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Enhanced Tropism of Species B1 Adenoviral-Based Vectors for Primary Human Airway Epithelial Cells.

Li N, Cooney AL, Zhang W, Ehrhardt A, Sinn PL.

Mol Ther Methods Clin Dev. 2019 Jul 12;14:228-236. doi: 10.1016/j.omtm.2019.07.001. eCollection 2019 Sep 13.


Novel AAV-mediated gene delivery system corrects CFTR function in pigs.

Cooney AL, Thornell IM, Singh BK, Shah VS, Stoltz DA, McCray PB Jr, Zabner J, Sinn PL.

Am J Respir Cell Mol Biol. 2019 Jun 11. doi: 10.1165/rcmb.2019-0006OC. [Epub ahead of print]


Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward.

Cooney AL, McCray PB Jr, Sinn PL.

Genes (Basel). 2018 Nov 7;9(11). pii: E538. doi: 10.3390/genes9110538. Review.


Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.

Cooney AL, Singh BK, Loza LM, Thornell IM, Hippee CE, Powers LS, Ostedgaard LS, Meyerholz DK, Wohlford-Lenane C, Stoltz DA, B McCray P Jr, Sinn PL.

Nucleic Acids Res. 2018 Oct 12;46(18):9591-9600. doi: 10.1093/nar/gky773.


Long-term correction of hemophilia A mice following lentiviral mediated delivery of an optimized canine factor VIII gene.

Staber JM, Pollpeter MJ, Anderson CG, Burrascano M, Cooney AL, Sinn PL, Rutkowski DT, Raschke WC, McCray PB.

Gene Ther. 2017 Nov;24(11):742-748. doi: 10.1038/gt.2017.67. Epub 2017 Sep 14.


Novel GP64 envelope variants for improved delivery to human airway epithelial cells.

Sinn PL, Hwang BY, Li N, Ortiz JLS, Shirazi E, Parekh KR, Cooney AL, Schaffer DV, McCray PB Jr.

Gene Ther. 2017 Oct;24(10):674-679. doi: 10.1038/gt.2017.78. Epub 2017 Sep 7.


Lentiviral Vectors Pseudotyped with Filoviral Glycoproteins.

Sinn PL, Coffin JE, Ayithan N, Holt KH, Maury W.

Methods Mol Biol. 2017;1628:65-78. doi: 10.1007/978-1-4939-7116-9_5.


CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.

Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Abou Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, Welsh MJ, Sinn PL, Schaffer DV, Zabner J.

JCI Insight. 2016 Sep 8;1(14):e88728. doi: 10.1172/jci.insight.88728.


Lentiviral-mediated phenotypic correction of cystic fibrosis pigs.

Cooney AL, Abou Alaiwa MH, Shah VS, Bouzek DC, Stroik MR, Powers LS, Gansemer ND, Meyerholz DK, Welsh MJ, Stoltz DA, Sinn PL, McCray PB Jr.

JCI Insight. 2016 Sep 8;1(14). pii: 88730. doi: 10.1172/jci.insight.88730.


Cell-to-Cell Contact and Nectin-4 Govern Spread of Measles Virus from Primary Human Myeloid Cells to Primary Human Airway Epithelial Cells.

Singh BK, Li N, Mark AC, Mateo M, Cattaneo R, Sinn PL.

J Virol. 2016 Jul 11;90(15):6808-6817. doi: 10.1128/JVI.00266-16. Print 2016 Aug 1.


Human, Pig, and Mouse Interferon-Induced Transmembrane Proteins Partially Restrict Pseudotyped Lentiviral Vectors.

Hornick AL, Li N, Oakland M, McCray PB Jr, Sinn PL.

Hum Gene Ther. 2016 May;27(5):354-62. doi: 10.1089/hum.2015.156.


Correction for Singh et al., The Nectin-4/Afadin Protein Complex and Intercellular Membrane Pores Contribute to Rapid Spread of Measles Virus in Primary Human Airway Epithelia.

Singh BK, Hornick AL, Krishnamurthy S, Locke AC, Mendoza CA, Mateo M, Miller-Hunt CL, Cattaneo R, Sinn PL.

J Virol. 2016 Feb 26;90(6):3278. doi: 10.1128/JVI.03144-15. Print 2016 Mar. No abstract available.


Connections matter--how viruses use cell–cell adhesion components.

Mateo M, Generous A, Sinn PL, Cattaneo R.

J Cell Sci. 2015 Feb 1;128(3):431-9. Review.


The Nectin-4/Afadin Protein Complex and Intercellular Membrane Pores Contribute to Rapid Spread of Measles Virus in Primary Human Airway Epithelia.

Singh BK, Hornick AL, Krishnamurthy S, Locke AC, Mendoza CA, Mateo M, Miller-Hunt CL, Cattaneo R, Sinn PL.

