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Non-alcoholic fatty liver disease and hypercholesterolemia: Roles of thyroid hormones, metabolites, and agonists.

Sinha RA, Bruinstroop E, Singh BK, Yen PM.

Thyroid. 2019 Aug 7. doi: 10.1089/thy.2018.0664. [Epub ahead of print]


Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.

Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, Sombetzki M, Bruinstroop E, Min LP, Sinha RA, Albani S, Yen PM, Schafer S, Cook SA.

Gastroenterology. 2019 May 9. pii: S0016-5085(19)40858-5. doi: 10.1053/j.gastro.2019.05.002. [Epub ahead of print]


Time-restricted feeding reduces high-fat diet associated placental inflammation and limits adverse effects on fetal organ development.

Upadhyay A, Anjum B, Godbole NM, Rajak S, Shukla P, Tiwari S, Sinha RA, Godbole MM.

Biochem Biophys Res Commun. 2019 Jun 25;514(2):415-421. doi: 10.1016/j.bbrc.2019.04.154. Epub 2019 May 1.


Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels.

Siong Tan HW, Anjum B, Shen HM, Ghosh S, Yen PM, Sinha RA.

Autophagy. 2019 Aug;15(8):1455-1459. doi: 10.1080/15548627.2019.1609847. Epub 2019 Apr 28.


The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts.

Pal S, Maurya SK, Chattopadhyay S, Pal China S, Porwal K, Kulkarni C, Sanyal S, Sinha RA, Chattopadhyay N.

Biochem Pharmacol. 2019 Jun;164:34-44. doi: 10.1016/j.bcp.2019.03.024. Epub 2019 Mar 15.


Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.

Zhou J, Ng B, Ko NSJ, Fiedler LR, Khin E, Lim A, Sahib NE, Wu Y, Chothani SP, Schafer S, Bay BH, Sinha RA, Cook SA, Yen PM.

Hum Mol Genet. 2019 Jun 15;28(12):1971-1981. doi: 10.1093/hmg/ddz033.


Reverse triiodothyronine (rT3) attenuates ischemia-reperfusion injury.

Rastogi L, Godbole MM, Sinha RA, Pradhan S.

Biochem Biophys Res Commun. 2018 Nov 30;506(3):597-603. doi: 10.1016/j.bbrc.2018.10.031. Epub 2018 Oct 23.


Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone.

Singh BK, Sinha RA, Yen PM.

Int J Mol Sci. 2018 Oct 22;19(10). pii: E3284. doi: 10.3390/ijms19103284. Review.


Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.

Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay BH, Sugii S, Sun L, Yen PM.

Autophagy. 2019 Jan;15(1):131-150. doi: 10.1080/15548627.2018.1511263. Epub 2018 Sep 13.


Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.

Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM.

Sci Signal. 2018 Jun 26;11(536). pii: eaam5855. doi: 10.1126/scisignal.aam5855.


Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro.

Zhou J, Sinha RA, Lesmana R, Yau WWY, Yen PM.

Methods Mol Biol. 2018;1801:111-122. doi: 10.1007/978-1-4939-7902-8_11.


Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism.

Kumar P, Godbole NM, Chaturvedi CP, Singh RS, George N, Upadhyay A, Anjum B, Godbole MM, Sinha RA.

Biochem Biophys Res Commun. 2018 Jul 20;502(3):375-381. doi: 10.1016/j.bbrc.2018.05.173.


Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD.

Bruinstroop E, Dalan R, Cao Y, Bee YM, Chandran K, Cho LW, Soh SB, Teo EK, Toh SA, Leow MKS, Sinha RA, Sadananthan SA, Michael N, Stapleton HM, Leung C, Angus PW, Patel SK, Burrell LM, Lim SC, Sum CF, Velan SS, Yen PM.

J Clin Endocrinol Metab. 2018 Jul 1;103(7):2698-2706. doi: 10.1210/jc.2018-00475.


Direct effects of thyroid hormones on hepatic lipid metabolism.

Sinha RA, Singh BK, Yen PM.

Nat Rev Endocrinol. 2018 May;14(5):259-269. doi: 10.1038/nrendo.2018.10. Epub 2018 Feb 23. Review.


Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia.

Farah BL, Landau DJ, Wu Y, Sinha RA, Loh A, Bay BH, Koeberl DD, Yen PM.

Mol Genet Metab. 2017 Nov;122(3):95-98. doi: 10.1016/j.ymgme.2017.08.013. Epub 2017 Sep 1.


Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet.

Iannucci LF, Cioffi F, Senese R, Goglia F, Lanni A, Yen PM, Sinha RA.

