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Items: 38


Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.

Korntner-Vetter M, Lefèvre S, Hu XW, George R, Singleton MR.

Life Sci Alliance. 2019 Aug 1;2(4). pii: e201900408. doi: 10.26508/lsa.201900408. Print 2019 Aug.


Structural basis for assembly of the CBF3 kinetochore complex.

Leber V, Nans A, Singleton MR.

EMBO J. 2018 Jan 17;37(2):269-281. doi: 10.15252/embj.201798134. Epub 2017 Dec 6.


Erratum: Structural Basis of Eco1-Mediated Cohesin Acetylation.

Chao WC, Wade BO, Bouchoux C, Jones AW, Purkiss AG, Federico S, O'Reilly N, Snijders AP, Uhlmann F, Singleton MR.

Sci Rep. 2017 Apr 11;7:46382. doi: 10.1038/srep46382. No abstract available.


Separase-securin complex: a cunning way to control chromosome segregation.

Singleton MR, Uhlmann F.

Nat Struct Mol Biol. 2017 Apr 6;24(4):337-339. doi: 10.1038/nsmb.3393. No abstract available.


Structural Basis of Eco1-Mediated Cohesin Acetylation.

Chao WC, Wade BO, Bouchoux C, Jones AW, Purkiss AG, Federico S, O'Reilly N, Snijders AP, Uhlmann F, Singleton MR.

Sci Rep. 2017 Mar 14;7:44313. doi: 10.1038/srep44313. Erratum in: Sci Rep. 2017 Apr 11;7:46382.


A molecular gate for DNA (comment on DOI 10.1002/bies.201600207).

Singleton MR.

Bioessays. 2017 Apr;39(4). doi: 10.1002/bies.201700021. Epub 2017 Mar 7. No abstract available.


Structural studies of RFCCtf18 reveal a novel chromatin recruitment role for Dcc1.

Wade BO, Liu HW, Samora CP, Uhlmann F, Singleton MR.

EMBO Rep. 2017 Apr;18(4):558-568. doi: 10.15252/embr.201642825. Epub 2017 Feb 10.


APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.

Sansregret L, Patterson JO, Dewhurst S, López-García C, Koch A, McGranahan N, Chao WCH, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M, Swanton C.

Cancer Discov. 2017 Feb;7(2):218-233. doi: 10.1158/2159-8290.CD-16-0645. Epub 2017 Jan 9.


Structure of the cohesin loader Scc2.

Chao WC, Murayama Y, Muñoz S, Jones AW, Wade BO, Purkiss AG, Hu XW, Borg A, Snijders AP, Uhlmann F, Singleton MR.

Nat Commun. 2017 Jan 6;8:13952. doi: 10.1038/ncomms13952.


An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation.

Matsuo Y, Maurer SP, Yukawa M, Zakian S, Singleton MR, Surrey T, Toda T.

J Cell Sci. 2016 Dec 15;129(24):4592-4606. Epub 2016 Nov 21.


Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome.

Samora CP, Saksouk J, Goswami P, Wade BO, Singleton MR, Bates PA, Lengronne A, Costa A, Uhlmann F.

Mol Cell. 2016 Aug 4;63(3):371-84. doi: 10.1016/j.molcel.2016.05.036. Epub 2016 Jul 7.


Getting to the heart of an unusual kinetochore.

Singleton MR.

Open Biol. 2016 Apr;6(4):160040. doi: 10.1098/rsob.160040. Epub 2016 Apr 13.


Structural Studies Reveal the Functional Modularity of the Scc2-Scc4 Cohesin Loader.

Chao WC, Murayama Y, Muñoz S, Costa A, Uhlmann F, Singleton MR.

Cell Rep. 2015 Aug 4;12(5):719-25. doi: 10.1016/j.celrep.2015.06.071. Epub 2015 Jul 23.


Centromeric binding and activity of Protein Phosphatase 4.

Lipinszki Z, Lefevre S, Savoian MS, Singleton MR, Glover DM, Przewloka MR.

Nat Commun. 2015 Jan 6;6:5894. doi: 10.1038/ncomms6894.


The Kinesin-12 Kif15 is a processive track-switching tetramer.

Drechsler H, McHugh T, Singleton MR, Carter NJ, McAinsh AD.

Elife. 2014 Mar 25;3:e01724. doi: 10.7554/eLife.01724.


Structural insights into the regulation of cohesion establishment by Wpl1.

Chatterjee A, Zakian S, Hu XW, Singleton MR.

EMBO J. 2013 Mar 6;32(5):677-87. doi: 10.1038/emboj.2013.16. Epub 2013 Feb 8.


The Ndc80 internal loop is required for recruitment of the Ska complex to establish end-on microtubule attachment to kinetochores.

Zhang G, Kelstrup CD, Hu XW, Kaas Hansen MJ, Singleton MR, Olsen JV, Nilsson J.

