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Items: 1 to 50 of 101

1.

Hepatocyte Stress Increases Expression of YAP and TAZ in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis.

Mooring M, Fowl BH, Lum SZC, Liu Y, Yao K, Softic S, Kirchner R, Bernstein A, Singhi AD, Jay DG, Kahn CR, Camargo FD, Yimlamai D.

Hepatology. 2019 Sep 10. doi: 10.1002/hep.30928. [Epub ahead of print]

PMID:
31505040
2.

DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth.

Miller-Ocuin JL, Liang X, Boone BA, Doerfler WR, Singhi AD, Tang D, Kang R, Lotze MT, Zeh HJ 3rd.

Oncoimmunology. 2019 Jun 11;8(9):e1605822. doi: 10.1080/2162402X.2019.1605822. eCollection 2019.

3.

Prolactin Promotes Fibrosis and Pancreatic Cancer Progression.

Tandon M, Coudriet GM, Criscimanna A, Socorro M, Eliliwi M, Singhi AD, Cruz-Monserrate Z, Bailey P, Lotze MT, Zeh H, Hu J, Goffin V, Gittes GK, Biankin AV, Esni F.

Cancer Res. 2019 Oct 15;79(20):5316-5327. doi: 10.1158/0008-5472.CAN-18-3064. Epub 2019 Aug 8.

PMID:
31395607
4.

A multimodality test to guide the management of patients with a pancreatic cyst.

Springer S, Masica DL, Dal Molin M, Douville C, Thoburn CJ, Afsari B, Li L, Cohen JD, Thompson E, Allen PJ, Klimstra DS, Schattner MA, Schmidt CM, Yip-Schneider M, Simpson RE, Fernandez-Del Castillo C, Mino-Kenudson M, Brugge W, Brand RE, Singhi AD, Scarpa A, Lawlor R, Salvia R, Zamboni G, Hong SM, Hwang DW, Jang JY, Kwon W, Swan N, Geoghegan J, Falconi M, Crippa S, Doglioni C, Paulino J, Schulick RD, Edil BH, Park W, Yachida S, Hijioka S, van Hooft J, He J, Weiss MJ, Burkhart R, Makary M, Canto MI, Goggins MG, Ptak J, Dobbyn L, Schaefer J, Sillman N, Popoli M, Klein AP, Tomasetti C, Karchin R, Papadopoulos N, Kinzler KW, Vogelstein B, Wolfgang CL, Hruban RH, Lennon AM.

Sci Transl Med. 2019 Jul 17;11(501). pii: eaav4772. doi: 10.1126/scitranslmed.aav4772.

PMID:
31316009
5.

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants.

Hutchings D, Jiang Z, Skaro M, Weiss MJ, Wolfgang CL, Makary MA, He J, Cameron JL, Zheng L, Klimstra DS, Brand RE, Singhi AD, Goggins M, Klein AP, Roberts NJ, Hruban RH.

Mod Pathol. 2019 Jul 8. doi: 10.1038/s41379-019-0317-6. [Epub ahead of print]

PMID:
31285527
6.

β-Catenin Activation Promotes Immune Escape and Resistance to Anti-PD-1 Therapy in Hepatocellular Carcinoma.

Ruiz de Galarreta M, Bresnahan E, Molina-Sánchez P, Lindblad KE, Maier B, Sia D, Puigvehi M, Miguela V, Casanova-Acebes M, Dhainaut M, Villacorta-Martin C, Singhi AD, Moghe A, von Felden J, Tal Grinspan L, Wang S, Kamphorst AO, Monga SP, Brown BD, Villanueva A, Llovet JM, Merad M, Lujambio A.

Cancer Discov. 2019 Aug;9(8):1124-1141. doi: 10.1158/2159-8290.CD-19-0074. Epub 2019 Jun 11.

PMID:
31186238
7.

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.

Belmonte FR, Dedousis N, Sipula I, Desai NA, Singhi AD, Chu Y, Zhang Y, Bannwarth S, Paquis-Flucklinger V, Harrington L, Shiva S, Jurczak MJ, O'Doherty RM, Kaufman BA.

PLoS One. 2019 May 28;14(5):e0203101. doi: 10.1371/journal.pone.0203101. eCollection 2019.

8.

Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures.

Singhi AD, Nikiforova MN, Chennat J, Papachristou GI, Khalid A, Rabinovitz M, Das R, Sarkaria S, Ayasso MS, Wald AI, Monaco SE, Nalesnik M, Ohori NP, Geller D, Tsung A, Zureikat AH, Zeh H, Marsh JW, Hogg M, Lee K, Bartlett DL, Pingpank JF, Humar A, Bahary N, Dasyam AK, Brand R, Fasanella KE, McGrath K, Slivka A.

