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Change in Cardiovascular Health and Incident Type 2 Diabetes and Impaired Fasting Glucose: The Whitehall II Study.

Climie RE, van Sloten TT, Périer MC, Tafflet M, Fayosse A, Dugravot A, Singh-Manoux A, Empana JP.

Diabetes Care. 2019 Aug 15. pii: dc190379. doi: 10.2337/dc19-0379. [Epub ahead of print]


Epidemiological transition in morbidity: 10-year data from emergency consultations in Dakar, Senegal.

Gaye B, Diop M, Narayanan K, Offredo L, Reese P, Antignac M, Diop V, Mbacké AB, Boyer Chatenet L, Marijon E, Singh-Manoux A, Diop IB, Jouven X.

BMJ Glob Health. 2019 Jul 19;4(4):e001396. doi: 10.1136/bmjgh-2019-001396. eCollection 2019.


Association of ideal cardiovascular health at age 50 with incidence of dementia: 25 year follow-up of Whitehall II cohort study.

Sabia S, Fayosse A, Dumurgier J, Schnitzler A, Empana JP, Ebmeier KP, Dugravot A, Kivimäki M, Singh-Manoux A.

BMJ. 2019 Aug 7;366:l4414. doi: 10.1136/bmj.l4414.


Association between major surgical admissions and the cognitive trajectory: 19 year follow-up of Whitehall II cohort study.

Krause BM, Sabia S, Manning HJ, Singh-Manoux A, Sanders RD.

BMJ. 2019 Aug 7;366:l4466. doi: 10.1136/bmj.l4466.


Does Poorer Pulmonary Function Accelerate Arterial Stiffening?

Okamoto M, Shipley MJ, Wilkinson IB, McEniery CM, Valencia-Hernández CA, Singh-Manoux A, Kivimaki M, Brunner EJ.

Hypertension. 2019 Aug 5:HYPERTENSIONAHA11913183. doi: 10.1161/HYPERTENSIONAHA.119.13183. [Epub ahead of print]


Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study.

Sommerlad A, Sabia S, Singh-Manoux A, Lewis G, Livingston G.

PLoS Med. 2019 Aug 2;16(8):e1002862. doi: 10.1371/journal.pmed.1002862. eCollection 2019 Aug.


The association between accelerometer-assessed physical activity and respiratory function in older adults differs between smokers and non-smokers.

Benadjaoud MA, Menai M, van Hees VT, Zipunnikov V, Regnaux JP, Kivimäki M, Singh-Manoux A, Sabia S.

Sci Rep. 2019 Jul 16;9(1):10270. doi: 10.1038/s41598-019-46771-y.


Association of Midlife Cardiovascular Risk Profiles With Cerebral Perfusion at Older Ages.

Suri S, Topiwala A, Chappell MA, Okell TW, Zsoldos E, Singh-Manoux A, Kivimäki M, Mackay CE, Ebmeier KP.

JAMA Netw Open. 2019 Jun 5;2(6):e195776. doi: 10.1001/jamanetworkopen.2019.5776.


Biomarker profiles of Alzheimer's disease and dynamic of the association between cerebrospinal fluid levels of β-amyloid peptide and tau.

Lafirdeen ASM, Cognat E, Sabia S, Hourregue C, Lilamand M, Dugravot A, Bouaziz-Amar E, Laplanche JL, Hugon J, Singh-Manoux A, Paquet C, Dumurgier J.

PLoS One. 2019 May 14;14(5):e0217026. doi: 10.1371/journal.pone.0217026. eCollection 2019.


Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis.

Kivimäki M, Singh-Manoux A, Pentti J, Sabia S, Nyberg ST, Alfredsson L, Goldberg M, Knutsson A, Koskenvuo M, Koskinen A, Kouvonen A, Nordin M, Oksanen T, Strandberg T, Suominen SB, Theorell T, Vahtera J, Väänänen A, Virtanen M, Westerholm P, Westerlund H, Zins M, Seshadri S, Batty GD, Sipilä PN, Shipley MJ, Lindbohm JV, Ferrie JE, Jokela M; IPD-Work consortium.

BMJ. 2019 Apr 17;365:l1495. doi: 10.1136/bmj.l1495.


Carotid artery wave intensity in mid- to late-life predicts cognitive decline: the Whitehall II study.

Chiesa ST, Masi S, Shipley MJ, Ellins EA, Fraser AG, Hughes AD, Patel RS, Khir AW, Halcox JP, Singh-Manoux A, Kivimaki M, Celermajer DS, Deanfield JE.

Eur Heart J. 2019 Jul 21;40(28):2300-2309. doi: 10.1093/eurheartj/ehz189.