J Virol. 2015 Jul;89(14):7089-96. doi: 10.1128/JVI.00821-15. Epub 2015 Apr 29. Erratum in: J Virol. 2016 Mar 15;90(6):3278.


Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy.

Yan Z, Stewart ZA, Sinn PL, Olsen JC, Hu J, McCray PB Jr, Engelhardt JF.

Hum Gene Ther Clin Dev. 2015 Mar;26(1):38-49. doi: 10.1089/humc.2014.154. Epub 2015 Feb 12. Review.


Hybrid nonviral/viral vector systems for improved piggyBac DNA transposon in vivo delivery.

Cooney AL, Singh BK, Sinn PL.

Mol Ther. 2015 Apr;23(4):667-74. doi: 10.1038/mt.2014.254. Epub 2015 Jan 5.


Different roles of the three loops forming the adhesive interface of nectin-4 in measles virus binding and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1.

Mateo M, Navaratnarajah CK, Willenbring RC, Maroun JW, Iankov I, Lopez M, Sinn PL, Cattaneo R.

J Virol. 2014 Dec;88(24):14161-71. doi: 10.1128/JVI.02379-14. Epub 2014 Oct 1.


piggyBac-mediated phenotypic correction of factor VIII deficiency.

Staber JM, Pollpeter MJ, Arensdorf A, Sinn PL, Rutkowski DT, McCray PB Jr.

Mol Ther Methods Clin Dev. 2014 Sep 10;1:14042. doi: 10.1038/mtm.2014.42. eCollection 2014.


Integrin α6β4 identifies human distal lung epithelial progenitor cells with potential as a cell-based therapy for cystic fibrosis lung disease.

Li X, Rossen N, Sinn PL, Hornick AL, Steines BR, Karp PH, Ernst SE, Adam RJ, Moninger TO, Levasseur DN, Zabner J.

PLoS One. 2013 Dec 12;8(12):e83624. doi: 10.1371/journal.pone.0083624. eCollection 2013.


piggyBac transposase tools for genome engineering.

Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan SJ, Joung JK, McCray PB Jr, Bushman FD, Sinn PL, Craig NL.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2279-87. doi: 10.1073/pnas.1305987110. Epub 2013 May 30.


Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors.

Oakland M, Maury W, McCray PB Jr, Sinn PL.

Mol Ther Nucleic Acids. 2013 Jan 29;2:e69. doi: 10.1038/mtna.2012.60.


Lentiviral vector gene transfer to porcine airways.

Sinn PL, Cooney AL, Oakland M, Dylla DE, Wallen TJ, Pezzulo AA, Chang EH, McCray PB Jr.

Mol Ther Nucleic Acids. 2012 Nov 27;1:e56. doi: 10.1038/mtna.2012.47.


Transcriptional targeting in the airway using novel gene regulatory elements.

Burnight ER, Wang G, McCray PB Jr, Sinn PL.

Am J Respir Cell Mol Biol. 2012 Aug;47(2):227-33. doi: 10.1165/rcmb.2011-0444OC. Epub 2012 Mar 23.


Advances in cell and gene-based therapies for cystic fibrosis lung disease.

Oakland M, Sinn PL, McCray PB Jr.

Mol Ther. 2012 Jun;20(6):1108-15. doi: 10.1038/mt.2012.32. Epub 2012 Feb 28. Review.


Adherens junction protein nectin-4 is the epithelial receptor for measles virus.

Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, Ramachandran S, McCray PB Jr, Cichutek K, von Messling V, Lopez M, Cattaneo R.

Nature. 2011 Nov 2;480(7378):530-3. doi: 10.1038/nature10639.


T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus.

Kondratowicz AS, Lennemann NJ, Sinn PL, Davey RA, Hunt CL, Moller-Tank S, Meyerholz DK, Rennert P, Mullins RF, Brindley M, Sandersfeld LM, Quinn K, Weller M, McCray PB Jr, Chiorini J, Maury W.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8426-31. doi: 10.1073/pnas.1019030108. Epub 2011 May 2.


Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein.

Brindley MA, Hunt CL, Kondratowicz AS, Bowman J, Sinn PL, McCray PB Jr, Quinn K, Weller ML, Chiorini JA, Maury W.

Virology. 2011 Jul 5;415(2):83-94. doi: 10.1016/j.virol.2011.04.002. Epub 2011 May 6.


Genetic therapies for cystic fibrosis lung disease.

Sinn PL, Anthony RM, McCray PB Jr.

Hum Mol Genet. 2011 Apr 15;20(R1):R79-86. doi: 10.1093/hmg/ddr104. Epub 2011 Mar 21. Review.


The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways.