Gut. 2019 Apr 10. pii: gutjnl-2018-317817. doi: 10.1136/gutjnl-2018-317817. [Epub ahead of print]

9.

Real-Time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations That Might Be Targeted With Existing Drugs or Used as Biomarkers.

Singhi AD, George B, Greenbowe JR, Chung J, Suh J, Maitra A, Klempner SJ, Hendifar A, Milind JM, Golan T, Brand RE, Zureikat AH, Roy S, Schrock AB, Miller VA, Ross JS, Ali SM, Bahary N.

Gastroenterology. 2019 Jun;156(8):2242-2253.e4. doi: 10.1053/j.gastro.2019.02.037. Epub 2019 Mar 2.

10.

Enhanced Neutrophil Extracellular Trap Formation in Acute Pancreatitis Contributes to Disease Severity and Is Reduced by Chloroquine.

Murthy P, Singhi AD, Ross MA, Loughran P, Paragomi P, Papachristou GI, Whitcomb DC, Zureikat AH, Lotze MT, Zeh Iii HJ, Boone BA.

Front Immunol. 2019 Jan 24;10:28. doi: 10.3389/fimmu.2019.00028. eCollection 2019.

11.

Early Detection of Pancreatic Cancer: Opportunities and Challenges.

Singhi AD, Koay EJ, Chari ST, Maitra A.

Gastroenterology. 2019 May;156(7):2024-2040. doi: 10.1053/j.gastro.2019.01.259. Epub 2019 Feb 2. Review.

12.

The sTRA Plasma Biomarker: Blinded Validation of Improved Accuracy Over CA19-9 in Pancreatic Cancer Diagnosis.

Staal B, Liu Y, Barnett D, Hsueh P, He Z, Gao C, Partyka K, Hurd MW, Singhi AD, Drake RR, Huang Y, Maitra A, Brand RE, Haab BB.

Clin Cancer Res. 2019 May 1;25(9):2745-2754. doi: 10.1158/1078-0432.CCR-18-3310. Epub 2019 Jan 7.

PMID:
30617132
13.

A mechanistic classification of clinical phenotypes in neuroblastoma.

Ackermann S, Cartolano M, Hero B, Welte A, Kahlert Y, Roderwieser A, Bartenhagen C, Walter E, Gecht J, Kerschke L, Volland R, Menon R, Heuckmann JM, Gartlgruber M, Hartlieb S, Henrich KO, Okonechnikov K, Altmüller J, Nürnberg P, Lefever S, de Wilde B, Sand F, Ikram F, Rosswog C, Fischer J, Theissen J, Hertwig F, Singhi AD, Simon T, Vogel W, Perner S, Krug B, Schmidt M, Rahmann S, Achter V, Lang U, Vokuhl C, Ortmann M, Büttner R, Eggert A, Speleman F, O'Sullivan RJ, Thomas RK, Berthold F, Vandesompele J, Schramm A, Westermann F, Schulte JH, Peifer M, Fischer M.

Science. 2018 Dec 7;362(6419):1165-1170. doi: 10.1126/science.aat6768.

PMID:
30523111
14.

Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.

Bernard V, Semaan A, Huang J, San Lucas FA, Mulu FC, Stephens BM, Guerrero PA, Huang Y, Zhao J, Kamyabi N, Sen S, Scheet PA, Taniguchi CM, Kim MP, Tzeng CW, Katz MH, Singhi AD, Maitra A, Alvarez HA.

Clin Cancer Res. 2019 Apr 1;25(7):2194-2205. doi: 10.1158/1078-0432.CCR-18-1955. Epub 2018 Nov 1.

PMID:
30385653
15.

CT Radiogenomic Characterization of the Alternative Lengthening of Telomeres Phenotype in Pancreatic Neuroendocrine Tumors.

McGovern JM, Singhi AD, Borhani AA, Furlan A, McGrath KM, Zeh HJ 3rd, Bahary N, Dasyam AK.

AJR Am J Roentgenol. 2018 Nov;211(5):1020-1025. doi: 10.2214/AJR.17.19490. Epub 2018 Aug 30.

PMID:
30160983
16.

GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling.

Ideno N, Yamaguchi H, Ghosh B, Gupta S, Okumura T, Steffen DJ, Fisher CG, Wood LD, Singhi AD, Nakamura M, Gutkind JS, Maitra A.

Gastroenterology. 2018 Nov;155(5):1593-1607.e12. doi: 10.1053/j.gastro.2018.08.006. Epub 2018 Aug 22.