5-year versus risk-category-specific screening intervals for cardiovascular disease prevention: a cohort study.

Lindbohm JV, Sipilä PN, Mars NJ, Pentti J, Ahmadi-Abhari S, Brunner EJ, Shipley MJ, Singh-Manoux A, Tabak AG, Kivimäki M.

Lancet Public Health. 2019 Apr;4(4):e189-e199. doi: 10.1016/S2468-2667(19)30023-4.


CSF level of β-amyloid peptide predicts mortality in Alzheimer's disease.

Boumenir A, Cognat E, Sabia S, Hourregue C, Lilamand M, Dugravot A, Bouaziz-Amar E, Laplanche JL, Hugon J, Singh-Manoux A, Paquet C, Dumurgier J.

Alzheimers Res Ther. 2019 Mar 28;11(1):29. doi: 10.1186/s13195-019-0481-4.


Association of Midlife Diet With Subsequent Risk for Dementia.

Akbaraly TN, Singh-Manoux A, Dugravot A, Brunner EJ, Kivimäki M, Sabia S.

JAMA. 2019 Mar 12;321(10):957-968. doi: 10.1001/jama.2019.1432.


Predicting cognitive resilience from midlife lifestyle and multi-modal MRI: A 30-year prospective cohort study.

Topiwala A, Suri S, Allan C, Valkanova V, Filippini N, Sexton CE, Heise V, Zsoldos E, Mahmood A, Singh-Manoux A, Mackay CE, Kivimäki M, Ebmeier KP.

PLoS One. 2019 Feb 19;14(2):e0211273. doi: 10.1371/journal.pone.0211273. eCollection 2019.


Raised blood pressure and risk of dementia: our response.

Abell JG, Sabia S, Singh-Manoux A.

Eur Heart J. 2019 Mar 1;40(9):787. doi: 10.1093/eurheartj/ehy917. No abstract available.


Hospitalisation of people with dementia: evidence from English electronic health records from 2008 to 2016.

Sommerlad A, Perera G, Mueller C, Singh-Manoux A, Lewis G, Stewart R, Livingston G.

Eur J Epidemiol. 2019 Jun;34(6):567-577. doi: 10.1007/s10654-019-00481-x. Epub 2019 Jan 16.


Association between gait and cognition in an elderly population based sample.

Valkanova V, Esser P, Demnitz N, Sexton CE, Zsoldos E, Mahmood A, Griffanti L, Kivimäki M, Singh-Manoux A, Dawes H, Ebmeier KP.

Gait Posture. 2018 Sep;65:240-245. doi: 10.1016/j.gaitpost.2018.07.178. Epub 2018 Jul 29.


Green and blue spaces and physical functioning in older adults: Longitudinal analyses of the Whitehall II study.

de Keijzer C, Tonne C, Sabia S, Basagaña X, Valentín A, Singh-Manoux A, Antó JM, Alonso J, Nieuwenhuijsen MJ, Sunyer J, Dadvand P.

Environ Int. 2019 Jan;122:346-356. doi: 10.1016/j.envint.2018.11.046. Epub 2018 Nov 29.


Re: Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008-2016.

Sommerlad A, Perera G, Singh-Manoux A, Lewis G, Stewart R, Livingston G.

Alzheimers Dement. 2019 Feb;15(2):313-314. doi: 10.1016/j.jalz.2018.11.001. Epub 2018 Dec 21. No abstract available.


Association of Change in Cardiovascular Risk Factors With Incident Cardiovascular Events.

van Sloten TT, Tafflet M, Périer MC, Dugravot A, Climie RED, Singh-Manoux A, Empana JP.

JAMA. 2018 Nov 6;320(17):1793-1804. doi: 10.1001/jama.2018.16975.


Reader response: Midlife cardiovascular fitness and dementia: A 44-year longitudinal population study in women.

Kivimäki M, Pentti J, Singh-Manoux A.

Neurology. 2018 Oct 16;91(16):762-763. doi: 10.1212/WNL.0000000000006348. No abstract available.


Obesity and loss of disease-free years owing to major non-communicable diseases: a multicohort study.

Nyberg ST, Batty GD, Pentti J, Virtanen M, Alfredsson L, Fransson EI, Goldberg M, Heikkilä K, Jokela M, Knutsson A, Koskenvuo M, Lallukka T, Leineweber C, Lindbohm JV, Madsen IEH, Magnusson Hanson LL, Nordin M, Oksanen T, Pietiläinen O, Rahkonen O, Rugulies R, Shipley MJ, Stenholm S, Suominen S, Theorell T, Vahtera J, Westerholm PJM, Westerlund H, Zins M, Hamer M, Singh-Manoux A, Bell JA, Ferrie JE, Kivimäki M.

