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Items: 37


Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes.

Goedel A, Zawada DM, Zhang F, Chen Z, Moretti A, Sinnecker D.

J Vis Exp. 2018 Sep 27;(139). doi: 10.3791/58134.


Change in Left Ventricular Ejection Fraction Following First Myocardial Infarction and Outcome.

Chew DS, Heikki H, Schmidt G, Kavanagh KM, Dommasch M, Bloch Thomsen PE, Sinnecker D, Raatikainen P, Exner DV.

JACC Clin Electrophysiol. 2018 May;4(5):672-682. doi: 10.1016/j.jacep.2017.12.015. Epub 2018 Mar 1.


Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.

Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A.

EMBO J. 2018 Jun 15;37(12). pii: e98133. doi: 10.15252/embj.201798133. Epub 2018 May 15.


Cardiac regeneration using HLA-matched induced pluripotent stem cells-no monkey business, but still a long and winding road ahead.

Sinnecker D.

J Thorac Dis. 2017 Mar;9(3):492-494. doi: 10.21037/jtd.2017.03.06. No abstract available.


Perspectives and Challenges of Pluripotent Stem Cells in Cardiac Arrhythmia Research.

Goedel A, My I, Sinnecker D, Moretti A.

Curr Cardiol Rep. 2017 Mar;19(3):23. doi: 10.1007/s11886-017-0828-z. Review.


Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D.

Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. No abstract available.


Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.

Rocchetti M, Sala L, Dreizehnter L, Crotti L, Sinnecker D, Mura M, Pane LS, Altomare C, Torre E, Mostacciuolo G, Severi S, Porta A, De Ferrari GM, George AL Jr, Schwartz PJ, Gnecchi M, Moretti A, Zaza A.

Cardiovasc Res. 2017 Apr 1;113(5):531-541. doi: 10.1093/cvr/cvx006.


Post-extrasystolic Blood Pressure Potentiation as a Risk Predictor in Cardiac Patients.

Steger A, Sinnecker D, Barthel P, Müller A, Gebhardt J, Schmidt G.

Arrhythm Electrophysiol Rev. 2016 May;5(1):27-30. doi: 10.15420/aer.2016.14.2.


Expiration-Triggered Sinus Arrhythmia Predicts Outcome in Survivors of Acute Myocardial Infarction.

Sinnecker D, Dommasch M, Steger A, Berkefeld A, Hoppmann P, Müller A, Gebhardt J, Barthel P, Hnatkova K, Huster KM, Laugwitz KL, Malik M, Schmidt G.

J Am Coll Cardiol. 2016 May 17;67(19):2213-2220. doi: 10.1016/j.jacc.2016.03.484.


Electrocardiographic and Cardiac Autonomic Indices - Implications of Sex-Specific Risk Stratification in Women After Acute Myocardial Infarction.

Ubrich R, Barthel P, Berkefeld A, Hnatkova K, Huster KM, Dommasch M, Sinnecker D, Steger A, Schmidt G, Malik M.

Curr Pharm Des. 2016;22(25):3817-28. Review.


Genetically Encoded Voltage Indicators in Circulation Research.

Kaestner L, Tian Q, Kaiser E, Xian W, Müller A, Oberhofer M, Ruppenthal S, Sinnecker D, Tsutsui H, Miyawaki A, Moretti A, Lipp P.

Int J Mol Sci. 2015 Sep 8;16(9):21626-42. doi: 10.3390/ijms160921626. Review.


Impact of sympathetic renal denervation: a randomized study in patients after renal transplantation (ISAR-denerve).

Schneider S, Promny D, Sinnecker D, Byrne RA, Müller A, Dommasch M, Wildenauer A, Schmidt G, Heemann U, Laugwitz KL, Baumann M.

Nephrol Dial Transplant. 2015 Nov;30(11):1928-36. doi: 10.1093/ndt/gfv311. Epub 2015 Sep 1.


Magnetic resonance imaging at 1.5-T in a patient with implantable leadless pacemaker.

Ubrich R, Kreiser K, Sinnecker D, Schneider S.

Eur Heart J. 2016 Aug 7;37(30):2441. doi: 10.1093/eurheartj/ehv360. Epub 2015 Aug 10. No abstract available.


