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2'-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells.

Nagaprashantha LD, Singhal J, Chikara S, Gugiu G, Horne D, Awasthi S, Salgia R, Singhal SS.

J Proteomics. 2018 Sep 21. pii: S1874-3919(18)30346-4. doi: 10.1016/j.jprot.2018.09.005. [Epub ahead of print]


Metastasis of breast tumor cells to brain is suppressed by targeting RLIP alone and in combination with 2'-Hydroxyflavanone.

Singhal J, Singhal P, Horne D, Salgia R, Awasthi S, Singhal SS.

Cancer Lett. 2018 Dec 1;438:144-153. doi: 10.1016/j.canlet.2018.09.015. Epub 2018 Sep 15.


IgA nephropathy secondary to liver disease.

Singhal J, Sharma J.

Pediatr Nephrol. 2018 Sep 3. doi: 10.1007/s00467-018-4051-y. [Epub ahead of print] No abstract available.


2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76.

Singhal J, Chikara S, Horne D, Salgia R, Awasthi S, Singhal SS.

Mol Carcinog. 2018 Aug 22. doi: 10.1002/mc.22894. [Epub ahead of print]


Biochemical characterization of Plasmodium complement factors binding protein for its role in immune modulation.

Sharma S, Kumar G, Vashishta M, Pandey R, Rathore S, Chourasia BK, Singhal J, Deshmukh A, Kalamuddin M, Paul G, Panda A, Tatiya S, Rawat K, Gupta D, Mohmmed A, Natarajan K, Malhotra P.

Biochem J. 2018 Sep 14;475(17):2877-2891. doi: 10.1042/BCJ20180142.


2'-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer.

Nagaprashantha LD, Singhal J, Li H, Warden C, Liu X, Horne D, Awasthi S, Salgia R, Singhal SS.

Oncotarget. 2018 Apr 6;9(26):18053-18068. doi: 10.18632/oncotarget.24720. eCollection 2018 Apr 6.


Rlip depletion prevents spontaneous neoplasia in TP53 null mice.

Awasthi S, Tompkins J, Singhal J, Riggs AD, Yadav S, Wu X, Singh S, Warden C, Liu Z, Wang J, Slavin TP, Weitzel JN, Yuan YC, Awasthi M, Srivastava SK, Awasthi YC, Singhal SS.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3918-3923. doi: 10.1073/pnas.1719586115. Epub 2018 Mar 23.


Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment.

Chikara S, Nagaprashantha LD, Singhal J, Horne D, Awasthi S, Singhal SS.

Cancer Lett. 2018 Jan 28;413:122-134. doi: 10.1016/j.canlet.2017.11.002. Epub 2017 Nov 4. Review.


2'-Hydroxyflavanone: A novel strategy for targeting breast cancer.

Singhal J, Nagaprashantha L, Chikara S, Awasthi S, Horne D, Singhal SS.

Oncotarget. 2017 Aug 24;8(43):75025-75037. doi: 10.18632/oncotarget.20499. eCollection 2017 Sep 26.


Translational opportunities for broad-spectrum natural phytochemicals and targeted agent combinations in breast cancer.

Dalasanur Nagaprashantha L, Adhikari R, Singhal J, Chikara S, Awasthi S, Horne D, Singhal SS.

Int J Cancer. 2018 Feb 15;142(4):658-670. doi: 10.1002/ijc.31085. Epub 2017 Nov 28. Review.


RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma.

Singhal SS, Nagaprashantha L, Singhal P, Singhal S, Singhal J, Awasthi S, Horne D.

Pharm Res. 2017 Aug;34(8):1673-1682. doi: 10.1007/s11095-017-2154-y. Epub 2017 Apr 6. Review.


Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer.

Singhal SS, Jain D, Singhal P, Awasthi S, Singhal J, Horne D.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):167-175. doi: 10.1016/j.bbcan.2017.03.009. Epub 2017 Mar 28. Review.


