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Items: 27


The Cross Talk between TbTim50 and PIP39, Two Aspartate-Based Protein Phosphatases, Maintains Cellular Homeostasis in Trypanosoma brucei.

Tripathi A, Singha UK, Paromov V, Hill S, Pratap S, Rose K, Chaudhuri M.

mSphere. 2019 Aug 7;4(4). pii: e00353-19. doi: 10.1128/mSphere.00353-19.


Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei.

Smith JT Jr, Singha UK, Misra S, Chaudhuri M.

mSphere. 2018 Jun 20;3(3). pii: e00204-18. doi: 10.1128/mSphere.00204-18. Print 2018 Jun 27.


The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei.

Weems E, Singha UK, Smith JT, Chaudhuri M.

Mol Biochem Parasitol. 2017 Dec;218:4-15. doi: 10.1016/j.molbiopara.2017.09.003. Epub 2017 Sep 28.


24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei.

Miller MB, Patkar P, Singha UK, Chaudhuri M, David Nes W.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Mar;1862(3):305-313. doi: 10.1016/j.bbalip.2016.12.003. Epub 2016 Dec 6.


Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei.

Leaver DJ, Patkar P, Singha UK, Miller MB, Haubrich BA, Chaudhuri M, Nes WD.

Chem Biol. 2015 Oct 22;22(10):1374-83. doi: 10.1016/j.chembiol.2015.08.017.


Tim62, a Novel Mitochondrial Protein in Trypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex.

Singha UK, Hamilton V, Chaudhuri M.

J Biol Chem. 2015 Sep 18;290(38):23226-39. doi: 10.1074/jbc.M115.663492. Epub 2015 Aug 3.


Down regulation of Tim50 in Trypanosoma brucei increases tolerance to oxidative stress.

Fullerton M, Singha UK, Duncan M, Chaudhuri M.

Mol Biochem Parasitol. 2015 Jan-Feb;199(1-2):9-18. doi: 10.1016/j.molbiopara.2015.03.002. Epub 2015 Mar 16.


Functional complementation analyses reveal that the single PRAT family protein of trypanosoma brucei is a divergent homolog of Tim17 in saccharomyces cerevisiae.

Weems E, Singha UK, Hamilton V, Smith JT, Waegemann K, Mokranjac D, Chaudhuri M.

Eukaryot Cell. 2015 Mar;14(3):286-96. doi: 10.1128/EC.00203-14. Epub 2015 Jan 9.


Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth.

Haubrich BA, Singha UK, Miller MB, Nes CR, Anyatonwu H, Lecordier L, Patkar P, Leaver DJ, Villalta F, Vanhollebeke B, Chaudhuri M, Nes WD.

J Lipid Res. 2015 Feb;56(2):331-41. doi: 10.1194/jlr.M054643. Epub 2014 Nov 25.


Trypanosome alternative oxidase possesses both an N-terminal and internal mitochondrial targeting signal.

Hamilton V, Singha UK, Smith JT, Weems E, Chaudhuri M.

Eukaryot Cell. 2014 Apr;13(4):539-47. doi: 10.1128/EC.00312-13. Epub 2014 Feb 21.


Protein translocase of mitochondrial inner membrane in Trypanosoma brucei.

Singha UK, Hamilton V, Duncan MR, Weems E, Tripathi MK, Chaudhuri M.

J Biol Chem. 2012 Apr 27;287(18):14480-93. doi: 10.1074/jbc.M111.322925. Epub 2012 Mar 9.


Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms.

Nes CR, Singha UK, Liu J, Ganapathy K, Villalta F, Waterman MR, Lepesheva GI, Chaudhuri M, Nes WD.

Biochem J. 2012 Apr 1;443(1):267-77. doi: 10.1042/BJ20111849.


Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei.

Sharma S, Singha UK, Chaudhuri M.

Mol Biochem Parasitol. 2010 Dec;174(2):89-100. doi: 10.1016/j.molbiopara.2010.07.003. Epub 2010 Jul 24.


