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Items: 1 to 50 of 115

1.

Inhibitors of Intracellular Gram-positive Bacteria Growth Synthesized via Povarov-Doebner Reactions.

Dayal N, Opoku-Temeng C, Mohammad H, Abutaleb NS, Hernandez D, Onyedibe KI, Wang M, Zeller M, Seleem MN, Sintim HO.

ACS Infect Dis. 2019 Sep 12. doi: 10.1021/acsinfecdis.9b00022. [Epub ahead of print]

PMID:
31512848
2.

Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors.

Dayal N, Mikek CG, Hernandez D, Naclerio GA, Yin Chu EF, Carter-Cooper BA, Lapidus RG, Sintim HO.

Eur J Med Chem. 2019 Oct 15;180:449-456. doi: 10.1016/j.ejmech.2019.06.089. Epub 2019 Jun 29.

PMID:
31330446
3.

Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 2,8-dioxabicyclo[3.2.1]octane core of squalestatins/zaragozic acids.

Sintim HO, Al Mamari HH, Almohseni HAA, Fegheh-Hassanpour Y, Hodgson DM.

Beilstein J Org Chem. 2019 May 31;15:1194-1202. doi: 10.3762/bjoc.15.116. eCollection 2019.

4.

Identification of nicotinamide aminonaphthyridine compounds as potent RET kinase inhibitors and antitumor activities against RET rearranged lung adenocarcinoma.

Wang M, Naganna N, Sintim HO.

Bioorg Chem. 2019 Sep;90:103052. doi: 10.1016/j.bioorg.2019.103052. Epub 2019 Jun 8.

PMID:
31226468
5.

Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics.

Opoku-Temeng C, Onyedibe KI, Aryal UK, Sintim HO.

J Proteomics. 2019 Jun 30;202:103368. doi: 10.1016/j.jprot.2019.04.018. Epub 2019 Apr 25.

PMID:
31028946
6.

Ligand-Based Stability Changes in Duplex DNA Measured with a Microscale Electrochemical Platform.

Robinson SM, Shen Z, Askim JR, Montgomery CB, Sintim HO, Semancik S.

Biosensors (Basel). 2019 Apr 12;9(2). pii: E54. doi: 10.3390/bios9020054.

7.

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis.

Naclerio GA, Karanja CW, Opoku-Temeng C, Sintim HO.

ChemMedChem. 2019 May 17;14(10):1000-1004. doi: 10.1002/cmdc.201900053. Epub 2019 Apr 30.

PMID:
30939229
8.

Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice.

Naganna N, Opoku-Temeng C, Choi EY, Larocque E, Chang ET, Carter-Cooper BA, Wang M, Torregrosa-Allen SE, Elzey BD, Lapidus RG, Sintim HO.

EBioMedicine. 2019 Feb;40:231-239. doi: 10.1016/j.ebiom.2019.01.012. Epub 2019 Jan 25.

9.

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides.

Elmanfi S, Zhou J, Sintim HO, Könönen E, Gürsoy M, Gürsoy UK.

J Oral Microbiol. 2018 Nov 27;11(1):1538927. doi: 10.1080/20002297.2018.1538927. eCollection 2019.

10.

Discriminating cyclic from linear nucleotides - CRISPR/Cas-related cyclic hexaadenosine monophosphate as a case study.

Wang M, Sintim HO.

Anal Biochem. 2019 Feb 15;567:21-26. doi: 10.1016/j.ab.2018.11.022. Epub 2018 Nov 28.

PMID:
30502320
11.

Berenil Binds Tightly to Parallel and Mixed Parallel/Antiparallel G-Quadruplex Motifs with Varied Thermodynamic Signatures.

Mikek CG, West SJ, Gwin JC, Dayal N, Sintim HO, Lewis EA.

ACS Omega. 2018 Sep 30;3(9):11582-11591. doi: 10.1021/acsomega.8b01621. Epub 2018 Sep 21.

12.

Miniaturized whole-cell bacterial bioreporter assay for identification of quorum sensing interfering compounds.

Ilina P, Ma X, Sintim HO, Tammela P.

J Microbiol Methods. 2018 Nov;154:40-45. doi: 10.1016/j.mimet.2018.10.005. Epub 2018 Oct 6.