Didymin: an orally active citrus flavonoid for targeting neuroblastoma.

Singhal SS, Singhal S, Singhal P, Singhal J, Horne D, Awasthi S.

Oncotarget. 2017 Apr 25;8(17):29428-29441. doi: 10.18632/oncotarget.15204. Review.


SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells.

Figarola JL, Singhal J, Tompkins JD, Rogers GW, Warden C, Horne D, Riggs AD, Awasthi S, Singhal SS.

J Biol Chem. 2015 Dec 18;290(51):30321-41. doi: 10.1074/jbc.M115.686352. Epub 2015 Nov 3.


Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.

Singhal SS, Singh SP, Singhal P, Horne D, Singhal J, Awasthi S.

Toxicol Appl Pharmacol. 2015 Dec 15;289(3):361-70. doi: 10.1016/j.taap.2015.10.006. Epub 2015 Oct 23. Review.


Bucky Tubes Induce Oxidative Stress Mediated Cell Death in Human Lung Cells.

Singhal J, Singh SP, Karuppiah S, Pandey AK.

Biomed Res Int. 2015;2015:560768. doi: 10.1155/2015/560768. Epub 2015 May 18.


RLIP76 Targeted Therapy for Kidney Cancer.

Singhal SS, Singhal J, Figarola J, Horne D, Awasthi S.

Pharm Res. 2015 Oct;32(10):3123-36. doi: 10.1007/s11095-015-1723-1. Epub 2015 May 29. Review.


2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention.

Singhal SS, Singhal J, Figarola JL, Riggs A, Horne D, Awasthi S.

Biochem Pharmacol. 2015 Aug 1;96(3):151-8. doi: 10.1016/j.bcp.2015.04.022. Epub 2015 May 6. Review.


Measurement of Intra-abdominal Pressure in Critically-ill Children.

Singhal J, Shanbag P.

J Clin Diagn Res. 2014 Dec;8(12):PC06-7. doi: 10.7860/JCDR/2014/10435.5345. Epub 2014 Dec 5.


Primary ovarian serous adenocarcinoma with ipsilateral axillary lymph node metastasis: a case report.

Saxena AK, Goyal N, Singhal J, Kumar P.

Indian J Surg Oncol. 2014 Sep;5(3):224-6. doi: 10.1007/s13193-014-0323-6. Epub 2014 Jun 19.


Reciprocal regulation of reactive oxygen species and phospho-CREB regulates voltage gated calcium channel expression during Mycobacterium tuberculosis infection.

Selvakumar A, Antony C, Singhal J, Tiwari BK, Singh Y, Natarajan K.

PLoS One. 2014 May 5;9(5):e96427. doi: 10.1371/journal.pone.0096427. eCollection 2014.


LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells.

Figarola JL, Singhal J, Rahbar S, Awasthi S, Singhal SS.

Apoptosis. 2014 May;19(5):776-88. doi: 10.1007/s10495-014-0974-3.


Parotid gland hemangioma.

Qureshi NA, Singhal J, Sharma J.

Indian Pediatr. 2013 Nov 8;50(11):1071-2. No abstract available.


Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression.

Singhal SS, Figarola J, Singhal J, Nagaprashantha L, Berz D, Rahbar S, Awasthi S.

Biochem Pharmacol. 2013 Dec 15;86(12):1664-72. doi: 10.1016/j.bcp.2013.09.022. Epub 2013 Oct 4.


Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression.

Nagaprashantha LD, Talamantes T, Singhal J, Guo J, Vatsyayan R, Rauniyar N, Awasthi S, Singhal SS, Prokai L.

PLoS One. 2013 Aug 5;8(8):e71654. doi: 10.1371/journal.pone.0071654. Print 2013.


RLIP76 protein knockdown attenuates obesity due to a high-fat diet.

Singhal SS, Figarola J, Singhal J, Reddy MA, Liu X, Berz D, Natarajan R, Awasthi S.

