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Items: 1 to 50 of 88

1.

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters.

McLean KJ, Straimer J, Hopp CS, Vega-Rodriguez J, Small-Saunders JL, Kanatani S, Tripathi A, Mlambo G, Dumoulin PC, Harris CT, Tong X, Shears MJ, Ankarklev J, Kafsack BFC, Fidock DA, Sinnis P.

Sci Rep. 2019 Sep 11;9(1):13131. doi: 10.1038/s41598-019-49348-x.

2.

Reply to Vanderberg, "Further Mechanisms and Locations in Which Antisporozoite Antibodies Neutralize Malaria Sporozoites".

Sinnis P, Zavala F.

MBio. 2019 Sep 10;10(5). pii: e02108-19. doi: 10.1128/mBio.02108-19. No abstract available.

3.

Proteomic Analysis of Plasmodium Merosomes: The Link between Liver and Blood Stages in Malaria.

Shears MJ, Sekhar Nirujogi R, Swearingen KE, Renuse S, Mishra S, Jaipal Reddy P, Moritz RL, Pandey A, Sinnis P.

J Proteome Res. 2019 Sep 6;18(9):3404-3418. doi: 10.1021/acs.jproteome.9b00324. Epub 2019 Jul 23.

PMID:
31335145
4.
5.

Comparative 3D genome organization in apicomplexan parasites.

Bunnik EM, Venkat A, Shao J, McGovern KE, Batugedara G, Worth D, Prudhomme J, Lapp SA, Andolina C, Ross LS, Lawres L, Brady D, Sinnis P, Nosten F, Fidock DA, Wilson EH, Tewari R, Galinski MR, Ben Mamoun C, Ay F, Le Roch KG.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3183-3192. doi: 10.1073/pnas.1810815116. Epub 2019 Feb 5.

6.

Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection.

Dundas K, Shears MJ, Sinnis P, Wright GJ.

Trends Parasitol. 2019 Feb;35(2):129-139. doi: 10.1016/j.pt.2018.11.008. Epub 2018 Dec 21. Review.

PMID:
30583849
7.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2019 Jan;25(1):188-189. doi: 10.1038/s41591-018-0315-0.

PMID:
30552419
8.

Antibody-Mediated Protection against Plasmodium Sporozoites Begins at the Dermal Inoculation Site.

Flores-Garcia Y, Nasir G, Hopp CS, Munoz C, Balaban AE, Zavala F, Sinnis P.

MBio. 2018 Nov 20;9(6). pii: e02194-18. doi: 10.1128/mBio.02194-18.

9.

A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission.

Schleicher TR, Yang J, Freudzon M, Rembisz A, Craft S, Hamilton M, Graham M, Mlambo G, Tripathi AK, Li Y, Cresswell P, Sinnis P, Dimopoulos G, Fikrig E.

Nat Commun. 2018 Jul 25;9(1):2908. doi: 10.1038/s41467-018-05374-3.

10.

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages.

Bunnik EM, Cook KB, Varoquaux N, Batugedara G, Prudhomme J, Cort A, Shi L, Andolina C, Ross LS, Brady D, Fidock DA, Nosten F, Tewari R, Sinnis P, Ay F, Vert JP, Noble WS, Le Roch KG.

Nat Commun. 2018 May 15;9(1):1910. doi: 10.1038/s41467-018-04295-5.

11.

Alpha-v-containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP.

Dundas K, Shears MJ, Sun Y, Hopp CS, Crosnier C, Metcalf T, Girling G, Sinnis P, Billker O, Wright GJ.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4477-4482. doi: 10.1073/pnas.1719660115. Epub 2018 Apr 9.

12.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2018 May;24(4):408-416. doi: 10.1038/nm.4512. Epub 2018 Mar 19. Erratum in: Nat Med. 2019 Jan;25(1):188-189.

13.

Host biotin is required for liver stage development in malaria parasites.

Dellibovi-Ragheb TA, Jhun H, Goodman CD, Walters MS, Ragheb DRT, Matthews KA, Rajaram K, Mishra S, McFadden GI, Sinnis P, Prigge ST.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2604-E2613. doi: 10.1073/pnas.1800717115. Epub 2018 Feb 26.

14.

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.

