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Items: 8


BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site.

Gordeeva J, Morozova N, Sierro N, Isaev A, Sinkunas T, Tsvetkova K, Matlashov M, Truncaite L, Morgan RD, Ivanov NV, Siksnys V, Zeng L, Severinov K.

Nucleic Acids Res. 2018 Nov 12. doi: 10.1093/nar/gky1125. [Epub ahead of print]


DnaQ exonuclease-like domain of Cas2 promotes spacer integration in a type I-E CRISPR-Cas system.

Drabavicius G, Sinkunas T, Silanskas A, Gasiunas G, Venclovas Č, Siksnys V.

EMBO Rep. 2018 Jul;19(7). pii: e45543. doi: 10.15252/embr.201745543. Epub 2018 Jun 11.


Cas3 nuclease-helicase activity assays.

Sinkunas T, Gasiunas G, Siksnys V.

Methods Mol Biol. 2015;1311:277-91. doi: 10.1007/978-1-4939-2687-9_18.


Directional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection.

Rutkauskas M, Sinkunas T, Songailiene I, Tikhomirova MS, Siksnys V, Seidel R.

Cell Rep. 2015 Mar 3. pii: S2211-1247(15)00135-7. doi: 10.1016/j.celrep.2015.01.067. [Epub ahead of print]


Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

Szczelkun MD, Tikhomirova MS, Sinkunas T, Gasiunas G, Karvelis T, Pschera P, Siksnys V, Seidel R.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9798-803. doi: 10.1073/pnas.1402597111. Epub 2014 May 27.


Molecular mechanisms of CRISPR-mediated microbial immunity.

Gasiunas G, Sinkunas T, Siksnys V.

Cell Mol Life Sci. 2014 Feb;71(3):449-65. Review.


In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus.

Sinkunas T, Gasiunas G, Waghmare SP, Dickman MJ, Barrangou R, Horvath P, Siksnys V.

EMBO J. 2013 Feb 6;32(3):385-94. doi: 10.1038/emboj.2012.352. Epub 2013 Jan 18.


Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system.

Sinkunas T, Gasiunas G, Fremaux C, Barrangou R, Horvath P, Siksnys V.

EMBO J. 2011 Apr 6;30(7):1335-42. doi: 10.1038/emboj.2011.41. Epub 2011 Feb 22.

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