Sampaio KL, Ettischer N, Stierhof YD, Jahn G, Kropff B, Mach M, Sinzger C.

Arch Virol. 2011 Dec;156(12):2145-55. doi: 10.1007/s00705-011-1105-x. Epub 2011 Sep 22.


The polymorphic HCMV glycoprotein UL20 is targeted for lysosomal degradation by multiple cytoplasmic dileucine motifs.

Jelcic I, Reichel J, Schlude C, Treutler E, Sinzger C, Steinle A.

Traffic. 2011 Oct;12(10):1444-56. doi: 10.1111/j.1600-0854.2011.01236.x. Epub 2011 Jul 12.


HCMV spread and cell tropism are determined by distinct virus populations.

Scrivano L, Sinzger C, Nitschko H, Koszinowski UH, Adler B.

PLoS Pathog. 2011 Jan 13;7(1):e1001256. doi: 10.1371/journal.ppat.1001256.


Efficiency of porcine endothelial cell infection with human cytomegalovirus depends on both virus tropism and endothelial cell vascular origin.

Millard AL, Häberli L, Sinzger C, Ghielmetti M, Schneider MK, Bossart W, Seebach JD, Mueller NJ.

Xenotransplantation. 2010 Jul-Aug;17(4):274-87. doi: 10.1111/j.1399-3089.2010.00594.x.


Mutational mapping of UL130 of human cytomegalovirus defines peptide motifs within the C-terminal third as essential for endothelial cell infection.

Schuessler A, Sampaio KL, Scrivano L, Sinzger C.

J Virol. 2010 Sep;84(18):9019-26. doi: 10.1128/JVI.00572-10. Epub 2010 Jun 30.


Improvement of a quantitative cell tropism assay for rapid and reliable characterization of human cytomegalovirus mutants.

Schuessler A, Sampaio KL, Sinzger C.

J Virol Methods. 2010 Aug;167(2):218-22. doi: 10.1016/j.jviromet.2010.03.031. Epub 2010 Apr 21.


Endothelial cells in human cytomegalovirus infection: one host cell out of many or a crucial target for virus spread?

Adler B, Sinzger C.

Thromb Haemost. 2009 Dec;102(6):1057-63. doi: 10.1160/TH09-04-0213. Review.


Charge cluster-to-alanine scanning of UL128 for fine tuning of the endothelial cell tropism of human cytomegalovirus.

Schuessler A, Sampaio KL, Sinzger C.

J Virol. 2008 Nov;82(22):11239-46. doi: 10.1128/JVI.01069-08. Epub 2008 Sep 3.


Cytomegalovirus cell tropism.

Sinzger C, Digel M, Jahn G.

Curr Top Microbiol Immunol. 2008;325:63-83. Review.


Entry route of HCMV into endothelial cells.

Sinzger C.

J Clin Virol. 2008 Mar;41(3):174-9. doi: 10.1016/j.jcv.2007.12.002. Epub 2008 Jan 18. Review.


Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E.

Sinzger C, Hahn G, Digel M, Katona R, Sampaio KL, Messerle M, Hengel H, Koszinowski U, Brune W, Adler B.

J Gen Virol. 2008 Feb;89(Pt 2):359-68. doi: 10.1099/vir.0.83286-0.


UL74 of human cytomegalovirus contributes to virus release by promoting secondary envelopment of virions.

Jiang XJ, Adler B, Sampaio KL, Digel M, Jahn G, Ettischer N, Stierhof YD, Scrivano L, Koszinowski U, Mach M, Sinzger C.

J Virol. 2008 Mar;82(6):2802-12. doi: 10.1128/JVI.01550-07. Epub 2008 Jan 9.


hDectin-1 is involved in uptake and cross-presentation of cellular antigens.

Weck MM, Appel S, Werth D, Sinzger C, Bringmann A, Grünebach F, Brossart P.

Blood. 2008 Apr 15;111(8):4264-72. Epub 2007 Aug 13.


TLR ligands differentially affect uptake and presentation of cellular antigens.

Weck MM, Grünebach F, Werth D, Sinzger C, Bringmann A, Brossart P.

Blood. 2007 May 1;109(9):3890-4. Epub 2007 Jan 11.


Effect of serum and CTL on focal growth of human cytomegalovirus.

Sinzger C, Mangin M, Weinstock C, Topp MS, Hebart H, Einsele H, Jahn G.

J Clin Virol. 2007 Feb;38(2):112-9. Epub 2007 Jan 3.


Role of human cytomegalovirus UL131A in cell type-specific virus entry and release.

Adler B, Scrivano L, Ruzcics Z, Rupp B, Sinzger C, Koszinowski U.

J Gen Virol. 2006 Sep;87(Pt 9):2451-60.


hCMV induced IL-6 release in trophoblast and trophoblast like cells.

Halwachs-Baumann G, Weihrauch G, Gruber HJ, Desoye G, Sinzger C.

J Clin Virol. 2006 Oct;37(2):91-7. Epub 2006 Aug 1.


Human cytomegalovirus subverts the functions of monocytes, impairing chemokine-mediated migration and leukocyte recruitment.

Frascaroli G, Varani S, Moepps B, Sinzger C, Landini MP, Mertens T.

J Virol. 2006 Aug;80(15):7578-89. Erratum in: J Virol. 2013 Dec;87(23):13082-3.


Evidence for direct transfer of cytoplasmic material from infected to uninfected cells during cell-associated spread of human cytomegalovirus.

Digel M, Sampaio KL, Jahn G, Sinzger C.

J Clin Virol. 2006 Sep;37(1):10-20. Epub 2006 Jul 11.


Evaluation of the COBAS Amplicor HCMV Monitor for early detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation.

Lengerke C, Ljubicic T, Meisner C, Loeffler J, Sinzger C, Einsele H, Hebart H.

Bone Marrow Transplant. 2006 Jul;38(1):53-60.


Transfection of dendritic cells with in vitro-transcribed CMV RNA induces polyclonal CD8+- and CD4+-mediated CMV-specific T cell responses.

Heine A, Grünebach F, Holderried T, Appel S, Weck MM, Dörfel D, Sinzger C, Brossart P.

Mol Ther. 2006 Feb;13(2):280-8. Epub 2005 Oct 10.

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