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Items: 43


The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation.

Murakami R, Singh CR, Morris J, Tang L, Harmon I, Takasu A, Miyoshi T, Ito K, Asano K, Uchiumi T.

Mol Cell Biol. 2018 Jul 30;38(16). pii: e00067-18. doi: 10.1128/MCB.00067-18. Print 2018 Aug 15.


Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy.

Khan A, Mann L, Papanna R, Lyu MA, Singh CR, Olson S, Eissa NT, Cirillo J, Das G, Hunter RL, Jagannath C.

Sci Rep. 2017 Nov 8;7(1):15010. doi: 10.1038/s41598-017-15290-z.


Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide.

Tang L, Morris J, Wan J, Moore C, Fujita Y, Gillaspie S, Aube E, Nanda J, Marques M, Jangal M, Anderson A, Cox C, Hiraishi H, Dong L, Saito H, Singh CR, Witcher M, Topisirovic I, Qian SB, Asano K.

Nucleic Acids Res. 2017 Nov 16;45(20):11941-11953. doi: 10.1093/nar/gkx808.


Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.

Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K.

Cell Rep. 2017 Mar 14;18(11):2651-2663. doi: 10.1016/j.celrep.2017.02.052.


Plasmonic nanomeshes: their ambivalent role as transparent electrodes in organic solar cells.

Stelling C, Singh CR, Karg M, König TA, Thelakkat M, Retsch M.

Sci Rep. 2017 Feb 15;7:42530. doi: 10.1038/srep42530.


The role of colloidal plasmonic nanostructures in organic solar cells.

Singh CR, Honold T, Gujar TP, Retsch M, Fery A, Karg M, Thelakkat M.

Phys Chem Chem Phys. 2016 Aug 17;18(33):23155-63. doi: 10.1039/c6cp04451d.


Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.

Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K.

Nucleic Acids Res. 2016 Oct 14;44(18):8704-8713. Epub 2016 Jun 20.


Alpha-foetoprotein in the diagnosis of prelabour rupture of membranes.

Singh CR, Bhat RG.

J Clin Diagn Res. 2014 Nov;8(11):OC01-2. doi: 10.7860/JCDR/2014/8259.5093. Epub 2014 Nov 20.


Morphology, Crystal Structure and Charge Transport in Donor-Acceptor Block Copolymer Thin Films.

Gupta G, Singh CR, Lohwasser RH, Himmerlich M, Krischok S, Müller-Buschbaum P, Thelakkat M, Hoppe H, Thurn-Albrecht T.

ACS Appl Mater Interfaces. 2015 Jun 17;7(23):12309-18. doi: 10.1021/am5049948. Epub 2014 Dec 22.


Molecular understanding of lung cancers-A review.

Singh CR, Kathiresan K.

Asian Pac J Trop Biomed. 2014 May;4(Suppl 1):S35-41. doi: 10.12980/APJTB.4.2014C597. Review.


TCA cycle-mediated generation of ROS is a key mediator for HeR-MRSA survival under β-lactam antibiotic exposure.

Rosato RR, Fernandez R, Paz LI, Singh CR, Rosato AE.

PLoS One. 2014 Jun 16;9(6):e99605. doi: 10.1371/journal.pone.0099605. eCollection 2014.


1.15 Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain.

Singh CR, Lovell S, Mehzabeen N, Chowdhury WQ, Geanes ES, Battaile KP, Roelofs J.

Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):418-23. doi: 10.1107/S2053230X14003884. Epub 2014 Mar 25.


Mechanisms by which synthetic 6,7-annulated-4-substituted indole compounds with anti-proliferative activity disrupt mitosis and block cytokinesis in human HL-60 tumor cells in vitro.

Perchellet JP, Perchellet EM, Singh CR, Monnett MT, Studer ER, Thornton PD, Brown N, Hill D, Neuenswander B, Lushington GH, Santini C, Buszek KR.

Anticancer Res. 2014 Apr;34(4):1643-55.