J Cell Sci. 2012 Jul 1;125(Pt 13):3243-53. doi: 10.1242/jcs.104208. Epub 2012 Mar 27.


Structure of yeast kinetochore Ndc10 DNA-binding domain reveals unexpected evolutionary relationship to tyrosine recombinases.

Perriches T, Singleton MR.

J Biol Chem. 2012 Feb 10;287(7):5173-9. doi: 10.1074/jbc.C111.318501. Epub 2012 Jan 3.


Biophysical characterization of the centromere-specific nucleosome from budding yeast.

Kingston IJ, Yung JS, Singleton MR.

J Biol Chem. 2011 Feb 4;286(5):4021-6. doi: 10.1074/jbc.M110.189340. Epub 2010 Nov 29.


Molecular architecture and assembly of the yeast kinetochore MIND complex.

Maskell DP, Hu XW, Singleton MR.

J Cell Biol. 2010 Sep 6;190(5):823-34. doi: 10.1083/jcb.201002059.


Mechanism of Holliday junction resolution by the human GEN1 protein.

Rass U, Compton SA, Matos J, Singleton MR, Ip SC, Blanco MG, Griffith JD, West SC.

Genes Dev. 2010 Jul 15;24(14):1559-69. doi: 10.1101/gad.585310.


Insights into kinetochore-DNA interactions from the structure of Cep3Delta.

Purvis A, Singleton MR.

EMBO Rep. 2008 Jan;9(1):56-62. Epub 2007 Dec 7.


Structure and mechanism of helicases and nucleic acid translocases.

Singleton MR, Dillingham MS, Wigley DB.

Annu Rev Biochem. 2007;76:23-50. Review.


Communication between subunits within an archaeal clamp-loader complex.

Seybert A, Singleton MR, Cook N, Hall DR, Wigley DB.

EMBO J. 2006 May 17;25(10):2209-18. Epub 2006 Apr 20.


Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks.

Singleton MR, Dillingham MS, Gaudier M, Kowalczykowski SC, Wigley DB.

Nature. 2004 Nov 11;432(7014):187-93.


Conformational changes induced by nucleotide binding in Cdc6/ORC from Aeropyrum pernix.

Singleton MR, Morales R, Grainge I, Cook N, Isupov MN, Wigley DB.

J Mol Biol. 2004 Oct 22;343(3):547-57.


Multiple roles for ATP hydrolysis in nucleic acid modifying enzymes.

Singleton MR, Wigley DB.

EMBO J. 2003 Sep 15;22(18):4579-83. Review.


Biochemical characterisation of the clamp/clamp loader proteins from the euryarchaeon Archaeoglobus fulgidus.

Seybert A, Scott DJ, Scaife S, Singleton MR, Wigley DB.

Nucleic Acids Res. 2002 Oct 15;30(20):4329-38.


Structure of the single-strand annealing domain of human RAD52 protein.

Singleton MR, Wentzell LM, Liu Y, West SC, Wigley DB.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13492-7. Epub 2002 Oct 7.


Modularity and specialization in superfamily 1 and 2 helicases.

Singleton MR, Wigley DB.

J Bacteriol. 2002 Apr;184(7):1819-26. Review. No abstract available.


Crystallization and preliminary X-ray analysis of RecG, a replication-fork reversal helicase from Thermotoga maritima complexed with a three-way DNA junction.

Singleton MR, Scaife S, Raven ND, Wigley DB.

Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1695-6. Epub 2001 Oct 25.


Structural analysis of DNA replication fork reversal by RecG.

Singleton MR, Scaife S, Wigley DB.

Cell. 2001 Oct 5;107(1):79-89.


Pyrrolidone carboxylpeptidase from Thermococcus litoralis.

Singleton MR, Littlechild JA.

Methods Enzymol. 2001;330:394-403. No abstract available.


Cloning, expression, and characterization of pyrrolidone carboxyl peptidase from the archaeon Thermococcus litoralis.

Singleton MR, Taylor SJ, Parrat JS, Littlechild JA.

Extremophiles. 2000 Oct;4(5):297-303.


DNA ligases in the repair and replication of DNA.

Timson DJ, Singleton MR, Wigley DB.

Mutat Res. 2000 Aug 30;460(3-4):301-18. Review.


Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides.

Singleton MR, Sawaya MR, Ellenberger T, Wigley DB.

Cell. 2000 Jun 9;101(6):589-600.


Structure of the adenylation domain of an NAD+-dependent DNA ligase.

Singleton MR, Håkansson K, Timson DJ, Wigley DB.

Structure. 1999 Jan 15;7(1):35-42.


Crystallization and preliminary X-ray diffraction studies of pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Thermococcus litoralis.

Singleton MR, Isupov MN, Littlechild JA.

Acta Crystallogr D Biol Crystallogr. 1999 Mar;55(Pt 3):702-3.


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