PMID:
30142336
17.

Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer.

Thakur PC, Miller-Ocuin JL, Nguyen K, Matsuda R, Singhi AD, Zeh HJ, Bahary N.

J Transl Med. 2018 Jul 9;16(1):190. doi: 10.1186/s12967-018-1562-z.

18.

Systemic Depletion of Nerve Growth Factor Inhibits Disease Progression in a Genetically Engineered Model of Pancreatic Ductal Adenocarcinoma.

Saloman JL, Singhi AD, Hartman DJ, Normolle DP, Albers KM, Davis BM.

Pancreas. 2018 Aug;47(7):856-863. doi: 10.1097/MPA.0000000000001090.

19.

Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age.

Chao DT, Shah NH, Zeh HJ 3rd, Singhi AD, Bahary N, McGrath KM, Fasanella KE, Zureikat AH, Whitcomb DC, Brand RE.

Gastroenterol Res Pract. 2018 Jun 5;2018:2380596. doi: 10.1155/2018/2380596. eCollection 2018.

20.

FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel for Neoadjuvant Treatment of Resectable and Borderline Resectable Pancreatic Head Adenocarcinoma.

Dhir M, Zenati MS, Hamad A, Singhi AD, Bahary N, Hogg ME, Zeh HJ 3rd, Zureikat AH.

Ann Surg Oncol. 2018 Jul;25(7):1896-1903. doi: 10.1245/s10434-018-6512-8. Epub 2018 May 14.

PMID:
29761331
21.

Hepatitis C Virus Mimics Effects of Glypican-3 on CD81 and Promotes Development of Hepatocellular Carcinomas via Activation of Hippo Pathway in Hepatocytes.

Xue Y, Mars WM, Bowen W, Singhi AD, Stoops J, Michalopoulos GK.

Am J Pathol. 2018 Jun;188(6):1469-1477. doi: 10.1016/j.ajpath.2018.02.013. Epub 2018 Mar 22.

22.

Loss of Chromatin-Remodeling Proteins and/or CDKN2A Associates With Metastasis of Pancreatic Neuroendocrine Tumors and Reduced Patient Survival Times.

Roy S, LaFramboise WA, Liu TC, Cao D, Luvison A, Miller C, Lyons MA, O'Sullivan RJ, Zureikat AH, Hogg ME, Tsung A, Lee KK, Bahary N, Brand RE, Chennat JS, Fasanella KE, McGrath K, Nikiforova MN, Papachristou GI, Slivka A, Zeh HJ, Singhi AD.

Gastroenterology. 2018 Jun;154(8):2060-2063.e8. doi: 10.1053/j.gastro.2018.02.026. Epub 2018 Mar 2.

23.

Current concepts in molecular genetics and management guidelines for pancreatic cystic neoplasms: an essential update for radiologists.

Kulzer M, Singhi AD, Furlan A, Heller MT, Katabathina VS, Mcgrath KM, Zeh HJ, Zureikat A, Dasyam AK.

Abdom Radiol (NY). 2018 Sep;43(9):2351-2368. doi: 10.1007/s00261-017-1452-5. Review.

PMID:
29404638
24.

Germline mutation prevalence in individuals with pancreatic cancer and a history of previous malignancy.

Dudley B, Karloski E, Monzon FA, Singhi AD, Lincoln SE, Bahary N, Brand RE.

Cancer. 2018 Apr 15;124(8):1691-1700. doi: 10.1002/cncr.31242. Epub 2018 Jan 23.

26.

An Unexpected Etiology of Pancreatic Panniculitis: A Case Report.

Evans AC, Singhi AD, Zeh HJ Rd, Bahary N, Brand RE.

J Pancreat Cancer. 2017;3(1):1-4. doi: 10.1089/crpc.2016.0021. Epub 2017 Jan 1.

27.

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia.

Singhi AD, McGrath K, Brand RE, Khalid A, Zeh HJ, Chennat JS, Fasanella KE, Papachristou GI, Slivka A, Bartlett DL, Dasyam AK, Hogg M, Lee KK, Marsh JW, Monaco SE, Ohori NP, Pingpank JF, Tsung A, Zureikat AH, Wald AI, Nikiforova MN.

Gut. 2018 Dec;67(12):2131-2141. doi: 10.1136/gutjnl-2016-313586. Epub 2017 Sep 28.

28.

A margin distance analysis of the impact of adjuvant chemoradiation on survival after pancreatoduodenectomy for pancreatic adenocarcinoma.