13.

Quorum sensing molecules regulate epithelial cytokine response and biofilm-related virulence of three Prevotella species.

Fteita D, Könönen E, Gürsoy M, Ma X, Sintim HO, Gürsoy UK.

Anaerobe. 2018 Dec;54:128-135. doi: 10.1016/j.anaerobe.2018.09.001. Epub 2018 Sep 3.

PMID:
30189320
14.

Correction to Synthesis of (-)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition-Rearrangement and Cross-electrophile Coupling.

Fegheh-Hassanpour Y, Arif T, Sintim HO, Al Mamari HH, Hodgson DM.

Org Lett. 2018 Sep 7;20(17):5528. doi: 10.1021/acs.orglett.8b02330. Epub 2018 Aug 20. No abstract available.

15.

N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria.

Opoku-Temeng C, Naclerio GA, Mohammad H, Dayal N, Abutaleb NS, Seleem MN, Sintim HO.

Eur J Med Chem. 2018 Jul 15;155:797-805. doi: 10.1016/j.ejmech.2018.06.023. Epub 2018 Jun 15.

PMID:
29957525
16.

Evidence of link between quorum sensing and sugar metabolism in Escherichia coli revealed via cocrystal structures of LsrK and HPr.

Ha JH, Hauk P, Cho K, Eo Y, Ma X, Stephens K, Cha S, Jeong M, Suh JY, Sintim HO, Bentley WE, Ryu KS.

Sci Adv. 2018 Jun 1;4(6):eaar7063. doi: 10.1126/sciadv.aar7063. eCollection 2018 Jun.

17.

Alkene protection against acid using a bromide substituent: application in a total synthesis of (-)-6,7-dideoxysqualestatin H5.

Almohseni HAA, Al Mamari HH, Valade A, Sintim HO, Hodgson DM.

Chem Commun (Camb). 2018 May 22;54(42):5354-5356. doi: 10.1039/c8cc02690d.

PMID:
29741545
18.

3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties.

Opoku-Temeng C, Dayal N, Aflaki Sooreshjani M, Sintim HO.

Bioorg Chem. 2018 Aug;78:418-426. doi: 10.1016/j.bioorg.2018.03.031. Epub 2018 Apr 17.

19.

Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor.

Opoku-Temeng C, Dayal N, Hernandez DE, Naganna N, Sintim HO.

Chem Commun (Camb). 2018 May 1;54(36):4521-4524. doi: 10.1039/c8cc01154k.

PMID:
29629444
20.

On the ozonolysis of unsaturated tosylhydrazones as a direct approach to diazocarbonyl compounds.

Fegheh-Hassanpour Y, Ebrahim F, Arif T, Sintim HO, Claridge TDW, Amin NT, Hodgson DM.

Org Biomol Chem. 2018 Apr 25;16(16):2876-2884. doi: 10.1039/c8ob00435h.

PMID:
29611856
21.

Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase.

Larocque EA, Naganna N, Opoku-Temeng C, Lambrecht AM, Sintim HO.

ChemMedChem. 2018 Jun 20;13(12):1172-1180. doi: 10.1002/cmdc.201700829. Epub 2018 May 22.

22.

Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels.

Wang M, Sooreshjani MA, Mikek C, Opoku-Temeng C, Sintim HO.

Future Med Chem. 2018 Jun 1;10(11):1301-1317. doi: 10.4155/fmc-2017-0322. Epub 2018 Mar 21.

23.

Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines.

Dayal N, Opoku-Temeng C, Hernandez DE, Sooreshjani MA, Carter-Cooper BA, Lapidus RG, Sintim HO.

Future Med Chem. 2018 Apr 1;10(7):823-835. doi: 10.4155/fmc-2017-0298. Epub 2018 Feb 13.

24.

Quorum-sensing molecule dihydroxy-2,3-pentanedione and its analogs as regulators of epithelial integrity.

Elmanfi S, Ma X, Sintim HO, Könönen E, Syrjänen S, Gursoy UK.

J Periodontal Res. 2018 Jun;53(3):414-421. doi: 10.1111/jre.12528. Epub 2018 Jan 17.

PMID:
29344966
25.

Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules.