Griesenbach U, Meng C, Farley R, Wasowicz MY, Munkonge FM, Chan M, Stoneham C, Sumner-Jones SG, Pringle IA, Gill DR, Hyde SC, Stevenson B, Holder E, Ban H, Hasegawa M, Cheng SH, Scheule RK, Sinn PL, McCray PB Jr, Alton EW.

Biomaterials. 2010 Mar;31(9):2665-72. doi: 10.1016/j.biomaterials.2009.12.005. Epub 2009 Dec 21.


Progress and prospects: prospects of repeated pulmonary administration of viral vectors.

Sinn PL, Burnight ER, McCray PB Jr.

Gene Ther. 2009 Sep;16(9):1059-65. doi: 10.1038/gt.2009.87. Epub 2009 Jul 30. Review.


Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors.

Quinn K, Brindley MA, Weller ML, Kaludov N, Kondratowicz A, Hunt CL, Sinn PL, McCray PB Jr, Stein CS, Davidson BL, Flick R, Mandell R, Staplin W, Maury W, Chiorini JA.

J Virol. 2009 Oct;83(19):10176-86. doi: 10.1128/JVI.00422-09. Epub 2009 Jul 22.


Lentivirus vector can be readministered to nasal epithelia without blocking immune responses.

Sinn PL, Arias AC, Brogden KA, McCray PB Jr.

J Virol. 2008 Nov;82(21):10684-92. doi: 10.1128/JVI.00227-08. Epub 2008 Sep 3.


Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed.

Leonard VH, Sinn PL, Hodge G, Miest T, Devaux P, Oezguen N, Braun W, McCray PB Jr, McChesney MB, Cattaneo R.

J Clin Invest. 2008 Jul;118(7):2448-58. doi: 10.1172/JCI35454.


In vivo imaging of gene transfer to the respiratory tract.

Griesenbach U, Meng C, Farley R, Cheng SH, Scheule RK, Davies MH, Wolstenholme-Hogg PC, ten Hove W, van der Hoeven P, Sinn PL, McCray PB Jr, Inoue M, Geddes DM, Hasegawa M, Frankel G, Wiles S, Alton EW.

Biomaterials. 2008 Apr;29(10):1533-40. Epub 2007 Dec 21.


Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector.

Sinn PL, Goreham-Voss JD, Arias AC, Hickey MA, Maury W, Chikkanna-Gowda CP, McCray PB Jr.

Hum Gene Ther. 2007 Dec;18(12):1244-52.


Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer.

Sinn PL, Burnight ER, Hickey MA, Blissard GW, McCray PB Jr.

J Virol. 2005 Oct;79(20):12818-27.


Gene transfer to respiratory epithelia with lentivirus pseudotyped with Jaagsiekte sheep retrovirus envelope glycoprotein.

Sinn PL, Penisten AK, Burnight ER, Hickey MA, Williams G, McCoy DM, Mallampalli RK, McCray PB.

Hum Gene Ther. 2005 Apr;16(4):479-88.


Viscoelastic gel formulations enhance airway epithelial gene transfer with viral vectors.

Sinn PL, Shah AJ, Donovan MD, McCray PB Jr.

Am J Respir Cell Mol Biol. 2005 May;32(5):404-10. Epub 2005 Feb 4.


Cells of respiratory epithelium.

Sinn PL, McCray PB Jr.

Methods Mol Biol. 2003;229:287-98. No abstract available.


Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha.

Sinn PL, Hickey MA, Staber PD, Dylla DE, Jeffers SA, Davidson BL, Sanders DA, McCray PB Jr.

J Virol. 2003 May;77(10):5902-10.


In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins.

Kang Y, Stein CS, Heth JA, Sinn PL, Penisten AK, Staber PD, Ratliff KL, Shen H, Barker CK, Martins I, Sharkey CM, Sanders DA, McCray PB Jr, Davidson BL.

J Virol. 2002 Sep;76(18):9378-88.


Gene transfer to airway epithelia using feline immunodeficiency virus-based lentivirus vectors.

Wang G, Sinn PL, Zabner J, McCray PB Jr.

Methods Enzymol. 2002;346:500-14. No abstract available.


Measles virus preferentially transduces the basolateral surface of well-differentiated human airway epithelia.

Sinn PL, Williams G, Vongpunsawad S, Cattaneo R, McCray PB Jr.

J Virol. 2002 Mar;76(5):2403-9.


Development of retroviral vectors for gene transfer to airway epithelia.

Wang G, Sinn PL, McCray PB Jr.

Curr Opin Mol Ther. 2000 Oct;2(5):497-506. Review.


Transgenic models as tools for studying the regulation of human renin expression.

Sinn PL, Sigmund CD.

Regul Pept. 2000 Jan 29;86(1-3):77-82. Review.


JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter.

Sinn PL, Zhang X, Sigmund CD.

Am J Physiol. 1999 Oct;277(4):F634-42. doi: 10.1152/ajprenal.1999.277.4.F634.


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