Ocuin LM, Miller-Ocuin JL, Zenati MS, Vargo JA, Singhi AD, Burton SA, Bahary N, Hogg ME, Zeh HJ 3rd, Zureikat AH.

J Gastrointest Oncol. 2017 Aug;8(4):696-704. doi: 10.21037/jgo.2017.04.02.

29.

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers.

Cohen JD, Javed AA, Thoburn C, Wong F, Tie J, Gibbs P, Schmidt CM, Yip-Schneider MT, Allen PJ, Schattner M, Brand RE, Singhi AD, Petersen GM, Hong SM, Kim SC, Falconi M, Doglioni C, Weiss MJ, Ahuja N, He J, Makary MA, Maitra A, Hanash SM, Dal Molin M, Wang Y, Li L, Ptak J, Dobbyn L, Schaefer J, Silliman N, Popoli M, Goggins MG, Hruban RH, Wolfgang CL, Klein AP, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Lennon AM.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10202-10207. doi: 10.1073/pnas.1704961114. Epub 2017 Sep 5.

30.

Neoadjuvant Treatment With Trastuzumab and FOLFOX Induces a Complete Pathologic Response in a Metastatic ERBB2 (HER2)-Amplified Duodenal Cancer.

Hamad A, Singhi AD, Bahary N, McGrath K, Amarin R, Zeh HJ, Zureikat AH.

J Natl Compr Canc Netw. 2017 Aug;15(8):983-988. doi: 10.6004/jnccn.2017.0140.

PMID:
28784859
31.

Gemcitabine/nab-paclitaxel as second-line therapy following FOLFIRINOX in metastatic/advanced pancreatic cancer-retrospective analysis of response.

Nguyen KT, Kalyan A, Beasley HS, Singhi AD, Sun W, Zeh HJ, Normolle D, Bahary N.

J Gastrointest Oncol. 2017 Jun;8(3):556-565. doi: 10.21037/jgo.2017.01.23.

32.

Targeted next-generation sequencing supports epidermoid metaplasia of the esophagus as a precursor to esophageal squamous neoplasia.

Singhi AD, Arnold CA, Lam-Himlin DM, Nikiforova MN, Voltaggio L, Canto MI, McGrath KM, Montgomery EA.

Mod Pathol. 2017 Nov;30(11):1613-1621. doi: 10.1038/modpathol.2017.73. Epub 2017 Jul 21.

33.

The CA19-9 and Sialyl-TRA Antigens Define Separate Subpopulations of Pancreatic Cancer Cells.

Barnett D, Liu Y, Partyka K, Huang Y, Tang H, Hostetter G, Brand RE, Singhi AD, Drake RR, Haab BB.

Sci Rep. 2017 Jun 22;7(1):4020. doi: 10.1038/s41598-017-04164-z.

34.

Identification of Targetable ALK Rearrangements in Pancreatic Ductal Adenocarcinoma.

Singhi AD, Ali SM, Lacy J, Hendifar A, Nguyen K, Koo J, Chung JH, Greenbowe J, Ross JS, Nikiforova MN, Zeh HJ, Sarkaria IS, Dasyam A, Bahary N.

J Natl Compr Canc Netw. 2017 May;15(5):555-562.

PMID:
28476735
35.

DNA testing of pancreatic cyst fluid: is it ready for prime time?

Singhi AD, Nikiforova MN, McGrath K.

Lancet Gastroenterol Hepatol. 2017 Jan;2(1):63-72. doi: 10.1016/S2468-1253(16)30084-X. Epub 2016 Dec 10. Review.

PMID:
28404017
36.

Response.

Singhi AD, Zeh HJ, Slivka A, McGrath K.

Gastrointest Endosc. 2017 Mar;85(3):686. doi: 10.1016/j.gie.2016.10.028. No abstract available.

PMID:
28215776
37.

Novel Biomarkers for Pancreatic Cysts.

Singh H, McGrath K, Singhi AD.

Dig Dis Sci. 2017 Jul;62(7):1796-1807. doi: 10.1007/s10620-017-4491-4. Epub 2017 Feb 14. Review.

PMID:
28197742
38.

THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.

Panebianco F, Kelly LM, Liu P, Zhong S, Dacic S, Wang X, Singhi AD, Dhir R, Chiosea SI, Kuan SF, Bhargava R, Dabbs D, Trivedi S, Gandhi M, Diaz R, Wald AI, Carty SE, Ferris RL, Lee AV, Nikiforova MN, Nikiforov YE.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2307-2312. doi: 10.1073/pnas.1614265114. Epub 2017 Feb 13.

39.

Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas.