J Biol Chem. 2013 Aug 9;288(32):23394-406. doi: 10.1074/jbc.M113.480194. Epub 2013 Jul 2.


Protective effect of topical application of α-tocopherol and/or N-acetyl cysteine on argemone oil/alkaloid-induced skin tumorigenesis in mice.

Pal A, Alam S, Singhal J, Kumar R, Ansari KM, Das M.

Nutr Cancer. 2013;65 Suppl 1:78-87. doi: 10.1080/01635581.2013.785005.


1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma.

Singhal SS, Figarola J, Singhal J, Leake K, Nagaprashantha L, Lincoln C, Gabriel Gugiu B, Horne D, Jove R, Awasthi S, Rahbar S.

Biochem Pharmacol. 2012 Dec 1;84(11):1419-27. doi: 10.1016/j.bcp.2012.08.020. Epub 2012 Aug 28.


RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer.

Leake K, Singhal J, Nagaprashantha LD, Awasthi S, Singhal SS.

PLoS One. 2012;7(4):e34582. doi: 10.1371/journal.pone.0034582. Epub 2012 Apr 3.


Suppression of dendritic cell-mediated responses by genes in calcium and cysteine protease pathways during Mycobacterium tuberculosis infection.

Singhal J, Agrawal N, Vashishta M, Priya NG, Tiwari BK, Singh Y, Raman R, Natarajan K.

J Biol Chem. 2012 Mar 30;287(14):11108-21. doi: 10.1074/jbc.M111.300319. Epub 2012 Feb 15.


Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma.

Singhal J, Nagaprashantha LD, Vatsyayan R, Ashutosh, Awasthi S, Singhal SS.

Cancer Prev Res (Phila). 2012 Mar;5(3):473-83. doi: 10.1158/1940-6207.CAPR-11-0318. Epub 2011 Dec 15.


Nutlin-3 enhances sorafenib efficacy in renal cell carcinoma.

Vatsyayan R, Singhal J, Nagaprashantha LD, Awasthi S, Singhal SS.

Mol Carcinog. 2013 Jan;52(1):39-48. doi: 10.1002/mc.20875. Epub 2011 Oct 17.


RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome.

Singhal J, Nagaprashantha L, Vatsyayan R, Awasthi S, Singhal SS.

PLoS One. 2011;6(9):e24688. doi: 10.1371/journal.pone.0024688. Epub 2011 Sep 13.


Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer.

Nagaprashantha LD, Vatsyayan R, Singhal J, Fast S, Roby R, Awasthi S, Singhal SS.

Biochem Pharmacol. 2011 Nov 1;82(9):1100-9. doi: 10.1016/j.bcp.2011.07.078. Epub 2011 Jul 23.


Targeting p53-null neuroblastomas through RLIP76.

Singhal J, Yadav S, Nagaprashantha LD, Vatsyayan R, Singhal SS, Awasthi S.

Cancer Prev Res (Phila). 2011 Jun;4(6):879-89. doi: 10.1158/1940-6207.CAPR-11-0025. Epub 2011 Mar 16.


2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma.

Nagaprashantha LD, Vatsyayan R, Singhal J, Lelsani P, Prokai L, Awasthi S, Singhal SS.

Carcinogenesis. 2011 Apr;32(4):568-75. doi: 10.1093/carcin/bgr021. Epub 2011 Feb 8.


Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.

Singhal SS, Wickramarachchi D, Yadav S, Singhal J, Leake K, Vatsyayan R, Chaudhary P, Lelsani P, Suzuki S, Yang S, Awasthi YC, Awasthi S.

Mol Cancer Ther. 2011 Jan;10(1):16-28. doi: 10.1158/1535-7163.MCT-10-0699.


Suppression of TLR2-induced IL-12, reactive oxygen species, and inducible nitric oxide synthase expression by Mycobacterium tuberculosis antigens expressed inside macrophages during the course of infection.