Downregulation of mitochondrial porin inhibits cell growth and alters respiratory phenotype in Trypanosoma brucei.

Singha UK, Sharma S, Chaudhuri M.

Eukaryot Cell. 2009 Sep;8(9):1418-28. doi: 10.1128/EC.00132-09. Epub 2009 Jul 17.


Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei.

Singha UK, Peprah E, Williams S, Walker R, Saha L, Chaudhuri M.

Mol Biochem Parasitol. 2008 May;159(1):30-43. doi: 10.1016/j.molbiopara.2008.01.003. Epub 2008 Feb 3.


Protein phosphatase 5 is required for Hsp90 function during proteotoxic stresses in Trypanosoma brucei.

Jones C, Anderson S, Singha UK, Chaudhuri M.

Parasitol Res. 2008 Apr;102(5):835-44. doi: 10.1007/s00436-007-0817-z. Epub 2008 Jan 12.


Trypanosoma brucei: differential requirement of membrane potential for import of proteins into mitochondria in two developmental stages.

Williams S, Saha L, Singha UK, Chaudhuri M.

Exp Parasitol. 2008 Mar;118(3):420-33. Epub 2007 Oct 15.


Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells.

Singha UK, Jiang Y, Yu S, Luo M, Lu Y, Zhang J, Xiao G.

J Cell Biochem. 2008 Feb 1;103(2):434-46.


Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma.

Francis LK, Alsayed Y, Leleu X, Jia X, Singha UK, Anderson J, Timm M, Ngo H, Lu G, Huston A, Ehrlich LA, Dimmock E, Lentzsch S, Hideshima T, Roodman GD, Anderson KC, Ghobrial IM.

Clin Cancer Res. 2006 Nov 15;12(22):6826-35.


Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma.

Alsayed Y, Ngo H, Runnels J, Leleu X, Singha UK, Pitsillides CM, Spencer JA, Kimlinger T, Ghobrial JM, Jia X, Lu G, Timm M, Kumar A, Côté D, Veilleux I, Hedin KE, Roodman GD, Witzig TE, Kung AL, Hideshima T, Anderson KC, Lin CP, Ghobrial IM.

Blood. 2007 Apr 1;109(7):2708-17.


Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley rats.

Kokkinakis DM, Rushing EJ, Shareef MM, Ahmed MM, Yang S, Singha UK, Luo J.

J Neuropathol Exp Neurol. 2004 Nov;63(11):1182-99.


Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress.

Kokkinakis DM, Liu X, Chada S, Ahmed MM, Shareef MM, Singha UK, Yang S, Luo J.

Cancer Res. 2004 Oct 15;64(20):7513-25.


Characterization of intracellular metabolites of axenic amastigotes of Leishmania donovani by 1H NMR spectroscopy.

Gupta N, Goyal N, Singha UK, Bhakuni V, Roy R, Rastogi AK.

Acta Trop. 1999 Jul 30;73(2):121-33.


Leishmania donovani: metabolite mapping of promastigotes using proton nuclear magnetic resonance spectroscopy.

Singha UK, Bhakuni V, Ali V, Roy R.

Mol Cell Biochem. 1996 Sep 6;162(1):17-22.


Killing of Leishmania donovani amastigotes by poly ICLC in hamsters.

Bhakuni V, Singha UK, Dutta GP, Levy HB, Maheshwari RK.

J Interferon Cytokine Res. 1996 Apr;16(4):321-5.


Reversal of T-cell unresponsiveness through serine-esterase inhibitors mediated enhanced lymphokine induced microbicidal activities in kala-azar.

Bimal S, Lal SL, Lal CS, Singha UK, Saran R, Sen AB, Sahay VK.

Indian J Exp Biol. 1992 Jan;30(1):54-6.


Drug targeting in Leishmania donovani infections using tuftsin-bearing liposomes as drug vehicles.

Guru PY, Agrawal AK, Singha UK, Singhal A, Gupta CM.

FEBS Lett. 1989 Mar 13;245(1-2):204-8.

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