Hopp CS, Bennett BL, Mishra S, Lehmann C, Hanson KK, Lin JW, Rousseau K, Carvalho FA, van der Linden WA, Santos NC, Bogyo M, Khan SM, Heussler V, Sinnis P.

PLoS Pathog. 2017 Sep 18;13(9):e1006586. doi: 10.1371/journal.ppat.1006586. eCollection 2017 Sep.

15.

Robust fluorescent labelling of micropipettes for use in fluorescence microscopy: application to the observation of a mosquito borne parasite infection.

Balaban AE, Neuman K, Sinnis P, Balaban RS.

J Microsc. 2018 Jan;269(1):78-84. doi: 10.1111/jmi.12610. Epub 2017 Aug 10.

16.

Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice.

Pal P, Balaban AE, Diamond MS, Sinnis P, Klein RS, Goldberg DE.

PLoS One. 2017 May 5;12(5):e0177142. doi: 10.1371/journal.pone.0177142. eCollection 2017.

17.

Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms.

Aguiar AC, Figueiredo FJ, Neuenfeldt PD, Katsuragawa TH, Drawanz BB, Cunico W, Sinnis P, Zavala F, Krettli AU.

Malar J. 2017 Mar 9;16(1):110. doi: 10.1186/s12936-017-1755-6.

18.

Integrating transcriptomic and proteomic data for accurate assembly and annotation of genomes.

Prasad TS, Mohanty AK, Kumar M, Sreenivasamurthy SK, Dey G, Nirujogi RS, Pinto SM, Madugundu AK, Patil AH, Advani J, Manda SS, Gupta MK, Dwivedi SB, Kelkar DS, Hall B, Jiang X, Peery A, Rajagopalan P, Yelamanchi SD, Solanki HS, Raja R, Sathe GJ, Chavan S, Verma R, Patel KM, Jain AP, Syed N, Datta KK, Khan AA, Dammalli M, Jayaram S, Radhakrishnan A, Mitchell CJ, Na CH, Kumar N, Sinnis P, Sharakhov IV, Wang C, Gowda H, Tu Z, Kumar A, Pandey A.

Genome Res. 2017 Jan;27(1):133-144. doi: 10.1101/gr.201368.115. Epub 2016 Nov 15.

19.

Palmitoyl transferases have critical roles in the development of mosquito and liver stages of Plasmodium.

Hopp CS, Balaban AE, Bushell ES, Billker O, Rayner JC, Sinnis P.

Cell Microbiol. 2016 Nov;18(11):1625-1641. doi: 10.1111/cmi.12601. Epub 2016 Jun 1.

20.

Overexpression of Plasmodium berghei ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites.

Voss C, Ehrenman K, Mlambo G, Mishra S, Kumar KA, Sacci JB Jr, Sinnis P, Coppens I.

MBio. 2016 Jun 28;7(3). pii: e00682-16. doi: 10.1128/mBio.00682-16.

21.

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics.

Swearingen KE, Lindner SE, Shi L, Shears MJ, Harupa A, Hopp CS, Vaughan AM, Springer TA, Moritz RL, Kappe SH, Sinnis P.

PLoS Pathog. 2016 Apr 29;12(4):e1005606. doi: 10.1371/journal.ppat.1005606. eCollection 2016 Apr.

22.

The Plasmodium PHIST and RESA-Like Protein Families of Human and Rodent Malaria Parasites.

Moreira CK, Naissant B, Coppi A, Bennett BL, Aime E, Franke-Fayard B, Janse CJ, Coppens I, Sinnis P, Templeton TJ.

PLoS One. 2016 Mar 29;11(3):e0152510. doi: 10.1371/journal.pone.0152510. eCollection 2016.

23.

Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.

Nemetski SM, Cardozo TJ, Bosch G, Weltzer R, O'Malley K, Ejigiri I, Kumar KA, Buscaglia CA, Nussenzweig V, Sinnis P, Levitskaya J, Bosch J.

Malar J. 2015 Aug 20;14:324. doi: 10.1186/s12936-015-0834-9.

24.

Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition.

Hopp CS, Chiou K, Ragheb DR, Salman AM, Khan SM, Liu AJ, Sinnis P.