The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasome.

De La Mota-Peynado A, Lee SY, Pierce BM, Wani P, Singh CR, Roelofs J.

J Biol Chem. 2013 Oct 11;288(41):29467-81. doi: 10.1074/jbc.M113.491662. Epub 2013 Aug 30.


Exposure of clinical MRSA heterogeneous strains to β-lactams redirects metabolism to optimize energy production through the TCA cycle.

Keaton MA, Rosato RR, Plata KB, Singh CR, Rosato AE.

PLoS One. 2013 Aug 5;8(8):e71025. doi: 10.1371/journal.pone.0071025. Print 2013.


Reconfiguration of the proteasome during chaperone-mediated assembly.

Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D.

Nature. 2013 May 23;497(7450):512-6. doi: 10.1038/nature12123. Epub 2013 May 5.


Targeting of PBP1 by β-lactams determines recA/SOS response activation in heterogeneous MRSA clinical strains.

Plata KB, Riosa S, Singh CR, Rosato RR, Rosato AE.

PLoS One. 2013 Apr 23;8(4):e61083. doi: 10.1371/journal.pone.0061083. Print 2013.


Random mutagenesis of yeast 25S rRNA identify bases critical for 60S subunit structural integrity and function.

Nemoto N, Udagawa T, Chowdhury W, Kitabatake M, Shin BS, Hiraishi H, Wang S, Singh CR, Brown SJ, Ohno M, Asano K.

Translation (Austin). 2013 Sep 10;1(2):e26402. doi: 10.4161/trla.26402. eCollection 2013.


Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode.

Singh CR, Watanabe R, Chowdhury W, Hiraishi H, Murai MJ, Yamamoto Y, Miles D, Ikeda Y, Asano M, Asano K.

Mol Cell Biol. 2012 Oct;32(19):3978-89. doi: 10.1128/MCB.00376-12. Epub 2012 Jul 30.


Mechanisms of translational regulation by a human eIF5-mimic protein.

Singh CR, Watanabe R, Zhou D, Jennings MD, Fukao A, Lee B, Ikeda Y, Chiorini JA, Campbell SG, Ashe MP, Fujiwara T, Wek RC, Pavitt GD, Asano K.

Nucleic Acids Res. 2011 Oct;39(19):8314-28. doi: 10.1093/nar/gkr339. Epub 2011 Jul 10.


Label-free proteomics and systems biology analysis of mycobacterial phagosomes in dendritic cells and macrophages.

Li Q, Singh CR, Ma S, Price ND, Jagannath C.

J Proteome Res. 2011 May 6;10(5):2425-39. doi: 10.1021/pr101245u. Epub 2011 Mar 30.


Analysis of phagosomal proteomes: from latex-bead to bacterial phagosomes.

Li Q, Jagannath C, Rao PK, Singh CR, Lostumbo G.

Proteomics. 2010 Nov;10(22):4098-116. doi: 10.1002/pmic.201000210. Review.


Yeast 18 S rRNA is directly involved in the ribosomal response to stringent AUG selection during translation initiation.

Nemoto N, Singh CR, Udagawa T, Wang S, Thorson E, Winter Z, Ohira T, Ii M, Valásek L, Brown SJ, Asano K.

J Biol Chem. 2010 Oct 15;285(42):32200-12. doi: 10.1074/jbc.M110.146662. Epub 2010 Aug 10.


The eukaryotic initiation factor (eIF) 4G HEAT domain promotes translation re-initiation in yeast both dependent on and independent of eIF4A mRNA helicase.

Watanabe R, Murai MJ, Singh CR, Fox S, Ii M, Asano K.

J Biol Chem. 2010 Jul 16;285(29):21922-33. doi: 10.1074/jbc.M110.132027. Epub 2010 May 12.


A systems biology approach to study the phagosomal proteome modulated by mycobacterial infections.

Rao PK, Singh CR, Jagannath C, Li Q.