Lancet Public Health. 2018 Oct;3(10):e490-e497. doi: 10.1016/S2468-2667(18)30139-7. Epub 2018 Sep 1.


Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study.

Sabia S, Fayosse A, Dumurgier J, Dugravot A, Akbaraly T, Britton A, Kivimäki M, Singh-Manoux A.

BMJ. 2018 Aug 1;362:k2927. doi: 10.1136/bmj.k2927.


Residential Surrounding Greenness and Cognitive Decline: A 10-Year Follow-up of the Whitehall II Cohort.

de Keijzer C, Tonne C, Basagaña X, Valentín A, Singh-Manoux A, Alonso J, Antó JM, Nieuwenhuijsen MJ, Sunyer J, Dadvand P.

Environ Health Perspect. 2018 Jul 12;126(7):077003. doi: 10.1289/EHP2875. eCollection 2018 Jul.


Unfavorable and favorable changes in modifiable risk factors and incidence of coronary heart disease: The Whitehall II cohort study.

Virtanen M, Vahtera J, Singh-Manoux A, Elovainio M, Ferrie JE, Kivimäki M.

Int J Cardiol. 2018 Oct 15;269:7-12. doi: 10.1016/j.ijcard.2018.07.005. Epub 2018 Jul 5.


Midlife contributors to socioeconomic differences in frailty during later life: a prospective cohort study.

Brunner EJ, Shipley MJ, Ahmadi-Abhari S, Valencia Hernandez C, Abell JG, Singh-Manoux A, Kawachi I, Kivimaki M.

Lancet Public Health. 2018 Jul;3(7):e313-e322. doi: 10.1016/S2468-2667(18)30079-3. Epub 2018 Jun 14.


Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension.

Abell JG, Kivimäki M, Dugravot A, Tabak AG, Fayosse A, Shipley M, Sabia S, Singh-Manoux A.

Eur Heart J. 2018 Sep 1;39(33):3119-3125. doi: 10.1093/eurheartj/ehy288.


Work stress and risk of death in men and women with and without cardiometabolic disease: a multicohort study.

Kivimäki M, Pentti J, Ferrie JE, Batty GD, Nyberg ST, Jokela M, Virtanen M, Alfredsson L, Dragano N, Fransson EI, Goldberg M, Knutsson A, Koskenvuo M, Koskinen A, Kouvonen A, Luukkonen R, Oksanen T, Rugulies R, Siegrist J, Singh-Manoux A, Suominen S, Theorell T, Väänänen A, Vahtera J, Westerholm PJM, Westerlund H, Zins M, Strandberg T, Steptoe A, Deanfield J; IPD-Work consortium.

Lancet Diabetes Endocrinol. 2018 Sep;6(9):705-713. doi: 10.1016/S2213-8587(18)30140-2. Epub 2018 Jun 5.


Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies.

Akbaraly T, Würtz P, Singh-Manoux A, Shipley MJ, Haapakoski R, Lehto M, Desrumaux C, Kähönen M, Lehtimäki T, Mikkilä V, Hingorani A, Humphries SE, Kangas AJ, Soininen P, Raitakari O, Ala-Korpela M, Kivimäki M.

Sci Rep. 2018 Jun 5;8(1):8620. doi: 10.1038/s41598-018-26441-1.


Clinical, socioeconomic, and behavioural factors at age 50 years and risk of cardiometabolic multimorbidity and mortality: A cohort study.

Singh-Manoux A, Fayosse A, Sabia S, Tabak A, Shipley M, Dugravot A, Kivimäki M.

PLoS Med. 2018 May 21;15(5):e1002571. doi: 10.1371/journal.pmed.1002571. eCollection 2018 May.


Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008-2016.

Sommerlad A, Perera G, Singh-Manoux A, Lewis G, Stewart R, Livingston G.

Alzheimers Dement. 2018 Jul;14(7):933-943. doi: 10.1016/j.jalz.2018.02.012. Epub 2018 Apr 25.


Prevention of dementia by targeting risk factors.

Kivimäki M, Singh-Manoux A.

Lancet. 2018 Apr 21;391(10130):1574-1575. doi: 10.1016/S0140-6736(18)30578-6. No abstract available.


Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study.

Zsoldos E, Filippini N, Mahmood A, Mackay CE, Singh-Manoux A, Kivimäki M, Jenkinson M, Ebmeier KP.