Opoku-Temeng C, Sintim HO.

Methods Mol Biol. 2017;1657:419-430. doi: 10.1007/978-1-4939-7240-1_31. Review.

PMID:
28889311
26.

Fluorescent 2-Aminopurine c-di-GMP and GpG Analogs as PDE Probes.

Zhou J, Opoku-Temeng C, Sintim HO.

Methods Mol Biol. 2017;1657:245-261. doi: 10.1007/978-1-4939-7240-1_19.

PMID:
28889299
27.

Dipeptidyl peptidase IV and quorum sensing signaling in biofilm-related virulence of Prevotella aurantiaca.

Fteita D, Musrati AA, Könönen E, Ma X, Gürsoy M, Peurla M, Söderling E, Sintim HO, Gürsoy UK.

Anaerobe. 2017 Dec;48:152-159. doi: 10.1016/j.anaerobe.2017.08.009. Epub 2017 Aug 15.

PMID:
28821458
28.

Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms.

Gürsoy UK, Gürsoy M, Könönen E, Sintim HO.

Front Cell Infect Microbiol. 2017 Jun 21;7:273. doi: 10.3389/fcimb.2017.00273. eCollection 2017.

29.

Synthesis of (-)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition-Rearrangement and Cross-electrophile Coupling.

Fegheh-Hassanpour Y, Arif T, Sintim HO, Al Mamari HH, Hodgson DM.

Org Lett. 2017 Jul 7;19(13):3540-3543. doi: 10.1021/acs.orglett.7b01513. Epub 2017 Jun 20. Erratum in: Org Lett. 2018 Sep 7;20(17):5528.

30.

Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach.

Ma X, Zhou J, Wang C, Carter-Cooper B, Yang F, Larocque E, Fine J, Tsuji G, Chopra G, Lapidus RG, Sintim HO.

ACS Med Chem Lett. 2017 Apr 14;8(5):492-497. doi: 10.1021/acsmedchemlett.6b00468. eCollection 2017 May 11.

31.

Aminoisoquinoline benzamides, FLT3 and Src-family kinase inhibitors, potently inhibit proliferation of acute myeloid leukemia cell lines.

Larocque E, Naganna N, Ma X, Opoku-Temeng C, Carter-Cooper B, Chopra G, Lapidus RG, Sintim HO.

Future Med Chem. 2017 Jul;9(11):1213-1225. doi: 10.4155/fmc-2017-0067. Epub 2017 May 11.

32.

Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase.

Dey RJ, Dey B, Zheng Y, Cheung LS, Zhou J, Sayre D, Kumar P, Guo H, Lamichhane G, Sintim HO, Bishai WR.

Nat Chem Biol. 2017 Feb;13(2):210-217. doi: 10.1038/nchembio.2254. Epub 2016 Dec 12.

PMID:
28106876
33.

Supramolecular polymer formation by cyclic dinucleotides and intercalators affects dinucleotide enzymatic processing.

Nakayama S, Zhou J, Zheng Y, Szmacinski H, Sintim HO.

Future Sci OA. 2016 Jan 29;2(1):FSO93. doi: 10.4155/fso.15.93. eCollection 2016 Mar.

34.

Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression.

Hauk P, Stephens K, Mckay R, Virgile CR, Ueda H, Ostermeier M, Ryu KS, Sintim HO, Bentley WE.

Nucleic Acids Res. 2016 Dec 1;44(21):10515-10525. Epub 2016 Oct 24.

35.

Construction and characterization of a multilayered gingival keratinocyte culture model: the TURK-U model.

Gursoy UK, Gursoy M, Könönen E, Sintim HO, Uitto VJ, Syrjänen S.

Cytotechnology. 2016 Dec;68(6):2345-2354. Epub 2016 Oct 17.

36.

Computational understanding and experimental characterization of twice-as-smart quadruplex ligands as chemical sensors of bacterial nucleotide second messengers.

Zhou J, Roembke BT, Paragi G, Laguerre A, Sintim HO, Fonseca Guerra C, Monchaud D.

Sci Rep. 2016 Sep 26;6:33888. doi: 10.1038/srep33888.

37.

Autoinducer-2 analogs and electric fields - an antibiotic-free bacterial biofilm combination treatment.