Int J Clin Exp Med. 2009 Sep 30;2(3):233-47.


The Delta fbpA mutant derived from Mycobacterium tuberculosis H37Rv has an enhanced susceptibility to intracellular antimicrobial oxidative mechanisms, undergoes limited phagosome maturation and activates macrophages and dendritic cells.

Katti MK, Dai G, Armitige LY, Rivera Marrero C, Daniel S, Singh CR, Lindsey DR, Dhandayuthapani S, Hunter RL, Jagannath C.

Cell Microbiol. 2008 Jun;10(6):1286-303. doi: 10.1111/j.1462-5822.2008.01126.x. Epub 2008 Jan 31.


Cadmium chloride-induced disruption of testicular steroidogenesis in rainbow trout, Oncorhynchus mykiss.

Lizardo-Daudt HM, Bains OS, Singh CR, Kennedy CJ.

Arch Environ Contam Toxicol. 2008 Jul;55(1):103-10.


Eukaryotic initiation factor (eIF) 1 carries two distinct eIF5-binding faces important for multifactor assembly and AUG selection.

Reibarkh M, Yamamoto Y, Singh CR, del Rio F, Fahmy A, Lee B, Luna RE, Ii M, Wagner G, Asano K.

J Biol Chem. 2008 Jan 11;283(2):1094-103. Epub 2007 Nov 1.


Localization and characterization of protein-protein interaction sites.

Singh CR, Asano K.

Methods Enzymol. 2007;429:139-61.


Yeast phenotypic assays on translational control.

Lee B, Udagawa T, Singh CR, Asano K.

Methods Enzymol. 2007;429:105-37.


Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo.

Singh CR, Udagawa T, Lee B, Wassink S, He H, Yamamoto Y, Anderson JT, Pavitt GD, Asano K.

J Mol Biol. 2007 Jul 6;370(2):315-30. Epub 2007 Apr 19.


Relating olfactory neurotoxicity to altered olfactory-mediated behaviors in rainbow trout exposed to three currently-used pesticides.

Tierney KB, Singh CR, Ross PS, Kennedy CJ.

Aquat Toxicol. 2007 Feb 15;81(1):55-64. Epub 2006 Nov 21.


Biosynthetic capacity of rainbow trout (Oncorhynchus mykiss) interrenal tissue after cadmium exposure.

Lizardo-Daudt HM, Bains OS, Singh CR, Kennedy CJ.

Arch Environ Contam Toxicol. 2007 Jan;52(1):90-6. Epub 2006 Oct 9.


An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation.

Singh CR, Lee B, Udagawa T, Mohammad-Qureshi SS, Yamamoto Y, Pavitt GD, Asano K.

EMBO J. 2006 Oct 4;25(19):4537-46. Epub 2006 Sep 21.


The reduced bactericidal function of complement C5-deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacterial phagosomes.

Daniel DS, Dai G, Singh CR, Lindsey DR, Smith AK, Dhandayuthapani S, Hunter RL Jr, Jagannath C.

J Immunol. 2006 Oct 1;177(7):4688-98.


The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G.

Yamamoto Y, Singh CR, Marintchev A, Hall NS, Hannig EM, Wagner G, Asano K.

Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16164-9. Epub 2005 Oct 27.


Eukaryotic translation initiation factor 5 is critical for integrity of the scanning preinitiation complex and accurate control of GCN4 translation.

Singh CR, Curtis C, Yamamoto Y, Hall NS, Kruse DS, He H, Hannig EM, Asano K.

Mol Cell Biol. 2005 Jul;25(13):5480-91.


The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection.

He H, von der Haar T, Singh CR, Ii M, Li B, Hinnebusch AG, McCarthy JE, Asano K.

Mol Cell Biol. 2003 Aug;23(15):5431-45.


Cystitis emphysematosa caused by Candida albicans.

Singh CR, Lytle WF Jr.

J Urol. 1983 Dec;130(6):1171-3.


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