Sci Rep. 2018 Apr 23;8(1):6411. doi: 10.1038/s41598-018-24398-9.


Testosterone and All-Cause Mortality in Older Men: The Role of Metabolic Syndrome.

Laouali N, Brailly-Tabard S, Helmer C, Ancelin ML, Tzourio C, Singh-Manoux A, Dugravot A, Elbaz A, Guiochon-Mantel A, Canonico M.

J Endocr Soc. 2018 Feb 26;2(4):322-335. doi: 10.1210/js.2018-00005. eCollection 2018 Apr 1.


Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts.

Tynkkynen J, Chouraki V, van der Lee SJ, Hernesniemi J, Yang Q, Li S, Beiser A, Larson MG, Sääksjärvi K, Shipley MJ, Singh-Manoux A, Gerszten RE, Wang TJ, Havulinna AS, Würtz P, Fischer K, Demirkan A, Ikram MA, Amin N, Lehtimäki T, Kähönen M, Perola M, Metspalu A, Kangas AJ, Soininen P, Ala-Korpela M, Vasan RS, Kivimäki M, van Duijn CM, Seshadri S, Salomaa V.

Alzheimers Dement. 2018 Jun;14(6):723-733. doi: 10.1016/j.jalz.2018.01.003. Epub 2018 Mar 6.


Exploring variability in basal ganglia connectivity with functional MRI in healthy aging.

Griffanti L, Stratmann P, Rolinski M, Filippini N, Zsoldos E, Mahmood A, Zamboni G, Douaud G, Klein JC, Kivimäki M, Singh-Manoux A, Hu MT, Ebmeier KP, Mackay CE.

Brain Imaging Behav. 2018 Dec;12(6):1822-1827. doi: 10.1007/s11682-018-9824-1.


Socioeconomic inequality in recovery from poor physical and mental health in mid-life and early old age: prospective Whitehall II cohort study.

Tanaka A, Shipley MJ, Welch CA, Groce NE, Marmot MG, Kivimaki M, Singh-Manoux A, Brunner EJ.

J Epidemiol Community Health. 2018 Apr;72(4):309-313. doi: 10.1136/jech-2017-209584. Epub 2018 Feb 8.


Cardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms.

Schmitz N, Deschênes SS, Burns RJ, Danna SM, Franco OH, Ikram MA, Kivimäki M, Singh-Manoux A, Tiemeier H.

Br J Psychiatry. 2018 Feb;212(2):96-102. doi: 10.1192/bjp.2017.26.


Long working hours and depressive symptoms: systematic review and meta-analysis of published studies and unpublished individual participant data.

Virtanen M, Jokela M, Madsen IE, Magnusson Hanson LL, Lallukka T, Nyberg ST, Alfredsson L, Batty GD, Bjorner JB, Borritz M, Burr H, Dragano N, Erbel R, Ferrie JE, Heikkilä K, Knutsson A, Koskenvuo M, Lahelma E, Nielsen ML, Oksanen T, Pejtersen JH, Pentti J, Rahkonen O, Rugulies R, Salo P, Schupp J, Shipley MJ, Siegrist J, Singh-Manoux A, Suominen SB, Theorell T, Vahtera J, Wagner GG, Wang JL, Yiengprugsawan V, Westerlund H, Kivimäki M.

Scand J Work Environ Health. 2018 May 1;44(3):239-250. doi: 10.5271/sjweh.3712. Epub 2018 Feb 8.


Transitions across cognitive states and death among older adults in relation to education: A multistate survival model using data from six longitudinal studies.

Robitaille A, van den Hout A, Machado RJM, Bennett DA, Čukić I, Deary IJ, Hofer SM, Hoogendijk EO, Huisman M, Johansson B, Koval AV, van der Noordt M, Piccinin AM, Rijnhart JJM, Singh-Manoux A, Skoog J, Skoog I, Starr J, Vermunt L, Clouston S, Muniz Terrera G.

Alzheimers Dement. 2018 Apr;14(4):462-472. doi: 10.1016/j.jalz.2017.10.003. Epub 2018 Feb 1.


The gait speed advantage of taller stature is lost with age.

Elbaz A, Artaud F, Dugravot A, Tzourio C, Singh-Manoux A.

Sci Rep. 2018 Jan 24;8(1):1485. doi: 10.1038/s41598-018-19882-1.


Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.

van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, Melo van Lent D, Tynkkynen J, Fischer K, Hernesniemi J, Haller T, Singh-Manoux A, Verhoeven A, Willemsen G, de Leeuw FA, Wagner H, van Dongen J, Hertel J, Budde K, Willems van Dijk K, Weinhold L, Ikram MA, Pietzner M, Perola M, Wagner M, Friedrich N, Slagboom PE, Scheltens P, Yang Q, Gertzen RE, Egert S, Li S, Hankemeier T, van Beijsterveldt CEM, Vasan RS, Maier W, Peeters CFW, Jörgen Grabe H, Ramirez A, Seshadri S, Metspalu A, Kivimäki M, Salomaa V, Demirkan A, Boomsma DI, van der Flier WM, Amin N, van Duijn CM.

Alzheimers Dement. 2018 Jun;14(6):707-722. doi: 10.1016/j.jalz.2017.11.012. Epub 2018 Jan 6. Erratum in: Alzheimers Dement. 2019 Feb;15(2):319.


Marriage and risk of dementia: systematic review and meta-analysis of observational studies.

Sommerlad A, Ruegger J, Singh-Manoux A, Lewis G, Livingston G.

J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):231-238. doi: 10.1136/jnnp-2017-316274. Epub 2017 Nov 28.


Body mass index and risk of dementia: Analysis of individual-level data from 1.3 million individuals.

Kivimäki M, Luukkonen R, Batty GD, Ferrie JE, Pentti J, Nyberg ST, Shipley MJ, Alfredsson L, Fransson EI, Goldberg M, Knutsson A, Koskenvuo M, Kuosma E, Nordin M, Suominen SB, Theorell T, Vuoksimaa E, Westerholm P, Westerlund H, Zins M, Kivipelto M, Vahtera J, Kaprio J, Singh-Manoux A, Jokela M.

Alzheimers Dement. 2018 May;14(5):601-609. doi: 10.1016/j.jalz.2017.09.016. Epub 2017 Nov 21.


Structural social relations and cognitive ageing trajectories: evidence from the Whitehall II cohort study.

Elovainio M, Sommerlad A, Hakulinen C, Pulkki-Råback L, Virtanen M, Kivimäki M, Singh-Manoux A.

Int J Epidemiol. 2017 Nov 7. doi: 10.1093/ije/dyx209. [Epub ahead of print]


Vitamin D and cognitive function: A Mendelian randomisation study.

Maddock J, Zhou A, Cavadino A, Kuźma E, Bao Y, Smart MC, Saum KU, Schöttker B, Engmann J, Kjærgaard M, Karhunen V, Zhan Y, Lehtimäki T, Rovio SP, Byberg L, Lahti J, Marques-Vidal P, Sen A, Perna L, Schirmer H, Singh-Manoux A, Auvinen J, Hutri-Kähönen N, Kähönen M, Kilander L, Räikkönen K, Melhus H, Ingelsson E, Guessous I, Petrovic KE, Schmidt H, Schmidt R, Vollenweider P, Lind L, Eriksson JG, Michaëlsson K, Raitakari OT, Hägg S, Pedersen NL, Herzig KH, Järvelin MR, Veijola J, Kivimaki M, Jorde R, Brenner H, Kumari M, Power C, Llewellyn DJ, Hyppönen E.

Sci Rep. 2017 Oct 16;7(1):13230. doi: 10.1038/s41598-017-13189-3.


The level of cognitive function and recognition of emotions in older adults.

Virtanen M, Singh-Manoux A, Batty GD, Ebmeier KP, Jokela M, Harmer CJ, Kivimäki M.

PLoS One. 2017 Oct 4;12(10):e0185513. doi: 10.1371/journal.pone.0185513. eCollection 2017.


Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study.

Singh-Manoux A, Dugravot A, Shipley M, Brunner EJ, Elbaz A, Sabia S, Kivimaki M.

Alzheimers Dement. 2018 Feb;14(2):178-186. doi: 10.1016/j.jalz.2017.06.2637. Epub 2017 Sep 21.


Long working hours as a risk factor for atrial fibrillation: a multi-cohort study.

Kivimäki M, Nyberg ST, Batty GD, Kawachi I, Jokela M, Alfredsson L, Bjorner JB, Borritz M, Burr H, Dragano N, Fransson EI, Heikkilä K, Knutsson A, Koskenvuo M, Kumari M, Madsen IEH, Nielsen ML, Nordin M, Oksanen T, Pejtersen JH, Pentti J, Rugulies R, Salo P, Shipley MJ, Suominen S, Theorell T, Vahtera J, Westerholm P, Westerlund H, Steptoe A, Singh-Manoux A, Hamer M, Ferrie JE, Virtanen M, Tabak AG; IPD-Work consortium.

Eur Heart J. 2017 Sep 7;38(34):2621-2628. doi: 10.1093/eurheartj/ehx324.

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