Subramanian S, Gerasopoulos K, Guo M, Sintim HO, Bentley WE, Ghodssi R.

Biomed Microdevices. 2016 Oct;18(5):95. doi: 10.1007/s10544-016-0120-9.

PMID:
27647148
38.

Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative.

Zheng Y, Tsuji G, Opoku-Temeng C, Sintim HO.

Chem Sci. 2016 Sep 1;7(9):6238-6244. doi: 10.1039/c6sc02103d. Epub 2016 Jun 16.

39.

Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules.

Opoku-Temeng C, Zhou J, Zheng Y, Su J, Sintim HO.

Chem Commun (Camb). 2016 Aug 4;52(60):9327-42. doi: 10.1039/c6cc03439j. Epub 2016 Jun 24. Review.

PMID:
27339003
40.

Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols.

Opoku-Temeng C, Sintim HO.

Sci Rep. 2016 May 6;6:25445. doi: 10.1038/srep25445.

41.

Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities.

Wang C, Carter-Cooper B, Du Y, Zhou J, Saeed MA, Liu J, Guo M, Roembke B, Mikek C, Lewis EA, Lapidus RG, Sintim HO.

Eur J Med Chem. 2016 Aug 8;118:266-75. doi: 10.1016/j.ejmech.2016.04.030. Epub 2016 Apr 20.

PMID:
27132164
42.

Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin.

Opoku-Temeng C, Sintim HO.

Chem Commun (Camb). 2016 Mar 7;52(19):3754-7. doi: 10.1039/c5cc10446g.

PMID:
26824279
43.

Cyclic dinucleotide detection with riboswitch-G-quadruplex hybrid.

Tsuji G, Sintim HO.

Mol Biosyst. 2016 Mar;12(3):773-7. doi: 10.1039/c5mb00751h.

PMID:
26739090
44.

Biofilms as "Connectors" for Oral and Systems Medicine: A New Opportunity for Biomarkers, Molecular Targets, and Bacterial Eradication.

Sintim HO, Gürsoy UK.

OMICS. 2016 Jan;20(1):3-11. doi: 10.1089/omi.2015.0146. Epub 2015 Nov 19. Review.

45.

Fluorescence, Phosphorescence, and Chemiluminescence.

Siraj N, El-Zahab B, Hamdan S, Karam TE, Haber LH, Li M, Fakayode SO, Das S, Valle B, Strongin RM, Patonay G, Sintim HO, Baker GA, Powe A, Lowry M, Karolin JO, Geddes CD, Warner IM.

Anal Chem. 2016 Jan 5;88(1):170-202. doi: 10.1021/acs.analchem.5b04109. Epub 2015 Dec 2. No abstract available.

PMID:
26575092
46.

Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover.

Orr MW, Donaldson GP, Severin GB, Wang J, Sintim HO, Waters CM, Lee VT.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5048-57. doi: 10.1073/pnas.1507245112. Epub 2015 Aug 24.

47.

Membrane Affinity of Platensimycin and Its Dialkylamine Analogs.

Rowe I, Guo M, Yasmann A, Cember A, Sintim HO, Sukharev S.

Int J Mol Sci. 2015 Aug 4;16(8):17909-32. doi: 10.3390/ijms160817909.

48.

Agents that inhibit bacterial biofilm formation.

Rabin N, Zheng Y, Opoku-Temeng C, Du Y, Bonsu E, Sintim HO.

Future Med Chem. 2015;7(5):647-71. doi: 10.4155/fmc.15.7. Review.

49.

Biofilm formation mechanisms and targets for developing antibiofilm agents.

Rabin N, Zheng Y, Opoku-Temeng C, Du Y, Bonsu E, Sintim HO.

Future Med Chem. 2015;7(4):493-512. doi: 10.4155/fmc.15.6. Review. Erratum in: Future Med Chem. 2015;7(10):1362.

50.

Bacterial secretions of nonpathogenic Escherichia coli elicit inflammatory pathways: a closer investigation of interkingdom signaling.

Zargar A, Quan DN, Carter KK, Guo M, Sintim HO, Payne GF, Bentley WE.

MBio. 2015 Mar 10;6(2):e00025. doi: 10.1128/mBio.00025-15.

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