Wood LD, Noë M, Hackeng W, Brosens LA, Bhaijee F, Debeljak M, Yu J, Suenaga M, Singhi AD, Zaheer A, Boyce A, Robinson C, Eshleman JR, Goggins MG, Hruban RH, Collins MT, Lennon AM, Montgomery EA.

Virchows Arch. 2017 Apr;470(4):391-400. doi: 10.1007/s00428-017-2086-2. Epub 2017 Feb 10.

40.

Impact of genomic profiling on the treatment and outcomes of patients with advanced gastrointestinal malignancies.

Dhir M, Choudry HA, Holtzman MP, Pingpank JF, Ahrendt SA, Zureikat AH, Hogg ME, Bartlett DL, Zeh HJ, Singhi AD, Bahary N.

Cancer Med. 2017 Jan;6(1):195-206. doi: 10.1002/cam4.992. Epub 2016 Dec 28.

41.

Crospovidone and Microcrystalline Cellulose: A Novel Description of Pharmaceutical Fillers in the Gastrointestinal Tract.

Shaddy SM, Arnold MA, Shilo K, Frankel WL, Harzman AE, Stanich PP, Singhi AD, Yearsley MM, Arnold CA.

Am J Surg Pathol. 2017 Apr;41(4):564-569. doi: 10.1097/PAS.0000000000000790.

PMID:
28009603
42.

Chronic Pancreatitis.

Stram M, Liu S, Singhi AD.

Surg Pathol Clin. 2016 Dec;9(4):643-659. doi: 10.1016/j.path.2016.05.008. Epub 2016 Oct 12. Review.

PMID:
27926364
43.

Morphology and genetics of pyloric gland adenomas in familial adenomatous polyposis.

Hackeng WM, Montgomery EA, Giardiello FM, Singhi AD, Debeljak M, Eshleman JR, Vieth M, Offerhaus GJ, Wood LD, Brosens LA.

Histopathology. 2017 Mar;70(4):549-557. doi: 10.1111/his.13105. Epub 2016 Dec 13.

44.

Programmed Death-Ligand 1 Expression Is Common in Gastric Cancer Associated With Epstein-Barr Virus or Microsatellite Instability.

Ma C, Patel K, Singhi AD, Ren B, Zhu B, Shaikh F, Sun W.

Am J Surg Pathol. 2016 Nov;40(11):1496-1506.

PMID:
27465786
45.

Lymphoepithelial cyst of pancreas: spectrum of radiological findings with pathologic correlation.

Borhani AA, Fasanella KE, Iranpour N, Zureikat AH, Singhi AD, Furlan A, Dasyam AK.

Abdom Radiol (NY). 2017 Mar;42(3):877-883. doi: 10.1007/s00261-016-0932-3.

PMID:
27738791
46.

The many faces of pancreatic serous cystadenoma: Radiologic and pathologic correlation.

Chu LC, Singhi AD, Haroun RR, Hruban RH, Fishman EK.

Diagn Interv Imaging. 2017 Mar;98(3):191-202. doi: 10.1016/j.diii.2016.08.005. Epub 2016 Sep 7. Review.

47.

Molecular Diagnostics in the Evaluation of Pancreatic Cysts.

Theisen BK, Wald AI, Singhi AD.

Surg Pathol Clin. 2016 Sep;9(3):441-56. doi: 10.1016/j.path.2016.04.008. Review.

PMID:
27523971
48.

Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors.

Singhi AD, Liu TC, Roncaioli JL, Cao D, Zeh HJ, Zureikat AH, Tsung A, Marsh JW, Lee KK, Hogg ME, Bahary N, Brand RE, McGrath KM, Slivka A, Cressman KL, Fuhrer K, O'Sullivan RJ.

Clin Cancer Res. 2017 Jan 15;23(2):600-609. doi: 10.1158/1078-0432.CCR-16-1113. Epub 2016 Jul 12.

49.

Small Bowel Adenocarcinoma Frequently Exhibits Lynch Syndrome-associated Mismatch Repair Protein Deficiency But Does Not Harbor Sporadic MLH1 Deficiency.

Xia M, Singhi AD, Dudley B, Brand R, Nikiforova M, Pai RK.

Appl Immunohistochem Mol Morphol. 2017 Jul;25(6):399-406. doi: 10.1097/PAI.0000000000000389.

PMID:
27258561
50.

Evaluation of indeterminate biliary strictures: Is it time to FISH or cut bait?

Singhi AD, Slivka A.

Gastrointest Endosc. 2016 Jun;83(6):1236-8. doi: 10.1016/j.gie.2016.02.002. No abstract available.

PMID:
27206587

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