[Fragmented QRS. Relevance in clinical practice].

Steger A, Sinnecker D, Berkefeld A, Müller A, Gebhardt J, Dommasch M, Huster KM, Barthel P, Schmidt G.

Herzschrittmacherther Elektrophysiol. 2015 Sep;26(3):235-41. doi: 10.1007/s00399-015-0390-6. German.


Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.

Gramlich M, Pane LS, Zhou Q, Chen Z, Murgia M, Schötterl S, Goedel A, Metzger K, Brade T, Parrotta E, Schaller M, Gerull B, Thierfelder L, Aartsma-Rus A, Labeit S, Atherton JJ, McGaughran J, Harvey RP, Sinnecker D, Mann M, Laugwitz KL, Gawaz MP, Moretti A.

EMBO Mol Med. 2015 May;7(5):562-76. doi: 10.15252/emmm.201505047.


Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets.

Orban M, Goedel A, Haas J, Sandrock-Lang K, Gärtner F, Jung CB, Zieger B, Parrotta E, Kurnik K, Sinnecker D, Wanner G, Laugwitz KL, Massberg S, Moretti A.

PLoS One. 2015 Jan 21;10(1):e0115978. doi: 10.1371/journal.pone.0115978. eCollection 2015.


Force-interval relationship predicts mortality in survivors of myocardial infarction with atrial fibrillation.

Sinnecker D, Barthel P, Huster KM, Müller A, Gebhardt J, Dommasch M, Schneider S, Steger A, Laugwitz KL, Malik M, Schmidt G.

Int J Cardiol. 2015 Mar 1;182:315-20. doi: 10.1016/j.ijcard.2015.01.018. Epub 2015 Jan 6.


Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity.

Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Guo Y, Kühl SJ, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A.

Stem Cells. 2015 Apr;33(4):1113-29. doi: 10.1002/stem.1923.


In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology.

Loewe A, Lutz Y, Wilhelms M, Sinnecker D, Barthel P, Scholz EP, Dössel O, Schmidt G, Seemann G.

Europace. 2014 Nov;16 Suppl 4:iv30-iv38. doi: 10.1093/europace/euu230.


Sex differences in the non-invasive risk stratification and prognosis after myocardial infarction.

Sinnecker D, Huster KM, Müller A, Dommasch M, Hapfelmeier A, Gebhardt J, Hnatkova K, Laugwitz KL, Malik M, Barthel P, Schmidt G.

J Electrocardiol. 2014 Nov-Dec;47(6):874-80. doi: 10.1016/j.jelectrocard.2014.08.010. Epub 2014 Aug 12.


Extending human induced pluripotent stem cell technology to infectious diseases: new model for viral myocarditis.

Sinnecker D, Laugwitz KL, Moretti A.

Circ Res. 2014 Aug 29;115(6):537-9. doi: 10.1161/CIRCRESAHA.114.304786. No abstract available.


Treatment of acute left main occlusion by early revascularization combined with extracorporeal circulation achieves substantial myocardial salvage as assessed by simultaneous positron emission tomography/magnetic resonance imaging.

Langwieser N, Sinnecker D, Rischpler C, Batrice A, van Marwick S, Schwaiger M, Laugwitz KL, Nekolla SG, Ibrahim T.

Resuscitation. 2014 Oct;85(10):e171-3. doi: 10.1016/j.resuscitation.2014.07.004. Epub 2014 Jul 15. No abstract available.


Postextrasystolic blood pressure potentiation predicts poor outcome of cardiac patients.

Sinnecker D, Dirschinger RJ, Barthel P, Müller A, Morley-Davies A, Hapfelmeier A, Dommasch M, Huster KM, Hasenfuss G, Laugwitz KL, Malik M, Schmidt G.

J Am Heart Assoc. 2014 Jun 3;3(3):e000857. doi: 10.1161/JAHA.114.000857.


Assessment of mean respiratory rate from ECG recordings for risk stratification after myocardial infarction.

Sinnecker D, Dommasch M, Barthel P, Müller A, Dirschinger RJ, Hapfelmeier A, Huster KM, Laugwitz KL, Malik M, Schmidt G.