Elife. 2015 Aug 13;4. doi: 10.7554/eLife.07789.

25.

Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains.

Herrera R, Anderson C, Kumar K, Molina-Cruz A, Nguyen V, Burkhardt M, Reiter K, Shimp R Jr, Howard RF, Srinivasan P, Nold MJ, Ragheb D, Shi L, DeCotiis M, Aebig J, Lambert L, Rausch KM, Muratova O, Jin A, Reed SG, Sinnis P, Barillas-Mury C, Duffy PE, MacDonald NJ, Narum DL.

Infect Immun. 2015 Oct;83(10):3771-80. doi: 10.1128/IAI.02676-14. Epub 2015 Jul 13.

26.

Active migration and passive transport of malaria parasites.

Douglas RG, Amino R, Sinnis P, Frischknecht F.

Trends Parasitol. 2015 Aug;31(8):357-62. doi: 10.1016/j.pt.2015.04.010. Epub 2015 May 20. Review.

PMID:
26001482
27.

Proteolytic Cleavage of the Plasmodium falciparum Circumsporozoite Protein Is a Target of Protective Antibodies.

Espinosa DA, Gutierrez GM, Rojas-López M, Noe AR, Shi L, Tse SW, Sinnis P, Zavala F.

J Infect Dis. 2015 Oct 1;212(7):1111-9. doi: 10.1093/infdis/jiv154. Epub 2015 Mar 11.

28.

The innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skin.

Hopp CS, Sinnis P.

Ann N Y Acad Sci. 2015 Apr;1342:37-43. doi: 10.1111/nyas.12661. Epub 2015 Feb 18. Review.

29.

Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses.

Radtke AJ, Kastenmüller W, Espinosa DA, Gerner MY, Tse SW, Sinnis P, Germain RN, Zavala FP, Cockburn IA.

PLoS Pathog. 2015 Feb 6;11(2):e1004637. doi: 10.1371/journal.ppat.1004637. eCollection 2015 Feb.

30.

The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium.

Ferguson DJ, Balaban AE, Patzewitz EM, Wall RJ, Hopp CS, Poulin B, Mohmmed A, Malhotra P, Coppi A, Sinnis P, Tewari R.

PLoS One. 2014 Dec 1;9(12):e113923. doi: 10.1371/journal.pone.0113923. eCollection 2014.

31.

A cysteine protease inhibitor of plasmodium berghei is essential for exo-erythrocytic development.

Lehmann C, Heitmann A, Mishra S, Burda PC, Singer M, Prado M, Niklaus L, Lacroix C, Ménard R, Frischknecht F, Stanway R, Sinnis P, Heussler V.

PLoS Pathog. 2014 Aug 28;10(8):e1004336. doi: 10.1371/journal.ppat.1004336. eCollection 2014 Aug.

32.

Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum.

Sack BK, Miller JL, Vaughan AM, Douglass A, Kaushansky A, Mikolajczak S, Coppi A, Gonzalez-Aseguinolaza G, Tsuji M, Zavala F, Sinnis P, Kappe SH.

Infect Immun. 2014 Feb;82(2):808-17. doi: 10.1128/IAI.01249-13. Epub 2013 Dec 9.

33.

The effect of antiretrovirals on Plasmodium falciparum liver stages.

Hobbs CV, De La Vega P, Penzak SR, Van Vliet J, Krzych U, Sinnis P, Borkowsky W, Duffy PE.

AIDS. 2013 Jun 19;27(10):1674-7. doi: 10.1097/QAD.0b013e3283621dd4.

34.

A key role for lipoic acid synthesis during Plasmodium liver stage development.

Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler EA, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D.

Cell Microbiol. 2013 Sep;15(9):1585-604. doi: 10.1111/cmi.12137. Epub 2013 Apr 5.

35.

A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites.

Millholland MG, Mishra S, Dupont CD, Love MS, Patel B, Shilling D, Kazanietz MG, Foskett JK, Hunter CA, Sinnis P, Greenbaum DC.

Cell Host Microbe. 2013 Jan 16;13(1):15-28. doi: 10.1016/j.chom.2012.12.001. Epub 2013 Jan 16.

36.

Total and putative surface proteomics of malaria parasite salivary gland sporozoites.