Gupta D, Sharma S, Singhal J, Satsangi AT, Antony C, Natarajan K.

J Immunol. 2010 May 15;184(10):5444-55. doi: 10.4049/jimmunol.0903283. Epub 2010 Apr 12.


A central role of RLIP76 in regulation of glycemic control.

Awasthi S, Singhal SS, Yadav S, Singhal J, Vatsyayan R, Zajac E, Luchowski R, Borvak J, Gryczynski K, Awasthi YC.

Diabetes. 2010 Mar;59(3):714-25. doi: 10.2337/db09-0911. Epub 2009 Dec 10.


hSET1: a novel approach for colon cancer therapy.

Yadav S, Singhal J, Singhal SS, Awasthi S.

Biochem Pharmacol. 2009 May 15;77(10):1635-41. doi: 10.1016/j.bcp.2009.02.019. Epub 2009 Mar 6.


RLIP76: a target for kidney cancer therapy.

Singhal SS, Singhal J, Yadav S, Sahu M, Awasthi YC, Awasthi S.

Cancer Res. 2009 May 15;69(10):4244-51. doi: 10.1158/0008-5472.CAN-08-3521. Epub 2009 May 5. Erratum in: Cancer Res. 2009 Nov 15;69(22):8832.


Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis.

Singhal SS, Yadav S, Vatsyayan R, Chaudhary P, Borvak J, Singhal J, Awasthi S.

Cancer Lett. 2009 Oct 8;283(2):152-8. doi: 10.1016/j.canlet.2009.03.033. Epub 2009 Apr 17.


Sclerotherapy for hydrocele revisited: a prospective randomised study.

Agrawal MS, Yadav H, Upadhyay A, Jaiman R, Singhal J, Singh AK.

Indian J Surg. 2009 Feb;71(1):23-8. doi: 10.1007/s12262-009-0006-7. Epub 2009 Mar 13.


Regression of prostate cancer xenografts by RLIP76 depletion.

Singhal SS, Roth C, Leake K, Singhal J, Yadav S, Awasthi S.

Biochem Pharmacol. 2009 Mar 15;77(6):1074-83. doi: 10.1016/j.bcp.2008.11.013. Epub 2008 Nov 25.


RLIP76: A novel glutathione-conjugate and multi-drug transporter.

Singhal SS, Yadav S, Roth C, Singhal J.

Biochem Pharmacol. 2009 Mar 1;77(5):761-9. doi: 10.1016/j.bcp.2008.10.006. Epub 2008 Oct 15. Review.


The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS.

Warnke MM, Wanigasekara E, Singhal SS, Singhal J, Awasthi S, Armstrong DW.

Anal Bioanal Chem. 2008 Dec;392(7-8):1325-33. doi: 10.1007/s00216-008-2383-3. Epub 2008 Sep 25.


RLIP76 in defense of radiation poisoning.

Singhal J, Singhal SS, Yadav S, Suzuki S, Warnke MM, Yacoub A, Dent P, Bae S, Sharma R, Awasthi YC, Armstrong DW, Awasthi S.

Int J Radiat Oncol Biol Phys. 2008 Oct 1;72(2):553-61. doi: 10.1016/j.ijrobp.2008.06.1497.


Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76.

Singhal SS, Yadav S, Singhal J, Sahu M, Sehrawat A, Awasthi S.

FEBS Lett. 2008 Oct 15;582(23-24):3408-14. doi: 10.1016/j.febslet.2008.09.001. Epub 2008 Sep 18.


Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1.

Singhal SS, Yadav S, Drake K, Singhal J, Awasthi S.

J Biol Chem. 2008 Jul 11;283(28):19714-29. doi: 10.1074/jbc.M708703200. Epub 2008 May 12.


Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1).

Singhal SS, Singhal J, Yadav S, Dwivedi S, Boor PJ, Awasthi YC, Awasthi S.

Cancer Res. 2007 May 1;67(9):4382-9.

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