Sci Rep. 2017 May 17;7(1):2023. doi: 10.1038/s41598-017-02205-1.


Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.

Ohba K, Sinha RA, Singh BK, Iannucci LF, Zhou J, Kovalik JP, Liao XH, Refetoff S, Sng JCG, Leow MK, Yen PM.

Thyroid. 2017 Jun;27(6):852-860. doi: 10.1089/thy.2016.0456. Epub 2017 May 24.


Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa).

Farah BL, Sinha RA, Wu Y, Singh BK, Lim A, Hirayama M, Landau DJ, Bay BH, Koeberl DD, Yen PM.

Sci Rep. 2017 Mar 20;7:44408. doi: 10.1038/srep44408.


Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging.

Zhou J, Chong SY, Lim A, Singh BK, Sinha RA, Salmon AB, Yen PM.

Aging (Albany NY). 2017 Feb 26;9(2):583-599. doi: 10.18632/aging.101181.


Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy.

Singh BK, Sinha RA, Ohba K, Yen PM.

Mol Cell Endocrinol. 2017 Dec 15;458:160-168. doi: 10.1016/j.mce.2017.02.018. Epub 2017 Feb 16. Review.


Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation.

Tripathi M, Zhang CW, Singh BK, Sinha RA, Moe KT, DeSilva DA, Yen PM.

Cell Death Dis. 2016 Dec 8;7(12):e2513. doi: 10.1038/cddis.2016.374.


Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis.

Sinha RA, Singh BK, Yen PM.

Endocr Rev. 2017 Feb 1;38(1):69-102. doi: 10.1210/er.2016-1103. Review.


Corrigendum to "Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells" [Biochem. Biophys. Res. Commun. 480 (2016) 461-467].

Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1517. doi: 10.1016/j.bbrc.2016.11.116. Epub 2016 Nov 26. No abstract available.


Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.

Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM.

Autophagy. 2017 Jan 2;13(1):169-186. doi: 10.1080/15548627.2016.1235123. Epub 2016 Nov 15.


Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells.

Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA.

Biochem Biophys Res Commun. 2016 Nov 18;480(3):461-467. doi: 10.1016/j.bbrc.2016.10.072. Epub 2016 Oct 20. Erratum in: Biochem Biophys Res Commun. 2017 Jan 22;482(4):1517.


Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.

Lim A, Zhou J, Sinha RA, Singh BK, Ghosh S, Lim KH, Chow PK, Woon ECY, Yen PM.

Biochem Biophys Res Commun. 2016 Oct 21;479(3):476-481. doi: 10.1016/j.bbrc.2016.09.086. Epub 2016 Sep 17.


Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD.

Sinha RA, Yen PM.

Cell Biosci. 2016 Jul 19;6:46. doi: 10.1186/s13578-016-0113-7. eCollection 2016. Review.


Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice.

Ohba K, Leow MK, Singh BK, Sinha RA, Lesmana R, Liao XH, Ghosh S, Refetoff S, Sng JC, Yen PM.

Endocrinology. 2016 Apr;157(4):1660-72. doi: 10.1210/en.2015-1848. Epub 2016 Feb 11.


Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle.

Lesmana R, Sinha RA, Singh BK, Zhou J, Ohba K, Wu Y, Yau WW, Bay BH, Yen PM.

Endocrinology. 2016 Jan;157(1):23-38. doi: 10.1210/en.2015-1632. Epub 2015 Nov 12.


Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency.

Farah BL, Landau DJ, Sinha RA, Brooks ED, Wu Y, Fung SYS, Tanaka T, Hirayama M, Bay BH, Koeberl DD, Yen PM.

J Hepatol. 2016 Feb;64(2):370-379. doi: 10.1016/j.jhep.2015.10.008. Epub 2015 Oct 20.


Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.

Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM.

J Biol Chem. 2016 Jan 1;291(1):198-214. doi: 10.1074/jbc.M115.668673. Epub 2015 Oct 9.


Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats.

Kumar P, Mohan V, Sinha RA, Chagtoo M, Godbole MM.

J Endocrinol. 2015 Nov;227(2):83-92. doi: 10.1530/JOE-15-0168.


Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling.

Sinha RA, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM.

Autophagy. 2015;11(8):1341-57. doi: 10.1080/15548627.2015.1061849.


An integrative approach identified genes associated with drug response in gastric cancer.

Zhou J, Yong WP, Yap CS, Vijayaraghavan A, Sinha RA, Singh BK, Xiu S, Manesh S, Ngo A, Lim A, Ang C, Xie C, Wong FY, Lin SJ, Wan WK, Tan IB, Flotow H, Tan P, Lim KH, Yen PM, Goh LK.