Lindner SE, Swearingen KE, Harupa A, Vaughan AM, Sinnis P, Moritz RL, Kappe SH.

Mol Cell Proteomics. 2013 May;12(5):1127-43. doi: 10.1074/mcp.M112.024505. Epub 2013 Jan 16.

37.

Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.

Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC.

Cell Host Microbe. 2012 Dec 13;12(6):815-23. doi: 10.1016/j.chom.2012.10.017.

38.

HIV nonnucleoside reverse transcriptase inhibitors and trimethoprim-sulfamethoxazole inhibit plasmodium liver stages.

Hobbs CV, Voza T, De La Vega P, Vanvliet J, Conteh S, Penzak SR, Fay MP, Anders N, Ilmet T, Li Y, Borkowsky W, Krzych U, Duffy PE, Sinnis P.

J Infect Dis. 2012 Dec 1;206(11):1706-14. doi: 10.1093/infdis/jis602.

39.

The skin: where malaria infection and the host immune response begin.

Sinnis P, Zavala F.

Semin Immunopathol. 2012 Nov;34(6):787-92. doi: 10.1007/s00281-012-0345-5. Epub 2012 Oct 2. Review.

40.

Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry.

Sinnis P, De La Vega P, Coppi A, Krzych U, Mota MM.

Methods Mol Biol. 2013;923:385-400.

41.

Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity.

Ejigiri I, Ragheb DR, Pino P, Coppi A, Bennett BL, Soldati-Favre D, Sinnis P.

PLoS Pathog. 2012;8(7):e1002725. doi: 10.1371/journal.ppat.1002725. Epub 2012 Jul 26.

42.
43.

Malaria in India: the center for the study of complex malaria in India.

Das A, Anvikar AR, Cator LJ, Dhiman RC, Eapen A, Mishra N, Nagpal BN, Nanda N, Raghavendra K, Read AF, Sharma SK, Singh OP, Singh V, Sinnis P, Srivastava HC, Sullivan SA, Sutton PL, Thomas MB, Carlton JM, Valecha N.

Acta Trop. 2012 Mar;121(3):267-73. doi: 10.1016/j.actatropica.2011.11.008. Epub 2011 Nov 28.

44.

Plasmodium protease ROM1 is important for proper formation of the parasitophorous vacuole.

Vera IM, Beatty WL, Sinnis P, Kim K.

PLoS Pathog. 2011 Sep;7(9):e1002197. doi: 10.1371/journal.ppat.1002197. Epub 2011 Sep 1.

45.

Dendritic cells and hepatocytes use distinct pathways to process protective antigen from plasmodium in vivo.

Cockburn IA, Tse SW, Radtke AJ, Srinivasan P, Chen YC, Sinnis P, Zavala F.

PLoS Pathog. 2011 Mar;7(3):e1001318. doi: 10.1371/journal.ppat.1001318. Epub 2011 Mar 17.

46.

Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes.

Ecker A, Lakshmanan V, Sinnis P, Coppens I, Fidock DA.

J Infect Dis. 2011 Jan 15;203(2):228-36. doi: 10.1093/infdis/jiq036.

47.

The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host.

Coppi A, Natarajan R, Pradel G, Bennett BL, James ER, Roggero MA, Corradin G, Persson C, Tewari R, Sinnis P.

J Exp Med. 2011 Feb 14;208(2):341-56. doi: 10.1084/jem.20101488. Epub 2011 Jan 24.

48.

What can we learn from an unnatural immune response?

Bennett BL, Sinnis P.

Trends Parasitol. 2010 Jul;26(7):319-21. doi: 10.1016/j.pt.2010.02.011. Epub 2010 Apr 27.

49.

Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum.

Kortagere S, Welsh WJ, Morrisey JM, Daly T, Ejigiri I, Sinnis P, Vaidya AB, Bergman LW.

J Chem Inf Model. 2010 May 24;50(5):840-9. doi: 10.1021/ci100039k.

50.

Noninvasive real-time monitoring of liver-stage development of bioluminescent Plasmodium parasites.

Mwakingwe A, Ting LM, Hochman S, Chen J, Sinnis P, Kim K.

J Infect Dis. 2009 Nov 1;200(9):1470-8. doi: 10.1086/606115.

PMID:
19811100

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