J Electrocardiol. 2014 Sep-Oct;47(5):700-4. doi: 10.1016/j.jelectrocard.2014.04.021. Epub 2014 May 4.


Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing.

Sinnecker D, Laugwitz KL, Moretti A.

Pharmacol Ther. 2014 Aug;143(2):246-52. doi: 10.1016/j.pharmthera.2014.03.004. Epub 2014 Mar 19. Review.


Nocturnal respiratory rate predicts non-sudden cardiac death in survivors of acute myocardial infarction.

Dommasch M, Sinnecker D, Barthel P, Müller A, Dirschinger RJ, Hapfelmeier A, Huster KM, Laugwitz KL, Malik M, Schmidt G.

J Am Coll Cardiol. 2014 Jun 10;63(22):2432-3. doi: 10.1016/j.jacc.2014.02.525. Epub 2014 Mar 5. No abstract available.


Pluripotent stem cell models of human heart disease.

Moretti A, Laugwitz KL, Dorn T, Sinnecker D, Mummery C.

Cold Spring Harb Perspect Med. 2013 Nov 1;3(11). pii: a014027. doi: 10.1101/cshperspect.a014027. Review.


Negating the dominant-negative allele: a new treatment paradigm for arrhythmias explored in human induced pluripotent stem cell-derived cardiomyocytes.

Sinnecker D, Moretti A, Laugwitz KL.

Eur Heart J. 2014 Apr;35(16):1019-21. doi: 10.1093/eurheartj/eht130. Epub 2013 Apr 12. No abstract available.


Induced pluripotent stem cell-derived cardiomyocytes: a versatile tool for arrhythmia research.

Sinnecker D, Goedel A, Laugwitz KL, Moretti A.

Circ Res. 2013 Mar 15;112(6):961-8. doi: 10.1161/CIRCRESAHA.112.268623. Review.


Transcatheter aortic-valve endocarditis confirmed by transesophageal echocardiography.

Orban M, Sinnecker D, Mair H, Nabauer M, Kupatt C, Schmitz C, Massberg S, Laugwitz KL, Barthel P.

Circulation. 2013 Jan 15;127(2):e265-6. doi: 10.1161/CIRCULATIONAHA.112.109033. No abstract available.


Modeling long-QT syndromes with iPS cells.

Sinnecker D, Goedel A, Dorn T, Dirschinger RJ, Moretti A, Laugwitz KL.

J Cardiovasc Transl Res. 2013 Feb;6(1):31-6. doi: 10.1007/s12265-012-9416-1. Epub 2012 Oct 18. Review.


Induced pluripotent stem cells in cardiovascular research.

Sinnecker D, Dirschinger RJ, Goedel A, Moretti A, Lipp P, Laugwitz KL.

Rev Physiol Biochem Pharmacol. 2012;163:1-26. doi: 10.1007/112_2012_6. Review.


Recapitulating long-QT syndrome using induced pluripotent stem cell technology.

Dirschinger RJ, Goedel A, Moretti A, Laugwitz KL, Sinnecker D.

Pediatr Cardiol. 2012 Aug;33(6):950-8. doi: 10.1007/s00246-012-0286-8. Epub 2012 Mar 13.


Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.

Jung CB, Moretti A, Mederos y Schnitzler M, Iop L, Storch U, Bellin M, Dorn T, Ruppenthal S, Pfeiffer S, Goedel A, Dirschinger RJ, Seyfarth M, Lam JT, Sinnecker D, Gudermann T, Lipp P, Laugwitz KL.

EMBO Mol Med. 2012 Mar;4(3):180-91. doi: 10.1002/emmm.201100194. Epub 2012 Jan 25.


Patient-specific induced pluripotent stem-cell models for long-QT syndrome.

Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Goedel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, Laugwitz KL.

N Engl J Med. 2010 Oct 7;363(15):1397-409. doi: 10.1056/NEJMoa0908679. Epub 2010 Jul 21.


Reversible photobleaching of enhanced green fluorescent proteins.

Sinnecker D, Voigt P, Hellwig N, Schaefer M.

Biochemistry. 2005 May 10;44(18):7085-94.


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