Carcinogenesis. 2015 Apr;36(4):441-51. doi: 10.1093/carcin/bgv014. Epub 2015 Mar 5.


Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism.

Sinha RA, Singh BK, Yen PM.

Trends Endocrinol Metab. 2014 Oct;25(10):538-45. doi: 10.1016/j.tem.2014.07.001. Epub 2014 Aug 12. Review.


β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver.

Farah BL, Sinha RA, Wu Y, Singh BK, Zhou J, Bay BH, Yen PM.

PLoS One. 2014 Jun 20;9(6):e98155. doi: 10.1371/journal.pone.0098155. eCollection 2014.


Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.

Aw DK, Sinha RA, Xie SY, Yen PM.

Biochem Biophys Res Commun. 2014 May 16;447(4):569-73. doi: 10.1016/j.bbrc.2014.04.031. Epub 2014 Apr 13.


Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism.

Aw DK, Sinha RA, Tan HC, Loh LM, Salvatore D, Yen PM.

J Clin Endocrinol Metab. 2014 Nov;99(11):3965-71. doi: 10.1210/jc.2013-3408. Epub 2014 Mar 19.


Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance.

Zhou J, Farah BL, Sinha RA, Wu Y, Singh BK, Bay BH, Yang CS, Yen PM.

PLoS One. 2014 Jan 29;9(1):e87161. doi: 10.1371/journal.pone.0087161. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e96884.


Resveratrol induces insulin gene expression in mouse pancreatic α-cells.

Xie S, Sinha RA, Singh BK, Li GD, Han W, Yen PM.

Cell Biosci. 2013 Dec 13;3(1):47. doi: 10.1186/2045-3701-3-47.


Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells.

Yap CS, Sinha RA, Ota S, Katsuki M, Yen PM.

Biochem Biophys Res Commun. 2013 Nov 1;440(4):635-9. doi: 10.1016/j.bbrc.2013.09.116. Epub 2013 Oct 5.


FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes.

Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM.

J Biol Chem. 2013 Oct 18;288(42):30365-72. doi: 10.1074/jbc.M113.504845. Epub 2013 Aug 30.


Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.

Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, Yen PM.

Hepatology. 2014 Apr;59(4):1366-80. doi: 10.1002/hep.26667. Epub 2014 Feb 18.


Biological and biomechanical responses to traditional epithelium-off and transepithelial riboflavin-UVA CXL techniques in rabbits.

Armstrong BK, Lin MP, Ford MR, Santhiago MR, Singh V, Grossman GH, Agrawal V, Sinha RA, Butler RS, Dupps WJ, Wilson SE.

J Refract Surg. 2013 May;29(5):332-41. doi: 10.3928/1081597X-20130415-04.


Iodine plus n-3 fatty acid supplementation augments rescue of postnatal neuronal abnormalities in iodine-deficient rat cerebellum.

Pal A, Mohan V, Modi DR, Sinha RA, Rastogi L, Kumar P, Godbole MM.

Br J Nutr. 2013 Aug;110(4):659-70. doi: 10.1017/S0007114512005569. Epub 2013 Jan 14.


Maternal thyroid hormone deficiency affects the fetal neocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis.

Mohan V, Sinha RA, Pathak A, Rastogi L, Kumar P, Pal A, Godbole MM.

Exp Neurol. 2012 Oct;237(2):477-88. doi: 10.1016/j.expneurol.2012.07.019. Epub 2012 Aug 7.


Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library.

Zhou J, Chen GB, Tang YC, Sinha RA, Wu Y, Yap CS, Wang G, Hu J, Xia X, Tan P, Goh LK, Yen PM.

BMC Med Genomics. 2012 Aug 9;5:34. doi: 10.1186/1755-8794-5-34.


Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.

Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM.

J Clin Invest. 2012 Jul;122(7):2428-38. doi: 10.1172/JCI60580. Epub 2012 Jun 11.


Novel pachymetric parameters based on corneal tomography for diagnosing keratoconus.

Ambrósio R Jr, Caiado AL, Guerra FP, Louzada R, Sinha RA, Luz A, Dupps WJ, Belin MW.

J Refract Surg. 2011 Oct;27(10):753-8. doi: 10.3928/1081597X-20110721-01. Epub 2011 Jul 29.


Method for optical coherence elastography of the cornea.

Ford MR, Dupps WJ Jr, Rollins AM, Sinha RA, Hu Z.

J Biomed Opt. 2011 Jan-Feb;16(1):016005. doi: 10.1117/1.3526701.

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